Detailed information for compound 911306

Basic information

Technical information
  • TDR Targets ID: 911306
  • Name: 2,5,7-Trimethyl-3-phenylpyrazolo[1,5-a]pyrimi dine
  • MW: 237.3 | Formula: C15H15N3
  • H donors: 0 H acceptors: 2 LogP: 3.15 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)n2c(n1)c(c1ccccc1)c(n2)C
  • InChi: 1S/C15H15N3/c1-10-9-11(2)18-15(16-10)14(12(3)17-18)13-7-5-4-6-8-13/h4-9H,1-3H3
  • InChiKey: KOCNNZCICBXQFP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2,5,7-Trimethyl-3-phenyl-pyrazolo[1,5-a]pyrimidine
  • Pyrazolo[1,5-a]pyrimidine, 2,5,7-trimethyl-3-phenyl-
  • STK184943
  • MLS001077184
  • SMR000472967
  • BAS 00523570
  • ZINC00326937

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Carboxylesterase family protein 0.0045 0.0999 0.1291
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.003 0.0622 0.1121
Loa Loa (eye worm) hypothetical protein 0.0014 0.019 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0026 0.0504 0.0489
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0045 0.0999 0.0985
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0372 0.3372
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0622 0.0607
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0197 0.0189
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Trichomonas vaginalis spcc417.12 protein, putative 0.0045 0.0999 0.9045
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0045 0.0999 0.0985
Brugia malayi CXXC zinc finger family protein 0.0028 0.0552 0.0679
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0152 0.0137
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.019 0.0183
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0622 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Brugia malayi ORL1-like opioid receptor 0.003 0.0622 0.0775
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0504 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0504 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0504 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0622 0.0775
Echinococcus granulosus neuroligin 0.0045 0.0999 0.0985
Onchocerca volvulus 0.003 0.0622 0.1121
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1104 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0622 0.0607
Echinococcus multilocularis para nitrobenzyl esterase 0.0045 0.0999 0.0985
Plasmodium vivax multidomain scavenger receptor, putative 0.0041 0.0888 1
Echinococcus multilocularis g protein coupled receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.003 0.0622 0.1121
Echinococcus granulosus lamin dm0 0.0026 0.0508 0.0493
Loa Loa (eye worm) carboxylesterase 0.0045 0.0999 0.1288
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni nuclear receptor nhr-48 0.0012 0.0152 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Mycobacterium tuberculosis Carboxylesterase LipT 0.0045 0.0999 1
Loa Loa (eye worm) nuclear hormone receptor 0.0012 0.0152 0.0128
Echinococcus granulosus allatostatin A receptor 0.003 0.0622 0.0607
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0012 0.0152 0.0132
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0622 0.0771
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0622 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0504 0.061
Echinococcus multilocularis fmrfamide receptor 0.003 0.0622 0.0607
Schistosoma mansoni lipoxygenase 0.0041 0.0888 0.0874
Brugia malayi MAP kinase sur-1 0.0049 0.1104 0.1435
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0622 0.0775
Onchocerca volvulus Bile acid receptor homolog 0.0175 0.434 1
Onchocerca volvulus 0.003 0.0622 0.1121
Brugia malayi hypothetical protein 0.0045 0.0999 0.1291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0504 0.0613
Schistosoma mansoni amine GPCR 0.003 0.0622 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0504 0.061
Echinococcus multilocularis pikachurin 0.0024 0.0444 0.0429
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0622 0.0607
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0622 0.0607
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0504 0.0489
Loa Loa (eye worm) acetylcholinesterase 1 0.0267 0.6706 0.9109
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0888 0.0874
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0622 0.0607
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.1104 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Schistosoma mansoni hypothetical protein 0.0358 0.9035 0.9033
Echinococcus multilocularis lamin 0.0026 0.0508 0.0493
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0504 0.0613
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0622 0.0607
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0012 0.0152 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Onchocerca volvulus 0.003 0.0622 0.1121
Echinococcus multilocularis Polycystic kidney disease protein 0.0041 0.0888 0.0874
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0622 0.0607
Brugia malayi G-protein coupled receptor 0.003 0.0622 0.0775
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Schistosoma mansoni opsin-like receptor 0.003 0.0622 0.0607
