Detailed information for compound 910357

Basic information

Technical information
  • TDR Targets ID: 910357
  • Name: N-(2-bromo-4-nitrophenyl)-1-(4-fluorophenyl)- 5-oxopyrrolidine-3-carboxamide
  • MW: 422.205 | Formula: C17H13BrFN3O4
  • H donors: 1 H acceptors: 4 LogP: 2.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CC(=O)N(C1)c1ccc(cc1)F)Nc1ccc(cc1Br)[N+](=O)[O-]
  • InChi: 1S/C17H13BrFN3O4/c18-14-8-13(22(25)26)5-6-15(14)20-17(24)10-7-16(23)21(9-10)12-3-1-11(19)2-4-12/h1-6,8,10H,7,9H2,(H,20,24)
  • InChiKey: CYZQWWRZXFYLQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-bromo-4-nitro-phenyl)-1-(4-fluorophenyl)-5-oxo-pyrrolidine-3-carboxamide
  • N-(2-bromo-4-nitrophenyl)-1-(4-fluorophenyl)-5-oxo-3-pyrrolidinecarboxamide
  • N-(2-bromo-4-nitro-phenyl)-1-(4-fluorophenyl)-5-keto-pyrrolidine-3-carboxamide
  • Oprea1_178542

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0252 0.1248 0.8145
Echinococcus granulosus histone lysine methyltransferase setb 0.0396 0.2121 0.2104
Echinococcus multilocularis chromobox protein 1 0.0211 0.1002 0.0982
Echinococcus multilocularis cpg binding protein 0.0153 0.0652 0.0632
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0979 0.5642 0.5632
Trypanosoma cruzi ISWI complex protein 0.0217 0.1036 0.7746
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0062 0.0098 0.0125
Loa Loa (eye worm) hypothetical protein 0.0306 0.1573 0.2532
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0328 0.1706 0.1688
Echinococcus multilocularis SAM and MBT domain containing protein 0.0146 0.0606 0.0586
Brugia malayi jmjC domain containing protein 0.0096 0.0309 0.0464
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0181 0.0818 0.0798
Brugia malayi Muscleblind-like protein 0.0306 0.1573 0.2506
Onchocerca volvulus 0.1209 0.7036 1
Schistosoma mansoni hypothetical protein 0.0299 0.1532 0.1514
Onchocerca volvulus 0.0189 0.087 0.0864
Echinococcus granulosus histone acetyltransferase MYST2 0.0166 0.0728 0.0708
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0127 0.0495 0.0309
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0155 0.0661 0.3507
Echinococcus multilocularis chromobox protein 1 0.0211 0.1002 0.0982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0396 0.2121 0.2104
Trichomonas vaginalis bromodomain-containing protein, putative 0.0077 0.019 0.0256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0252 0.1248 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0232 0.0316
Brugia malayi jmjC domain containing protein 0.0096 0.0309 0.0464
Brugia malayi mbt repeat family protein 0.0146 0.0606 0.0944
Schistosoma mansoni methyl-cpg binding protein mbd 0.0242 0.1186 0.1167
Toxoplasma gondii PHD-finger domain-containing protein 0.0098 0.0316 0.0939
Entamoeba histolytica hypothetical protein 0.0113 0.0408 0.5
Plasmodium vivax JmjC domain containing protein 0.0096 0.0309 0.2016
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0299 0.1532 0.1514
Echinococcus multilocularis peregrin 0.0336 0.1757 0.1739
Echinococcus multilocularis beta LACTamase domain containing family member 0.0252 0.1248 0.1229
Loa Loa (eye worm) hypothetical protein 0.0396 0.2121 0.3426
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.1248 0.1761
Loa Loa (eye worm) beta-lactamase 0.0252 0.1248 0.2001
Loa Loa (eye worm) hypothetical protein 0.0544 0.3012 0.488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.1706 0.1688
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.1248 0.1761
Toxoplasma gondii ABC1 family protein 0.0252 0.1248 0.7882
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0252 0.1248 0.1981
Plasmodium vivax SET domain protein, putative 0.0155 0.0661 0.4313
Loa Loa (eye worm) hypothetical protein 0.0118 0.0441 0.0684
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Brugia malayi PHD-finger family protein 0.0363 0.1922 0.307
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.1274 0.2023
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0524 0.0504
Loa Loa (eye worm) RNA binding protein 0.0132 0.0524 0.082
Loa Loa (eye worm) hypothetical protein 0.0132 0.0521 0.0815
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0524 0.0504
