Detailed information for compound 911199

Basic information

Technical information
  • TDR Targets ID: 911199
  • Name: ethyl 3-cyano-7-methylpyrazolo[1,5-a]pyrimidi ne-6-carboxylate
  • MW: 230.223 | Formula: C11H10N4O2
  • H donors: 0 H acceptors: 4 LogP: 0.66 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(cnc2n1ncc2C#N)C(=O)OCC
  • InChi: 1S/C11H10N4O2/c1-3-17-11(16)9-6-13-10-8(4-12)5-14-15(10)7(9)2/h5-6H,3H2,1-2H3
  • InChiKey: ZAGMWHIPZBPEAT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 3-cyano-7-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylate
  • 3-cyano-7-methyl-6-pyrazolo[1,5-a]pyrimidinecarboxylic acid ethyl ester
  • 3-Cyano-7-methyl-pyrazolo[1,5-a]pyrimidine-6-carboxylic acid ethyl ester
  • BAS 00853320
  • EU-0039007
  • ZINC00077146
  • A1963/0082607

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni alpha-1 adrenergic receptor 0.0947 1 1
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0972 0.0972
Loa Loa (eye worm) G-protein coupled receptor 0.0947 1 1
Schistosoma mansoni opsin-like receptor 0.0947 1 1
Schistosoma mansoni biogenic amine receptor 0.0947 1 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0093 0.199
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0035 0.0035
Schistosoma mansoni survival motor neuron protein 0.0047 0.0335 0.0335
Echinococcus granulosus tm gpcr rhodopsin 0.0947 1 1
Onchocerca volvulus 0.0047 0.0335 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0119 0.0511
Onchocerca volvulus 0.003 0.015 0.0115
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0467 0.0534
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2019 0.1991
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.083 0.874 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0447 0.0447
Onchocerca volvulus 0.0947 1 1
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0035 0.0206 0.0236
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0137 0.3755
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0364 0.0364
Echinococcus granulosus dro:myosuppressin receptor 0.0947 1 1
Echinococcus granulosus sex peptide receptor 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Schistosoma mansoni amine GPCR 0.0947 1 1
Schistosoma mansoni adenoreceptor 0.0947 1 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0947 1 1
Loa Loa (eye worm) TYRA-2 protein 0.0947 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0947 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0467 0.0534
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0035 0.0206 0.0236
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni hypothetical protein 0.0947 1 1
Brugia malayi Dopamine receptor protein 2 0.0947 1 1
Brugia malayi hypothetical protein 0.0232 0.2318 0.2318
Echinococcus granulosus RUN 0.0019 0.0035 0.0035
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0956
Schistosoma mansoni neuropeptide F-like receptor 0.0947 1 1
Mycobacterium tuberculosis Probable reductase 0.0106 0.0963 0.1102
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0325 0.0372
Echinococcus granulosus neuropeptide Y receptor 0.0947 1 1
Loa Loa (eye worm) neuropeptide F receptor 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Leishmania major hypothetical protein, conserved 0.0025 0.0093 0.0956
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0137 0.4201
Echinococcus multilocularis G protein coupled receptor 139 0.0947 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0035 0.1078
Echinococcus granulosus 7tm_1 domain containing protein 0.0947 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0467 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0947 1 1
Plasmodium falciparum glutathione reductase 0.0046 0.0325 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0364 0.0364
Brugia malayi jmjC domain containing protein 0.0058 0.0447 0.0447
Brugia malayi G-protein coupled receptor 0.0947 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0947 1 1
Brugia malayi sulfakinin receptor protein 0.0947 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0972 0.4187
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1309 0.1309
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni neuropeptide receptor 0.0947 1 1
Brugia malayi larval opioid receptor 0.0947 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0364 0.7797
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0972 0.4187
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0447 0.0447
Schistosoma mansoni amine GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0137 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0947 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0947 1 1
Loa Loa (eye worm) esterase D 0.0035 0.0206 0.0172
Loa Loa (eye worm) hypothetical protein 0.0025 0.0093 0.0058
Echinococcus granulosus peptide allatostatin:somatostatin 0.0947 1 1
Echinococcus granulosus expressed conserved protein 0.0091 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni hypothetical protein 0.0947 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0947 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0137 0.4201
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0963 0.1102
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.2855
Schistosoma mansoni neuropeptide F-like receptor 0.0947 1 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0561 0.0561
Schistosoma mansoni loxhd1 0.0019 0.0035 0.0035
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0409 0.0409
Schistosoma mansoni hypothetical protein 0.004 0.0256 0.0256
Schistosoma mansoni lipoxygenase 0.0054 0.0409 0.0409
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0467 0.0534
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0972 0.1112
Mycobacterium ulcerans hypothetical protein 0.0035 0.0206 0.0236
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0137 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0467 0.0467
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0561 0.0561
Onchocerca volvulus 0.0947 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0272 0.1173
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0947 1 1
Brugia malayi hypothetical protein 0.0947 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.013 0.013
Echinococcus granulosus neuropeptide FF receptor 2 0.0947 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0947 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Echinococcus multilocularis neuropeptide receptor 0.0947 1 1
