Detailed information for compound 911414

Basic information

Technical information
  • TDR Targets ID: 911414
  • Name: 2-(2-methylpropyl)-4-phenylphthalazin-1-one
  • MW: 278.348 | Formula: C18H18N2O
  • H donors: 0 H acceptors: 1 LogP: 4.19 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1nc(c2ccccc2)c2c(c1=O)cccc2)C
  • InChi: 1S/C18H18N2O/c1-13(2)12-20-18(21)16-11-7-6-10-15(16)17(19-20)14-8-4-3-5-9-14/h3-11,13H,12H2,1-2H3
  • InChiKey: DNXIBLBDRWCOAO-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-isobutyl-4-phenyl-phthalazin-1-one
  • 2-isobutyl-4-phenyl-1-phthalazinone
  • 2-(2-methylpropyl)-4-phenyl-phthalazin-1-one
  • CBMicro_042539
  • ZINC00127179
  • A2448/0103807
  • EU-0005657
  • BIM-0042283.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Endoplasmin precursor 0.0097 0.1604 0.1604
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0103 0.0024
Echinococcus multilocularis cpg binding protein 0.003 0.0381 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Loa Loa (eye worm) glutathione reductase 0.005 0.0741 0.0741
Trypanosoma brucei DNA topoisomerase ii 0.0014 0.0103 0.0077
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0203 0.3507 0.5
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0102 0.0145
Schistosoma mansoni DNA helicase recq1 0.001 0.0036 0.0013
Mycobacterium ulcerans hypothetical protein 0.0026 0.0312 0.0503
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1641 0.2339
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.1631 0.2296
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0286 0.0286
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0014 0.0103 0.0262
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0312 0.0453
Mycobacterium tuberculosis Conserved hypothetical protein 0.0017 0.015 0.0173
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0017 0.015 0.0176
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0286 0.0401
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Plasmodium vivax PST-A protein 0.0017 0.015 0.0132
Echinococcus multilocularis abhydrolase domain containing 3 0.0017 0.015 0.0214
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0027 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0091 0.1497 0.289
Treponema pallidum heat shock protein 90 0.0091 0.1497 1
Entamoeba histolytica heat shock protein 90, putative 0.0097 0.1604 0.3112
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0283 0.4954 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0027
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0482 0.0687
Toxoplasma gondii hypothetical protein 0.0017 0.015 0.0176
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.123 0.1721
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Brugia malayi AF-10 protein 0.002 0.0214 0.0214
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0022 0.0238 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0908 0.1681
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0312 0.0503
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0089 0.1459 0.8924
Plasmodium vivax unspecified product 0.0017 0.015 0.0132
Schistosoma mansoni kinase 0.005 0.0755 0.1042
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0741 0.1383
Loa Loa (eye worm) heat shock protein 90 0.0097 0.1604 0.1604
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0012 0.0065 0.0093
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0741 0.105
Schistosoma mansoni chromobox protein 0.0148 0.2518 0.3565
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0158 0.019
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0036 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.1345 0.8217
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.015 0.0173
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0014 0.0103 0.0077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1044 0.1044
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0014 0.0103 0.0077
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Echinococcus granulosus heat shock protein 90 0.0083 0.1351 0.1926
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0038
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0312 0.0503
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0158 0.019
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0286 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.021 0.0295
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0091 0.1497 0.2928
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0152 0.0179
Echinococcus granulosus chromobox protein 1 0.0148 0.2518 0.359
Schistosoma mansoni hypothetical protein 0.0017 0.0147 0.0172
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0014 0.0103 0.0147
Leishmania major hypothetical protein, conserved 0.0017 0.015 0.0173
Brugia malayi Uncoordinated protein 44 0.0014 0.0102 0.0102
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0027 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Plasmodium vivax unspecified product 0.0017 0.015 0.0132
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1641 0.2339
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.2155 0.2155
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0966 0.0966
Schistosoma mansoni endoplasmin 0.0097 0.1604 0.2258
Echinococcus granulosus dnaJ subfamily B 0.0398 0.7014 1
Echinococcus multilocularis jumonji domain containing protein 0.0086 0.1403 0.2001
Schistosoma mansoni hypothetical protein 0.0398 0.7014 1
Leishmania major mitochondrial DNA topoisomerase II 0.0014 0.0103 0.0077
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0286 0.0401
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0014 0.0103 0.0147
Onchocerca volvulus 0.0064 0.1008 0.6116
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.015 0.0121
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0103 0.0077
Plasmodium falciparum heat shock protein 90 0.0097 0.1604 0.2426
Toxoplasma gondii thioredoxin reductase 0.005 0.0741 0.1091
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.021 0.0295
Plasmodium falciparum DNA gyrase subunit B 0.0014 0.0103 0.0103