Schistosoma mansoni zinc finger protein 0.0288 0.1465 0.1447
Onchocerca volvulus Alhambra homolog 0.0299 0.1532 0.1845
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Schistosoma mansoni hypothetical protein 0.0523 0.2884 0.2868
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0328 0.1706 0.1688
Trichomonas vaginalis esterase, putative 0.0252 0.1248 0.1761
Schistosoma mansoni jumonji/arid domain-containing protein 0.0396 0.2117 0.21
Entamoeba histolytica hypothetical protein 0.0113 0.0408 0.5
Entamoeba histolytica hypothetical protein 0.0113 0.0408 0.5
Echinococcus granulosus geminin 0.0523 0.2884 0.2868
Loa Loa (eye worm) hypothetical protein 0.0615 0.3442 0.558
Trypanosoma cruzi hypothetical protein, conserved 0.0252 0.1248 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0242 0.1186 0.1167
Toxoplasma gondii PHD-finger domain-containing protein 0.0299 0.1532 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.066 0.1032
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0796 0.1119
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0105 0.036 0.042
Trypanosoma brucei ISWI complex protein 0.0217 0.1036 0.7746
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0252 0.1248 0.2001
Leishmania major hypothetical protein, conserved 0.0252 0.1248 1
Brugia malayi Pre-SET motif family protein 0.0155 0.0661 0.1033
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0189 0.087 0.085
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0022 0.0017
Brugia malayi jmjC domain containing protein 0.0979 0.5642 0.9078
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0365 0.0554
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0524 0.0504
Echinococcus granulosus tar DNA binding protein 0.0132 0.0524 0.0504
Echinococcus granulosus muscleblind protein 0.0306 0.1573 0.1555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0155 0.0661 0.0641
Echinococcus granulosus polycomb protein SCMH1 0.0146 0.0606 0.0586
Schistosoma mansoni jumonji domain containing protein 0.0778 0.4426 0.4414
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0326 0.1698 0.168
Loa Loa (eye worm) acetyltransferase 0.0181 0.0818 0.13
Trichomonas vaginalis chromobox protein, putative 0.0211 0.1002 0.1411
Echinococcus granulosus jumonji domain containing 1A 0.0096 0.0309 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Schistosoma mansoni cpg binding protein 0.0119 0.0447 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0252 0.1248 0.1761
Mycobacterium ulcerans lipase LipD 0.0252 0.1248 0.5
Echinococcus granulosus chromobox protein 1 0.0211 0.1002 0.0982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Brugia malayi jmjC domain containing protein 0.0096 0.0309 0.0464
Loa Loa (eye worm) hypothetical protein 0.0166 0.0728 0.1152
Brugia malayi chromobox protein homolog 3 0.0118 0.0441 0.0678
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0509 0.2803 0.2788
Schistosoma mansoni chromobox protein 0.0211 0.1002 0.0982
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Echinococcus multilocularis polycomb protein SCMH1 0.0146 0.0606 0.0586
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0096 0.0309 0.0884
Brugia malayi hypothetical protein 0.0113 0.0408 0.0624
Trichomonas vaginalis set domain proteins, putative 0.1209 0.7036 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0166 0.0728 0.0708
Mycobacterium ulcerans esterase/lipase LipP 0.0252 0.1248 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0146 0.0611 0.0591
Trichomonas vaginalis chromobox protein, putative 0.0127 0.0495 0.069
Trichomonas vaginalis chromobox protein, putative 0.0127 0.0495 0.069
Brugia malayi CHD4 protein 0.0068 0.0139 0.019
Schistosoma mansoni hypothetical protein 0.0292 0.1493 0.1475
Brugia malayi Bromodomain containing protein 0.0336 0.1757 0.2803
Echinococcus multilocularis lysine specific demethylase 6a 0.0096 0.0309 0.0288
Loa Loa (eye worm) hypothetical protein 0.1002 0.5783 0.9401
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0856 0.4902 0.4891
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0098 0.0316 0.0078
Echinococcus granulosus zinc finger protein 0.0288 0.1465 0.1447
Schistosoma mansoni hypothetical protein 0.0308 0.1585 0.1566
