Detailed information for compound 911712

Basic information

Technical information
  • TDR Targets ID: 911712
  • Name: 2-[(4-bromo-3-chlorophenyl)carbamoyl]benzoic acid
  • MW: 354.583 | Formula: C14H9BrClNO3
  • H donors: 2 H acceptors: 3 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1C(=O)O)Nc1ccc(c(c1)Cl)Br
  • InChi: 1S/C14H9BrClNO3/c15-11-6-5-8(7-12(11)16)17-13(18)9-3-1-2-4-10(9)14(19)20/h1-7H,(H,17,18)(H,19,20)
  • InChiKey: IORYTMQSSWVCCC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-bromo-3-chloro-phenyl)carbamoyl]benzoic acid
  • 2-[[(4-bromo-3-chlorophenyl)amino]-oxomethyl]benzoic acid
  • ST036394
  • AG-690/11548153
  • BAS 00632295
  • ARONIS018484
  • N-(4-Bromo-3-chloro-phenyl)-phthalamic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0106 0.0284
Mycobacterium tuberculosis Probable reductase 0.011 0.2735 0.7297
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Loa Loa (eye worm) hypothetical protein 0.0103 0.2544 0.6819
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0219 0.0414
Plasmodium falciparum thioredoxin reductase 0.0048 0.0936 0.092
Echinococcus granulosus jumonji domain containing protein 0.0084 0.1977 0.3739
Plasmodium falciparum lysophospholipase, putative 0.0144 0.3742 0.373
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0018 0.004
Brugia malayi chromobox protein homolog 3 0.0081 0.1886 0.3566
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.3742 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0219 0.0211
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0259 0.0647
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.2735 0.7297
Echinococcus granulosus heat shock protein 90 0.0095 0.2294 0.4338
Trichomonas vaginalis heat shock protein, putative 0.0089 0.2124 0.5655
Brugia malayi Hsp90 protein 0.0063 0.1366 0.2584
Echinococcus granulosus chromobox protein 1 0.0144 0.3731 0.7057
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.1886 0.5015
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0063 0.1366 0.3258
Schistosoma mansoni hypothetical protein 0.0172 0.4565 1
Mycobacterium ulcerans hypothetical protein 0.0144 0.3742 1
Leishmania major hypothetical protein, conserved 0.0217 0.5851 1
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.1289 0.1282
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0265
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1413 0.3096
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0106 0.02
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1413 0.3096
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.3742 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.0219 0.0414
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0259 0.049
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0259 0.0647
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.0219 0.0587
Loa Loa (eye worm) hypothetical protein 0.0081 0.1886 0.5054
Schistosoma mansoni chromobox protein 0.0024 0.0219 0.0479
Trichomonas vaginalis heat shock protein, putative 0.0089 0.2124 0.5655
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0158 0.014
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.2735 0.7297
Brugia malayi Bromodomain containing protein 0.006 0.1289 0.2438
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0034
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0106 0.0232
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.2337 0.3976
Trypanosoma cruzi heat shock protein 90, putative 0.004 0.0688 0.1148
Plasmodium vivax PST-A protein 0.0144 0.3742 0.3733
Loa Loa (eye worm) hypothetical protein 0.0063 0.1377 0.3691
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0106 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.0539
Schistosoma mansoni endoplasmin 0.0095 0.2294 0.5025
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0936 0.177
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0245 0.0608
Entamoeba histolytica heat shock protein 90, putative 0.0095 0.2294 0.5889
Schistosoma mansoni chromobox protein 0.0144 0.3731 0.8174
Plasmodium vivax hypothetical protein, conserved 0.002 0.0106 0.0092
Echinococcus granulosus bloom syndrome protein 0.0024 0.0245 0.0462
Schistosoma mansoni kinase 0.0049 0.0957 0.2097
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1012 0.2713
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.316 0.8469
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0099 0.0081
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0219 0.0414
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.0539
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Plasmodium falciparum lysophospholipase, putative 0.0144 0.3742 0.373
Echinococcus granulosus tar DNA binding protein 0.0064 0.1413 0.2673
Echinococcus multilocularis jumonji domain containing protein 0.0084 0.1977 0.3739
Schistosoma mansoni chromobox protein 0.0024 0.0219 0.0479
Loa Loa (eye worm) hypothetical protein 0.0051 0.1012 0.2713
