Detailed information for compound 911415

Basic information

Technical information
  • TDR Targets ID: 911415
  • Name: 4-[[3-[(2-ethoxyphenyl)carbamoyl]-5,6,7,8-tet rahydro-4H-cyclohepta[d]thiophen-2-yl]amino]- 4-oxobutanoic acid
  • MW: 430.517 | Formula: C22H26N2O5S
  • H donors: 3 H acceptors: 4 LogP: 4.04 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccccc1NC(=O)c1c(NC(=O)CCC(=O)O)sc2c1CCCCC2
  • InChi: 1S/C22H26N2O5S/c1-2-29-16-10-7-6-9-15(16)23-21(28)20-14-8-4-3-5-11-17(14)30-22(20)24-18(25)12-13-19(26)27/h6-7,9-10H,2-5,8,11-13H2,1H3,(H,23,28)(H,24,25)(H,26,27)
  • InChiKey: BYUNIXCXMTZCHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-[[3-[(2-ethoxyphenyl)carbamoyl]-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophen-2-yl]amino]-4-oxo-butanoic acid
  • 4-[[3-[[(2-ethoxyphenyl)amino]-oxomethyl]-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophen-2-yl]amino]-4-oxobutanoic acid
  • 4-[[3-[(2-ethoxyphenyl)carbamoyl]-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiophen-2-yl]amino]-4-keto-butyric acid
  • A2259/0095119
  • CBMicro_044227
  • 4-[(3-{[(2-ethoxyphenyl)amino]carbonyl}-5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)amino]-4-oxobutanoic acid
  • MLS000673486
  • SMR000298134
  • BIM-0044377.P001
  • Oprea1_761678

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Bacillus subtilis 4'-phosphopantetheinyl transferase ffp Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K00142 aminoadipate-semialdehyde dehydrogenase [EC1.2.1.31], putative Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Onchocerca volvulus Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum expressed protein Get druggable targets OG5_129301 All targets in OG5_129301
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Echinococcus multilocularis L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Echinococcus granulosus L aminoadipate semialdehyde Get druggable targets OG5_129301 All targets in OG5_129301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase Get druggable targets OG5_129301 All targets in OG5_129301
Cryptosporidium parvum phosphopantetheinyl transferase Get druggable targets OG5_129301 All targets in OG5_129301
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis proteinx0005 Get druggable targets OG5_129301 All targets in OG5_129301
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Trichomonas vaginalis conserved hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 197 aa 22.3 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Entamoeba histolytica hypothetical protein 4'-phosphopantetheinyl transferase ffp   224 aa 198 aa 28.3 %
Candida albicans aminoadipate-semialdehyde dehydrogenase small subunit 4'-phosphopantetheinyl transferase ffp   224 aa 183 aa 27.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Onchocerca volvulus 4'-phosphopantetheinyl transferase ffp   224 aa 186 aa 26.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0013 0.0027 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0074 0.0773 0.1045
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0603 0.0817
Schistosoma mansoni hypothetical protein 0.0041 0.0371 0.0346
Plasmodium vivax PST-A protein 0.0371 0.4375 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0103 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0183
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0074 0.0773 0.1708
Schistosoma mansoni thyroid hormone receptor 0.0027 0.02 0.0174
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0025 0.017 0.0228
Brugia malayi hypothetical protein 0.0014 0.0045 0.0061
Schistosoma mansoni hypothetical protein 0.0494 0.5875 0.5864
Mycobacterium ulcerans esterase/lipase LipP 0.0025 0.017 0.032
Brugia malayi Amidase family protein 0.0013 0.0031 0.0042
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.1092 0.109
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0058 0.0056
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Schistosoma mansoni cpg binding protein 0.0037 0.0317 0.0291
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0059
Mycobacterium ulcerans hydrolase 0.0022 0.0137 0.0243
Echinococcus granulosus death domain containing protein 0.0015 0.0058 0.0056
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus abhydrolase domain containing protein 13 0.0022 0.0137 0.0135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0765 0.0741
Plasmodium vivax 6-phosphofructokinase, putative 0.002 0.0115 0.0193
Mycobacterium ulcerans 6-phosphofructokinase 0.0074 0.0773 0.1708
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.0963 0.0961
Brugia malayi bZIP transcription factor family protein 0.009 0.0963 0.1305
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0137 0.0051
Mycobacterium tuberculosis Probable lipase LipE 0.0025 0.017 0.032
Onchocerca volvulus 0.0071 0.0729 0.6591
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0137 0.0394
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.02 0.0174
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0214 0.0422
Mycobacterium tuberculosis Conserved protein 0.0025 0.017 0.032
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.017 0.0129
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.02 0.0269
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0137 0.0051
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0553 0.6597 0.6596
