TDR Targets

Basic information

Technical information

TDR Targets ID: 912074
Name: 2-[(4-diethylaminophenyl)methylidene]indene-1 ,3-dione
MW: 305.37 | Formula: C20H19NO2
H donors: 0 H acceptors: 2 LogP: 4.36 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ccc(cc1)C=C1C(=O)c2c(C1=O)cccc2)CC
InChi: 1S/C20H19NO2/c1-3-21(4-2)15-11-9-14(10-12-15)13-18-19(22)16-7-5-6-8-17(16)20(18)23/h5-13H,3-4H2,1-2H3
InChiKey: QSKPRAZBWICXDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(4-diethylaminophenyl)methylene]indane-1,3-dione
2-(4-diethylaminobenzylidene)indane-1,3-quinone
34200-53-8
1H-Indene-1,3(2H)-dione, 2-[[4-(diethylamino)phenyl]methylene]-
1H-Indene-1,3(2H)-dione, 2-((4-(diethylamino)phenyl)methylene)-
2-((4-(Diethylamino)phenyl)methylene)-1H-indene-1,3(2H)-dione
2-(p-(Diethylamino)benzylidene)-1,3-indandione
EINECS 251-874-7
A0607/0028107
ZINC00059595

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0022	0.0123	1
Mycobacterium ulcerans	methionyl-tRNA synthetase	0.0054	0.0718	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0034	0.0343	0.107
Brugia malayi	methionyl-tRNA synthetase	0.0021	0.0103	0.0103
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.0022	0.0123	0.0328
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0032	0.0312	0.0463
Brugia malayi	RNA recognition motif domain containing protein	0.0188	0.3202	0.3202
Schistosoma mansoni	tar DNA-binding protein	0.0188	0.3202	0.4745
Brugia malayi	MH2 domain containing protein	0.0034	0.0343	0.0343
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0032	0.0312	0.0312
Trypanosoma cruzi	methionyl-tRNA synthetase, putative	0.0054	0.0718	1
Schistosoma mansoni	tar DNA-binding protein	0.0188	0.3202	0.4745
Schistosoma mansoni	hypothetical protein	0.038	0.6748	1
Loa Loa (eye worm)	hypothetical protein	0.0557	1	1
Trypanosoma brucei	methionyl-tRNA synthetase, putative	0.0054	0.0718	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0312	0.3409
Giardia lamblia	Methionyl-tRNA synthetase	0.0054	0.0718	1
Echinococcus multilocularis	leucyl tRNA synthetase	0.0021	0.0103	0.0321
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0252	0.2165
Brugia malayi	TAR-binding protein	0.0188	0.3202	0.3202
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Loa Loa (eye worm)	tyrosyl-tRNA synthetase	0.0033	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0066	0.0066
Schistosoma mansoni	tar DNA-binding protein	0.0188	0.3202	0.4745
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.0343	0.0343
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0176	0.2975	0.929
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0034	0.0343	0.107
Schistosoma mansoni	Smad4	0.0034	0.0343	0.0508
Brugia malayi	latrophilin 2 splice variant baaae	0.038	0.6748	0.6748
Schistosoma mansoni	hypothetical protein	0.0176	0.2975	0.4408
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0176	0.2975	0.929
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0103	0.0103
Echinococcus multilocularis	methionine tRNA synthetase	0.0054	0.0718	0.2242
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Schistosoma mansoni	methionine-tRNA synthetase	0.0054	0.0718	0.1064
Echinococcus granulosus	replication factor c subunit 1	0.0022	0.0123	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0103	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0103	0.0103
Schistosoma mansoni	hypothetical protein	0.0176	0.2975	0.4408
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0032	0.0312	0.3409
Loa Loa (eye worm)	hypothetical protein	0.038	0.6748	0.6748
Plasmodium vivax	methionine--tRNA ligase, putative	0.0054	0.0718	1
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.0022	0.0123	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0034	0.0343	0.107
Loa Loa (eye worm)	methionyl-tRNA synthetase	0.0054	0.0718	0.0718
Brugia malayi	isocitrate dehydrogenase	0.0032	0.0312	0.0312
Brugia malayi	MH1 domain containing protein	0.0034	0.0343	0.0343
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0032	0.0312	0.3409
Plasmodium falciparum	methionine--tRNA ligase	0.0054	0.0718	1
Loa Loa (eye worm)	Smad1	0.0034	0.0343	0.0343
Echinococcus multilocularis	isocitrate dehydrogenase	0.0032	0.0312	0.0976
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0032	0.0312	0.3185
Echinococcus granulosus	tar DNA binding protein	0.0188	0.3202	1
Echinococcus granulosus	methionine tRNA synthetase	0.0054	0.0718	0.2242
Loa Loa (eye worm)	transcription factor SMAD2	0.0493	0.8817	0.8817
Echinococcus multilocularis	Smad4	0.0034	0.0343	0.107
Loa Loa (eye worm)	hypothetical protein	0.0158	0.2636	0.2636
Schistosoma mansoni	DNA ligase IV	0.0022	0.0123	0.0182
Giardia lamblia	Replication factor C, subunit 1	0.0022	0.0123	0.0328
Echinococcus granulosus	GPCR family 2	0.0176	0.2975	0.929
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0312	0.3185
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0312	0.0976
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0312	0.0976
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0021	0.0103	0.0321
Leishmania major	methionyl-tRNA synthetase, putative	0.0054	0.0718	1
Brugia malayi	methionyl-tRNA synthetase	0.0054	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0252	0.0252
Plasmodium falciparum	replication factor C subunit 1, putative	0.0022	0.0123	0.0328
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0343	0.0508
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0032	0.0312	0.0976
Treponema pallidum	DNA ligase (lig)	0.0022	0.0123	1
