Detailed information for compound 911007

Basic information

Technical information
  • TDR Targets ID: 911007
  • Name: 2-amino-4-(4-ethoxyphenyl)-6-methoxypyridine- 3,5-dicarbonitrile
  • MW: 294.308 | Formula: C16H14N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.76 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)c1c(C#N)c(N)nc(c1C#N)OC
  • InChi: 1S/C16H14N4O2/c1-3-22-11-6-4-10(5-7-11)14-12(8-17)15(19)20-16(21-2)13(14)9-18/h4-7H,3H2,1-2H3,(H2,19,20)
  • InChiKey: NPBUHDNKIKSKML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-(4-ethoxyphenyl)-6-methoxy-pyridine-3,5-dicarbonitrile
  • 2-amino-4-(4-ethoxyphenyl)-6-methoxy-dinicotinonitrile
  • BAS 00381298
  • 2-Amino-4-(4-ethoxy-phenyl)-6-methoxy-pyridine-3,5-dicarbonitrile
  • EU-0035176
  • Oprea1_679115
  • ChemDiv1_000943
  • Oprea1_633381

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni zinc finger protein 0.0022 0.0251 0.0251
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.121 0.1209
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0425 0.0423
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0192 0.019
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0192 0.0192
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Leishmania major DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Echinococcus multilocularis tar DNA binding protein 0.0213 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0213 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0192 0.3142
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0192 0.019
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.4289 0.4289
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0103 0.0103
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.1044 0.1043
Brugia malayi MH2 domain containing protein 0.0134 0.5969 0.5968
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.4289 0.4289
Echinococcus multilocularis zinc finger protein 0.0022 0.0251 0.0249
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0611 0.5
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0192 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0611 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.2604 0.2603
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.1044 0.1043
Schistosoma mansoni tar DNA-binding protein 0.0213 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.1943 0.1941
Loa Loa (eye worm) hypothetical protein 0.0044 0.1353 0.1352
Schistosoma mansoni tar DNA-binding protein 0.0213 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.4289 0.4289
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0103 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Loa Loa (eye worm) hypothetical protein 0.0081 0.325 0.3249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.4289 0.4289
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.4289 0.4289
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0192 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0192 0.3142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.1943 0.1941
Loa Loa (eye worm) hypothetical protein 0.002 0.0103 0.0101
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0192 0.019
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0192 0.019
Brugia malayi hypothetical protein 0.003 0.0611 0.0609
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0192 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.5969 0.5968
Schistosoma mansoni hypothetical protein 0.0024 0.0313 0.0313
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0213 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.5969 0.5968
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0611 0.5
Schistosoma mansoni tar DNA-binding protein 0.0213 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0192 0.0192
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0192 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0425 0.0425
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0611 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.4289 0.4289
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0425 0.0423
Brugia malayi Bromodomain containing protein 0.0086 0.3501 0.35
Echinococcus granulosus tar DNA binding protein 0.0213 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.019
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0192 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.4289 0.4289
Schistosoma mansoni tar DNA-binding protein 0.0213 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.2604 0.2603
Brugia malayi hypothetical protein 0.0019 0.0076 0.0075
Loa Loa (eye worm) RNA binding protein 0.0213 1 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0192 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0192 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.4289 0.4289
Brugia malayi PHD-finger family protein 0.0029 0.0564 0.0562
Brugia malayi Bromodomain containing protein 0.0044 0.1349 0.1347
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0313 0.0311
Schistosoma mansoni hypothetical protein 0.0038 0.1044 0.1044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0103 0.0103
Leishmania major hypothetical protein, conserved 0.003 0.0611 1
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0192 0.3142
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Schistosoma mansoni DNA polymerase eta 0.0021 0.0192 0.0192
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0103 0.0101
Loa Loa (eye worm) hypothetical protein 0.0047 0.1492 0.149
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0103 0.0101
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0192 0.3142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.0018 0.0001 0.0001
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.121 0.1209
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0192 0.3142
Loa Loa (eye worm) hypothetical protein 0.0056 0.1943 0.1941
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.4289 0.4289
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Echinococcus granulosus zinc finger protein 0.0022 0.0251 0.0249
Loa Loa (eye worm) TAR-binding protein 0.0213 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0103 0.0103
Echinococcus granulosus dna polymerase eta 0.0021 0.0192 0.019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.1943 0.1941
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0611 0.5
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0139 0.0137
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0103 0.0101
Brugia malayi TAR-binding protein 0.0213 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0611 1
Schistosoma mansoni tar DNA-binding protein 0.0213 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0192 0.3142
Loa Loa (eye worm) hypothetical protein 0.0049 0.1604 0.1602
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0192 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0192 0.5
Echinococcus multilocularis dna polymerase eta 0.0021 0.0192 0.019
Trypanosoma brucei unspecified product 0.0021 0.0192 0.3142
Leishmania major DNA polymerase eta, putative 0.0021 0.0192 0.3142
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0611 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Echinococcus granulosus dna polymerase kappa 0.0021 0.0192 0.019
Giardia lamblia DINP protein human, muc B family 0.0021 0.0192 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0192 0.3142
Schistosoma mansoni bromodomain containing protein 0.0073 0.2814 0.2814
Loa Loa (eye worm) hypothetical protein 0.003 0.0611 0.0609

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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