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.015 0.0121
Trypanosoma brucei heat shock protein 84, putative 0.0065 0.1015 0.1943
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0302 0.0431
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0027
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0482 0.0687
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Chlamydia trachomatis acyltransferase family protein 0.0017 0.015 0.9114
Schistosoma mansoni amidase 0.0099 0.1641 0.231
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.021 0.021
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.1631 0.3167
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Echinococcus granulosus tar DNA binding protein 0.0066 0.1044 0.1489
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0014 0.0103 0.0024
Giardia lamblia Heat shock protein HSP 90-alpha 0.0083 0.1351 0.8241
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.1631 0.1631
Plasmodium falciparum thioredoxin reductase 0.0017 0.0158 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0036 0.0492 0.0492
Onchocerca volvulus 0.0028 0.0352 0.2028
Mycobacterium ulcerans putative regultory protein 0.0014 0.0103 0.0077
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0017 0.015 0.0173
Schistosoma mansoni DNA topoisomerase II 0.0014 0.0103 0.0109
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0158 0.0145
Brugia malayi jmjC domain containing protein 0.002 0.021 0.021
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Schistosoma mansoni hypothetical protein 0.0024 0.0286 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0027 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0097 0.1604 0.3112
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0103 0.4027
Trichomonas vaginalis heat shock protein, putative 0.0057 0.087 0.1601
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0339 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0908 0.1681
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0368 0.0368
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0103 0.0024
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0302 0.0302
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0014 0.0103 0.0077
Plasmodium vivax endoplasmin, putative 0.0097 0.1604 0.2391
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.021
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Plasmodium falciparum lysophospholipase, putative 0.0017 0.015 0.0176
Entamoeba histolytica hypothetical protein 0.0035 0.0482 0.0803
Entamoeba histolytica hypothetical protein 0.0017 0.015 0.0121
Mycobacterium ulcerans heat shock protein 90 0.0091 0.1497 0.2928
Plasmodium falciparum exported lipase 2 0.0017 0.015 0.0176
Plasmodium falciparum glutathione reductase 0.005 0.0741 0.1091
Schistosoma mansoni hypothetical protein 0.0178 0.3046 0.4321
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0103 0.0077
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0014 0.0103 0.0103
Echinococcus multilocularis heat shock protein 90 0.0097 0.1604 0.2288
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0017 0.015 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0027 0.0027
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0102 0.0107
Mycobacterium tuberculosis Possible two component sensor kinase 0.0014 0.0103 0.0077
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Schistosoma mansoni hypothetical protein 0.0035 0.0482 0.0651
Trypanosoma brucei trypanothione reductase 0.005 0.0741 0.1383
Mycobacterium tuberculosis Possible lysophospholipase 0.0283 0.4954 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.1884 0.3721
Entamoeba histolytica DNA topoisomerase II, putative 0.0014 0.0103 0.0024
Schistosoma mansoni hypothetical protein 0.0067 0.1049 0.1462
Echinococcus granulosus jumonji domain containing 1A 0.002 0.021 0.0299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0038
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0104 0.011
Leishmania major heat shock protein, putative 0.0065 0.1015 0.1943
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.1884 0.3721
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0214 0.0305
Brugia malayi Protein kinase domain containing protein 0.0014 0.0108 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Treponema pallidum NADH oxidase 0.0017 0.0158 0.065
Toxoplasma gondii hypothetical protein 0.0017 0.015 0.0176
Echinococcus granulosus abhydrolase domain containing protein 13 0.0017 0.015 0.0214
Plasmodium falciparum lysophospholipase, putative 0.0017 0.015 0.0176
Brugia malayi MGC79044 protein 0.0017 0.015 0.015
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.021 0.0299
Echinococcus multilocularis Chromo domain 0.0024 0.0286 0.0408
Trypanosoma cruzi heat shock protein 90, putative 0.0097 0.1604 0.3148
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0017 0.015 0.0173
Echinococcus granulosus cpg binding protein 0.003 0.0381 0.0543
Brugia malayi jmjC domain containing protein 0.002 0.021 0.021
Echinococcus granulosus chromobox protein 1 0.0148 0.2518 0.359
Trypanosoma brucei heat shock protein 90, putative 0.0097 0.1604 0.3148
Plasmodium falciparum phd finger protein, putative 0.0062 0.0966 0.1438
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0017 0.015 0.0214
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.1884 0.3721
Echinococcus granulosus Chromo domain 0.0024 0.0286 0.0408
Trichomonas vaginalis chromobox protein, putative 0.0148 0.2518 0.4991
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.1631 0.2326
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Schistosoma mansoni chromobox protein 0.0148 0.2518 0.3565
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0027 0.0038
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0214 0.0275
Plasmodium vivax alpha/beta hydrolase, putative 0.0017 0.015 0.0132
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.015 0.0121
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0283 0.4954 1
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0286 0.0286
