Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0109 | 0.2231 | 0.375 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Schistosoma mansoni | tyrosine kinase | 0.0439 | 0.9853 | 1 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0241 | 0.527 | 0.527 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0014 | 0.0041 | 0.0041 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0507 | 0.0507 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0249 | 0.0252 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1433 | 0.1454 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0912 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0198 | 0.4286 | 0.4286 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0096 | 0.0097 |
Echinococcus granulosus | smad | 0.0017 | 0.0096 | 0.0096 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0014 | 0.0041 | 0.0041 |
Echinococcus granulosus | Smad4 | 0.0017 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.3613 | 0.3613 |
Echinococcus granulosus | tar DNA binding protein | 0.0198 | 0.4286 | 0.4286 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.4286 | 0.435 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0507 | 0.0852 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0912 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0507 | 0.0514 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0507 | 0.0507 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0445 | 1 | 1 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0014 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0017 | 0.0096 | 0.0096 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0246 | 0.5393 | 0.5393 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0017 | 0.0096 | 0.0096 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.0912 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0507 | 0.0514 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0041 | 0.0042 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0507 | 0.0507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.4286 | 0.435 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0507 | 0.0507 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0912 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0017 | 0.0096 | 0.0096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.4286 | 0.435 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0912 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0075 | 0.1433 | 0.2408 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.4286 | 0.435 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0017 | 0.0096 | 0.0096 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0249 | 0.0249 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2231 | 0.2231 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0912 | 0.0912 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0074 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0014 | 0.0041 | 0.0041 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0507 | 0.0507 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0507 | 0.0514 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0017 | 0.0096 | 0.0096 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0912 | 0.1534 |
Echinococcus multilocularis | tar DNA binding protein | 0.0198 | 0.4286 | 0.4286 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0486 | 0.0817 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0109 | 0.2231 | 0.2231 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0096 | 0.0161 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0181 | 0.3904 | 0.3904 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Echinococcus granulosus | c src tyrosine kinase | 0.0014 | 0.0041 | 0.0041 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0124 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0507 | 0.0507 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0017 | 0.0096 | 0.0097 |
Echinococcus multilocularis | Smad4 | 0.0017 | 0.0096 | 0.0096 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0096 | 0.0097 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0074 | 0.0074 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0014 | 0.0041 | 0.0041 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0014 | 0.0041 | 0.0041 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0507 | 0.0852 |
Brugia malayi | MH1 domain containing protein | 0.0017 | 0.0096 | 0.0161 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0507 | 0.0507 |
Brugia malayi | RNA binding protein | 0.0198 | 0.4286 | 0.7205 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0014 | 0.0041 | 0.0041 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.1433 | 0.1433 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0014 | 0.0041 | 0.0041 |
Brugia malayi | Smad1 | 0.0017 | 0.0096 | 0.0161 |
Onchocerca volvulus | 0.0241 | 0.527 | 0.5 | |
Brugia malayi | MH2 domain containing protein | 0.0246 | 0.5393 | 0.9067 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Brugia malayi | Pax transcription factor protein 2 | 0.0241 | 0.527 | 0.886 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0246 | 0.5393 | 0.5393 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.027 | 0.5948 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0507 | 0.0514 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0017 | 0.0096 | 0.0096 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0041 | 0.0042 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0124 |
Brugia malayi | SRC-1 | 0.0014 | 0.0041 | 0.007 |
Loa Loa (eye worm) | TAR-binding protein | 0.0198 | 0.4286 | 0.4286 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0912 | 1 |
Echinococcus multilocularis | smad | 0.0017 | 0.0096 | 0.0096 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0041 | 0.0042 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0074 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0074 | 0.0075 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0014 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | SRC-1 | 0.0014 | 0.0041 | 0.0041 |
Schistosoma mansoni | Smad4 | 0.0017 | 0.0096 | 0.0097 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0014 | 0.0041 | 0.0042 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0181 | 0.3904 | 0.6563 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0109 | 0.2231 | 0.375 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0445 | 1 | 1 |
Schistosoma mansoni | smad | 0.0017 | 0.0096 | 0.0097 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0096 | 0.0161 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0912 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0014 | 0.0041 | 0.0041 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0912 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0507 | 0.0507 |
Schistosoma mansoni | tar DNA-binding protein | 0.0198 | 0.4286 | 0.435 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0014 | 0.0041 | 0.0041 |
Brugia malayi | TAR-binding protein | 0.0198 | 0.4286 | 0.7205 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0198 | 0.4286 | 0.7205 |
Loa Loa (eye worm) | Smad1 | 0.0017 | 0.0096 | 0.0096 |
Schistosoma mansoni | tyrosine kinase | 0.0014 | 0.0041 | 0.0042 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0198 | 0.4286 | 0.4286 |
Schistosoma mansoni | smad1 5 8 and | 0.0017 | 0.0096 | 0.0097 |
Brugia malayi | MH2 domain containing protein | 0.0017 | 0.0096 | 0.0161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.