Detailed information for compound 910621

Basic information

Technical information
  • TDR Targets ID: 910621
  • Name: 2-amino-4-(5-methyl-4-nitrothiophen-2-yl)-6,7 ,8,9-tetrahydro-5H-cyclohepta[e]pyridine-3-ca rbonitrile
  • MW: 328.389 | Formula: C16H16N4O2S
  • H donors: 1 H acceptors: 4 LogP: 4.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(N)nc2c(c1c1cc(c(s1)C)[N+](=O)[O-])CCCCC2
  • InChi: 1S/C16H16N4O2S/c1-9-13(20(21)22)7-14(23-9)15-10-5-3-2-4-6-12(10)19-16(18)11(15)8-17/h7H,2-6H2,1H3,(H2,18,19)
  • InChiKey: CDLGWSUVIRZOTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(5-methyl-4-nitro-2-thienyl)-6,7,8,9-tetrahydro-5H-cyclohepta[e]pyridine-3-carbonitrile
  • 2-amino-4-(5-methyl-4-nitro-thiophen-2-yl)-6,7,8,9-tetrahydro-5H-cyclohepta[e]pyridine-3-carbonitrile
  • CBMicro_026966
  • Oprea1_492134
  • BIM-0026971.P001
  • Oprea1_823567

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0763 0.2861
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.1699 0.1659
Brugia malayi glutaminase DH11.1 0.0268 0.8795 0.8789
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0763 0.0919
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0419 0.1381
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0551 0.1949
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0551 0.1949
Echinococcus multilocularis muscleblind protein 1 0.0152 0.4809 0.5796
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0763 0.0919
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0551 0.1949
Schistosoma mansoni biogenic amine (5HT) receptor 0.0253 0.8298 0.9428
Echinococcus multilocularis muscleblind protein 0.0152 0.4809 0.5796
Mycobacterium tuberculosis Conserved protein 0.0035 0.0763 0.0929
Trypanosoma cruzi trypanothione reductase, putative 0.0083 0.2421 1
Brugia malayi beta-lactamase family protein 0.0035 0.0763 0.0717
Schistosoma mansoni cpg binding protein 0.0092 0.274 0.3038
Plasmodium falciparum thioredoxin reductase 0.0083 0.2421 1
Echinococcus multilocularis GPCR, family 2 0.0016 0.0097 0.0117
Mycobacterium ulcerans beta-lactamase 0.0035 0.0763 0.0257
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0551 0.0522
Echinococcus multilocularis cpg binding protein 0.0092 0.274 0.3302
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.4402 0.5305
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0763 0.061
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1699 0.1842
Leishmania major hypothetical protein, conserved 0.0035 0.0763 0.2861
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.1508 0.1817
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0189 0.6088 0.8376
Brugia malayi CXXC zinc finger family protein 0.0087 0.2568 0.2532
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0551 0.1949
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0098 0.0118
Loa Loa (eye worm) hypothetical protein 0.0017 0.016 0.016
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0377 0.0322
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0097 0.0117
Onchocerca volvulus 0.0026 0.0473 0.0318
Echinococcus granulosus intermediate filament protein 0.0026 0.0473 0.057
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.1508 1
Brugia malayi hypothetical protein 0.0036 0.0809 0.0764
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0809 0.0975
Onchocerca volvulus 0.0035 0.0763 0.0612
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.4402 0.5305
Loa Loa (eye worm) hypothetical protein 0.0034 0.0721 0.0721
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0377 0.033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0551 0.1949
Schistosoma mansoni lamin 0.0026 0.0473 0.0432
Echinococcus granulosus lamin 0.0026 0.0473 0.057
Schistosoma mansoni ap endonuclease 0.0056 0.1508 0.1622
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.021 0.6817 0.9395
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.1508 0.6068
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1699 0.1842
Onchocerca volvulus 0.0035 0.0763 0.0612
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Brugia malayi beta-lactamase 0.0035 0.0763 0.0717
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0034 0.0721 0.0718
Schistosoma mansoni hypothetical protein 0.0036 0.0809 0.0819
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0185 0.5942 0.672
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0763 0.0929
Brugia malayi TAR-binding protein 0.0062 0.1699 0.1659
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0551 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.4402 0.4374
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0763 0.0929
Schistosoma mansoni cpg binding protein 0.0092 0.274 0.3038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0306 0.0241
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0189 0.6088 0.8797
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0306 0.0369
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0098 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0763 0.0765
Loa Loa (eye worm) thioredoxin reductase 0.0083 0.2421 0.2421
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0377 0.1201
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0809 0.0975
Entamoeba histolytica hypothetical protein 0.0036 0.0809 0.3822
Entamoeba histolytica hypothetical protein 0.0036 0.0809 0.3822
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0763 0.2861
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0763 0.0929
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0551 0.1949
Echinococcus granulosus lamin dm0 0.0026 0.0473 0.057
Schistosoma mansoni intermediate filament proteins 0.0026 0.0473 0.0432
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0287 0.024
Loa Loa (eye worm) hypothetical protein 0.0253 0.8298 0.8298
Mycobacterium tuberculosis Probable oxidoreductase 0.021 0.6817 0.9395
Echinococcus multilocularis musashi 0.0026 0.0473 0.057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0551 0.1949
Plasmodium falciparum glutathione reductase 0.0083 0.2421 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Loa Loa (eye worm) glutaminase 2 0.0268 0.8795 0.8795
Echinococcus multilocularis lamin dm0 0.0026 0.0473 0.057