Onchocerca volvulus 0.0252 0.1248 0.1424
Loa Loa (eye worm) CHromoDomain protein family member 0.0068 0.0139 0.0192
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0326 0.1698 0.168
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Loa Loa (eye worm) hypothetical protein 0.0146 0.0606 0.0953
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Mycobacterium leprae Probable lipase LipE 0.0252 0.1248 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1609 0.9449 1
Schistosoma mansoni hypothetical protein 0.17 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Mycobacterium leprae conserved hypothetical protein 0.0252 0.1248 0.5
Schistosoma mansoni phd/f-box containing protein 0.0096 0.0309 0.0288
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0574 0.3194 0.3179
Brugia malayi F/Y-rich N-terminus family protein 0.0167 0.0734 0.1151
Schistosoma mansoni zinc finger protein 0.0217 0.1036 0.1017
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0524 0.0504
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0133 0.0529 0.0509
Schistosoma mansoni sex comb on midleg homolog 0.0146 0.0606 0.0586
Mycobacterium ulcerans hypothetical protein 0.0252 0.1248 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Loa Loa (eye worm) heterochromatin protein 1 0.0211 0.1002 0.1599
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0146 0.0606 0.0586
Brugia malayi PHD-finger family protein 0.0132 0.0521 0.0807
Loa Loa (eye worm) mbt repeat family protein 0.0146 0.0606 0.0953
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0146 0.0606 0.0473
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0979 0.5642 0.5632
Echinococcus multilocularis geminin 0.0523 0.2884 0.2868
Trypanosoma cruzi hypothetical protein, conserved 0.0252 0.1248 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0796 0.1119
Echinococcus granulosus lysine specific demethylase 6a 0.0096 0.0309 0.0288
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0328 0.1706 0.2748
Brugia malayi TAR-binding protein 0.0132 0.0524 0.0812
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0068 0.0139 0.0118
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0309 0.0469
Echinococcus multilocularis lysine specific demethylase 5A 0.0362 0.1912 0.1895
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0441 0.0613
Loa Loa (eye worm) hypothetical protein 0.0299 0.1532 0.2465
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.066 0.1032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1063 0.615 1
Brugia malayi Heterochromatin protein 1 0.0211 0.1002 0.1583
Giardia lamblia PHD finger protein 15 0.0299 0.1532 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0155 0.0661 0.0641
Echinococcus granulosus PHD finger protein rhinoceros 0.0299 0.1532 0.1514
Echinococcus granulosus jumonji domain containing protein 0.0416 0.2239 0.2223
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0742 0.0674
Brugia malayi Bromodomain containing protein 0.0546 0.3028 0.4856
Brugia malayi beta-lactamase family protein 0.0252 0.1248 0.1981
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0098 0.0316 0.0078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.1706 0.1688
Leishmania major hypothetical protein, conserved 0.0217 0.1036 0.7746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0524 0.082
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0096 0.0309 0.0288
Schistosoma mansoni hypothetical protein 0.0885 0.5075 0.5065
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0524 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0252 0.1248 0.1229
Loa Loa (eye worm) hypothetical protein 0.0096 0.0309 0.0469
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0259 0.129 0.1271
Schistosoma mansoni hypothetical protein 0.0523 0.2884 0.2868
Schistosoma mansoni hypothetical protein 0.0098 0.0316 0.0295
Trichomonas vaginalis chromobox protein, putative 0.0211 0.1002 0.1411
Plasmodium vivax hypothetical protein, conserved 0.0299 0.1532 1
Echinococcus multilocularis muscleblind protein 1 0.0306 0.1573 0.1555
Brugia malayi AF-10 protein 0.0098 0.0316 0.0476
Brugia malayi beta-lactamase family protein 0.0252 0.1248 0.1981
