Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0177 | 0.6418 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0068 | 0.1507 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0068 | 0.1507 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0257 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0068 | 0.1507 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0068 | 0.1507 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0177 | 0.6418 | 0.6372 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.005 | 0.072 | 0.1122 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0177 | 0.6418 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0177 | 0.6418 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0177 | 0.6418 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0257 | 1 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.0177 | 0.6418 | 0.6372 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0046 | 0.0548 | 0.0854 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0068 | 0.1507 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0177 | 0.6418 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.005 | 0.072 | 0.1122 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0177 | 0.6418 | 0.6308 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0041 | 0.0297 | 0.0174 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0177 | 0.6418 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0068 | 0.1507 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.072 | 0.0436 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0177 | 0.6418 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.