TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 358.355 | Formula: C17H21F3N2O3
H donors: 1 H acceptors: 2 LogP: 1.3 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COCCNC(=O)C1CCC(=O)N(C1)Cc1cccc(c1)C(F)(F)F
InChi: 1S/C17H21F3N2O3/c1-25-8-7-21-16(24)13-5-6-15(23)22(11-13)10-12-3-2-4-14(9-12)17(18,19)20/h2-4,9,13H,5-8,10-11H2,1H3,(H,21,24)
InChiKey: LIVIPFDFYGEVLR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	esterase, putative	0.0108	0.1019	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0108	0.1019	0.1363
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0071	0.0693
Onchocerca volvulus		0.0087	0.0781	0.7491
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0071	0.0126
Brugia malayi	fatty acid elongation protein 3	0.0087	0.0781	0.1644
Brugia malayi	Thioredoxin reductase	0.0037	0.0208	0.042
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0101	0.0937	0.1202
Schistosoma mansoni	fatty acid acyl transferase-related	0.0087	0.0781	0.1041
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.1252	0.267
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Echinococcus multilocularis	geminin	0.0368	0.3979	0.3972
Brugia malayi	fatty acid elongation protein 3	0.0087	0.0781	0.1644
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0208	0.0444
Schistosoma mansoni	elongation of fatty acids protein 1	0.0087	0.0781	0.1041
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0145	0.018
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0283	0.0353
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0	0.5
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0219	0.027
Loa Loa (eye worm)	fatty acid elongation protein 3	0.043	0.4691	1
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0208	0.014
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0666	0.1419
Echinococcus multilocularis	tumor protein p63	0.0695	0.7706	0.7703
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0219	0.0281
Leishmania major	trypanothione reductase	0.0037	0.0208	0.042
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0071	0.0693
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0825	0.1758
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0071	0.0126
Mycobacterium tuberculosis	Probable reductase	0.0083	0.0743	0.0973
Trypanosoma cruzi	polo-like protein kinase, putative	0.0101	0.0937	0.1977
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0071	0.0126
Loa Loa (eye worm)	jmjC domain-containing protein	0.0064	0.0521	0.1111
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0219	0.0281
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.043	0.4691	1
Leishmania major	hypothetical protein, conserved	0.0077	0.0666	0.1398
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0071	0.0693
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0825	0.1758
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1252	0.1679
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0101	0.0937	0.1977
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0868	0.1112
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0034	0.0183	0.0223
Trypanosoma brucei	Fatty acid elongase	0.0087	0.0781	0.1644
Onchocerca volvulus	Elongation of very long chain fatty acids protein 5 homolog	0.0087	0.0781	0.7491
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0071	0.0093
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Schistosoma mansoni	cellular tumor antigen P53	0.0102	0.095	0.127
Onchocerca volvulus		0.0102	0.095	0.9273
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0666	0.1398
Plasmodium vivax	hypothetical protein, conserved	0.0108	0.1019	0.2172
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Schistosoma mansoni	jumonji domain containing protein	0.0081	0.0711	0.0947
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0283	0.0272
Onchocerca volvulus		0.0108	0.1019	1
Echinococcus granulosus	microtubule associated protein 2	0.0668	0.74	0.9603
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0083	0.0743	0.0973
Brugia malayi	Fatty acid elongation protein 3	0.043	0.4691	1
Toxoplasma gondii	GNS1/SUR4 family protein	0.043	0.4691	1
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1252	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0666	0.1419
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0108	0.1019	0.1335
Trypanosoma brucei	Fatty acid elongase	0.0087	0.0781	0.1644
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	0.043	0.4691	1
Brugia malayi	chromobox protein homolog 3	0.0042	0.0265	0.0541
Trypanosoma brucei	elongation of very long chain fatty acids protein, putative	0.0087	0.0781	0.1644
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0688	0.7633	1
Plasmodium vivax	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0087	0.0781	0.1665
Schistosoma mansoni	eyes absent homolog	0.0091	0.0825	0.11
Plasmodium vivax	elongation of very long chain fatty acids protein 3, putative	0.0087	0.0781	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Schistosoma mansoni	elongation of fatty acids protein 1	0.0087	0.0781	0.1041
