Detailed information for compound 910432

Basic information

Technical information
  • TDR Targets ID: 910432
  • Name: 8-(4-methoxyphenyl)-11,11-dimethyl-7,8,10,12- tetrahydropyrido[3,2-a]phenanthridin-9-one
  • MW: 384.47 | Formula: C25H24N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1Nc2ccc3c(c2C2=C1C(=O)CC(C2)(C)C)cccn3
  • InChi: 1S/C25H24N2O2/c1-25(2)13-18-22-17-5-4-12-26-19(17)10-11-20(22)27-24(23(18)21(28)14-25)15-6-8-16(29-3)9-7-15/h4-12,24,27H,13-14H2,1-3H3
  • InChiKey: XCPDYISMPLCKGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • Oprea1_318839
  • Oprea1_163526
  • ChemDiv1_022986
  • A2426/0102772
  • 8-(4-Methoxyphenyl)-11,11-dimethyl-8,10,11,12-tetrahydrobenzo[a][4,7]phenanthrolin-9(7H)-one
  • BAS 02876019

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major putative PfkB family sugar kinase 0.0011 0.0297 0.0309
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.113 0.1175
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0857 0.0891
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0162 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0162 0.0162
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0016 0.0857 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0499 0.0217
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0162 0.0169
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.113 0.1175
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0499 0.0217
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.1476 0.5
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.113 0.1175
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0162 0.0169
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.113 0.1175
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.1476 0.1535
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.1759 0.1829
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0162 0.0162
Echinococcus multilocularis NMDA receptor 0.0016 0.0857 0.0891
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0042 0.3608 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.1759 0.1829
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0162 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0042 0.3608 0.5
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0016 0.0857 0.0891
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0162 0.0162
Leishmania major adenosine kinase-like protein 0.0011 0.0297 0.0309
Brugia malayi Glutamate receptor 2 precursor 0.0016 0.0857 0.0857
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.113 0.0894
Echinococcus granulosus dna polymerase kappa 0.0019 0.113 0.1175
Toxoplasma gondii kinase, pfkB family protein 0.0099 0.9618 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.1759 0.1829
Loa Loa (eye worm) hypothetical protein 0.0019 0.113 0.113
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0162 0.0162
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.1759 0.1829
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0025 0.1759 0.1829
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0162 0.0169
Loa Loa (eye worm) MH2 domain-containing protein 0.0102 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0162 0.0169
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0016 0.0857 0.0891
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0162 0.0162
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0042 0.3608 1
Brugia malayi ecdysteroid receptor 0.001 0.0162 0.0162
Schistosoma mansoni thyroid hormone receptor 0.001 0.0162 0.0169
Brugia malayi Adenosine kinase-like 0.0099 0.9618 0.9618
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.113 0.7064
Entamoeba histolytica kinase, PfkB family 0.0011 0.0297 0.2011
Echinococcus multilocularis nmda type glutamate receptor 0.0059 0.5367 0.558
Loa Loa (eye worm) hypothetical protein 0.0011 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0162 0.0162
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.1476 0.1265
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Mycobacterium leprae Probable adenosine kinase adk 0.0011 0.0297 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Echinococcus granulosus ribokinase 0.0011 0.0297 0.0309
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.113 0.1175
Trypanosoma brucei adenosine kinase, putative 0.0099 0.9618 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Loa Loa (eye worm) glutamate receptor 1 0.0016 0.0857 0.0857
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0016 0.0857 0.0891
Echinococcus granulosus glutamate receptor subunit protein glur 0.0016 0.0857 0.0891
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0162 0.0162
Schistosoma mansoni coup transcription factor 0.001 0.0162 0.0169
Echinococcus granulosus glutamate receptor 2 0.0025 0.1759 0.1829
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0162 0.0162
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0025 0.1759 0.1829
Trypanosoma cruzi adenosine kinase, putative 0.0099 0.9618 1
Schistosoma mansoni adenosine kinase 0.0099 0.9618 1
Entamoeba histolytica Flap nuclease, putative 0.0022 0.1476 1
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0857 0.0891
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.113 0.113
Echinococcus granulosus FTZ F1 alpha 0.001 0.0162 0.0169
Trypanosoma cruzi adenosine kinase, putative 0.0011 0.0297 0.0309
Schistosoma mansoni flap endonuclease-1 0.002 0.1248 0.1297
Leishmania major DNA polymerase eta, putative 0.0019 0.113 0.1175
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.113 0.113
Leishmania major tagatose-6-phosphate kinase-like protein 0.0011 0.0297 0.0309
Leishmania major DNA polymerase kappa, putative 0.0019 0.113 0.1175
Leishmania major adenosine kinase-like protein 0.0011 0.0297 0.0309
Brugia malayi Glutamate receptor 1 precursor 0.0016 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.113 0.1175
Entamoeba histolytica fructokinase, putative 0.0011 0.0297 0.2011
Echinococcus multilocularis dna polymerase kappa 0.0019 0.113 0.1175
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0162 0.0169
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0162 0.0193
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0162 0.0169
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.1476 1
Trypanosoma cruzi adenosine kinase, putative 0.0011 0.0297 0.0309
Onchocerca volvulus 0.0011 0.0297 0.0353
Trypanosoma cruzi ribokinase, putative 0.0011 0.0297 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Schistosoma mansoni nuclear hormone receptor 0.001 0.0162 0.0169
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0162 0.0169
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.113 0.7654
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Schistosoma mansoni glutamate receptor NMDA 0.0025 0.1759 0.1829
Schistosoma mansoni glutamate receptor AMPA 0.0016 0.0857 0.0891
Echinococcus multilocularis ribokinase 0.0011 0.0297 0.0309
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0025 0.1759 0.1829