Brugia malayi heat shock protein 90 0.0095 0.2294 0.4338
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0099 0.0187
Plasmodium falciparum glutathione reductase 0.0048 0.0936 0.092
Echinococcus multilocularis heat shock protein 0.0095 0.2294 0.4338
Brugia malayi amidase 0.0104 0.2567 0.4855
Loa Loa (eye worm) hypothetical protein 0.006 0.1289 0.3454
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0099 0.0091
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.092 0.2423
Schistosoma mansoni hypothetical protein 0.002 0.0106 0.0232
Schistosoma mansoni hypothetical protein 0.0024 0.0219 0.0479
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0089 0.2124 0.5655
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0063 0.1366 0.2584
Brugia malayi AF-10 protein 0.002 0.0106 0.02
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0219 0.0211
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0219 0.0414
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.2337 0.3976
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0219 0.0479
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0219 0.0539
Brugia malayi hypothetical protein 0.0024 0.0219 0.0414
Brugia malayi glutathione reductase 0.0048 0.0936 0.177
Echinococcus granulosus heat shock protein 0.0095 0.2294 0.4338
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0219 0.0539
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.3742 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Loa Loa (eye worm) RecQ helicase 0.0024 0.0245 0.0655
Schistosoma mansoni heat shock protein 0.0095 0.2294 0.5025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Plasmodium falciparum heat shock protein 90 0.0095 0.2294 0.228
Trypanosoma cruzi monoglyceride lipase, putative 0.0144 0.3742 0.6384
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Echinococcus granulosus geminin 0.0172 0.4565 0.8633
Trypanosoma brucei heat shock protein 84, putative 0.0063 0.1366 0.2312
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0018 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1012 0.1914
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Mycobacterium tuberculosis Conserved protein 0.0025 0.0259 0.0647
Trichomonas vaginalis chromobox protein, putative 0.0087 0.2065 0.5495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Onchocerca volvulus Alhambra homolog 0.006 0.1289 0.5051
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0099 0.0216
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0219 0.0206
Brugia malayi jmjC domain containing protein 0.0019 0.0099 0.0187
Brugia malayi Heterochromatin protein 1 0.0144 0.3731 0.7057
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0936 0.2508
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0106 0.015
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0099 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.3742 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.092 0.2423
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.2337 0.6264
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.002 0.0106 0.0098
Entamoeba histolytica hypothetical protein 0.0024 0.0219 0.00000000034452
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Plasmodium vivax heat shock protein 90, putative 0.0063 0.1366 0.1355
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1413 0.3787
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0099 0.0216
Schistosoma mansoni fatty-acid amide hydrolase 0.0104 0.2567 0.5624
Echinococcus multilocularis chromobox protein 1 0.0144 0.3731 0.7057
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.1289 0.2438
Plasmodium vivax heat shock protein, putative 0.0359 1 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.2735 0.3779
Toxoplasma gondii heat shock protein 75, putative 0.0063 0.1366 0.136
Trypanosoma brucei heat shock protein 90, putative 0.0095 0.2294 0.3901
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0018 0.0005
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0099 0.0187
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0099 0.0187
Brugia malayi jmjC domain containing protein 0.0073 0.1659 0.3137
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.2735 0.7297
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.3093 0.8257
Echinococcus multilocularis Chromo domain 0.0024 0.0219 0.0414
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Trypanosoma cruzi Heat shock protein 83, putative 0.0095 0.2294 0.3901
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0544 0.1028
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.002 0.0106 0.015
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.2337 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0099 0.0265
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Giardia lamblia PHD finger protein 15 0.006 0.1289 0.5479
Trypanosoma cruzi heat shock protein 90, putative 0.0095 0.2294 0.3901
