Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | nuclear hormone receptor | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.013 | 0.0645 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | hypothetical protein | 0.0543 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0232 | 0.2952 | 0.4484 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0232 | 0.2952 | 1 |
Brugia malayi | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0232 | 0.2952 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0232 | 0.2952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0232 | 0.2952 | 0.4484 |
Echinococcus granulosus | FTZ F1 alpha | 0.0232 | 0.2952 | 0.4484 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0232 | 0.2952 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0232 | 0.2952 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.013 | 0.0645 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0232 | 0.2952 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0232 | 0.2952 | 0.2952 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0232 | 0.2952 | 1 |
Onchocerca volvulus | 0.0232 | 0.2952 | 0.2952 | |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.013 | 0.0645 | 0.0645 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0232 | 0.2952 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0232 | 0.2952 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0232 | 0.2952 | 0.4484 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0392 | 0.6582 | 1 |
Brugia malayi | steroid hormone receptor | 0.0522 | 0.9534 | 0.9534 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.013 | 0.0645 | 0.2184 |
Schistosoma mansoni | nuclear hormone receptor | 0.0232 | 0.2952 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0232 | 0.2952 | 0.2952 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0232 | 0.2952 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0232 | 0.2952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0232 | 0.2952 | 0.4484 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0232 | 0.2952 | 0.4484 |
Schistosoma mansoni | coup transcription factor | 0.0232 | 0.2952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.0362 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0522 | 0.9534 | 0.9534 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0232 | 0.2952 | 0.2952 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0232 | 0.2952 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0232 | 0.2952 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.0362 | 0.0362 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0232 | 0.2952 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0232 | 0.2952 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | nuclear receptor RXR | 0.013 | 0.0645 | 0.0645 |
Brugia malayi | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.013 | 0.0645 | 0.0645 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0232 | 0.2952 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0232 | 0.2952 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0232 | 0.2952 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.0362 | 0.0362 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0232 | 0.2952 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0232 | 0.2952 | 0.4484 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.013 | 0.0645 | 0.2184 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0232 | 0.2952 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0232 | 0.2952 | 0.4484 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0232 | 0.2952 | 0.2952 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.0645 | 0.0645 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0543 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2952 | 0.2952 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.013 | 0.0645 | 0.2184 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0232 | 0.2952 | 0.2952 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0232 | 0.2952 | 0.4484 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
F (ADMET) | = 56 % | Oral bioavailability in mouse | ChEMBL. | 3172134 |
MIC (functional) | = 0.25 ug ml-1 | Minimum inhibitory concentration against S. pyogenes C203 | ChEMBL. | 3172134 |
MIC (functional) | = 0.5 ug ml-1 | Minimum inhibitory concentration againstPark strain of S. pneumoniae | ChEMBL. | 3172134 |
MIC (functional) | = 1 ug ml-1 | Minimum inhibitory concentration against X1.1 strain of S. aureus | ChEMBL. | 3172134 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against 222 strain of S. epidermidis | ChEMBL. | 3172134 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against sens CL strain of Haemophilus influenzae | ChEMBL. | 3172134 |
MIC (functional) | = 2 ug ml-1 | Minimum inhibitory concentration against res 76 strain of Haemophilus influenzae | ChEMBL. | 3172134 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration against Epil strain of S. epidermidis | ChEMBL. | 3172134 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration against X514 strain of Salmonella | ChEMBL. | 3172134 |
MIC (functional) | = 8 ug ml-1 | Minimum inhibitory concentration against X68 strain of K. pneumoniae | ChEMBL. | 3172134 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration against EC14 strain E. coli | ChEMBL. | 3172134 |
MIC (functional) | = 16 ug ml-1 | Minimum inhibitory concentration against EC14 strain E. coli | ChEMBL. | 3172134 |
MIC (functional) | = 64 ug ml-1 | Minimum inhibitory concentration against V41 strain of S. aureus | ChEMBL. | 3172134 |
MIC (functional) | = 64 ug ml-1 | Minimum inhibitory concentration against S13E strain of S. aureus | ChEMBL. | 3172134 |
MIC (functional) | = 64 ug ml-1 | Minimum inhibitory concentration against N9 strain of Shigella sonnei | ChEMBL. | 3172134 |
MIC (functional) | > 128 ug ml-1 | Minimum inhibitory concentration against EB17 strain of E. aerogenes | ChEMBL. | 3172134 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.