Detailed information for compound 911535

Basic information

Technical information
  • TDR Targets ID: 911535
  • Name: 3-(3-fluoro-4-methylphenyl)-2-(4-nitrophenyl) -1,3-thiazolidin-4-one
  • MW: 332.349 | Formula: C16H13FN2O3S
  • H donors: 0 H acceptors: 3 LogP: 3.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(N1c1ccc(c(c1)F)C)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C16H13FN2O3S/c1-10-2-5-13(8-14(10)17)18-15(20)9-23-16(18)11-3-6-12(7-4-11)19(21)22/h2-8,16H,9H2,1H3
  • InChiKey: WDIWHJPZBBMZKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3-fluoro-4-methyl-phenyl)-2-(4-nitrophenyl)thiazolidin-4-one
  • 3-(3-fluoro-4-methylphenyl)-2-(4-nitrophenyl)-4-thiazolidinone
  • 3-(3-fluoro-4-methyl-phenyl)-2-(4-nitrophenyl)-1,3-thiazolidin-4-one
  • EU-0037146

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0047 0.235 0.3638
Schistosoma mansoni hypothetical protein 0.0102 0.6459 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Loa Loa (eye worm) RNA binding protein 0.0064 0.3585 0.3585
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3585 0.5551
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.235 0.235
Schistosoma mansoni hypothetical protein 0.0047 0.235 0.3638
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.235 0.235
Loa Loa (eye worm) hypothetical protein 0.0047 0.235 0.235
Echinococcus multilocularis GPCR, family 2 0.0047 0.235 0.6553
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 1 1
Brugia malayi RNA binding protein 0.0064 0.3585 0.3585
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.3585 0.3585
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.235 0.6553
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0 0.5
Echinococcus granulosus tar DNA binding protein 0.0064 0.3585 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.3585 0.3585
Loa Loa (eye worm) TAR-binding protein 0.0064 0.3585 0.3585
Loa Loa (eye worm) hypothetical protein 0.0149 1 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3585 0.5551
Loa Loa (eye worm) hypothetical protein 0.0102 0.6459 0.6459
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.6459 0.6459
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.235 0.6553
Echinococcus granulosus GPCR family 2 0.0047 0.235 0.6553
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.235 0.6553
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3585 0.5551
Schistosoma mansoni hypothetical protein 0.0047 0.235 0.3638
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3585 0.5551
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.235 0.6553
Echinococcus multilocularis tar DNA binding protein 0.0064 0.3585 1
Brugia malayi Latrophilin receptor protein 2 0.0047 0.235 0.235
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3585 0.5551
Schistosoma mansoni hypothetical protein 0.0047 0.235 0.3638
Brugia malayi TAR-binding protein 0.0064 0.3585 0.3585

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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