Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Trypanosoma brucei | Fatty acid elongase | 0.0109 | 0.1836 | 0.1836 |
Mycobacterium leprae | isoleucyl-tRNA synthetase IleS | 0.0034 | 0.042 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.042 | 0.042 |
Leishmania major | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1836 | 0.1836 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0109 | 0.1836 | 1 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0034 | 0.042 | 0.042 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0017 | 0.0096 | 0.0882 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0048 | 0.0688 | 0.3748 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0109 | 0.1836 | 0.1836 |
Onchocerca volvulus | 0.0109 | 0.1836 | 1 | |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0034 | 0.042 | 0.385 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0109 | 0.1836 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0109 | 0.1836 | 1 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0048 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.042 | 0.042 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0109 | 0.1836 | 1 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0539 | 1 | 1 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0034 | 0.042 | 0.2287 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.0109 | 0.1836 | 0.1836 |
Leishmania major | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0022 | 0.0188 | 0.0188 |
Brugia malayi | methionyl-tRNA synthetase | 0.0062 | 0.0952 | 0.0952 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.005 | 0.005 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0048 | 0.0688 | 0.0688 |
Trypanosoma brucei | Long chain fatty acyl elongase | 0.0109 | 0.1836 | 0.1836 |
Brugia malayi | protein ZK524.3 | 0.0015 | 0.005 | 0.005 |
Loa Loa (eye worm) | ELO-9 protein | 0.0109 | 0.1836 | 0.1836 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0109 | 0.1836 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0096 | 0.0096 |
Mycobacterium ulcerans | isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 0.0494 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0539 | 1 | 1 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0048 | 0.0688 | 0.3748 |
Toxoplasma gondii | fatty acid elongase | 0.0109 | 0.1836 | 0.1836 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 0.4409 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0017 | 0.0096 | 0.101 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.007 | 0.109 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.007 | 0.109 | 0.594 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0022 | 0.0188 | 0.1026 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0052 | 0.0764 | 0.0764 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0109 | 0.1836 | 0.1836 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0109 | 0.1836 | 0.1836 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Trypanosoma brucei | elongation of very long chain fatty acids protein, putative | 0.0109 | 0.1836 | 0.1836 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0109 | 0.1836 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Trypanosoma brucei | Fatty acid elongase | 0.0109 | 0.1836 | 0.1836 |
Onchocerca volvulus | 0.0109 | 0.1836 | 1 | |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0539 | 1 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0109 | 0.1836 | 1 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0109 | 0.1836 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0952 | 0.0952 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0109 | 0.1836 | 0.1836 |
Trypanosoma brucei | Fatty acid elongase | 0.0539 | 1 | 1 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0539 | 1 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.0539 | 1 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0539 | 1 | 1 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0022 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0281 | 0.0281 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0109 | 0.1836 | 0.1836 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0027 | 0.0281 | 0.1533 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.007 | 0.109 | 0.594 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0034 | 0.042 | 0.042 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Brugia malayi | GNS1/SUR4 family protein | 0.0109 | 0.1836 | 0.1836 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0539 | 1 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.042 | 0.4409 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 0.042 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.007 | 0.109 | 0.594 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0062 | 0.0952 | 1 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0034 | 0.042 | 1 |
Brugia malayi | glycyl-tRNA synthetase | 0.0048 | 0.0688 | 0.0688 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0034 | 0.042 | 0.2287 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0109 | 0.1836 | 1 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.042 | 0.042 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0022 | 0.0188 | 0.1026 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0034 | 0.042 | 0.2287 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0017 | 0.0096 | 0.0113 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0109 | 0.1836 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0015 | 0.005 | 0.1188 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0539 | 1 | 1 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0048 | 0.0688 | 0.0688 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0062 | 0.0952 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.046 | 0.8498 | 1 |
Mycobacterium tuberculosis | Isoleucyl-tRNA synthetase IleS | 0.0022 | 0.0189 | 0.0223 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.046 | 0.8498 | 1 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0109 | 0.1836 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0034 | 0.042 | 0.2287 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.0034 | 0.042 | 0.042 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 1 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0027 | 0.0281 | 0.1533 |
Onchocerca volvulus | 0.0027 | 0.0281 | 0.1533 | |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0022 | 0.0188 | 0.4486 |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0034 | 0.042 | 0.042 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0048 | 0.0688 | 0.3748 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0034 | 0.042 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0109 | 0.1836 | 0.1836 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0109 | 0.1836 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0109 | 0.1836 | 0.1836 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0034 | 0.042 | 0.042 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.