Toxoplasma gondii heat shock protein HSP90 0.0095 0.2294 0.2288
Echinococcus granulosus peregrin 0.006 0.1289 0.2438
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.00000000034452
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Echinococcus multilocularis chromobox protein 2 0.0024 0.0219 0.0414
Brugia malayi TAR-binding protein 0.0064 0.1413 0.2673
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.00000000034452
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0219 0.0479
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1413 0.3096
Giardia lamblia Grp94/Hsp90 0.0089 0.2124 0.908
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.0539
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0089 0.2124 0.361
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0087 0.2065 0.8712
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0197 0.5287 1
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Schistosoma mansoni heat shock protein 0.0063 0.1366 0.2994
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0219 0.0201
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0245 0.0462
Schistosoma mansoni chromobox protein 0.0144 0.3731 0.8174
Schistosoma mansoni hypothetical protein 0.0172 0.4565 1
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0099 0.0216
Leishmania major hypothetical protein, conserved 0.0019 0.0099 0.0138
Trichomonas vaginalis heat shock protein, putative 0.0055 0.1137 0.3005
Trichomonas vaginalis chromobox protein, putative 0.0144 0.3731 0.9972
Echinococcus granulosus fatty acid amide hydrolase 1 0.0104 0.2567 0.4855
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.2337 0.442
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0099 0.0265
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1012 0.1914
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0936 0.0924
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0018 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.5851 1
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.2294 0.3901
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1659 0.3634
Trichomonas vaginalis hypothetical protein 0.0024 0.0219 0.0539
Plasmodium vivax JmjC domain containing protein 0.0019 0.0099 0.0085
Echinococcus multilocularis heat shock protein 90 0.0081 0.1895 0.3583
Trichomonas vaginalis endoplasmin, putative 0.0069 0.1536 0.4077
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0104 0.2567 0.4855
Brugia malayi RNA binding protein 0.0064 0.1413 0.2673
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0018 0.001
Plasmodium falciparum endoplasmin, putative 0.0069 0.1536 0.1521
Trichomonas vaginalis heat shock protein, putative 0.0069 0.1536 0.4077
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0219 0.0414
Trypanosoma cruzi heat shock protein 90, putative 0.0081 0.1895 0.3217
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.2337 0.6013
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0104 0.2567 0.4855
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0219 0.0201
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0219 0.0201
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.2294 0.3901
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Trypanosoma cruzi heat shock protein 85, putative 0.0095 0.2294 0.3901
Brugia malayi Protein cec-1. 0.0024 0.0219 0.0414
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.0144 0.3742 1
Echinococcus granulosus chromobox protein 2 0.0024 0.0219 0.0414
Leishmania major trypanothione reductase 0.0048 0.0936 0.1574
Echinococcus multilocularis peregrin 0.006 0.1289 0.2438
Trypanosoma brucei heat shock protein 90, putative 0.0095 0.2294 0.3901
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Loa Loa (eye worm) heterochromatin protein 1 0.0144 0.3731 1
Mycobacterium tuberculosis Possible lysophospholipase 0.0144 0.3742 1
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0219 0.0211
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Mycobacterium ulcerans hypothetical protein 0.0025 0.0259 0.0647
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0081 0.1895 0.3583
Treponema pallidum heat shock protein 90 0.0089 0.2124 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Plasmodium vivax endoplasmin, putative 0.0095 0.2294 0.2283
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Toxoplasma gondii heat shock protein 90, putative 0.0095 0.2294 0.2288
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0245 0.0462
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0099 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1413 0.3787
Schistosoma mansoni jumonji domain containing protein 0.0157 0.4104 0.8991
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0219 0.0479
Leishmania major heat shock protein, putative 0.0063 0.1366 0.2312
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.3093 0.8257
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Loa Loa (eye worm) heat shock protein 75 0.0063 0.1366 0.3662