Schistosoma mansoni opsin-like receptor 0.0947 1 1
Brugia malayi chromobox protein homolog 3 0.0038 0.0239 0.0239
Mycobacterium tuberculosis Possible conserved membrane protein 0.0035 0.0206 0.0236
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0947 1 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0947 1 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0142 0.0142
Mycobacterium ulcerans hypothetical protein 0.0035 0.0206 0.0236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0947 1 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.0561 0.0561
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0364 1
Echinococcus granulosus serotonin receptor 0.0947 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0447 0.0447
Echinococcus multilocularis g protein coupled receptor 0.0947 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0325 0.0291
Mycobacterium ulcerans hypothetical protein 0.0035 0.0206 0.0236
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0372 0.0339
Echinococcus granulosus allatostatin A receptor 0.0947 1 1
Echinococcus granulosus neuropeptide Y receptor 0.0947 1 1
Onchocerca volvulus 0.0232 0.2322 0.2295
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0864 0.8709
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0364 0.1568
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0972 0.4187
Loa Loa (eye worm) neuropeptide F receptor 0.0947 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0947 1 1
Echinococcus multilocularis g protein coupled receptor 0.0947 1 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0093 0.2855
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0947 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Brugia malayi AKH receptor 0.0947 1 1
Echinococcus granulosus hypothetical protein 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Echinococcus multilocularis S formylglutathione hydrolase 0.0035 0.0206 0.0206
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0972 0.0972
Brugia malayi Pre-SET motif family protein 0.0204 0.2019 0.2019
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0467 0.0534
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0947 1 1
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0972 0.1112
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.027 0.1163
Trichomonas vaginalis chromobox protein, putative 0.0041 0.027 0.1163
Echinococcus granulosus biogenic amine 5HT receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0467 0.0467
Brugia malayi hypothetical protein 0.0947 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0947 1 1
Echinococcus granulosus neuropeptide receptor A26 0.0947 1 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0864 0.0864
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.083 0.874 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0093 0.0956
Brugia malayi G protein-coupled receptor 0.0947 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0447 0.0413
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0325 0.3347
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0035 0.0206 0.0236
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0947 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0364 0.1568
Brugia malayi Esterase D 0.0035 0.0206 0.0206
Echinococcus multilocularis serotonin receptor 0.0947 1 1
Brugia malayi RE15519p 0.0947 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0364 0.3745
Schistosoma mansoni chromobox protein 0.0068 0.0561 0.0561
Mycobacterium tuberculosis Conserved protein 0.0035 0.0206 0.0236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0864 0.0864
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Toxoplasma gondii thioredoxin reductase 0.0046 0.0325 0.697
Brugia malayi Dopamine receptor protein 1 0.0947 1 1
Brugia malayi G-protein coupled receptor 0.0947 1 1
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0972 1
Onchocerca volvulus 0.0947 1 1
Leishmania major trypanothione reductase 0.0046 0.0325 0.3347
Echinococcus granulosus alpha 1A adrenergic receptor 0.0947 1 1
Schistosoma mansoni neuropeptide receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0364 0.3745
Brugia malayi GnHR receptor homolog 0.0947 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0325 0.0325
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0947 1 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0947 1 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0972 0.0898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0142
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0947 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0142 0.3037
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Echinococcus multilocularis g-protein coupled receptor 0.0947 1 1
Onchocerca volvulus 0.0049 0.0348 0.0314
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0972 0.094
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Brugia malayi neuropeptide F receptor 0.0947 1 1
Echinococcus multilocularis RUN 0.0019 0.0035 0.0035
Echinococcus granulosus g protein coupled receptor 0.0947 1 1
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Echinococcus granulosus 7TM GPCR rhodopsin 0.0947 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0947 1 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0972 0.094
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0947 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.109 0.1247
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0947 1 1
Echinococcus multilocularis serotonin receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0272 0.0238
Trypanosoma brucei trypanothione reductase 0.0046 0.0325 0.3347
Schistosoma mansoni amine GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0947 1 1
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0447 0.0447
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0364 0.0364
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0947 1 1
Brugia malayi follicle stimulating hormone receptor 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Schistosoma mansoni hypothetical protein 0.0047 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.004 0.0256 0.0256
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0561 0.2417