Brugia malayi putative neuropeptide receptor 0.003 0.0622 0.0775
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Dopamine receptor 0.003 0.0622 0.0775
Schistosoma mansoni cellular tumor antigen P53 0.0056 0.1286 0.1273
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0444 0.0429
Echinococcus multilocularis musashi 0.0026 0.0508 0.0493
Loa Loa (eye worm) hypothetical protein 0.0041 0.0888 0.1136
Schistosoma mansoni loxhd1 0.0041 0.0888 0.0874
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis lamin dm0 0.0026 0.0508 0.0493
Schistosoma mansoni gliotactin 0.0045 0.0999 0.0985
Schistosoma mansoni adenoreceptor 0.003 0.0622 0.0607
Echinococcus multilocularis RUN 0.0041 0.0888 0.0874
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0504 0.0489
Brugia malayi tailless protein 0.0012 0.0152 0.0132
Loa Loa (eye worm) hypothetical protein 0.0041 0.0888 0.1136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0504 0.061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.119 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0622 0.0607
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0444 0.0531
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0444 0.0531
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.2777 0.2766
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0504 0.0613
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0622 0.0771
Echinococcus multilocularis orexin receptor type 2 0.003 0.0622 0.0607
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0999 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0508 0.0619
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0372 0.5
Schistosoma mansoni amine GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis tumor protein p63 0.0385 0.9732 0.9731
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0622 0.0607
Echinococcus multilocularis slit 2 protein 0.0024 0.0444 0.0429
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0444 0.0527
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0622 0.0607
Schistosoma mansoni intermediate filament proteins 0.0026 0.0508 0.0493
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0622 0.0607
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Brugia malayi Carboxylesterase family protein 0.0045 0.0999 0.1291
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Schistosoma mansoni myosin xvIII 0.003 0.0622 0.0607
Onchocerca volvulus 0.0045 0.0999 0.2021
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0504 0.0613
Brugia malayi hypothetical protein 0.0012 0.0152 0.0132
Echinococcus granulosus neuropeptide receptor 0.003 0.0622 0.0607
Schistosoma mansoni coup transcription factor 0.0026 0.0504 0.0489
Brugia malayi Doublecortin family protein 0.0041 0.0888 0.1139
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0026 0.0504 0.0489
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0622 0.0607
Echinococcus multilocularis acetylcholinesterase 0.0267 0.6706 0.6701
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.1104 0.109
Schistosoma mansoni hypothetical protein 0.0358 0.9035 0.9033
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0999 0.0985
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0622 0.0607
Echinococcus granulosus pikachurin 0.0024 0.0444 0.0429
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus granulosus carboxylesterase 5A 0.0267 0.6706 0.6701
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0372 0.0357
Echinococcus multilocularis carboxylesterase 5A 0.0267 0.6706 0.6701
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.0504 0.0489
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0622 0.0607
Schistosoma mansoni acetylcholinesterase 0.0045 0.0999 0.0985
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0622 0.0607
Trypanosoma brucei protein kinase, putative 0.0049 0.1104 1
Schistosoma mansoni amine GPCR 0.003 0.0622 0.0607
Onchocerca volvulus 0.0045 0.0999 0.2021
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0197 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0504 0.061
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0013 0.0162 0.0141
Echinococcus granulosus Polycystic kidney disease protein 0.0041 0.0888 0.0874
Onchocerca volvulus 0.0045 0.0999 0.2021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0504 0.0613
Onchocerca volvulus 0.003 0.0622 0.1121
Brugia malayi ecdysone receptor 0.0012 0.0152 0.0132
Brugia malayi hypothetical protein 0.0041 0.0888 0.1139
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Schistosoma mansoni hypothetical protein 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0622 0.0607
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0026 0.0504 0.0489
Onchocerca volvulus 0.003 0.0622 0.1121
Echinococcus multilocularis FTZ F1 alpha 0.0026 0.0504 0.0489
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0292 0.7357 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Echinococcus granulosus neuropeptide receptor 0.003 0.0622 0.0607
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0152 0.0137
Echinococcus multilocularis ecdysone induced protein 78C 0.0026 0.0504 0.0489