Leishmania major DNA topoisomerase ii 0.0014 0.0103 0.0077
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0014 0.0103 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0732 0.1317
Leishmania major trypanothione reductase 0.005 0.0741 0.1383
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0147 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0102 0.0102
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0158 0.019
Schistosoma mansoni jun-related protein 0.0067 0.1049 0.1462
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Trypanosoma cruzi DNA topoisomerase II, putative 0.0014 0.0103 0.0077
Schistosoma mansoni hypothetical protein 0.0017 0.0147 0.0172
Loa Loa (eye worm) endoplasmin 0.0097 0.1604 0.1604
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0103 0.0103
Onchocerca volvulus Alhambra homolog 0.0062 0.0966 0.5853
Schistosoma mansoni jumonji/arid domain-containing protein 0.0077 0.123 0.1721
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.04 0.0635
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0022 0.0238 0.034
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0158 0.019
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0158 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0158 0.065
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1044 0.1489
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0158 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0027
Trichomonas vaginalis sensor histidine kinase, putative 0.0014 0.0103 0.0024
Brugia malayi steroid hormone receptor 0.001 0.0027 0.0027
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0014 0.0103 0.0077
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0017 0.015 0.0176
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0283 0.4954 1
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0966 0.1399
Brugia malayi CHD4 protein 0.0026 0.0315 0.0315
Brugia malayi CXXC zinc finger family protein 0.0028 0.0352 0.0352
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.021 0.0299
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0158 0.019
Brugia malayi hypothetical protein 0.0024 0.0288 0.0288
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0103 0.0473
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0916 0.1273
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.021 0.021
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0286 0.0408
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0315 0.0412
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.015 0.0176
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.3863 0.7768
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.1631 0.3204
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.2111 0.4185
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0312 0.0444
Loa Loa (eye worm) hypothetical protein 0.0062 0.0966 0.0966
Echinococcus granulosus jumonji domain containing protein 0.0086 0.1403 0.2001
Schistosoma mansoni hypothetical protein 0.002 0.0214 0.0268
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0017 0.015 0.0173
Loa Loa (eye worm) RNA binding protein 0.0066 0.1044 0.1044
Brugia malayi Hsp90 protein 0.0065 0.1015 0.1015
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0741 0.1057
Loa Loa (eye worm) hypothetical protein 0.0024 0.0288 0.0288
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0091 0.1497 1
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0732 0.1317
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0091 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Mycobacterium ulcerans hydrolase 0.0017 0.015 0.0173
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1631 0.3204
Brugia malayi amidase 0.0099 0.1641 0.1641
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0038
Schistosoma mansoni phd/f-box containing protein 0.002 0.021 0.0262
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.7014 1
Echinococcus granulosus GPCR family 2 0.0017 0.0147 0.0209
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0014 0.0103 0.0077
Mycobacterium tuberculosis Probable reductase 0.0113 0.1884 0.3721
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.021 0.0299
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0007
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0741 0.1383
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0012 0.0065 0.0093
Brugia malayi Protein C20orf22 0.0017 0.015 0.015
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0312 0.0503
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.1631 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.021 0.0262
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0286 0.0386
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.021 0.0268
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0102 0.0145
Entamoeba histolytica hypothetical protein 0.0024 0.0286 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0036 0.0052
Trypanosoma brucei Heat shock protein 83, putative 0.0097 0.1604 0.3148
Echinococcus granulosus abhydrolase domain containing 3 0.0017 0.015 0.0214
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0315 0.0315
Mycobacterium ulcerans hypothetical protein 0.0283 0.4954 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0014 0.0103 0.0077
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0065 0.1015 0.1448
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0158 0.0226
Echinococcus multilocularis heat shock protein 0.0097 0.1604 0.2288
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0022 0.0245 0.0323
Leishmania major hypothetical protein, conserved 0.002 0.021 0.0295
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0038
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0352 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0347 0.0526
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0027 0.0038
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0014 0.0103 0.0077
Trypanosoma brucei heat shock protein 90, putative 0.0097 0.1604 0.3148
Toxoplasma gondii heat shock protein 90, putative 0.0097 0.1604 0.2426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0027