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0013 0.0031 0.0029
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0022 0.0137 0.0051
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.02 0.0199
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0214 0.0422
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0045 0.0044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.02 0.0199
Schistosoma mansoni 6-phosphofructokinase 0.0074 0.0773 0.0748
Trichomonas vaginalis conserved hypothetical protein 0.0371 0.4375 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0933 0.1262
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0109 0.1196 0.1195
Mycobacterium tuberculosis Possible lysophospholipase 0.0371 0.4375 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0183
Onchocerca volvulus 0.0025 0.017 0.1346
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.4375 1
Brugia malayi nuclear receptor NHR-88 0.0013 0.0027 0.0036
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0022 0.0137 0.0394
Echinococcus granulosus fatty acid amide hydrolase 1 0.0013 0.0031 0.0029
Plasmodium falciparum epoxide hydrolase 2 0.0022 0.0137 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0079
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Loa Loa (eye worm) amidase 0.0013 0.0031 0.004
Mycobacterium tuberculosis Probable esterase LipL 0.0025 0.017 0.032
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0137 0.0243
Echinococcus multilocularis abhydrolase domain containing 3 0.0022 0.0137 0.0135
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.4161 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0137 0.0243
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0045 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0.0027 0.0025
Toxoplasma gondii hypothetical protein 0.0022 0.0137 0.0394
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0137 0.0243
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.017 0.0129
Schistosoma mansoni fatty-acid amide hydrolase 0.0013 0.0031 0.0005
Trypanosoma brucei monoglyceride lipase, putative 0.0371 0.4375 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.4375 1
Loa Loa (eye worm) DR-78 0.0013 0.0027 0.0034
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.002 0.0115 0.0193
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.4375 1
Brugia malayi ecdysteroid receptor 0.0027 0.02 0.0272
Loa Loa (eye worm) amidase 0.0013 0.0031 0.004
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0074 0.0773 0.1796
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.02 0.0174
Plasmodium falciparum esterase, putative 0.0022 0.0137 0.0243
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.1092 0.1068
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0027 0.0025
Echinococcus granulosus fatty acid amide hydrolase 1 0.0109 0.1196 0.1195
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0137 0.0051
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0103 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0214 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0079 0.0829 0.0827
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.02 0.0174
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Toxoplasma gondii hypothetical protein 0.0022 0.0137 0.0394
Trichomonas vaginalis phosphofructokinase, putative 0.0074 0.0773 0.1545
Mycobacterium ulcerans lysophospholipase 0.0371 0.4375 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.017 0.0144
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.1967 0.4457
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0371 0.4375 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.02 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Brugia malayi nuclear hormone receptor 0.0013 0.0027 0.0036
Loa Loa (eye worm) phosphofructokinase 0.0074 0.0773 0.1045
Plasmodium vivax unspecified product 0.0022 0.0137 0.0243
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0137 0.011
Trichomonas vaginalis esterase, putative 0.0025 0.017 0.0129
Echinococcus granulosus abhydrolase domain containing 3 0.0022 0.0137 0.0135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0025 0.017 0.023
Loa Loa (eye worm) beta-lactamase 0.0025 0.017 0.0228
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0045 0.0019
Mycobacterium ulcerans hypothetical protein 0.0371 0.4375 1
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0058 0.0032
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0027 0.0036
Trypanosoma brucei Alpha/beta hydrolase family, putative 0.0022 0.0137 0.0243
Echinococcus multilocularis tar DNA binding protein 0.0043 0.0397 0.0395
Schistosoma mansoni hypothetical protein 0.0116 0.1277 0.1254
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0397 0.0371
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Echinococcus multilocularis CREB binding protein 0.0091 0.0978 0.0977
Onchocerca volvulus 0.01 0.1092 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0214 0.1795
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.02 0.0199
Mycobacterium ulcerans hypothetical protein 0.0022 0.0137 0.0243
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0157 0.1779 0.4025
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5875 0.5874
Brugia malayi nuclear receptor RXR 0.0014 0.0045 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.02 0.0272
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0025 0.017 0.032