Schistosoma mansoni polycystin 1-related 0.0019 0.0035 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0093 0.0956
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0364 0.3745
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0947 1 1
Brugia malayi phosphofructokinase 0.0107 0.0972 0.0972
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus g protein coupled receptor 0.0947 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0947 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0947 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0364 0.3745
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0035
Echinococcus granulosus neuropeptide receptor 0.0947 1 1
Trypanosoma brucei protein kinase, putative 0.005 0.0364 0.3745
Brugia malayi Serotonin receptor 0.0947 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0561 0.0528
Echinococcus multilocularis g protein coupled receptor 0.0947 1 1
Brugia malayi neuropeptide F receptor 0.0947 1 1
Schistosoma mansoni amine GPCR 0.0947 1 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0947 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0947 1 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0467 0.0467
Brugia malayi putative neuropeptide receptor NPR1 0.0947 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.015 0.0115
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0137 0.2928
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0272 0.0272
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0325 0.0325
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0963 0.1102
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0142 0.0142
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.2318 0.2318
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0325 1
Echinococcus granulosus neuropeptides capa receptor 0.0947 1 1
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0864 0.0864
Echinococcus granulosus orexin receptor type 2 0.0947 1 1
Plasmodium vivax SET domain protein, putative 0.0029 0.0142 0.4358
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1309 0.1309
Schistosoma mansoni hypothetical protein 0.004 0.0256 0.0256
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0035 0.0206 0.0236
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0972 1
Brugia malayi ORL1-like opioid receptor 0.0947 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0142 0.0142
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0137 0.0589
Schistosoma mansoni neuropeptide receptor 0.0947 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0947 1 1
Echinococcus granulosus neuropeptides capa receptor 0.0947 1 1
Brugia malayi Dopamine receptor 0.0947 1 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0272 0.0272
Brugia malayi 6-phosphofructokinase 0.0107 0.0972 0.0972
Echinococcus multilocularis orexin receptor type 2 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0467 0.4803
Schistosoma mansoni amine GPCR 0.0947 1 1
Echinococcus multilocularis somatostatin receptor 0.0947 1 1
Brugia malayi hypothetical protein 0.0947 1 1
Brugia malayi hypothetical protein 0.0025 0.0093 0.0093
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0972 1
Schistosoma mansoni neuropeptide receptor 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0963 0.1102
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0035 0.0206 0.083
Loa Loa (eye worm) glutathione reductase 0.0046 0.0325 0.0291
Brugia malayi hypothetical protein 0.0947 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0947 1 1
Echinococcus granulosus G protein coupled receptor 139 0.0947 1 1
Brugia malayi 6-phosphofructokinase 0.0107 0.0972 0.0972
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.109 0.1036
Brugia malayi jmjC domain containing protein 0.0058 0.0447 0.0447
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.088 0.088
Onchocerca volvulus 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0137 0.2928
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0963 0.0887
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0972 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis fmrfamide receptor 0.0947 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0119 0.0511
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0142
Brugia malayi hypothetical protein 0.0947 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0947 1 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0947 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0364 0.3745
Echinococcus multilocularis neuropeptides capa receptor 0.0947 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0447 0.0447
Mycobacterium tuberculosis Probable conserved exported protein 0.0035 0.0206 0.0236
Echinococcus multilocularis neuropeptides capa receptor 0.0947 1 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.8367 0.8367
Brugia malayi Doublecortin family protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis tumor protein p63 0.0331 0.3386 0.3386
Loa Loa (eye worm) hypothetical protein 0.0311 0.3168 0.3144
Schistosoma mansoni rab6-interacting 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0137 0.2928
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0239 0.1028
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0137 0.4201
Brugia malayi hypothetical protein 0.0947 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0364 0.3745
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0947 1 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0447 0.0447
Echinococcus granulosus tumor protein p63 0.0331 0.3386 0.3386
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0137 0.0589
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0364 0.1568
Brugia malayi Serotonin receptor 0.0947 1 1
Echinococcus granulosus g protein coupled receptor 0.0947 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0364 0.0364
Echinococcus multilocularis dro:myosuppressin receptor 0.0947 1 1
Brugia malayi glutathione reductase 0.0046 0.0325 0.0325
Echinococcus granulosus tm gpcr rhodopsin 0.0947 1 1
Brugia malayi hypothetical protein 0.0947 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0035 0.0035
Schistosoma mansoni neuropeptide f receptor 76f 0.0947 1 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0206 0.0236
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Brugia malayi CHE-14 protein 0.0041 0.0272 0.0272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0947 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0963 0.1102