Brugia malayi	jmjC domain containing protein	0.0102	0.0949	0.2003
Echinococcus granulosus	elongation of very long chain fatty acids	0.0087	0.0781	0.1
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0071	0.0151
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0087	0.0781	0.077
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0083	0.0743	0.0973
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0868	0.1158
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0849	0.821
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0071	0.0126
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.1252	0.2651
Trypanosoma cruzi	hypothetical protein, conserved	0.0108	0.1019	0.2152
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0108	0.1019	0.1335
Mycobacterium ulcerans	lipase LipD	0.0108	0.1019	1
Giardia lamblia	PHD finger protein 15	0.0031	0.0145	0.1439
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0849	0.1112
Onchocerca volvulus	Alhambra homolog	0.0031	0.0145	0.0782
Echinococcus multilocularis	peregrin	0.0031	0.0145	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Entamoeba histolytica	hypothetical protein	0.004	0.0244	0.2514
Giardia lamblia	Kinase, PLK	0.0101	0.0937	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0045	0.0301	0.2428
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.0868	0.1829
Echinococcus granulosus	tar DNA binding protein	0.0128	0.1252	0.1612
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1252	0.1679
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0214	0.0203
Mycobacterium tuberculosis	Probable lipase LipD	0.0108	0.1019	0.1335
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0071	0.0126
Loa Loa (eye worm)	RNA binding protein	0.0128	0.1252	0.267
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0868	0.0857
Onchocerca volvulus		0.0108	0.1019	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0012	0.0025
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0244	0.0233
Echinococcus multilocularis	microtubule associated protein 2	0.0668	0.74	0.7397
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0397	0.0847
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.1019	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.1153	0.2458
Onchocerca volvulus		0.0033	0.0163	0.097
Loa Loa (eye worm)	hypothetical protein	0.0102	0.095	0.2025
Mycobacterium tuberculosis	Conserved protein	0.0108	0.1019	0.1335
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0208	0.0444
Brugia malayi	glutathione reductase	0.0037	0.0208	0.042
Toxoplasma gondii	LsmAD domain-containing protein	0.0077	0.0666	0.1146
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Plasmodium falciparum	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0087	0.0781	0.1665
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0301	0.2871
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1252	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0071	0.0151
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0102	0.0949	0.0938
Brugia malayi	TAR-binding protein	0.0128	0.1252	0.2651
Leishmania major	long chain polyunsaturated fatty acid elongation enzyme-like protein	0.0087	0.0781	0.1644
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0208	0.0444
Toxoplasma gondii	fatty acid elongase	0.0087	0.0781	0.1399
Mycobacterium ulcerans	esterase/lipase LipP	0.0108	0.1019	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0214	0.0263
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0127	0.1141
Leishmania major	hypothetical protein, conserved	0.0108	0.1019	0.2152
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0087	0.0781	0.077
Plasmodium falciparum	phd finger protein, putative	0.0031	0.0145	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0636	0.62
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0781	0.1665
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Brugia malayi	fatty acid elongation protein 3	0.0087	0.0781	0.1644
Leishmania major	fatty acid elongase, putative	0.043	0.4691	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0038	0.0219	0.0208
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0071	0.0693
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Mycobacterium tuberculosis	Probable hydrolase	0.0108	0.1019	0.1335
Brugia malayi	Heterochromatin protein 1	0.0074	0.0636	0.1334
Leishmania major	fatty acid elongase, putative	0.043	0.4691	1
Trypanosoma cruzi	fatty acid elongase, putative	0.043	0.4691	1
Mycobacterium ulcerans	beta-lactamase	0.0108	0.1019	1
Brugia malayi	PHD-finger family protein	0.0031	0.0145	0.0284
Trypanosoma cruzi	fatty acid elongase, putative	0.043	0.4691	1
Mycobacterium tuberculosis	Conserved protein	0.0108	0.1019	0.1335
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.0087	0.0781	0.1665
Loa Loa (eye worm)	heterochromatin protein 1	0.0074	0.0636	0.1356