Loa Loa (eye worm) hypothetical protein 0.0155 0.066 0.1042
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0309 0.0469
Echinococcus multilocularis histone acetyltransferase MYST2 0.0166 0.0728 0.0708
Loa Loa (eye worm) bromodomain containing protein 0.0254 0.1261 0.2022
Echinococcus multilocularis snurportin 1 0.0308 0.1585 0.1566
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.1274 0.1799
Schistosoma mansoni methyl-cpg binding protein mbd 0.0242 0.1186 0.1167
Echinococcus multilocularis JmjC domain containing protein 4 0.0096 0.0309 0.0288
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0396 0.2121 0.2104
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Brugia malayi jmjC domain containing protein 0.0396 0.2117 0.3384
Echinococcus granulosus SAM and MBT domain containing protein 0.0146 0.0606 0.0586
Brugia malayi Bromodomain containing protein 0.1073 0.6212 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.0591 0.057
Schistosoma mansoni hypothetical protein 0.0106 0.0365 0.0344
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0242 0.1186 0.1167
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0098 0.0316 0.0939
Entamoeba histolytica hypothetical protein 0.0113 0.0408 0.5
Echinococcus granulosus JmjC domain containing protein 4 0.0096 0.0309 0.0288
Echinococcus multilocularis phd:f box containing protein 0.0096 0.0309 0.0288
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.0408 0.0387
Echinococcus granulosus chromobox protein 1 0.0211 0.1002 0.0982
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0509 0.2803 0.2788
Brugia malayi RNA binding protein 0.0132 0.0524 0.0812
Toxoplasma gondii histone lysine methyltransferase SET1 0.0269 0.1351 0.865
Brugia malayi Pre-SET motif family protein 0.1063 0.615 0.99
Onchocerca volvulus 0.0119 0.0447 0.0238
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1585 0.255
Echinococcus granulosus beta LACTamase domain containing family member 0.0252 0.1248 0.1229
Brugia malayi CXXC zinc finger family protein 0.0119 0.0447 0.0688
Brugia malayi jmjC domain containing protein 0.0096 0.0309 0.0464
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Brugia malayi PHD-finger family protein 0.0299 0.1532 0.244
Schistosoma mansoni phosphatidylserine receptor 0.0096 0.0309 0.0288
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0328 0.1706 0.1688
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0166 0.0728 0.114
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.0408 0.0387
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0068 0.0139 0.0118
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0856 0.4902 0.4891
Echinococcus granulosus lysine specific demethylase 5A 0.0396 0.2117 0.21
Echinococcus multilocularis jumonji domain containing protein 0.0416 0.2239 0.2223
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.1274 0.2044
Loa Loa (eye worm) hypothetical protein 0.0306 0.1573 0.2532
Echinococcus multilocularis muscleblind protein 0.0306 0.1573 0.1555
Echinococcus granulosus peregrin 0.0336 0.1757 0.1739
Schistosoma mansoni protein phosphatase 2C 0.0096 0.0309 0.0288
Schistosoma mansoni hypothetical protein 0.0113 0.0408 0.0387
Echinococcus granulosus histone acetyltransferase KAT2B 0.0077 0.019 0.0169
Echinococcus multilocularis PHD finger protein rhinoceros 0.0299 0.1532 0.1514
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0166 0.0728 0.0708
Loa Loa (eye worm) jmjC domain-containing protein 0.0617 0.3455 0.5603
Onchocerca volvulus 0.0252 0.1248 0.1424
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0309 0.0469
Schistosoma mansoni cpg binding protein 0.0153 0.0652 0.0632
Schistosoma mansoni jumonji domain containing protein 0.0096 0.0309 0.0288
Loa Loa (eye worm) PHD-finger family protein 0.0299 0.1532 0.2465
Toxoplasma gondii PHD-finger domain-containing protein 0.0299 0.1532 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0155 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0396 0.2121 0.2104
Brugia malayi RNA, U transporter 1 0.0082 0.0221 0.0322
Echinococcus granulosus fetal alzheimer antigen falz 0.0326 0.1698 0.168
Onchocerca volvulus 0.0252 0.1248 0.1424