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0508 0.0616
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0622 0.0607
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0012 0.0152 0.0137
Echinococcus granulosus acetylcholinesterase 0.0267 0.6706 0.6701
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Onchocerca volvulus 0.003 0.0622 0.1121
Brugia malayi nuclear receptor NHR-67 0.0012 0.0152 0.0132
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0504 0.0613
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0504 0.0613
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Brugia malayi conserved hypotetical protein 0.0012 0.0152 0.0132
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0026 0.0504 0.0489
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0162 0.0146
Schistosoma mansoni amine GPCR 0.003 0.0622 0.0607
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0622 0.0607
Brugia malayi Carboxylesterase family protein 0.0267 0.6706 0.9109
Schistosoma mansoni histamine h1 receptor 0.003 0.0622 0.0607
Brugia malayi Carboxylesterase family protein 0.0045 0.0999 0.1291
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.1104 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0999 0.0985
Echinococcus granulosus cpg binding protein 0.0029 0.0593 0.0578
Schistosoma mansoni nuclear receptor 0.0012 0.0152 0.0137
Schistosoma mansoni hypothetical protein 0.0395 1 1
Onchocerca volvulus 0.003 0.0622 0.1121
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0045 0.0999 1
Brugia malayi laminin alpha chain 0.0024 0.0444 0.0531
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0504 0.0613
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni nuclear hormone receptor 0.0026 0.0504 0.0489
Schistosoma mansoni hypothetical protein 0.003 0.0622 0.0607
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0152 0.0137
Brugia malayi intermediate filament protein 0.0026 0.0508 0.0619
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0504 0.084
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0622 0.0775
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1104 1
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0622 0.0607
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0372 0.5
Echinococcus granulosus neuropeptide s receptor 0.003 0.0622 0.0607
Schistosoma mansoni rab6-interacting 0.0041 0.0888 0.0874
Loa Loa (eye worm) hypothetical protein 0.0012 0.0149 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0504 0.0613
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0622 0.0775
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0372 0.0433
Loa Loa (eye worm) hypothetical protein 0.0024 0.0444 0.0527
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.1104 0.109
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0622 0.0771
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0026 0.0504 0.0489
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0622 0.0607
Echinococcus multilocularis cpg binding protein 0.0029 0.0593 0.0578
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0012 0.0152 0.0137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Echinococcus multilocularis neuropeptide receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.019 0.0179
Echinococcus multilocularis lipoxygenase domain containing protein 0.0041 0.0888 0.0874
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.003 0.0622 0.1121
Schistosoma mansoni opsin-like receptor 0.003 0.0622 0.0607
Schistosoma mansoni thyroid hormone receptor 0.0026 0.0504 0.0489
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0622 0.0607
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0162 0.0146
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0045 0.0999 0.0985
Onchocerca volvulus 0.0045 0.0999 0.2021
Brugia malayi Dopamine receptor protein 1 0.003 0.0622 0.0775
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.019 0.0175
Onchocerca volvulus 0.0041 0.0888 0.1757
Echinococcus granulosus lamin 0.0026 0.0508 0.0493
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.019 0.0175
Schistosoma mansoni neuroligin 3 (S09 family) 0.0045 0.0999 0.0985
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis fmrfamide receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.1104 0.1432
Brugia malayi nuclear hormone receptor 0.0012 0.0152 0.0132
Echinococcus granulosus intermediate filament protein 0.0026 0.0508 0.0493
Loa Loa (eye worm) carboxylesterase 0.0267 0.6706 0.9109
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0622 0.0607
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0504 0.061
Onchocerca volvulus 0.003 0.0622 0.1121
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0267 0.6706 0.6701
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0012 0.0152 0.0137
Brugia malayi Carboxylesterase family protein 0.0267 0.6706 0.9109
Echinococcus multilocularis thyroid hormone receptor alpha 0.0026 0.0504 0.0489
Echinococcus granulosus g protein coupled receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0152 0.0137
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0622 0.0607
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0152 0.0137