Schistosoma mansoni endoplasmin 0.0097 0.1604 0.2258
Trypanosoma cruzi serine peptidase, putative 0.0017 0.015 0.0173
Echinococcus granulosus heat shock protein 90 0.0097 0.1604 0.2288
Loa Loa (eye worm) hypothetical protein 0.002 0.021 0.021
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.1345 0.2579
Echinococcus multilocularis lysine specific demethylase 5A 0.0075 0.1201 0.1712
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0014 0.0103 0.0077
Plasmodium vivax heat shock protein 86, putative 0.0097 0.1604 0.2391
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0245 0.0279
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0014 0.0103 0.0077
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0156 0.014
Schistosoma mansoni DNA helicase recq5 0.001 0.0036 0.0013
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0286 0.0401
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0065 0.1015 0.1448
Schistosoma mansoni cpg binding protein 0.003 0.0381 0.0507
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.123 0.123
Trichomonas vaginalis receptor histidine kinase, putative 0.0014 0.0103 0.0024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0158 0.0766
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Onchocerca volvulus 0.0065 0.1022 0.6202
Schistosoma mansoni pyruvate dehydrogenase 0.0014 0.0103 0.0109
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0286 0.0401
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0027 0.0027
Entamoeba histolytica heat shock protein 90, putative 0.0097 0.1604 0.3112
Brugia malayi PHD-finger family protein 0.0022 0.0243 0.0243
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Brugia malayi Bromodomain containing protein 0.0062 0.0966 0.0966
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Brugia malayi hypothetical protein 0.0035 0.0482 0.0482
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0017 0.015 0.0176
Brugia malayi kinase, mitochondrial precursor 0.0014 0.0103 0.0103
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.015 0.0173
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0283 0.4954 1
Toxoplasma gondii hypothetical protein 0.0017 0.015 0.0176
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0482 0.0651
Trichomonas vaginalis hypothetical protein 0.0024 0.0286 0.0401
Trypanosoma cruzi heat shock protein, putative 0.0065 0.1015 0.1943
Toxoplasma gondii Hsp90 domain-containing protein 0.0369 0.6501 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0014 0.0103 0.0473
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0203 0.3507 0.5
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0017 0.015 0.0121
Trichomonas vaginalis heat shock protein, putative 0.0071 0.1123 0.2122
Trichomonas vaginalis chromobox protein, putative 0.0089 0.1459 0.2812
Trypanosoma cruzi heat shock protein 90, putative 0.0083 0.1351 0.263
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0014 0.0103 0.0147
Echinococcus multilocularis PHD finger protein rhinoceros 0.0062 0.0966 0.1377
Echinococcus multilocularis jun protein 0.0082 0.1325 0.1889
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Brugia malayi PHD-finger family protein 0.0062 0.0966 0.0966
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0286 0.0286
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.1631 0.1631
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0103 0.4027
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0283 0.4954 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0158 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Loa Loa (eye worm) amidase 0.0012 0.0065 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0103 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.021 0.021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Giardia lamblia PHD finger protein 15 0.0062 0.0966 0.5829
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0091 0.1497 0.2928
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0297 0.0387
Echinococcus granulosus Phospholipase carboxylesterase 0.0017 0.015 0.0214
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0014 0.0103 0.0077
Plasmodium falciparum heat shock protein 90, putative 0.0057 0.087 0.1289
Echinococcus multilocularis chromobox protein 1 0.0148 0.2518 0.359
Plasmodium vivax heat shock protein 90, putative 0.0065 0.1015 0.1476
Echinococcus granulosus phd:f box containing protein 0.002 0.021 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.021 0.0268
Loa Loa (eye worm) hypothetical protein 0.008 0.1285 0.1285
Plasmodium falciparum epoxide hydrolase 2 0.0017 0.015 0.0176
Loa Loa (eye worm) hypothetical protein 0.0564 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0158 0.019
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0027 0.0027
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.015 0.0121
Plasmodium vivax JmjC domain containing protein 0.002 0.021 0.0224
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0492 0.0492
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0012 0.0065 0.0093
Brugia malayi glutathione reductase 0.005 0.0741 0.0741
Leishmania major hypothetical protein, conserved 0.0017 0.015 0.0173
Brugia malayi jmjC domain containing protein 0.002 0.021 0.021
Plasmodium falciparum esterase, putative 0.0017 0.015 0.0176
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Plasmodium vivax PST-A protein 0.0017 0.015 0.0132
Mycobacterium tuberculosis Conserved protein 0.0014 0.0103 0.0077
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0014 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0312 0.0503
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0014 0.0103 0.0024
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Schistosoma mansoni peptidase 0.0017 0.015 0.0176
Entamoeba histolytica hypothetical protein 0.0035 0.0482 0.0803
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0014 0.0104 0.0104
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0014 0.0103 0.0077
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0102 0.0102
