Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.1693 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0477 | 0.0477 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.1693 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0477 | 0.0477 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.1693 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.1693 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0477 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.1693 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3066 | 0.3066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0477 | 0.0477 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3066 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.1693 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.1693 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0477 | 0.0477 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0477 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0477 | 0.0477 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3066 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.1693 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3066 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3066 | 0.3066 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0477 | 0.0477 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.1693 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0022 | 0.1693 | 0.1693 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0103 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0477 | 0.0477 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3066 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3066 | 0.3066 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | ap endonuclease | 0.0022 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.1693 | 0.1693 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0477 | 0.0477 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.1693 | 0.5 |
Onchocerca volvulus | 0.001 | 0.0477 | 0.5 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.1693 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0477 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0022 | 0.1693 | 0.1693 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0022 | 0.1693 | 0.1693 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0477 | 0.0477 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.1693 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.1693 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0477 | 0.0477 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3066 | 0.3066 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0103 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0103 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0103 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0477 | 0.0477 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.1693 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0477 | 0.0477 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0477 | 0.0477 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3066 | 0.3066 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0477 | 0.0477 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0477 | 0.0477 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0477 | 0.0477 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.