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0551 0.0664
Entamoeba histolytica hypothetical protein 0.0036 0.0809 0.3822
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0419 0.0622
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.1508 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0419 0.1381
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0097 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4402 0.4949
Brugia malayi Protein kinase domain containing protein 0.0017 0.016 0.0112
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0551 0.1949
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0763 0.0257
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0377 0.033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1508 0.6068
Schistosoma mansoni hypothetical protein 0.0166 0.5284 0.5964
Onchocerca volvulus 0.0035 0.0763 0.0612
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0306 0.0369
Brugia malayi isocitrate dehydrogenase 0.0016 0.0098 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.1508 0.6068
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0551 0.0664
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0763 0.0929
Loa Loa (eye worm) glutaminase 0.0268 0.8795 0.8795
Mycobacterium tuberculosis Conserved protein 0.0035 0.0763 0.0929
Schistosoma mansoni ap endonuclease 0.0056 0.1508 0.1622
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.1508 0.1817
Schistosoma mansoni hypothetical protein 0.0017 0.016 0.0072
Echinococcus multilocularis serotonin receptor 0.0253 0.8298 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.7249 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0763 0.0929
Plasmodium vivax thioredoxin reductase, putative 0.0083 0.2421 1
Loa Loa (eye worm) glutathione reductase 0.0083 0.2421 0.2421
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1259 0.1217
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0763 0.0763
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.049 0.059
Loa Loa (eye worm) hypothetical protein 0.0026 0.0456 0.0456
Brugia malayi intermediate filament protein 0.0026 0.0473 0.0427
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0478 0.0432
Loa Loa (eye worm) hypothetical protein 0.0253 0.8298 0.8298
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0189 0.6088 0.8376
Loa Loa (eye worm) hypothetical protein 0.0049 0.1259 0.1259
Toxoplasma gondii exonuclease III APE 0.0056 0.1508 0.2731
Onchocerca volvulus 0.0302 1 1
Plasmodium falciparum thioredoxin reductase 0.0029 0.0551 0.1949
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0189 0.6088 0.8376
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0098 0.0049
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0763 0.061
Echinococcus multilocularis lamin 0.0026 0.0473 0.057
Brugia malayi beta-lactamase family protein 0.0035 0.0763 0.0717
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0473 0.0427
Brugia malayi hypothetical protein 0.0025 0.0419 0.0372
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.1508 0.6068
Echinococcus granulosus tar DNA binding protein 0.0062 0.1699 0.2048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0763 0.0717
Trichomonas vaginalis glutaminase, putative 0.0268 0.8795 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0551 0.0877
Loa Loa (eye worm) RNA binding protein 0.0062 0.1699 0.1699
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0189 0.6088 0.8376
Toxoplasma gondii histone lysine methyltransferase SET1 0.0165 0.526 1
Plasmodium falciparum glutathione reductase 0.0029 0.0551 0.1949
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.1699 0.1699
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0098 0.0118
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0721 0.0676
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.1508 0.6068
Brugia malayi Thioredoxin reductase 0.0083 0.2421 0.2384
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0419 0.1381
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0377 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4402 0.4949
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0097 0.0117
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0763 0.2861
Loa Loa (eye worm) hypothetical protein 0.0025 0.0419 0.0419
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.016 0.0193
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0083 0.2421 0.3249
Echinococcus multilocularis tar DNA binding protein 0.0062 0.1699 0.2048
Mycobacterium ulcerans lipase LipD 0.0035 0.0763 0.0257
Schistosoma mansoni hypothetical protein 0.0166 0.5284 0.5964
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1508 0.1481
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0097 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0097 0.0117
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0551 0.1949
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.1508 0.1971
Leishmania major hypothetical protein, conserved 0.0017 0.016 0.0267
Trypanosoma brucei trypanothione reductase 0.0083 0.2421 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.1508 1
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0551 0.0633
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Echinococcus granulosus cpg binding protein 0.0092 0.274 0.3302
Toxoplasma gondii kringle domain-containing protein 0.0017 0.016 0.012
Entamoeba histolytica hypothetical protein 0.0036 0.0809 0.3822
Onchocerca volvulus 0.0026 0.0473 0.0318
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.016 0.0267
Echinococcus multilocularis serotonin receptor 0.0253 0.8298 1
Mycobacterium ulcerans glutaminase 0.0268 0.8795 1
Brugia malayi Kringle domain containing protein 0.0017 0.016 0.0112
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0473 0.0473
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0287 0.024
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0763 0.0257
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0377 0.0454
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0098 0.0098
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.016 0.0267
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0306 0.0369