Plasmodium falciparum BEM46-like protein, putative 0.0017 0.015 0.0176
Toxoplasma gondii phospholipase 0.0017 0.015 0.0176
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.015 0.0176
Schistosoma mansoni cpg binding protein 0.003 0.0381 0.0507
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0802 0.1185
Loa Loa (eye worm) heat shock protein 75 0.0065 0.1015 0.1015
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0005 0.0007
Brugia malayi jmjC domain containing protein 0.0203 0.3507 0.3507
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0027 0.0038
Brugia malayi nuclear receptor NHR-88 0.001 0.0027 0.0027
Chlamydia trachomatis hydrolase 0.0017 0.015 0.9114
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0091 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Onchocerca volvulus 0.0024 0.0286 0.1615
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0014 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0027 0.0027
Echinococcus granulosus fatty acid amide hydrolase 1 0.0012 0.0065 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Trypanosoma cruzi serine peptidase, putative 0.0017 0.015 0.0173
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.015 0.0121
Brugia malayi chromobox protein homolog 3 0.0083 0.1345 0.1345
Schistosoma mansoni heat shock protein 0.0065 0.1015 0.1415
Plasmodium vivax DNA topoisomerase II, putative 0.0014 0.0103 0.0058
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0005 0.0005
Echinococcus multilocularis GPCR, family 2 0.0017 0.0147 0.0209
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0017 0.015 0.0132
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1604 0.3148
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0027 0.0027
Toxoplasma gondii peptidase S15, putative 0.0017 0.015 0.0176
Brugia malayi Probable DNA topoisomerase II 0.0014 0.0103 0.0103
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.1325 0.1889
Mycobacterium leprae Probable two-component sensor kinase 0.0014 0.0103 0.0077
Trichomonas vaginalis endoplasmin, putative 0.0071 0.1123 0.2122
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0339 0.0509
Loa Loa (eye worm) hypothetical protein 0.0083 0.1345 0.1345
Brugia malayi bZIP transcription factor family protein 0.0082 0.1325 0.1325
Brugia malayi ecdysteroid receptor 0.001 0.0027 0.0027
Echinococcus granulosus geminin 0.0178 0.3046 0.4343
Schistosoma mansoni jumonji domain containing protein 0.002 0.021 0.0262
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0027 0.0038
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0027 0.0027
Brugia malayi hypothetical protein 0.0064 0.1008 0.1008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0158 0.019
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0014 0.0103 0.0473
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0286 0.0386
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0286 0.0386
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0286 0.0408
Plasmodium vivax glutathione reductase, putative 0.005 0.0741 0.105
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0158 0.0145
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.015 0.0121
Mycobacterium ulcerans two component regulator - sensor kinase 0.0014 0.0103 0.0077
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0099 0.1641 0.2339
Echinococcus multilocularis phd:f box containing protein 0.002 0.021 0.0299
Plasmodium vivax lysophospholipase, putative 0.0017 0.015 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Onchocerca volvulus 0.0025 0.0297 0.1684
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0312 0.0444
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0014 0.0103 0.0024
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0283 0.4954 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0223 0.3863 0.7768
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.079 0.079
Giardia lamblia Kinase, PLK 0.0099 0.1631 1
Schistosoma mansoni jumonji domain containing protein 0.0161 0.2755 0.3905
Echinococcus granulosus peregrin 0.0062 0.0966 0.1377
Loa Loa (eye worm) hypothetical protein 0.0127 0.2129 0.2129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0347 0.0526
Trichomonas vaginalis chromobox protein, putative 0.0148 0.2518 0.4991
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0247 0.0326
Onchocerca volvulus 0.0024 0.0286 0.1615
Plasmodium falciparum thioredoxin reductase 0.005 0.0741 0.1091
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0027 0.0038
Toxoplasma gondii phospholipase/carboxylesterase 0.0017 0.015 0.0176
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Loa Loa (eye worm) amidase 0.0012 0.0065 0.0065
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.015 0.0176
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.021 0.0299
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0302 0.0434
Mycobacterium leprae Probable two component sensor kinase MprB 0.0014 0.0103 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0027 0.0027
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0014 0.0103 0.0024
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0102 0.0145
Schistosoma mansoni cpg binding protein 0.0028 0.0352 0.0466
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0103
Brugia malayi jmjC domain containing protein 0.002 0.021 0.021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.079 0.079
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0214 0.0275
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0158 0.019
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0103 0.0147
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0966 0.1438
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.2111 0.4185
Plasmodium falciparum exported lipase 1 0.0017 0.015 0.0176
Loa Loa (eye worm) hypothetical protein 0.0099 0.1641 0.1641
Trichomonas vaginalis heat shock protein, putative 0.0091 0.1497 0.289
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.3863 0.7768
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Brugia malayi Amidase family protein 0.0012 0.0065 0.0065
