Detailed information for compound 911460

Basic information

Technical information
  • TDR Targets ID: 911460
  • Name: 2-(4-bromophenyl)-3-[3-(trifluoromethyl)pheny l]-1,3-thiazolidin-4-one
  • MW: 402.229 | Formula: C16H11BrF3NOS
  • H donors: 0 H acceptors: 1 LogP: 4.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)C1SCC(=O)N1c1cccc(c1)C(F)(F)F
  • InChi: 1S/C16H11BrF3NOS/c17-12-6-4-10(5-7-12)15-21(14(22)9-23-15)13-3-1-2-11(8-13)16(18,19)20/h1-8,15H,9H2
  • InChiKey: GJZWFGPOKQOABJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-bromophenyl)-3-[3-(trifluoromethyl)phenyl]thiazolidin-4-one
  • 2-(4-bromophenyl)-3-[3-(trifluoromethyl)phenyl]-4-thiazolidinone
  • EU-0003951
  • ChemDiv1_002460

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0093 0.2208 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0404 0.0521
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0114 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0027 0.0561 0.055
Echinococcus granulosus basement membrane specific heparan sulfate 0.0009 0.0114 0.0102
Echinococcus granulosus basement membrane specific heparan sulfate 0.0009 0.0114 0.0102
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0561 0.0824
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0119 0.0107
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Schistosoma mansoni ap endonuclease 0.0019 0.0352 0.0352
Plasmodium vivax acyl-CoA synthetase, putative 0.0069 0.1619 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.036 0.0348
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.036 0.0464
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.05 0.0633
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0274 0.1629
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0404 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0404 0.0393
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0093 0.2208 0.5352
Loa Loa (eye worm) hypothetical protein 0.0093 0.2208 0.2921
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0393 0.237
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0027 0.0561 0.0714
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.7514 1
Mycobacterium ulcerans hypothetical protein 0.016 0.3899 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.7531 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0404 0.0504
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0009 0.0114 0.0114
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0119 0.0973
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0352 0.6192
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0026 0.009
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.034 0.034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.1524 0.347
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Trichomonas vaginalis antibiotic synthetase, putative 0.0027 0.0561 1
Brugia malayi polk-prov protein 0.0006 0.0026 0.0066
Mycobacterium ulcerans hypothetical protein 0.0093 0.2208 0.5634
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0261 0.025
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.05 0.3039
Brugia malayi isocitrate dehydrogenase 0.0015 0.0261 0.1135
Schistosoma mansoni hypothetical protein 0.0167 0.409 0.409
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Loa Loa (eye worm) hypothetical protein 0.0069 0.1619 0.2137
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0561 0.1381
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.019 0.0219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0352 0.0435
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0027 0.0561 0.0714
Onchocerca volvulus 0.0048 0.1088 0.4651
Schistosoma mansoni hypothetical protein 0.0009 0.0114 0.0114
Echinococcus granulosus cpg binding protein 0.003 0.0628 0.0616
Echinococcus multilocularis dna polymerase eta 0.0045 0.0998 0.0987
Schistosoma mansoni DNA helicase recq5 0.001 0.0119 0.0119
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.036 0.036
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0593 0.0775
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.021 0.0264
Schistosoma mansoni hypothetical protein 0.0011 0.0156 0.0156
Echinococcus granulosus Low density lipoprotein receptor class A cysteine rich 0.0009 0.0114 0.0102
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.036 0.0464
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0053 0.0041
Brugia malayi basement membrane proteoglycan precursor 0.0009 0.0114 0.0463
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0404 0.3304
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Leishmania major acetyl-CoA synthetase, putative 0.0027 0.0561 0.0732
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0027 0.0561 0.0824
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0053 0.0041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0352 0.5
Onchocerca volvulus 0.0027 0.0561 0.2136
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.036 0.1629
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.1524 0.347
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0352 0.8619
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0458 0.812
Entamoeba histolytica acyl-coA synthetase, putative 0.0093 0.2208 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0561 0.073
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0261 0.025
Leishmania major DNA polymerase kappa, putative 0.0019 0.036 0.0464
Brugia malayi RNA, U transporter 1 0.0081 0.1915 0.8667
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0027 0.0561 0.0732
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0027 0.0561 0.4587
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0027 0.0561 0.055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0119 0.0973
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Echinococcus granulosus 5'partial|Low density lipoprotein receptor class A cysteine rich 0.0009 0.0114 0.0102
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0352 0.0453
Brugia malayi AMP-binding enzyme family protein 0.0093 0.2208 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0026 0.009
Schistosoma mansoni hypothetical protein 0.0402 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0352 0.0452
Loa Loa (eye worm) hypothetical protein 0.0069 0.1619 0.2137