Schistosoma mansoni opsin-like receptor 0.003 0.0622 0.0607
Echinococcus granulosus fmrfamide receptor 0.003 0.0622 0.0607
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0504 0.0613
Echinococcus multilocularis neuropeptide receptor 0.003 0.0622 0.0607
Echinococcus granulosus BC026374 protein S09 family 0.0045 0.0999 0.0985
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi neuropeptide F receptor 0.003 0.0622 0.0775
Brugia malayi Serotonin receptor 0.003 0.0622 0.0775
Brugia malayi hypothetical protein 0.0014 0.019 0.0183
Schistosoma mansoni polycystin 1-related 0.0041 0.0888 0.0874
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0504 0.0613
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0444 0.0429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0026 0.0504 0.0489
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0622 0.0607
Echinococcus granulosus serotonin receptor 0.003 0.0622 0.0607
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.1104 0.109
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0622 0.0607
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.1104 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Onchocerca volvulus 0.0028 0.0552 0.0954
Loa Loa (eye worm) hypothetical protein 0.0024 0.0444 0.0527
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0622 0.0607
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Schistosoma mansoni ap endonuclease 0.0021 0.0372 0.0357
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0622 0.0607
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0152 0.0132
Echinococcus granulosus FTZ F1 alpha 0.0026 0.0504 0.0489
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1352 0.1338
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.1104 1
Schistosoma mansoni biogenic amine receptor 0.003 0.0622 0.0607
Echinococcus granulosus Nuclear hormone receptor HR96 0.0012 0.0152 0.0137
Schistosoma mansoni cpg binding protein 0.0029 0.0593 0.0578
Echinococcus granulosus tumor protein p63 0.0385 0.9732 0.9731
Brugia malayi hypothetical protein 0.0014 0.019 0.0183
Brugia malayi nuclear receptor NHR-88 0.0026 0.0504 0.0613
Brugia malayi Carboxylesterase family protein 0.0045 0.0999 0.1291
Brugia malayi follicle stimulating hormone receptor 0.0292 0.7357 1
Echinococcus multilocularis somatostatin receptor 0.003 0.0622 0.0607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0372 0.0357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0026 0.0504 0.0489
Echinococcus granulosus g-protein coupled receptor 0.003 0.0622 0.0607
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.1104 1
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Loa Loa (eye worm) nuclear receptor NHR-67 0.0012 0.0152 0.0128
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0622 0.0607
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0508 0.0616
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Brugia malayi nuclear hormone receptor family member odr-7 0.0012 0.0152 0.0132
Loa Loa (eye worm) hypothetical protein 0.0014 0.019 0.0179
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis serotonin receptor 0.003 0.0622 0.0607
Brugia malayi Melatonin receptor type 1A 0.003 0.0622 0.0775
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.1104 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni cell polarity protein 0.0024 0.0444 0.0429
Brugia malayi nuclear receptor RXR 0.0014 0.019 0.0183
Loa Loa (eye worm) hypothetical protein 0.0024 0.0444 0.0527
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0026 0.0504 0.0489
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0152 0.0137
Loa Loa (eye worm) hypothetical protein 0.0267 0.6706 0.9109
Schistosoma mansoni slit 0.0024 0.0444 0.0429
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0622 0.0607
Echinococcus multilocularis serotonin receptor 0.003 0.0622 0.0607
Brugia malayi nuclear receptor RXR 0.0012 0.0152 0.0132
Loa Loa (eye worm) hypothetical protein 0.0267 0.6706 0.9109
Schistosoma mansoni retinoic acid receptor RXR 0.0026 0.0504 0.0489
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0622 0.0607
Schistosoma mansoni hypothetical protein 0.0041 0.0888 0.0874
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0504 0.061
Echinococcus granulosus slit 2 protein 0.0024 0.0444 0.0429
Onchocerca volvulus 0.003 0.0622 0.1121
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0622 0.0607
Schistosoma mansoni zinc finger protein 0.0012 0.0152 0.0137
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni ap endonuclease 0.0021 0.0372 0.0357
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis acetylcholinesterase 0.0267 0.6706 0.6701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0026 0.0504 0.0489
Onchocerca volvulus 0.0026 0.0508 0.085
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0444 0.0429
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.019 0.0175
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0012 0.0152 0.0137
Schistosoma mansoni amine GPCR 0.003 0.0622 0.0607
Mycobacterium ulcerans carboxylesterase, LipT 0.0045 0.0999 1
Echinococcus multilocularis allatostatin A receptor 0.003 0.0622 0.0607
