Detailed information for compound 910355

Basic information

Technical information
  • TDR Targets ID: 910355
  • Name: 1-(4-iodophenyl)sulfonylpiperidine
  • MW: 351.204 | Formula: C11H14INO2S
  • H donors: 0 H acceptors: 2 LogP: 2.57 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Ic1ccc(cc1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C11H14INO2S/c12-10-4-6-11(7-5-10)16(14,15)13-8-2-1-3-9-13/h4-7H,1-3,8-9H2
  • InChiKey: OVTHYVDHBBNZJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • EU-0073770
  • Oprea1_456752
  • T5580136
  • ZINC03901895
  • Oprea1_709549

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0043 0.2347 0.286
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0038 0.1845 0.1355
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0091 0.6793 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0566 0.0834
Loa Loa (eye worm) RNA binding protein 0.0126 1 1
Leishmania major hypothetical protein, conserved 0.005 0.2971 0.3862
Loa Loa (eye worm) hypothetical protein 0.0048 0.2802 0.2802
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0566 0.0834
Schistosoma mansoni tar DNA-binding protein 0.0126 1 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0566 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.2901 0.2598
Trypanosoma cruzi GMP reductase 0.0091 0.6793 1
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0091 0.6793 0.5
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0566 0.0834
Trypanosoma brucei GMP reductase 0.0091 0.6793 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0566 0.0834
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.2971 0.4723
Onchocerca volvulus Putative GMP reductase 0.0038 0.1845 1
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0091 0.6793 0.6656
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.2901 0.2598
Brugia malayi MAP kinase sur-1 0.0049 0.2901 0.2474
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.2971 0.0181
Loa Loa (eye worm) IMP dehydrogenase 1 0.0091 0.6793 0.6793
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2901 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.2971 0.4723
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0566 0.0834
Loa Loa (eye worm) hypothetical protein 0.0024 0.0566 0.0566
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0566 0.0834
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0086 0.629 1
Loa Loa (eye worm) TAR-binding protein 0.0126 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.2971 0.0181
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.2802 0.2369
Echinococcus multilocularis tar DNA binding protein 0.0126 1 1
Schistosoma mansoni tar DNA-binding protein 0.0126 1 1
Brugia malayi hypothetical protein 0.0032 0.1325 0.0804
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0091 0.6793 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.2971 0.4723
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0086 0.629 1
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.2901 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.2802 0.2369
Loa Loa (eye worm) hypothetical protein 0.005 0.2971 0.2971
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0038 0.1845 0.1355
Trypanosoma cruzi GMP reductase 0.0091 0.6793 1
Toxoplasma gondii IMP dehydrogenas 0.0091 0.6793 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.2901 0.3749
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0043 0.2347 0.3456
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0566 0.0834
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0566 0.5
Brugia malayi GMP reductase 0.0038 0.1845 0.1355
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0091 0.6793 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0566 0.0834
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.2901 0.2598
Leishmania major inosine-5-monophosphate dehydrogenase 0.0091 0.6793 1
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.2901 0.2598
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0566 0.0834
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.2971 0.0181
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0566 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.2802 0.2802
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.2901 0.3749
Schistosoma mansoni tar DNA-binding protein 0.0126 1 1
Brugia malayi TAR-binding protein 0.0126 1 1
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0091 0.6793 0.6656
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.2901 0.2598
Loa Loa (eye worm) GMP reductase 0.0038 0.1845 0.1845
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0126 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.2971 0.0181
Loa Loa (eye worm) hypothetical protein 0.0033 0.1385 0.1385
Loa Loa (eye worm) hypothetical protein 0.0024 0.0566 0.0566
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0086 0.629 0.926
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0091 0.6793 1
Schistosoma mansoni hypothetical protein 0.0033 0.1385 0.1018
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0091 0.6793 0.6656
Loa Loa (eye worm) hypothetical protein 0.0024 0.0566 0.0566
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0091 0.6793 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0048 0.2771 0.408
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2901 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1385 0.0868
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2901 0.5
Brugia malayi hypothetical protein 0.005 0.2971 0.2549
Echinococcus granulosus tar DNA binding protein 0.0126 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0566 0.0834
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.2901 0.5
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0091 0.6793 0.66
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.2901 0.2901
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0048 0.2771 0.3541
Schistosoma mansoni tar DNA-binding protein 0.0126 1 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0091 0.6793 1
Brugia malayi RNA recognition motif domain containing protein 0.0126 1 1
Leishmania major guanosine monophosphate reductase 0.0091 0.6793 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0091 0.6793 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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