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Trypanosoma cruzi hypothetical protein, conserved 0.0217 0.5851 1
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.1198 0.3169
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0018 0.5
Plasmodium falciparum heat shock protein 90, putative 0.0055 0.1137 0.1121
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0081 0.1886 0.7868
Trypanosoma brucei monoglyceride lipase, putative 0.0144 0.3742 0.6384
Echinococcus multilocularis geminin 0.0172 0.4565 0.8633
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.3742 1
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.2337 0.6228
Onchocerca volvulus 0.0063 0.1377 0.5467
Giardia lamblia Heat shock protein HSP 90-alpha 0.0081 0.1895 0.8091
Echinococcus granulosus phd:f box containing protein 0.0019 0.0099 0.0187
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0018 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0544 0.1191
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0063 0.1366 0.2584
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Toxoplasma gondii Hsp90 domain-containing protein 0.0359 1 1
Toxoplasma gondii thioredoxin reductase 0.0048 0.0936 0.0929
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0219 0.0479
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0219 0.0206
Plasmodium vivax glutathione reductase, putative 0.0048 0.0936 0.0924
Echinococcus multilocularis chromobox protein 1 0.0144 0.3731 0.7057
Schistosoma mansoni endoplasmin 0.0095 0.2294 0.5025
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0219 0.0414
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1413 0.2673
Giardia lamblia Heat shock protein HSP 90-alpha 0.0095 0.2294 0.9812
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0219 0.0539
Brugia malayi Thioredoxin reductase 0.0048 0.0936 0.177
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Brugia malayi Endoplasmin precursor 0.0095 0.2294 0.4338
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.1289 0.1282
Trypanosoma brucei trypanothione reductase 0.0048 0.0936 0.1574
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Entamoeba histolytica heat shock protein 90, putative 0.0095 0.2294 0.5889
Trichomonas vaginalis chromobox protein, putative 0.0144 0.3731 0.9972
Schistosoma mansoni heat shock protein 0.0095 0.2294 0.5025
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0063 0.1366 0.5417
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.3742 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0219 0.0414
Brugia malayi jmjC domain containing protein 0.0019 0.0099 0.0187
Loa Loa (eye worm) heat shock protein 90 0.0095 0.2294 0.6147
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.2337 0.512
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0094 0.0207
Schistosoma mansoni amidase 0.0104 0.2567 0.5624
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0099 0.0187
Brugia malayi CHD4 protein 0.0024 0.0219 0.0414
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0259 0.0413
Trypanosoma brucei Heat shock protein 83, putative 0.0095 0.2294 0.3901
Brugia malayi SET domain containing protein 0.0024 0.0219 0.0414
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.1659 0.3137
Trichomonas vaginalis heat shock protein, putative 0.0095 0.2294 0.6111
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.1659 0.3634
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0144 0.3742 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.0259 0.0647
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.1198 0.3169
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0099 0.0138
Leishmania major monoglyceride lipase, putative 0.0144 0.3742 0.6384
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0259 0.0647
Loa Loa (eye worm) RNA binding protein 0.0064 0.1413 0.3787
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1413 0.3096
Schistosoma mansoni hypothetical protein 0.006 0.1289 0.2824
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.2735 0.7297
Brugia malayi jmjC domain containing protein 0.0019 0.0099 0.0187
Brugia malayi jmjC domain containing protein 0.0197 0.5287 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.2337 0.442
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1413 0.2673
Loa Loa (eye worm) glutathione reductase 0.0048 0.0936 0.2508
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.2337 0.3976
Trichomonas vaginalis chromobox protein, putative 0.0087 0.2065 0.5495
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0018 0.0034
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0106 0.0098
Loa Loa (eye worm) PHD-finger family protein 0.006 0.1289 0.3454
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.3093 0.5989
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.1289 0.2824
Trypanosoma brucei monoglyceride lipase, putative 0.0144 0.3742 0.6384