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0027 0.0036
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.02 0.1633
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.0526
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.02 0.0269
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0137 0.0243
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.02 0.0272
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.02 0.0269
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0183
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0016 0.006 0.0033
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0013 0.0031 0.0029
Onchocerca volvulus 0.0025 0.017 0.1346
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Brugia malayi nuclear receptor NHR-67 0.0013 0.0027 0.0036
Echinococcus granulosus Phospholipase carboxylesterase 0.0022 0.0137 0.0135
Onchocerca volvulus 0.0027 0.02 0.1633
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0371 0.4375 1
Trichomonas vaginalis phosphofructokinase, putative 0.0074 0.0773 0.1545
Chlamydia trachomatis hydrolase 0.0022 0.0137 0.5759
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Echinococcus granulosus monoacylglycerol lipase abhd12 0.0022 0.0137 0.0135
Echinococcus granulosus CREB binding protein 0.0091 0.0978 0.0977
Brugia malayi MGC83647 protein 0.0022 0.0137 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.02 0.0269
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0137 0.0051
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0027 0.0036
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.02 0.0174
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.02 0.0199
Entamoeba histolytica hypothetical protein 0.0028 0.0214 0.0234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.02 0.0199
Schistosoma mansoni fatty-acid amide hydrolase 0.0109 0.1196 0.1173
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.02 0.0272
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Brugia malayi MGC79044 protein 0.0022 0.0137 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.02 0.0272
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5875 0.5874
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Plasmodium vivax lysophospholipase, putative 0.0022 0.0137 0.0243
Brugia malayi beta-lactamase family protein 0.0025 0.017 0.023
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0371 0.4375 1
Brugia malayi hypothetical protein 0.0013 0.0027 0.0036
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0109 0.1196 0.1195
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0.0027 0.0025
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0371 0.4375 1
Echinococcus multilocularis jun protein 0.009 0.0963 0.0961
Brugia malayi 6-phosphofructokinase 0.0074 0.0773 0.1047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0339 0.0337
Toxoplasma gondii ABC1 family protein 0.0025 0.017 0.0992
Echinococcus multilocularis beta LACTamase domain containing family member 0.0025 0.017 0.0168
Schistosoma mansoni thyroid hormone receptor 0.0027 0.02 0.0174
Loa Loa (eye worm) RNA binding protein 0.0043 0.0397 0.0535
Plasmodium falciparum esterase, putative 0.0371 0.4375 1
Mycobacterium leprae Probable lipase LipE 0.0025 0.017 0.032
Loa Loa (eye worm) CBP-B 0.0091 0.0978 0.1324
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0137 0.0051
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0103 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0397 0.0371
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0397 0.0371
Entamoeba histolytica hypothetical protein 0.0022 0.0137 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0027 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0603 0.0817
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0058 0.0079
Leishmania major hypothetical protein, conserved 0.0022 0.0137 0.0243
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.02 0.0199
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.002 0.0115 0.0203
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.02 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Echinococcus multilocularis monoacylglycerol lipase abhd12 0.0022 0.0137 0.0135
Echinococcus granulosus 6 phosphofructokinase 0.0074 0.0773 0.0771
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0.0027 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.02 0.1633
Loa Loa (eye worm) hypothetical protein 0.006 0.0603 0.0815
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0103 0.0101
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.4375 1
Brugia malayi nuclear receptor NHR-88 0.0027 0.02 0.0272
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0137 0.0051
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.02 0.0174
Plasmodium falciparum alpha/beta-hydrolase, putative 0.0022 0.0137 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.02 0.0272
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.067 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0103 0.0101
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0013 0.0031 0.0005
Onchocerca volvulus 0.0035 0.0293 0.25
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0022 0.0137 0.0394
Schistosoma mansoni jun-related protein 0.0073 0.0758 0.0734
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0013 0.0031 0.0029
Leishmania major ATP-dependent phosphofructokinase 0.0074 0.0773 0.1708