Schistosoma mansoni ran 0.0021 0.0404 0.0404
Brugia malayi CXXC zinc finger family protein 0.0028 0.0587 0.2619
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0049 0.1108 0.9061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0037 0.0463
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0093 0.2208 0.5634
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0404 0.0393
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0464 0.0453
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Echinococcus granulosus low density lipoprotein receptor ldl 0.0009 0.0114 0.0102
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.3899 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0119 0.0142
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.095 0.1251
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0009 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.036 0.0445
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0009 0.0114 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.2208 0.5634
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0352 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0027 0.0561 0.1381
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0261 0.1551
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0352 0.034
Loa Loa (eye worm) hypothetical protein 0.0006 0.0026 0.0019
Trypanosoma brucei unspecified product 0.0019 0.036 0.0464
Schistosoma mansoni DNA helicase recq1 0.001 0.0119 0.0119
Trypanosoma brucei unspecified product 0.0013 0.021 0.0264
Loa Loa (eye worm) hypothetical protein 0.0027 0.0561 0.073
Loa Loa (eye worm) hypothetical protein 0.0117 0.2835 0.3754
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0027 0.0561 0.0824
Schistosoma mansoni importin-beta 2 0.0005 0.0012 0.0012
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0027 0.0561 0.0824
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0404 0.244
Echinococcus granulosus geminin 0.0167 0.409 0.4083
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.2208 0.5634
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0045 0.0998 0.1311
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0156 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0156 0.0144
Echinococcus granulosus dna polymerase eta 0.0045 0.0998 0.0987
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0587 0.0765
Echinococcus granulosus low density lipoprotein receptor protein 0.0009 0.0114 0.0102
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0135
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.036 0.0462
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1088 0.1088
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0093 0.2208 0.5634
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.036 0.0445
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0026 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.036 0.1583
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0269 0.22
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0261 0.025
Brugia malayi AMP-binding enzyme family protein 0.0093 0.2208 1
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.7514 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Schistosoma mansoni hypothetical protein 0.0304 0.7531 0.7531
Plasmodium falciparum importin beta, putative 0.0028 0.0593 0.3619
Echinococcus multilocularis low density lipoprotein receptor protein 0.0009 0.0114 0.0102
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0027 0.0561 0.1381
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0404 0.0504
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0119 0.0487
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0119 0.0487
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0464 0.8235
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.021 0.0264
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0261 0.1135
Trichomonas vaginalis ran, putative 0.0021 0.0404 0.7142
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0561 0.25
Onchocerca volvulus 0.0027 0.0561 0.2136
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0053 0.0041
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0027 0.0561 0.254
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.036 0.0861
Schistosoma mansoni acetyl-CoA synthetase 0.0027 0.0561 0.0561
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0352 0.0841
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0593 0.0582
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0027 0.0561 0.0732
Schistosoma mansoni ap endonuclease 0.0019 0.0352 0.0352
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0261 0.1551
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Schistosoma mansoni cpg binding protein 0.003 0.0628 0.0628
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0561 0.0824
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0261 0.025
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.095 0.1234
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0069 0.1619 0.3732
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.05 0.3039
Loa Loa (eye worm) hypothetical protein 0.0069 0.1619 0.2137
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Onchocerca volvulus 0.0093 0.2208 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.036 0.6333
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0026 0.0019
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0404 0.0523
Schistosoma mansoni DNA polymerase eta 0.0045 0.0998 0.0998
Mycobacterium ulcerans acetyl-CoA synthetase 0.0027 0.0561 0.1381
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.7514 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0093 0.2208 1
Schistosoma mansoni hypothetical protein 0.0167 0.409 0.409
Brugia malayi Low-density lipoprotein receptor-related protein, putative 0.0009 0.0114 0.0463
Leishmania major DNA polymerase kappa, putative 0.0006 0.0026 0.0019
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0119 0.0107
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0458 0.0576
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0404 0.1785
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0027 0.0561 0.1381
Echinococcus multilocularis snurportin 1 0.0304 0.7531 0.7529
Leishmania major DNA polymerase eta, putative 0.0045 0.0998 0.1314