Plasmodium falciparum phd finger protein, putative 0.0299 0.1532 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Loa Loa (eye worm) MBCTL1 0.0166 0.0728 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0232 0.0316
Brugia malayi MH2 domain containing protein 0.0125 0.0481 0.0743
Trichomonas vaginalis conserved hypothetical protein 0.0118 0.0441 0.0613
Schistosoma mansoni bromodomain containing protein 0.0071 0.0155 0.0134
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0481 0.075
Loa Loa (eye worm) hypothetical protein 0.0106 0.0365 0.056
Schistosoma mansoni bromodomain containing protein 0.0907 0.5209 0.5198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0328 0.1706 0.1688
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0524 0.0504
Mycobacterium ulcerans beta-lactamase 0.0252 0.1248 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0252 0.1248 0.1761
Loa Loa (eye worm) hypothetical protein 0.0096 0.0309 0.0469
Echinococcus granulosus phd:f box containing protein 0.0096 0.0309 0.0288
Schistosoma mansoni jumonji/arid domain-containing protein 0.0396 0.2117 0.21
Brugia malayi acetyltransferase, GNAT family protein 0.0181 0.0818 0.1287
Echinococcus multilocularis zinc finger protein 0.0288 0.1465 0.1447
Schistosoma mansoni cpg binding protein 0.0153 0.0652 0.0632
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0524 0.082
Schistosoma mansoni hypothetical protein 0.0217 0.1036 0.1017
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0077 0.019 0.1242
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0118 0.0441 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0022 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0252 0.1248 1
Brugia malayi mbt repeat family protein 0.0146 0.0606 0.0944
Schistosoma mansoni sex comb on midleg homolog 0.0146 0.0606 0.0586
Loa Loa (eye worm) hypothetical protein 0.0581 0.3237 0.5246
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0252 0.1248 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0481 0.075
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0068 0.0139 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0105 0.036 0.2351
Echinococcus multilocularis jumonji domain containing 1A 0.0096 0.0309 0.0288
Echinococcus multilocularis dnaJ subfamily B 0.17 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0252 0.1248 0.1761
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0077 0.019 0.0256
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.013 0.0514 0.0493
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0062 0.0098 0.0125
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0328 0.1706 0.1688
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.0408 0.0387
Echinococcus granulosus snurportin 1 0.0308 0.1585 0.1566
Echinococcus granulosus cpg binding protein 0.0153 0.0652 0.0632
Trypanosoma cruzi ISWI complex protein 0.0217 0.1036 0.7746
Loa Loa (eye worm) PHD-finger family protein 0.0292 0.1493 0.2401
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0096 0.0309 0.0884
Brugia malayi beta-lactamase 0.0252 0.1248 0.1981
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0574 0.3194 0.3179
Loa Loa (eye worm) CXXC zinc finger family protein 0.0119 0.0447 0.0695
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0181 0.0818 0.0798
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0166 0.0728 0.0708
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0524 0.0504
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0328 0.1706 0.272
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0742 0.1041
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.013 0.0514 0.0493
Onchocerca volvulus 0.0146 0.0606 0.0473
Loa Loa (eye worm) hypothetical protein 0.0252 0.1248 0.2001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0062 0.0098 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0396 0.2117 0.3419
Schistosoma mansoni chromobox protein 0.0211 0.1002 0.0982
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.066 0.1042
Loa Loa (eye worm) hypothetical protein 0.0093 0.0287 0.0432
Loa Loa (eye worm) hypothetical protein 0.0512 0.2822 0.457

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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