Loa Loa (eye worm) TAR-binding protein 0.0043 0.0397 0.0535
Brugia malayi hypothetical protein 0.0071 0.0729 0.0987
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0.0027 0.0025
Loa Loa (eye worm) nuclear receptor NHR-67 0.0013 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0015 0.0058 0.0077
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.02 0.0199
Plasmodium vivax PST-A protein 0.0022 0.0137 0.0243
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0371 0.4375 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.02 0.0199
Leishmania major Bem46-like serine peptidase,Serine peptidase, Clan SC, Family S09X 0.0022 0.0137 0.0243
Plasmodium falciparum lysophospholipase, putative 0.0371 0.4375 1
Toxoplasma gondii protein c14orf29, putative 0.0022 0.0137 0.0394
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0025 0.017 0.032
Leishmania major monoglyceride lipase, putative 0.0371 0.4375 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0103 0.0139
Brugia malayi phosphofructokinase 0.0074 0.0773 0.1047
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0076
Brugia malayi TAZ zinc finger family protein 0.0091 0.0978 0.1326
Mycobacterium tuberculosis Probable hydrolase 0.0025 0.017 0.032
Echinococcus granulosus cpg binding protein 0.0037 0.0317 0.0315
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0137 0.0243
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.02 0.0199
Mycobacterium ulcerans hypothetical protein 0.0022 0.0137 0.0243
Plasmodium falciparum lysophospholipase, putative 0.0371 0.4375 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0025 0.017 0.032
Schistosoma mansoni hypothetical protein 0.0038 0.0339 0.0313
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.002 0.0115 0.4566
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.02 0.0199
Brugia malayi conserved hypotetical protein 0.0013 0.0027 0.0036
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Plasmodium vivax lysophospholipase, putative 0.0022 0.0137 0.0243
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0059
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.1092 0.1479
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0293 0.0395
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0091 0.0978 0.0954
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0058 0.0077
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0.0027 0.0025
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0.0027 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.02 0.0269
Schistosoma mansoni family S9 unassigned peptidase (S09 family) 0.0022 0.0137 0.011
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0027 0.0025
Plasmodium falciparum esterase, putative 0.0022 0.0137 0.0243
Mycobacterium ulcerans hypothetical protein 0.0025 0.017 0.032
Plasmodium falciparum alpha/beta hydrolase fold domain containing protein, putative 0.0022 0.0137 0.0243
Loa Loa (eye worm) hypothetical protein 0.0618 0.738 1
Brugia malayi small heat shock protein 0.0618 0.738 1
Plasmodium vivax alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.02 0.0174
Brugia malayi amidase 0.0109 0.1196 0.1621
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.02 0.0269
Schistosoma mansoni hypothetical protein 0.0073 0.0758 0.0734
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.002 0.0115 0.0193
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.02 0.0269
Echinococcus granulosus CREB binding protein 0.0091 0.0978 0.0977
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.0526
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.02 0.0199
Brugia malayi ecdysone receptor 0.0013 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0059
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Chlamydia trachomatis acyltransferase family protein 0.0022 0.0137 0.5759
Echinococcus granulosus FTZ F1 alpha 0.0027 0.02 0.0199
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0214 0.0422
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Loa Loa (eye worm) nuclear hormone receptor 0.0013 0.0027 0.0034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.02 0.0199
Plasmodium falciparum exported lipase 2 0.0022 0.0137 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Trichomonas vaginalis phosphofructokinase, putative 0.0074 0.0773 0.1545
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0137 0.0243
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0013 0.0027 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0183
Schistosoma mansoni cpg binding protein 0.0037 0.0317 0.0291
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.02 0.0199
Brugia malayi steroid hormone receptor 0.0027 0.02 0.0272
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.02 0.0199
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.02 0.0272
Plasmodium falciparum exported lipase 1 0.0022 0.0137 0.0243
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.02 0.0199
Brugia malayi hypothetical protein 0.0014 0.0045 0.0061
Entamoeba histolytica ;Alias 0.0022 0.0137 0.0051
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.1967 0.4457
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0074 0.0773 0.1708
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.017 0.032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0214 0.0422
Loa Loa (eye worm) hypothetical protein 0.0027 0.02 0.0269