Giardia lamblia DINP protein human, muc B family 0.0019 0.036 0.8824
Entamoeba histolytica Ran family GTPase 0.0021 0.0404 0.183
Loa Loa (eye worm) hypothetical protein 0.0069 0.1619 0.2137
Brugia malayi Importin beta-1 subunit 0.0028 0.0593 0.2647
Loa Loa (eye worm) hypothetical protein 0.0027 0.0561 0.073
Schistosoma mansoni importin beta-1 0.0028 0.0593 0.0593
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0261 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0561 0.25
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0027 0.0561 0.1381
Entamoeba histolytica acyl-CoA synthetase, putative 0.0093 0.2208 1
Onchocerca volvulus 0.0027 0.0561 0.2136
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.2208 0.2928
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Entamoeba histolytica HEAT repeat domain containing protein 0.0005 0.0012 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0352 0.6192
Toxoplasma gondii propionate-CoA ligase 0.0027 0.0561 0.4587
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.095 0.1234
Brugia malayi enteropeptidase precursor 0.0009 0.0114 0.0463
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0009 0.0114 0.0114
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0261 0.0332
Trichomonas vaginalis antibiotic synthetase, putative 0.0027 0.0561 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0261 0.0332
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0664 0.5432
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.095 0.1234
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0261 0.2136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.1524 0.347
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0119 0.0666
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.2208 0.2928
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0027 0.0561 0.0824
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0561 0.0824
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0464 0.8235
Entamoeba histolytica hypothetical protein 0.0023 0.0458 0.2073
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0027 0.0561 0.0714
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.021 0.0264
Echinococcus granulosus bloom syndrome protein 0.0023 0.0464 0.0453
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0026 0.0026
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0026 0.0215
Echinococcus granulosus importin subunit beta 1 0.0028 0.0593 0.0582
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.05 0.0651
Loa Loa (eye worm) low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0135
Loa Loa (eye worm) hypothetical protein 0.0048 0.1088 0.1431
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0458 0.812
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.05 0.409
Echinococcus granulosus tumor protein p63 0.0329 0.8154 0.8152
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0027 0.0561 0.0824
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0114 0.0102
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0119 0.0107
Brugia malayi hypothetical protein 0.0016 0.0279 0.1216
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.036 0.6333
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0458 0.812
Entamoeba histolytica acyl-CoA synthetase, putative 0.0093 0.2208 1
Leishmania major DNA damage repair protein, putative 0.0006 0.0026 0.0019
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.036 0.0348
Leishmania major importin beta-1 subunit, putative 0.0023 0.0458 0.0594
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0027 0.0561 0.4587
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.05 0.0633
Loa Loa (eye worm) hypothetical protein 0.0093 0.2208 0.2921
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0027 0.0561 0.073
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0352 0.2116
Loa Loa (eye worm) hypothetical protein 0.001 0.0119 0.0142
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.05 0.3039
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0027 0.0561 0.0824
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1223 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0096 0.0084
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.019 0.3249
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0998 0.1297
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0037 0.0463
Plasmodium vivax acetyl-CoA synthetase, putative 0.0027 0.0561 0.3417
Loa Loa (eye worm) oxidoreductase 0.0027 0.0561 0.073
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0093 0.2208 0.5634
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0027 0.0561 0.0824
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.019 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0026 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.3491 0.4627
Leishmania major GTP-binding protein, putative 0.0021 0.0404 0.0523
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0352 0.034
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.036 0.036
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.0009 0.0114 0.0135
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0261 0.025
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0464 0.2059
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0119 0.0107
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0027 0.0561 0.0732
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0561 0.0824
Trypanosoma brucei unspecified product 0.0013 0.021 0.0264
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0561 0.25
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0352 0.0435
Entamoeba histolytica recQ family helicase, putative 0.0012 0.019 0.0862
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0352 0.0453
Schistosoma mansoni ran 0.0021 0.0404 0.0404
Leishmania major acetyl-CoA synthetase, putative 0.0027 0.0561 0.0732
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0096 0.0084
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0352 0.1548
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Brugia malayi Low-density lipoprotein receptor domain class A containing protein 0.0009 0.0114 0.0463
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.3491 0.4637
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0093 0.0371
Toxoplasma gondii exonuclease III APE 0.0019 0.0352 0.2878