Echinococcus multilocularis chromobox protein 1 0.0148 0.2518 0.359
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0103
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0036 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1044 0.1456
Plasmodium vivax hypothetical protein, conserved 0.0017 0.015 0.0132
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.1144 0.163
Brugia malayi heat shock protein 90 0.0097 0.1604 0.1604
Trypanosoma cruzi heat shock protein 85, putative 0.0083 0.1351 0.263
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.021 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0062 0.0966 0.1344
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0076 0.0076
Plasmodium vivax lysophospholipase, putative 0.0017 0.015 0.0132
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.1144 0.163
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0103 0.0103
Echinococcus granulosus lysine specific demethylase 5A 0.0077 0.123 0.1753
Echinococcus multilocularis Ankyrin 0.0014 0.0104 0.0148
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0017 0.015 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.1022 0.1022
Brugia malayi jmjC domain containing protein 0.0077 0.123 0.123
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0014 0.0103 0.0077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0286 0.0401
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0036 0.0000000001317
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0286 0.0371
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0315 0.0449
Leishmania major developmentally regulated phosphoprotein-like protein 0.0014 0.0103 0.0077
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0286 0.0386
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0286 0.0343
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Echinococcus granulosus calcium activated potassium channel 0.0009 0.0004 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0027 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Mycobacterium ulcerans hypothetical protein 0.0017 0.015 0.0173
Plasmodium falciparum esterase, putative 0.0283 0.4954 0.7607
Leishmania major hypothetical protein, conserved 0.0014 0.0103 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Loa Loa (eye worm) hypothetical protein 0.0052 0.079 0.079
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0091 0.1497 0.2928
Loa Loa (eye worm) hypothetical protein 0.0022 0.0243 0.0243
Echinococcus granulosus heat shock protein 0.0097 0.1604 0.2288
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0286 0.0401
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.2111 0.4185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0286 0.0401
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0147 0.0209
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0014 0.0103 0.0077
Trichomonas vaginalis DNA topoisomerase II, putative 0.0014 0.0103 0.0024
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0065 0.1015 0.19
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0286 0.0371
Brugia malayi Protein cec-1. 0.0024 0.0286 0.0286
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0158 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0027
Echinococcus granulosus Ankyrin 0.0014 0.0104 0.0148
Echinococcus multilocularis heat shock protein 90 0.0083 0.1351 0.1926
Trypanosoma cruzi Heat shock protein 83, putative 0.0097 0.1604 0.3148
Mycobacterium ulcerans hypothetical protein 0.0026 0.0312 0.0503
Trichomonas vaginalis chromobox protein, putative 0.0089 0.1459 0.2812
Plasmodium falciparum glutathione reductase 0.0017 0.0158 0.0189
Brugia malayi TAR-binding protein 0.0066 0.1044 0.1044
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0741 0.0741
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1044 0.1044
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0014 0.0103 0.0077
Plasmodium falciparum heat shock protein 90, putative 0.0369 0.6501 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0147 0.0147
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.021 0.0295
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0036 0.0052
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0102 0.0468
Echinococcus multilocularis endoplasmin 0.0091 0.1497 0.2134
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1044 0.1456
Giardia lamblia Heat shock protein HSP 90-alpha 0.0097 0.1604 0.9831
Entamoeba histolytica hypothetical protein 0.0017 0.015 0.0121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0027 0.0027
Brugia malayi RNA binding protein 0.0066 0.1044 0.1044
Giardia lamblia Pms1-like protein 0.0014 0.0103 0.0418
Schistosoma mansoni chromobox protein 0.0024 0.0286 0.0371
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0036 0.0036
Plasmodium falciparum esterase, putative 0.0017 0.015 0.0176
Chlamydia trachomatis DNA gyrase subunit B 0.0014 0.0103 0.4027
Toxoplasma gondii hypothetical protein 0.0017 0.015 0.0176
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0014 0.0103 0.0077
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0017 0.015 0.015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0286 0.0401
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.1631 0.3204
Schistosoma mansoni chromobox protein 0.0024 0.0286 0.0371
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.015 0.0176
Brugia malayi Heterochromatin protein 1 0.0148 0.2518 0.2518
Trypanosoma brucei monoglyceride lipase, putative 0.0283 0.4954 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0076 0.0076
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.015 0.0176
Schistosoma mansoni hypothetical protein 0.0036 0.0492 0.0666
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0014 0.0103 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.4954 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0099 0.1641 0.231
Giardia lamblia Grp94/Hsp90 0.0091 0.1497 0.9155
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0014 0.0103 0.0077
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0286 0.0401