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0108	0.1019	0.1008
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trypanosoma brucei	trypanothione reductase	0.0037	0.0208	0.042
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Schistosoma mansoni	chromobox protein	0.0074	0.0636	0.0845
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0108	0.1019	0.1363
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.0868	0.185
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0034	0.0183	0.0172
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0358	0.3441
Mycobacterium ulcerans	hypothetical protein	0.0108	0.1019	1
Schistosoma mansoni	hypothetical protein	0.0368	0.3979	0.5369
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0145	0.0309
Echinococcus granulosus	elongation of very long chain fatty acids	0.0087	0.0781	0.1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0108	0.1019	0.1309
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0636	0.0625
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0219	0.0467
Brugia malayi	hypothetical protein	0.0091	0.0825	0.1737
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trypanosoma brucei	polo-like protein kinase	0.0101	0.0937	0.1977
Brugia malayi	hypothetical protein	0.0077	0.0666	0.1398
Schistosoma mansoni	hypothetical protein	0.004	0.0244	0.0315
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0071	0.0637
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0071	0.0693
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0244	0.0302
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0101	0.0937	0.0926
Mycobacterium tuberculosis	Probable lipase LipE	0.0108	0.1019	0.1335
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.1019	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.1252	0.267
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0244	0.0315
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0012	0.0015
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0868	0.1112
Trypanosoma cruzi	polo-like protein kinase, putative	0.0101	0.0937	0.1977
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0868	0.0857
Entamoeba histolytica	hypothetical protein	0.004	0.0244	0.2514
Trypanosoma cruzi	hypothetical protein, conserved	0.0108	0.1019	0.2152
Brugia malayi	Bromodomain containing protein	0.0031	0.0145	0.0284
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.1252	0.1242
Schistosoma mansoni	elongation of fatty acids protein 1	0.0087	0.0781	0.1041
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0087	0.0781	0.7491
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0265	0.0565
Brugia malayi	RNA binding protein	0.0128	0.1252	0.2651
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0083	0.0743	0.0973
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0083	0.0743	0.709
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0145	0.0309
Schistosoma mansoni	hypothetical protein	0.0034	0.0183	0.0233
Brugia malayi	Hypothetical 34.1 kDa protein C40H1.4 in chromosome III	0.0087	0.0781	0.1644
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0208	0.0273
Toxoplasma gondii	ABC1 family protein	0.0108	0.1019	0.1922
Schistosoma mansoni	kinase	0.0051	0.0373	0.0489
Trichomonas vaginalis	penicillin-binding protein, putative	0.0108	0.1019	1
Plasmodium falciparum	glutathione reductase	0.0037	0.0208	0.0444
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0012	0.0115
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0101	0.0937	0.1997
Entamoeba histolytica	hypothetical protein	0.004	0.0244	0.2514
Plasmodium falciparum	ataxin-2 like protein, putative	0.0077	0.0666	0.1419
Echinococcus granulosus	geminin	0.0368	0.3979	0.5156
Mycobacterium tuberculosis	Probable esterase LipL	0.0108	0.1019	0.1335
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0071	0.0637
Brugia malayi	jmjC domain containing protein	0.0038	0.0219	0.0443
Trypanosoma brucei	Long chain fatty acyl elongase	0.0087	0.0781	0.1644
Mycobacterium leprae	Probable lipase LipE	0.0108	0.1019	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0101	0.0937	0.1977
Echinococcus granulosus	peregrin	0.0031	0.0145	0.0173
Brugia malayi	fatty acid elongation protein 3	0.0087	0.0781	0.1644
Brugia malayi	GNS1/SUR4 family protein	0.043	0.4691	1
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0127	0.1141
Brugia malayi	MH2 domain containing protein	0.0119	0.1153	0.2439
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0087	0.0781	0.1665
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0849	0.1112
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0163	0.0346
Mycobacterium leprae	conserved hypothetical protein	0.0108	0.1019	1
Trichomonas vaginalis	CAMK family protein kinase	0.005	0.0358	0.3441
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0071	0.0637
Echinococcus granulosus	chromobox protein 1	0.0074	0.0636	0.0811
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.1153	0.2458
Trypanosoma cruzi	PAB1-binding protein , putative	0.0077	0.0666	0.1398