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0261 0.0332
Plasmodium falciparum acyl-CoA synthetase 0.0069 0.1619 1
Echinococcus granulosus snurportin 1 0.0304 0.7531 0.7529
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.3491 0.4637
Trichomonas vaginalis helicase, putative 0.0006 0.0037 0.0463
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0009 0.0114 0.0463
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0352 0.1594
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0027 0.0561 0.1381
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.1619 0.4112
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0261 0.0332
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0027 0.0561 0.0714
Brugia malayi Calcium binding EGF domain containing protein 0.0009 0.0114 0.0463
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.036 0.0445
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0008 0.0068 0.0055
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0466 0.0562
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0593 0.0775
Echinococcus multilocularis geminin 0.0167 0.409 0.4083
Onchocerca volvulus 0.0027 0.0561 0.2136
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Loa Loa (eye worm) hypothetical protein 0.0025 0.05 0.0649
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0026 0.0019
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0261 0.0314
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0593 0.4852
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0096 0.0112
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0027 0.0561 0.25
Schistosoma mansoni hypothetical protein 0.0009 0.0114 0.0114
Leishmania major 4-coumarate:coa ligase-like protein 0.0093 0.2208 0.2928
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0261 0.0314
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0069 0.1619 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.036 0.0464
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0009 0.0114 0.0135
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Mycobacterium ulcerans acyl-CoA synthetase 0.0093 0.2208 0.5634
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0352 0.0249
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.036 0.0348
Leishmania major DNA polymerase eta, putative 0.0031 0.0664 0.087
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.036 0.0445
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0114 0.0102
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0026 0.0215
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0027 0.0561 0.1381
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.1524 0.347
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0026 0.0019
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.036 0.0861
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0098
Loa Loa (eye worm) RecQ helicase 0.0023 0.0464 0.0601
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.7514 1
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0998 0.1314
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0664 0.0852
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.036 0.0271
Echinococcus granulosus dna polymerase kappa 0.0019 0.036 0.0348
Schistosoma mansoni cpg binding protein 0.0028 0.0587 0.0587
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.1185 0.1548
Loa Loa (eye worm) hypothetical protein 0.0093 0.2208 0.2921
Leishmania major pantothenate kinase subunit, putative 0.0008 0.0068 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Echinococcus multilocularis tumor protein p63 0.0329 0.8154 0.8152
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.036 0.0271
Loa Loa (eye worm) hypothetical protein 0.0028 0.0593 0.0773
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.0119 0.2452
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0053 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Echinococcus multilocularis Low density lipoprotein receptor, class A, cysteine rich 0.0009 0.0114 0.0102
Loa Loa (eye worm) hypothetical protein 0.0009 0.0114 0.0135
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0093 0.2208 0.5352
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0027 0.0561 0.3417
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0037 0.0463
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0261 0.2136
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0026 0.0019
Brugia malayi CUB domain containing protein 0.0009 0.0114 0.0463
Loa Loa (eye worm) hypothetical protein 0.0069 0.1619 0.2137
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.036 0.0464
Leishmania major hypothetical protein, conserved 0.0025 0.05 0.0651
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0027 0.0561 0.1381
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0026 0.0019
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0998 0.4488
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0261 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0561 0.25
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1384 0.1384
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0009 0.0114 0.0102
Brugia malayi hypothetical protein 0.0025 0.05 0.2223
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0027 0.0561 0.25
Brugia malayi AMP-binding enzyme family protein 0.0093 0.2208 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0352 0.2116
Echinococcus granulosus low density lipoprotein receptor ldl 0.0009 0.0114 0.0102
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.019 0.0238
Plasmodium vivax importin-beta 2, putative 0.0028 0.0593 0.3619
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0037 0.0463
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0093 0.2208 0.5634
Toxoplasma gondii HEAT repeat-containing protein 0.0005 0.0012 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0561 0.1381
Onchocerca volvulus 0.0028 0.0587 0.226
Echinococcus multilocularis cpg binding protein 0.003 0.0628 0.0616
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0009 0.0114 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.036 0.0464
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0404 0.244

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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