Toxoplasma gondii ABC1 family protein 0.0035 0.0763 0.1288
Echinococcus granulosus GPCR family 2 0.0016 0.0097 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.4402 0.4949
Trichomonas vaginalis esterase, putative 0.0035 0.0763 0.061
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.1508 0.1481
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0763 0.061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.4402 0.5305
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0473 0.0473
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0377 0.1201
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0377 0.0322
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.2568 0.2568
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0551 0.0505
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0097 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1699 0.1842
Trichomonas vaginalis glutathione reductase, putative 0.0029 0.0551 0.0362
Brugia malayi hypothetical protein 0.0016 0.0114 0.0066
Brugia malayi Muscleblind-like protein 0.0152 0.4809 0.4784
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.021 0.6817 0.9395
Loa Loa (eye worm) hypothetical protein 0.0026 0.0473 0.0473
Echinococcus granulosus geminin 0.0166 0.5284 0.6368
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0377 0.054
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.1508 0.1508
Schistosoma mansoni glutaminase 0.0268 0.8795 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1259 0.1259
Leishmania major trypanothione reductase 0.0083 0.2421 1
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0763 0.0929
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0551 0.1949
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.021 0.6817 1
Brugia malayi RNA binding protein 0.0062 0.1699 0.1659
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0551 0.1949
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0049 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1699 0.1842
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0098 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0062 0.1699 0.1699
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.2438 0.2938
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.1508 0.1161
Loa Loa (eye worm) hypothetical protein 0.0152 0.4809 0.4809
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.4402 0.5305
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.2438 0.2938
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0097 0.0049
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0306 0.0369
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0377 0.1201
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.016 0.0267
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0377 0.1201
Onchocerca volvulus 0.0087 0.2568 0.2447
Echinococcus granulosus biogenic amine 5HT receptor 0.0253 0.8298 1
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0809 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0419 0.1381
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0763 0.061
Trichomonas vaginalis mercuric reductase, putative 0.0029 0.0551 0.0362
Schistosoma mansoni tar DNA-binding protein 0.0062 0.1699 0.1842
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0763 0.061
Brugia malayi glutathione reductase 0.0083 0.2421 0.2384
Echinococcus granulosus muscleblind protein 0.0152 0.4809 0.5796
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0377 0.0322
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.016 0.0193
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0377 0.0454
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0763 0.0929
Loa Loa (eye worm) hypothetical protein 0.0302 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0098 0.0118
Leishmania major hypothetical protein, conserved 0.0025 0.0419 0.1381
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Schistosoma mansoni cpg binding protein 0.0087 0.2568 0.2841
Loa Loa (eye worm) hypothetical protein 0.0152 0.4809 0.4809
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0098 0.0118
Loa Loa (eye worm) hypothetical protein 0.0016 0.0097 0.0097
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0551 0.1949
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0419 0.1381
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.1508 0.6068
Mycobacterium ulcerans hypothetical protein 0.0035 0.0763 0.0257
Loa Loa (eye worm) histone methyltransferase 0.0027 0.049 0.049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0763 0.0929
Loa Loa (eye worm) beta-lactamase 0.0035 0.0763 0.0763
Trichomonas vaginalis chaperonin, putative 0.0024 0.0377 0.0159
Mycobacterium tuberculosis Probable dehydrogenase 0.0189 0.6088 0.8376
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0419 0.1381
Toxoplasma gondii thioredoxin reductase 0.0083 0.2421 0.45
Schistosoma mansoni lamin 0.0026 0.0473 0.0432
Giardia lamblia NADH oxidase lateral transfer candidate 0.0029 0.0551 0.1538
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0551 0.0877
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.4402 0.4402
Loa Loa (eye worm) hypothetical protein 0.0035 0.0763 0.0763
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1259 0.1217
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.049 0.059
Echinococcus multilocularis geminin 0.0166 0.5284 0.6368
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0551 0.1949
Plasmodium vivax glutathione reductase, putative 0.0083 0.2421 1
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0377 0.0377
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0098 0.0118
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.1508 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0763 0.2861
Mycobacterium tuberculosis Probable reductase 0.0189 0.6088 0.8376
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.1508 0.1466
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0551 0.1949
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0377 0.1201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0763 0.0765

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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