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0026 0.0504 0.0489
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0014 0.019 0.0179
Schistosoma mansoni neuropeptide receptor 0.003 0.0622 0.0607
Schistosoma mansoni steroid hormone receptor ad4bp 0.0026 0.0504 0.0489
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0622 0.0775
Loa Loa (eye worm) hypothetical protein 0.0014 0.019 0.0179
Echinococcus multilocularis g protein coupled receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0504 0.061
Schistosoma mansoni lamin 0.0026 0.0508 0.0493
Schistosoma mansoni lamin 0.0026 0.0508 0.0493
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Echinococcus multilocularis sex peptide receptor 0.003 0.0622 0.0607
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0622 0.0607
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0622 0.0771
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0622 0.0607
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0149 0.0124
Brugia malayi Dopamine receptor protein 2 0.003 0.0622 0.0775
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.2777 0.2766
Schistosoma mansoni neuropeptide receptor 0.003 0.0622 0.0607
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0888 0.0874
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0622 0.0771
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.1104 0.109
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.0056 0.1286 0.2708
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0622 0.0607
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Brugia malayi AKH receptor 0.003 0.0622 0.0775
Onchocerca volvulus 0.0045 0.0999 0.2021
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0622 0.0607
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0622 0.0775
Echinococcus multilocularis neuroligin 0.0045 0.0999 0.0985
Echinococcus granulosus lipoxygenase domain containing protein 0.0041 0.0888 0.0874
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0504 0.084
Schistosoma mansoni hypothetical protein 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0026 0.0504 0.061
Brugia malayi neuropeptide F receptor 0.003 0.0622 0.0775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0508 0.0616
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Onchocerca volvulus 0.003 0.0622 0.1121
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0026 0.0504 0.0489
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0504 0.0613
Schistosoma mansoni lipoxygenase 0.0114 0.2777 0.2766
Onchocerca volvulus 0.003 0.0622 0.1121
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.019 0.0175
Brugia malayi EGF-like domain containing protein 0.0024 0.0444 0.0531
Brugia malayi nuclear receptor NHR-88 0.0012 0.0152 0.0132
Loa Loa (eye worm) carboxylesterase 0.0045 0.0999 0.1288
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0504 0.0613
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0026 0.0504 0.0489
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0622 0.0607
Brugia malayi steroid hormone receptor 0.0026 0.0504 0.0613
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0622 0.0607
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0012 0.0152 0.0137
Schistosoma mansoni cpg binding protein 0.0029 0.0593 0.0578
Brugia malayi G-protein coupled receptor 0.003 0.0622 0.0775
Plasmodium falciparum LCCL domain-containing protein 0.0041 0.0888 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0622 0.0607
Brugia malayi sulfakinin receptor protein 0.003 0.0622 0.0775
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0622 0.0607
Onchocerca volvulus 0.0026 0.0504 0.084
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus g protein coupled receptor 0.003 0.0622 0.0607
Brugia malayi Serotonin receptor 0.003 0.0622 0.0775
Echinococcus granulosus para nitrobenzyl esterase 0.0045 0.0999 0.0985
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0622 0.0607
Echinococcus multilocularis geminin 0.0358 0.9035 0.9033
Schistosoma mansoni nuclear receptor 0.0012 0.0152 0.0137
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Schistosoma mansoni RAR-like nuclear receptor 0.0026 0.0504 0.0489
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.019 0.0183
Schistosoma mansoni hypothetical protein 0.003 0.0622 0.0607
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0622 0.0607
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.1104 0.109
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.1104 0.895
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0622 0.0607
Schistosoma mansoni rab6-interacting 0.0041 0.0888 0.0874
Loa Loa (eye worm) hypothetical protein 0.0045 0.0999 0.1288
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0622 0.0607
Brugia malayi larval opioid receptor 0.003 0.0622 0.0775
Loa Loa (eye worm) hypothetical protein 0.0026 0.0496 0.0599
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1104 1
Schistosoma mansoni biogenic amine receptor 0.003 0.0622 0.0607
Brugia malayi hypothetical protein 0.0041 0.0888 0.1139
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0444 0.0429