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0087	0.0781	0.1665
Leishmania major	fatty acid elongase, putative	0.043	0.4691	1
Schistosoma mansoni	microtubule-associated protein tau	0.0668	0.74	1
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	0.043	0.4691	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0071	0.0093
Mycobacterium tuberculosis	Probable dehydrogenase	0.0083	0.0743	0.0973
Trypanosoma cruzi	fatty acid elongase, putative	0.0087	0.0781	0.1644
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0071	0.0693
Brugia malayi	GNS1/SUR4 family protein	0.0087	0.0781	0.1644
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0012	0.0115
Plasmodium vivax	ataxin-2 like protein, putative	0.0077	0.0666	0.1419
Onchocerca volvulus		0.0087	0.0781	0.7491
Loa Loa (eye worm)	ELO-9 protein	0.0087	0.0781	0.1665
Trypanosoma cruzi	fatty acid elongase, putative	0.043	0.4691	1
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0102	0.0949	0.1218
Brugia malayi	beta-lactamase	0.0108	0.1019	0.2152
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	0.043	0.4691	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0145	0.0133
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0145	0.0173
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0042	0.0265	0.2049
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0208	0.042
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0108	0.1019	0.2172
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0265	0.2514
Onchocerca volvulus		0.0108	0.1019	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0108	0.1019	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0101	0.0937	0.9134
Schistosoma mansoni	elongation of fatty acids protein 1	0.0087	0.0781	0.1041
Brugia malayi	beta-lactamase family protein	0.0108	0.1019	0.2152
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0108	0.1019	0.2152
Trichomonas vaginalis	penicillin-binding protein, putative	0.0108	0.1019	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0071	0.0693
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0849	0.1112
Mycobacterium tuberculosis	Conserved protein	0.0108	0.1019	0.1335
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0145	0.0309
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0208	0.0444
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Schistosoma mansoni	serine/threonine protein kinase	0.0101	0.0937	0.1252
Brugia malayi	hypothetical protein	0.005	0.0356	0.0735
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0087	0.0781	0.1665
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0.0937	0.9185
Echinococcus granulosus	chromobox protein 1	0.0074	0.0636	0.0811
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0868	0.1158
Trypanosoma brucei	hypothetical protein, conserved	0.0108	0.1019	0.2152
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0012	0.0015
Trypanosoma brucei	Fatty acid elongase	0.043	0.4691	1
Brugia malayi	hypothetical protein	0.004	0.0244	0.0497
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Schistosoma mansoni	chromobox protein	0.0074	0.0636	0.0845
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0083	0.0743	0.0973
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0108	0.1019	0.1335
Brugia malayi	beta-lactamase family protein	0.0108	0.1019	0.2152
Trichomonas vaginalis	chromobox protein, putative	0.0074	0.0636	0.62
Loa Loa (eye worm)	beta-lactamase	0.0108	0.1019	0.2172
Echinococcus granulosus	tumor protein p63	0.0695	0.7706	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0108	0.1019	1
Trichomonas vaginalis	chromobox protein, putative	0.0045	0.0301	0.2871
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0071	0.0151
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0071	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1019	0.2172
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1252	0.1679
Leishmania major	fatty acid elongase, putative	0.0087	0.0781	0.1644
Trypanosoma cruzi	fatty acid elongase, putative	0.043	0.4691	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0077	0.0666	0.1398
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0101	0.0937	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0868	0.1158
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0071	0.0693
Plasmodium vivax	GNS1/SUR4 domain containing protein	0.043	0.4691	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0012	0.0025
Echinococcus multilocularis	chromobox protein 1	0.0074	0.0636	0.0625
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0265	0.2514
Schistosoma mansoni	hypothetical protein	0.0031	0.0145	0.018
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0087	0.0781	0.7491
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0208	0.0444
Schistosoma mansoni	hypothetical protein	0.0368	0.3979	0.5369
Entamoeba histolytica	hypothetical protein	0.004	0.0244	0.2514

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 911956