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Brugia malayi hypothetical protein 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0049 0.0348 0.0314
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0947 1 1
Brugia malayi MAP kinase sur-1 0.005 0.0364 0.0364
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0972 0.0972
Echinococcus granulosus fmrfamide receptor 0.0947 1 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0947 1 1
Echinococcus multilocularis fmrfamide receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis protein patched 0.0041 0.0272 0.0272
Echinococcus multilocularis neuropeptide receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0947 1 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0947 1 1
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0035 0.0206 0.0236
Brugia malayi Heterochromatin protein 1 0.0068 0.0561 0.0561
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.2318 0.2318
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0972 0.4187
Onchocerca volvulus 0.0947 1 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0035 0.0035
Schistosoma mansoni lipoxygenase 0.0019 0.0035 0.0035
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0035 0.1078
Echinococcus granulosus neuropeptide s receptor 0.0947 1 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0972 1
Schistosoma mansoni patched 1 0.0041 0.0272 0.0272
Echinococcus granulosus g-protein coupled receptor 0.0947 1 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0409 0.0409
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0561 0.2417
Loa Loa (eye worm) hypothetical protein 0.0038 0.0239 0.0204
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus somatostatin receptor 0.0947 1 1
Brugia malayi putative neuropeptide receptor 0.0947 1 1
Schistosoma mansoni hypothetical protein 0.0947 1 1
Schistosoma mansoni chromobox protein 0.0068 0.0561 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.0801 0.0801
Trichomonas vaginalis set domain proteins, putative 0.0232 0.2322 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0947 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0142 0.0142
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0947 1 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0947 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0262 0.0262
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0467 0.0467
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0972 1
Schistosoma mansoni myosin xvIII 0.0947 1 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0947 1 1
Echinococcus multilocularis sex peptide receptor 0.0947 1 1
Schistosoma mansoni biogenic amine receptor 0.0947 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0963 0.1102
Schistosoma mansoni hypothetical protein 0.0947 1 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0137 0.1406
Echinococcus multilocularis G-protein coupled receptor, putative 0.0947 1 1
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0035 0.0206 0.0236
Plasmodium falciparum thioredoxin reductase 0.0046 0.0325 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0035 0.0206 0.0236
Echinococcus granulosus S formylglutathione hydrolase 0.0035 0.0206 0.0206
Brugia malayi hypothetical protein 0.0119 0.1109 0.1109
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0972 0.0972
Schistosoma mansoni biogenic amine receptor 0.0947 1 1
Plasmodium vivax glutathione reductase, putative 0.0046 0.0325 1
Echinococcus granulosus chromobox protein 1 0.0068 0.0561 0.0561
Onchocerca volvulus 0.0947 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.109 0.1247
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.083 0.874 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0947 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0137 0.4201
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0947 1 1
Echinococcus multilocularis protein dispatched 1 0.0047 0.0335 0.0335
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0947 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0232 0.2318 0.2291
Brugia malayi hypothetical protein 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0107
Echinococcus multilocularis allatostatin A receptor 0.0947 1 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.027 0.0236
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0093 0.2855
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.109 0.1247
Onchocerca volvulus 0.004 0.0262 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0947 1 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0864 0.0832
Onchocerca volvulus 0.0947 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0947 1 1
Echinococcus granulosus neuropeptide receptor 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Brugia malayi Thioredoxin reductase 0.0046 0.0325 0.0325
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0 0.5
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0447 0.0447
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0972 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0364 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0239 0.1028
Brugia malayi hypothetical protein 0.0947 1 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0364 0.1568
Onchocerca volvulus 0.0947 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0335 0.0335
Schistosoma mansoni histamine h1 receptor 0.0947 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0947 1 1
Brugia malayi Melatonin receptor type 1A 0.0947 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0348 0.0348
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0239 0.0204
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0947 1 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0272 0.0238
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0972 0.094
Loa Loa (eye worm) hypothetical protein 0.0947 1 1
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0364 0.0364
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0947 1 1
Onchocerca volvulus 0.0947 1 1
Schistosoma mansoni opsin-like receptor 0.0947 1 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0364 0.3745
Schistosoma mansoni hypothetical protein 0.004 0.0256 0.0256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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