Brugia malayi	topoisomerase	0.0022	0.0123	0.0123
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.0022	0.0123	0.0328
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0312	0.3409
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0034	0.0343	0.0508
Brugia malayi	Isocitrate dehydrogenase	0.0032	0.0312	0.0312
Toxoplasma gondii	isocitrate dehydrogenase	0.0032	0.0312	0.3409
Leishmania major	hypothetical protein, conserved	0.0029	0.0252	0.2422
Schistosoma mansoni	leucyl-tRNA synthetase	0.0021	0.0103	0.0152
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0176	0.2975	0.2975
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0176	0.2975	0.929
Loa Loa (eye worm)	nuclear factor I	0.0019	0.0066	0.0066
Schistosoma mansoni	hypothetical protein	0.0176	0.2975	0.4408
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0176	0.2975	0.2975
Schistosoma mansoni	tar DNA-binding protein	0.0188	0.3202	0.4745
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0252	0.2422
Brugia malayi	MH2 domain containing protein	0.0034	0.0343	0.0343
Brugia malayi	RNA binding protein	0.0188	0.3202	0.3202
Schistosoma mansoni	methionine-tRNA synthetase	0.0021	0.0103	0.0152
Toxoplasma gondii	methionyl-tRNA synthetase	0.0054	0.0718	1
Wolbachia endosymbiont of Brugia malayi	methionyl-tRNA synthetase	0.0054	0.0718	1
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0343	0.0508
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0032	0.0312	0.0976
Loa Loa (eye worm)	MH2 domain-containing protein	0.0493	0.8817	0.8817
Chlamydia trachomatis	DNA ligase	0.0022	0.0123	1
Brugia malayi	hypothetical protein	0.0158	0.2636	0.2636
Loa Loa (eye worm)	RNA binding protein	0.0188	0.3202	0.3202
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0252	0.2422
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0032	0.0312	0.0976
Mycobacterium leprae	Probable methionyl-tRNA synthase MetS	0.0054	0.0718	1
Echinococcus granulosus	smad	0.0034	0.0343	0.107
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0557	1	1
Echinococcus granulosus	Smad4	0.0034	0.0343	0.107
Brugia malayi	MH1 domain containing protein	0.0019	0.0066	0.0066
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0252	0.2422
Brugia malayi	MH2 domain containing protein	0.0493	0.8817	0.8817
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0176	0.2975	0.929
Echinococcus multilocularis	tar DNA binding protein	0.0188	0.3202	1
Schistosoma mansoni	hypothetical protein	0.0176	0.2975	0.4408
Onchocerca volvulus		0.0158	0.2636	0.8853
Schistosoma mansoni	chromosome transmission fidelity factor	0.0022	0.0123	0.0182
Brugia malayi	hypothetical protein	0.0018	0.0064	0.0064
Schistosoma mansoni	tar DNA-binding protein	0.0188	0.3202	0.4745
Echinococcus multilocularis	smad	0.0034	0.0343	0.107
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0034	0.0343	0.107
Brugia malayi	MH1 domain containing protein	0.0034	0.0343	0.0343
Onchocerca volvulus		0.0033	0.0338	0.1136
Schistosoma mansoni	topbp1	0.0022	0.0123	0.0182
Mycobacterium tuberculosis	Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase)	0.0054	0.0718	1
Plasmodium vivax	replication factor C subunit 1, putative	0.0022	0.0123	0.0328
Schistosoma mansoni	topbp1	0.0022	0.0123	0.0182
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0021	0.0103	0.0321
Echinococcus multilocularis	replication factor c subunit 1	0.0022	0.0123	0.0384
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.2977	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0252	0.2165
Onchocerca volvulus		0.0022	0.0123	0.0413
Brugia malayi	protein ZK524.3	0.0021	0.0103	0.0103
Brugia malayi	Pax transcription activation domain interacting protein	0.0022	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Brugia malayi	DKFZp564C0469 protein	0.0022	0.0123	0.0123
Schistosoma mansoni	smad	0.0034	0.0343	0.0508
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.0343	0.0343
Brugia malayi	Smad1	0.0034	0.0343	0.0343
Schistosoma mansoni	smad1 5 8 and	0.0034	0.0343	0.0508
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0032	0.0312	0.3185
Echinococcus multilocularis	GPCR, family 2	0.0176	0.2975	0.929
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0032	0.0312	0.3185
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2977	0.2977
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0123	0.0123
Toxoplasma gondii	ATPase, AAA family protein	0.0022	0.0123	0.0328
Trichomonas vaginalis	methionine-tRNA synthetase, putative	0.0054	0.0718	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0252	0.2422
Brugia malayi	hypothetical protein	0.0029	0.0252	0.0252
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.0022	0.0123	0.0123
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0557	1	1
Echinococcus multilocularis	nibrin	0.0022	0.0123	0.0384
Echinococcus granulosus	nibrin	0.0022	0.0123	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2975	0.2975
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0188	0.3202	0.3202
Brugia malayi	MH1 domain containing protein	0.0019	0.0066	0.0066
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0022	0.0123	0.0328
Brugia malayi	Latrophilin receptor protein 2	0.0176	0.2975	0.2975
Brugia malayi	N-terminal motif family protein	0.0176	0.2977	0.2977
Brugia malayi	hypothetical protein	0.0022	0.0123	0.0123
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0252	0.2165
Loa Loa (eye worm)	TAR-binding protein	0.0188	0.3202	0.3202

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 912074