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Echinococcus multilocularis flap endonuclease 1 0.0022 0.1476 0.1535
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0016 0.0857 0.0891
Echinococcus granulosus dna polymerase eta 0.0019 0.113 0.1175
Echinococcus multilocularis adenosine kinase 0.0099 0.9618 1
Echinococcus granulosus adenosine kinase 0.0099 0.9618 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.1476 1
Plasmodium falciparum flap endonuclease 1 0.0022 0.1476 0.5
Onchocerca volvulus 0.0087 0.8419 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0162 0.0169
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0162 0.0169
Brugia malayi nuclear receptor NHR-88 0.001 0.0162 0.0162
Loa Loa (eye worm) glutamate receptor 2 0.0016 0.0857 0.0857
Giardia lamblia DINP protein human, muc B family 0.0019 0.113 0.7064
Onchocerca volvulus 0.001 0.0162 0.0193
Entamoeba histolytica tagatose-6-phosphate kinase, putative 0.0011 0.0297 0.2011
Leishmania major tagatose-6-phosphate kinase-like protein 0.0011 0.0297 0.0309
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0162 0.0169
Echinococcus multilocularis glutamate receptor 2 0.0016 0.0857 0.0891
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.113 0.7064
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0011 0.0297 0.0309
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0162 0.0169
Brugia malayi nuclear hormone receptor 0.001 0.0162 0.0162
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0042 0.3608 1
Trypanosoma brucei adenosine kinase, putative 0.0099 0.9618 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0162 0.0169
Trypanosoma brucei unspecified product 0.0013 0.0499 0.0217
Trypanosoma cruzi adenosine kinase, putative 0.0099 0.9618 1
Schistosoma mansoni ribokinase 0.0011 0.0297 0.0309
Loa Loa (eye worm) hypothetical protein 0.001 0.0162 0.0162
Loa Loa (eye worm) transcription factor SMAD2 0.0102 1 1
Echinococcus multilocularis glutamate receptor 2 0.0025 0.1759 0.1829
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0162 0.0169
Leishmania major ribokinase, putative 0.0011 0.0297 0.0309
Brugia malayi Ribokinase 0.0011 0.0297 0.0297
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0162 0.0169
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0059 0.5367 0.558
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0857 0.0891
Echinococcus granulosus nmda type glutamate receptor 0.0059 0.5367 0.558
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Echinococcus granulosus flap endonuclease 1 0.0022 0.1476 0.1535
Schistosoma mansoni glutamate receptor kainate 0.0016 0.0857 0.0891
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.1476 0.1535
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.113 0.0894
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.113 0.1175
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0162 0.0162
Leishmania major adenosine kinase, putative 0.0099 0.9618 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0162 0.0169
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.113 0.2516
Schistosoma mansoni glutamate receptor NMDA 0.0016 0.0857 0.0891
Onchocerca volvulus Ribokinase homolog 0.0011 0.0297 0.0353
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.113 0.1175
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.113 0.0894
Echinococcus granulosus glutamate NMDA receptor subunit 0.0016 0.0857 0.0891
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0162 0.0162
Schistosoma mansoni DNA polymerase eta 0.0019 0.113 0.1175
Brugia malayi steroid hormone receptor 0.001 0.0162 0.0162
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0016 0.0857 0.0891
Echinococcus multilocularis dna polymerase eta 0.0019 0.113 0.1175
Schistosoma mansoni ATP-binding cassette transporter 0.0016 0.0857 0.0891
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0499 0.0217
Trypanosoma brucei unspecified product 0.0019 0.113 0.0894
Entamoeba histolytica ribokinase, putative 0.0011 0.0297 0.2011
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0162 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0162 0.0162
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0162 0.0169
Loa Loa (eye worm) hypothetical protein 0.0099 0.9618 0.9618
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0162 0.0169
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.113 0.2516
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0162 0.0169
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0162 0.0169
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.113 0.2516
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0011 0.0297 0.0309
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.113 0.1175
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0162 0.0193
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0162 0.0169
Brugia malayi hypothetical protein 0.0011 0.0297 0.0297
Brugia malayi Flap endonuclease-1 0.0022 0.1476 0.1476
Schistosoma mansoni adenosine kinase 0.0099 0.9618 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.113 0.2516
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0162 0.0162
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0162 0.0162
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0162 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0162 0.0162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0162 0.0169
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.1476 0.1476
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0162 0.0162
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0016 0.0857 0.0891
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.113 0.0894
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.1476 0.1265
Schistosoma mansoni thyroid hormone receptor 0.001 0.0162 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0162 0.0162
Chlamydia trachomatis glutamine binding protein 0.0042 0.3608 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.113 0.0894
Entamoeba histolytica Hypothetical protein T24C12.3, putative 0.0011 0.0297 0.2011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0162 0.0169
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0162 0.0169
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.113 0.1175
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0025 0.1759 0.1829
Onchocerca volvulus Putative pyridoxal kinase 0.0011 0.0297 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0162 0.0162
Schistosoma mansoni hypothetical protein 0.0016 0.0857 0.0891
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0162 0.0169
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.113 0.113
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0042 0.3608 0.5
Trypanosoma brucei unspecified product 0.0013 0.0499 0.0217
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0162 0.0193

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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