Toxoplasma gondii peptidase S15, putative 0.0022 0.0137 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.017 0.0129
Brugia malayi Amidase family protein 0.0013 0.0031 0.0042
Trypanosoma cruzi serine peptidase, putative 0.0022 0.0137 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0025 0.017 0.0144
Schistosoma mansoni hypothetical protein 0.0015 0.0058 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0103 0.0101
Brugia malayi nuclear hormone receptor 0.0027 0.02 0.0272
Trypanosoma cruzi monoglyceride lipase, putative 0.0371 0.4375 1
Mycobacterium ulcerans beta-lactamase 0.0025 0.017 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.017 0.032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0603 0.0815
Echinococcus multilocularis Phospholipase carboxylesterase 0.0022 0.0137 0.0135
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0214 0.0422
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0137 0.0051
Brugia malayi TAR-binding protein 0.0043 0.0397 0.0537
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.0526
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0043 0.0397 0.0535
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0214 0.0422
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0059
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0079 0.0829 0.0827
Echinococcus multilocularis Ankyrin 0.0016 0.006 0.0058
Plasmodium falciparum lysophospholipase, putative 0.0022 0.0137 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0.0027 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0025 0.017 0.032
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Toxoplasma gondii hypothetical protein 0.0022 0.0137 0.0394
Schistosoma mansoni peptidase 0.0022 0.0137 0.011
Leishmania major hypothetical protein, conserved 0.0025 0.017 0.032
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0.0027 0.0025
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0058 0.0297
Schistosoma mansoni 6-phosphofructokinase 0.0074 0.0773 0.0748
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0137 0.0243
Schistosoma mansoni CREB-binding protein 2 0.0091 0.0978 0.0954
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.4161 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0137 0.0243
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.02 0.0174
Schistosoma mansoni netrin receptor unc5 0.0015 0.0058 0.0032
Brugia malayi hypothetical protein 0.0013 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0103 0.0101
Plasmodium falciparum BEM46-like protein, putative 0.0022 0.0137 0.0243
Schistosoma mansoni hypothetical protein 0.0116 0.1277 0.1254
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.02 0.0272
Trichomonas vaginalis penicillin-binding protein, putative 0.0025 0.017 0.0129
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0214 0.0422
Entamoeba histolytica phosphofructokinase, putative 0.0074 0.0773 0.1545
Trypanosoma cruzi hydrolase, alpha/beta fold family, putative 0.0022 0.0137 0.0243
Brugia malayi Protein C20orf22 0.0022 0.0137 0.0185
Brugia malayi RNA binding protein 0.0043 0.0397 0.0537
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.1967 0.4457
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0214 0.1795
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0058 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0027 0.02 0.0199
Toxoplasma gondii phospholipase 0.0022 0.0137 0.0394
Brugia malayi hypothetical protein 0.0038 0.0339 0.0459
Plasmodium vivax 6-phosphofructokinase, putative 0.002 0.0115 0.0193
Giardia lamblia Cgi67 serine protease precursor-like protein 0.0022 0.0137 0.0054
Brugia malayi Death domain containing protein 0.0015 0.0058 0.0079
Plasmodium vivax PST-A protein 0.0022 0.0137 0.0243
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.02 0.0199
Trichomonas vaginalis Clan SC, family S9, unassigned serine peptidase 0.0022 0.0137 0.0051
Brugia malayi RNA recognition motif domain containing protein 0.0043 0.0397 0.0537
Echinococcus granulosus fatty acid amide hydrolase 1 0.0109 0.1196 0.1195
Plasmodium vivax PST-A protein 0.0022 0.0137 0.0243
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0058 0.0056
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0022 0.0137 0.0051
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0214 0.0444
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0076
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.1092 0.109
Schistosoma mansoni nuclear hormone receptor 0.0027 0.02 0.0174
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0137 0.0243
Plasmodium falciparum lysophospholipase, putative 0.0371 0.4375 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.02 0.0272
Plasmodium falciparum prodrug activation and resistance esterase 0.0022 0.0137 0.0243
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0058 0.0056
Entamoeba histolytica hypothetical protein 0.0022 0.0137 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0397 0.0371
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0371 0.0503
Loa Loa (eye worm) hypothetical protein 0.01 0.1092 0.1477
Trypanosoma brucei monoglyceride lipase, putative 0.0371 0.4375 1
Brugia malayi beta-lactamase family protein 0.0025 0.017 0.023
Mycobacterium ulcerans lipase LipD 0.0025 0.017 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Trypanosoma cruzi Serine peptidase, Clan SC, Family S09X, putative 0.0022 0.0137 0.0243
Entamoeba histolytica hypothetical protein 0.0038 0.0339 0.0526