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0014 0.0103 0.0262
Loa Loa (eye worm) hypothetical protein 0.001 0.0027 0.0027
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.015 0.0176
Loa Loa (eye worm) heterochromatin protein 1 0.0148 0.2518 0.2518
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0286 0.0386
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.1884 0.3721
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0103 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0027 0.0027
Trichomonas vaginalis heat shock protein, putative 0.0083 0.1351 0.259
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0147 0.0209
Schistosoma mansoni heat shock protein 0.0097 0.1604 0.2258
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0158 0.019
Plasmodium vivax PST-A protein 0.0283 0.4954 0.7596
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0286
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0014 0.0103 0.0077
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0158 0.0158
Toxoplasma gondii protein c14orf29, putative 0.0017 0.015 0.0176
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0017 0.015 0.0173
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0027 0.0038
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0027 0.0038
Plasmodium falciparum lysophospholipase, putative 0.0283 0.4954 0.7607
Echinococcus multilocularis calcium activated potassium channel 0.0009 0.0004 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0014 0.0103 0.0147
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.015 0.0121
Schistosoma mansoni hypothetical protein 0.0178 0.3046 0.4321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Entamoeba histolytica hypothetical protein 0.0024 0.0286 0.0401
Plasmodium falciparum prodrug activation and resistance esterase 0.0017 0.015 0.0176
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0014 0.0103 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Echinococcus granulosus bloom syndrome protein 0.0025 0.0302 0.0431
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0017 0.015 0.0176
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0286 0.0286
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0014 0.0103 0.0077
Plasmodium vivax alpha/beta hydrolase, putative 0.0017 0.015 0.0132
Leishmania major monoglyceride lipase, putative 0.0283 0.4954 1
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.4954 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0158 0.0188
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.1631 0.2326
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0286 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.3863 0.7768
Echinococcus granulosus endoplasmin 0.0091 0.1497 0.2134
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Plasmodium vivax heat shock protein, putative 0.0369 0.6501 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0147 0.0147
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0102 0.0145
Entamoeba histolytica hypothetical protein 0.0035 0.0482 0.0803
Mycobacterium ulcerans DNA gyrase subunit B 0.0014 0.0103 0.0077
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0158 0.065
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.04 0.0635
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0083 0.1351 0.1926
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0014 0.0103 0.0077
Schistosoma mansoni hypothetical protein 0.0017 0.0147 0.0172
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0312 0.0503
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0158 0.0189
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0014 0.0103 0.0262
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0147 0.0147
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0017 0.015 0.0176
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0158 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Echinococcus granulosus Chromobox protein 3 0.0024 0.0286 0.0408
Echinococcus multilocularis chromobox protein 2 0.0024 0.0286 0.0408
Trypanosoma brucei developmentally regulated phosphoprotein 0.0014 0.0103 0.0077
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0286 0.0408
Schistosoma mansoni phosphatidylserine receptor 0.002 0.021 0.0262
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Mycobacterium tuberculosis Conserved protein 0.0026 0.0312 0.0503
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0017 0.015 0.0214
Mycobacterium ulcerans hypothetical protein 0.0017 0.015 0.0173
Loa Loa (eye worm) helicase 0.0024 0.0286 0.0286
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0091 0.0053
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0014 0.0103 0.0077
Brugia malayi Thioredoxin reductase 0.005 0.0741 0.0741
Plasmodium falciparum lysophospholipase, putative 0.0283 0.4954 0.7607
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0207 0.0258
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0014 0.0103 0.0077
Plasmodium vivax PST-A protein 0.0017 0.015 0.0132
Schistosoma mansoni heat shock protein 0.0097 0.1604 0.2258
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.1345 0.2579
Echinococcus granulosus FTZ F1 alpha 0.001 0.0027 0.0038
Leishmania major heat shock protein 83-1 0.0097 0.1604 0.3148
Schistosoma mansoni hypothetical protein 0.0017 0.0147 0.0172
Plasmodium falciparum lysophospholipase, putative 0.0283 0.4954 0.7607
Plasmodium falciparum endoplasmin, putative 0.0071 0.1123 0.1681
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.021 0.0299
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0158 0.019
Toxoplasma gondii DNA topoisomerase 2, putative 0.0014 0.0103 0.0103
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.1884 0.3721
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0158 0.0138
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0065 0.1015 0.616
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0741 0.1057
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0302 0.0434
Brugia malayi Death domain containing protein 0.0014 0.0102 0.0102
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1604 0.3148
