Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0065 | 0.2644 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 0.2644 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 0.2644 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 0.2644 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 0.2644 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 0.2644 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.