Brugia malayi CXXC zinc finger family protein 0.0035 0.0293 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0137 0.0051
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.02 0.0174
Brugia malayi putative amidase 0.0013 0.0031 0.0042
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.02 0.0272
Brugia malayi 6-phosphofructokinase 0.0074 0.0773 0.1047
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.02 0.0272
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Mycobacterium tuberculosis Probable lipase LipD 0.0025 0.017 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.017 0.032
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.02 0.0272
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0.0027 0.0025
Echinococcus granulosus jun protein 0.009 0.0963 0.0961
Echinococcus granulosus GPCR family 2 0.0019 0.0103 0.0101
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0214 0.0422
Schistosoma mansoni coup transcription factor 0.0027 0.02 0.0174
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Mycobacterium leprae conserved hypothetical protein 0.0025 0.017 0.032
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0045 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.02 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.02 0.0272
Echinococcus multilocularis 6 phosphofructokinase 0.0074 0.0773 0.0771
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0339 0.0337
Echinococcus granulosus geminin 0.0116 0.1277 0.1275
Echinococcus granulosus tar DNA binding protein 0.0043 0.0397 0.0395
Echinococcus granulosus Ankyrin 0.0016 0.006 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Leishmania major hypothetical protein, conserved 0.0022 0.0137 0.0243
Loa Loa (eye worm) 6-phosphofructokinase 0.0074 0.0773 0.1045
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0214 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.02 0.0272
Schistosoma mansoni amidase 0.0109 0.1196 0.1173
Plasmodium vivax PST-A protein 0.0022 0.0137 0.0243
Trichomonas vaginalis D-aminoacylase, putative 0.0025 0.017 0.0129
Plasmodium vivax PST-A protein 0.0022 0.0137 0.0243
Onchocerca volvulus 0.0025 0.017 0.1346
Entamoeba histolytica phosphofructokinase, putative 0.0074 0.0773 0.1545
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.002 0.0115 0.4566
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0339 0.0313
Schistosoma mansoni cpg binding protein 0.0035 0.0293 0.0267
Brugia malayi tailless protein 0.0013 0.0027 0.0036
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0045 0.0059
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0045 0.0019
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Brugia malayi Uncoordinated protein 44 0.0015 0.0058 0.0079
Mycobacterium tuberculosis Conserved protein 0.0025 0.017 0.032
Toxoplasma gondii hypothetical protein 0.0022 0.0137 0.0394
Plasmodium vivax lysophospholipase, putative 0.0022 0.0137 0.0243
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0074 0.0773 0.1708
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.02 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.02 0.0272
Echinococcus multilocularis cpg binding protein 0.0037 0.0317 0.0315
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0074 0.0773 0.1708
Schistosoma mansoni hypothetical protein 0.0019 0.0103 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.0074 0.0773 0.1545
Schistosoma mansoni tar DNA-binding protein 0.0043 0.0397 0.0371
Trypanosoma brucei Serine peptidase, Clan SC, Family S09X 0.0022 0.0137 0.0243
Entamoeba histolytica phosphofructokinase, putative 0.0074 0.0773 0.1545
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0045 0.0061
Brugia malayi beta-lactamase 0.0025 0.017 0.023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0371 0.0501
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0034
Echinococcus granulosus beta LACTamase domain containing family member 0.0025 0.017 0.0168
Plasmodium vivax unspecified product 0.0022 0.0137 0.0243
Trypanosoma cruzi Alpha/beta hydrolase family, putative 0.0022 0.0137 0.0243
Toxoplasma gondii phospholipase/carboxylesterase 0.0022 0.0137 0.0394
Loa Loa (eye worm) hypothetical protein 0.0109 0.1196 0.1619
Loa Loa (eye worm) hypothetical protein 0.0019 0.0103 0.0137
Echinococcus multilocularis geminin 0.0116 0.1277 0.1275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.02 0.0269
Mycobacterium tuberculosis Conserved protein 0.0025 0.017 0.032
Brugia malayi Protein kinase domain containing protein 0.0015 0.0058 0.0079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.0963 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0371 0.4375 1
Plasmodium falciparum alpha/beta hydrolase, putative 0.0022 0.0137 0.0243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4161 0.9499
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0025 0.017 0.032
Loa Loa (eye worm) hypothetical protein 0.0025 0.017 0.0228
Loa Loa (eye worm) hypothetical protein 0.0022 0.0137 0.0183

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9054 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 23.5283 um PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) [Related pubchem assays: 1490 (qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase)), 1819 (Probe Development Summary of Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase))] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.