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0027 0.0038
Echinococcus granulosus PHD finger protein rhinoceros 0.0062 0.0966 0.1377
Loa Loa (eye worm) hypothetical protein 0.001 0.0036 0.0036
Trypanosoma brucei polo-like protein kinase 0.0099 0.1631 0.3204
Schistosoma mansoni hypothetical protein 0.0014 0.0102 0.0107
Trypanosoma cruzi monoglyceride lipase, putative 0.0283 0.4954 1
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0584 0.1061
Brugia malayi SET domain containing protein 0.0025 0.0297 0.0297
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0283 0.4954 1
Trypanosoma brucei monoglyceride lipase, putative 0.0283 0.4954 1
Schistosoma mansoni fatty-acid amide hydrolase 0.0012 0.0065 0.0055
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1044 0.1456
Mycobacterium tuberculosis Probable two component sensor kinase 0.0014 0.0103 0.0077
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0214 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1044 0.1456
Plasmodium vivax PST-A protein 0.0017 0.015 0.0132
Plasmodium vivax lysophospholipase, putative 0.0017 0.015 0.0132
Brugia malayi putative amidase 0.0012 0.0065 0.0065
Echinococcus multilocularis Phospholipase carboxylesterase 0.0017 0.015 0.0214
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0017 0.015 0.0714
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0065 0.0055
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Brugia malayi Amidase family protein 0.0012 0.0065 0.0065
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0017 0.015 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0286 0.0401
Loa Loa (eye worm) hypothetical protein 0.0014 0.0102 0.0102
Toxoplasma gondii heat shock protein 75, putative 0.0065 0.1015 0.1514
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0027 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0286 0.0401
Mycobacterium ulcerans lysophospholipase 0.0283 0.4954 1
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0017 0.015 0.0173
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1044 0.1044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0147 0.0209
Plasmodium falciparum alpha/beta hydrolase, putative 0.0017 0.015 0.0176
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0312 0.0503
Trypanosoma cruzi heat shock protein 85, putative 0.0097 0.1604 0.3148
Plasmodium vivax PST-A protein 0.0017 0.015 0.0132
Schistosoma mansoni protein phosphatase 2C 0.002 0.021 0.0262
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0286 0.0386
Plasmodium falciparum DNA topoisomerase 2 0.0014 0.0103 0.0103
Loa Loa (eye worm) RecQ helicase 0.0025 0.0302 0.0302
Brugia malayi nuclear hormone receptor 0.001 0.0027 0.0027
Trypanosoma brucei heat shock protein, putative 0.0097 0.1604 0.3148
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0017 0.015 0.0173
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0158 0.0189
Brugia malayi MGC83647 protein 0.0017 0.015 0.015
Mycobacterium ulcerans two component sensor kinase MprB 0.0014 0.0103 0.0077
Toxoplasma gondii heat shock protein HSP90 0.0097 0.1604 0.2426
Echinococcus granulosus death domain containing protein 0.0014 0.0102 0.0145
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.015 0.0121
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0158 0.019
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0024 0.0286 0.0401
Loa Loa (eye worm) TOPoisomerase family member 0.0014 0.0103 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0158 0.019
Loa Loa (eye worm) hypothetical protein 0.0106 0.1764 0.1764
Echinococcus multilocularis geminin 0.0178 0.3046 0.4343
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0283 0.4954 1
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0014 0.0103 0.0077
Entamoeba histolytica hypothetical protein 0.0035 0.0482 0.0803
Echinococcus granulosus jun protein 0.0082 0.1325 0.1889
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0014 0.0103 0.0077
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0036 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.1631 0.3167
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0014 0.0103 0.0077
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0283 0.4954 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0027 0.0038
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.2111 0.4185
Entamoeba histolytica ;Alias 0.0017 0.015 0.0121
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0014 0.0103 0.0077
Echinococcus granulosus chromobox protein 2 0.0024 0.0286 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Toxoplasma gondii PHD-finger domain-containing protein 0.0062 0.0966 0.1438
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.1884 0.3721
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.1325 0.1889
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0103
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0158 0.0189
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0315 0.0449
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.04 0.0635
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0014 0.0103 0.0103
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0065 0.0045
Plasmodium vivax DNA gyrase subunit B, putative 0.0014 0.0103 0.0058
Echinococcus granulosus fatty acid amide hydrolase 1 0.0099 0.1641 0.2339
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.015 0.0121
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1044 0.1456
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0286 0.0343
Schistosoma mansoni hypothetical protein 0.0062 0.0966 0.1344
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0027 0.0038
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0312 0.0503
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0158 0.0226
Echinococcus multilocularis peregrin 0.0062 0.0966 0.1377
Schistosoma mansoni netrin receptor unc5 0.0014 0.0102 0.0107

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.0119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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