Plasmodium vivax heat shock protein 86, putative 0.0095 0.2294 0.2283
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0219 0.0539
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0259 0.0647
Echinococcus granulosus heat shock protein 90 0.0081 0.1895 0.3583
Echinococcus granulosus Chromobox protein 3 0.0024 0.0219 0.0414
Brugia malayi PHD-finger family protein 0.002 0.0106 0.02
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.0144 0.3742 1
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0219 0.0414
Trypanosoma cruzi heat shock protein 85, putative 0.0081 0.1895 0.3217
Plasmodium falciparum phd finger protein, putative 0.006 0.1289 0.1273
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0099 0.0187
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0219 0.0539
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0936 0.177
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0099 0.0187
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0099 0.0138
Mycobacterium ulcerans heat shock protein 90 0.0089 0.2124 0.5655
Echinococcus multilocularis heat shock protein 90 0.0095 0.2294 0.4338
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Trichomonas vaginalis valacyclovir hydrolase, putative 0.0144 0.3742 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1413 0.3096
Plasmodium vivax hypothetical protein, conserved 0.006 0.1289 0.1277
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0219 0.0206
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.0219 0.0414
Trichomonas vaginalis heat shock protein, putative 0.0081 0.1895 0.5039
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0089 0.2124 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.3121 0.8364
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.2735 0.7297
Loa Loa (eye worm) helicase 0.0024 0.0219 0.0587
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0099 0.0216
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0197 0.5287 1
Mycobacterium ulcerans lysophospholipase 0.0144 0.3742 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.2337 0.442
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.00000000034452
Echinococcus granulosus endoplasmin 0.0089 0.2124 0.4017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0544 0.1457
Trypanosoma cruzi heat shock protein, putative 0.0063 0.1366 0.2312
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0099 0.0187
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0936 0.2465
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Plasmodium falciparum lysophospholipase, putative 0.0144 0.3742 0.373
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.1289 0.2438
Echinococcus granulosus chromobox protein 1 0.0144 0.3731 0.7057
Trypanosoma brucei heat shock protein, putative 0.0095 0.2294 0.3901
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0259 0.049
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0219 0.0539
Loa Loa (eye worm) hypothetical protein 0.0019 0.0099 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.1886 0.5015
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1659 0.4445
Echinococcus granulosus fatty acid amide hydrolase 1 0.0104 0.2567 0.4855
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0219 0.0479
Echinococcus multilocularis lysine specific demethylase 5A 0.0073 0.1659 0.3137
Giardia lamblia Kinase, PLK 0.0096 0.2337 1
Brugia malayi jmjC domain containing protein 0.0019 0.0099 0.0187
Echinococcus multilocularis endoplasmin 0.0089 0.2124 0.4017
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0259 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0144 0.3742 1
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0099 0.0091
Loa Loa (eye worm) endoplasmin 0.0095 0.2294 0.6147
Echinococcus granulosus Chromo domain 0.0024 0.0219 0.0414
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0099 0.0187
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.3093 0.8257
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0219 0.0539
Loa Loa (eye worm) hypothetical protein 0.0024 0.0219 0.0587
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0245 0.0608
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0099 0.0265
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0936 0.1574
Trypanosoma brucei hypothetical protein, conserved 0.0217 0.5851 1
Brugia malayi PHD-finger family protein 0.006 0.1289 0.2438
Trypanosoma brucei polo-like protein kinase 0.0096 0.2337 0.3976
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0259 0.0647
Loa Loa (eye worm) hypothetical protein 0.0104 0.2567 0.688
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0099 0.0138
Plasmodium falciparum esterase, putative 0.0144 0.3742 0.373
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0259 0.0413
Leishmania major heat shock protein 83-1 0.0095 0.2294 0.3901

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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