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0504 0.061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Brugia malayi nuclear hormone receptor family member nhr-6 0.0012 0.0152 0.0132
Echinococcus granulosus acetylcholinesterase 0.0267 0.6706 0.6701
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi nuclear hormone receptor 0.0026 0.0504 0.0613
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0622 0.0607
Echinococcus multilocularis g protein coupled receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0622 0.0775
Onchocerca volvulus 0.003 0.0622 0.1121
Brugia malayi GnHR receptor homolog 0.003 0.0622 0.0775
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0552 0.0675
Loa Loa (eye worm) hypothetical protein 0.0175 0.434 0.5866
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0372 0.3372
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) DR-78 0.0012 0.0152 0.0128
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0622 0.0607
Echinococcus granulosus hypothetical protein 0.003 0.0622 0.0607
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0372 0.0429
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0622 0.1121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0026 0.0504 0.0489
Echinococcus multilocularis BC026374 protein (S09 family) 0.0045 0.0999 0.0985
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0622 0.0771
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0622 0.0607
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0026 0.0504 0.0489
Echinococcus granulosus orexin receptor type 2 0.003 0.0622 0.0607
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0622 0.0771
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.1104 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus RUN 0.0041 0.0888 0.0874
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0504 0.0613
Brugia malayi hypothetical protein 0.0012 0.0152 0.0132
Schistosoma mansoni biogenic amine receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0622 0.0775
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus ecdysone induced protein 78C 0.0026 0.0504 0.0489
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Echinococcus granulosus sex peptide receptor 0.003 0.0622 0.0607
Schistosoma mansoni cpg binding protein 0.0028 0.0552 0.0537
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Brugia malayi G protein-coupled receptor 0.003 0.0622 0.0775
Brugia malayi RE15519p 0.003 0.0622 0.0775
Schistosoma mansoni neuropeptide receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.0041 0.0888 0.1757
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Schistosoma mansoni BC026374 protein (S09 family) 0.0045 0.0999 0.0985
Echinococcus granulosus g protein coupled receptor 0.003 0.0622 0.0607
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0622 0.0607
Brugia malayi Nuclear hormone receptor E75 0.0012 0.0152 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0152 0.0128
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0622 0.0607
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0059 0.0044
Schistosoma mansoni neuropeptide receptor 0.003 0.0622 0.0607
Echinococcus multilocularis nuclear receptor nhr 48 0.0012 0.0152 0.0137
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0045 0.0999 0.9045
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0372 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.019 0.0179
Echinococcus granulosus geminin 0.0358 0.9035 0.9033
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.1104 1
Echinococcus granulosus somatostatin receptor 0.003 0.0622 0.0607
Onchocerca volvulus 0.003 0.0622 0.1121
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0026 0.0504 0.0489
Echinococcus multilocularis biogenic amine (5HT) receptor 0.003 0.0622 0.0607
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0622 0.0607
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0012 0.0152 0.0128
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0622 0.0607
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.0056 0.1286 0.1682
Brugia malayi hypothetical protein 0.003 0.0622 0.0775
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0622 0.0607
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0026 0.0504 0.0489
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0622 0.0607
Loa Loa (eye worm) hypothetical protein 0.003 0.0622 0.0771
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0622 0.1121
Echinococcus granulosus nuclear receptor nhr 48 0.0012 0.0152 0.0137
Brugia malayi orphan nuclear receptor NR2E1 0.0012 0.0152 0.0132
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.1104 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0622 0.0607
Brugia malayi ecdysteroid receptor 0.0175 0.434 0.5868
Onchocerca volvulus 0.003 0.0622 0.1121
Onchocerca volvulus 0.0026 0.0508 0.085
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0622 0.0607
Echinococcus granulosus thyroid hormone receptor alpha 0.0012 0.0152 0.0137
Loa Loa (eye worm) doublecortin family protein 0.0041 0.0888 0.1136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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