Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0162 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0228 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0032 | 0.0032 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.013 | 0.0359 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0113 | 0.1203 | 0.1203 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0032 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.066 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0168 | 0.0637 |
Onchocerca volvulus | 0.0036 | 0.0228 | 0.0232 | |
Brugia malayi | Bromodomain containing protein | 0.0236 | 0.2747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0223 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0143 | 0.1581 | 0.6002 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0036 | 0.0228 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0054 | 0.0464 | 0.1054 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0228 | 0.0716 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0274 | 0.0409 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0159 | 0.6454 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.066 | 0.1499 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0036 | 0.0228 | 0.0754 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0071 | 0.0673 | 0.1529 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0054 | 0.0456 | 0.0456 |
Trypanosoma cruzi | ISWI complex protein | 0.0048 | 0.0387 | 1 |
Schistosoma mansoni | chromodomain helicase DNA binding protein | 0.0017 | 0.0001 | 0.0003 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0227 | 0.2634 | 0.2634 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0162 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0223 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0062 | 0.0556 | 0.0556 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0227 | 0.2634 | 0.598 |
Echinococcus granulosus | zinc finger protein | 0.0062 | 0.0556 | 0.1263 |
Brugia malayi | Bromodomain containing protein | 0.0121 | 0.1296 | 0.4718 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0036 | 0.0228 | 0.0754 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0228 | 0.0831 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0071 | 0.0673 | 0.1529 |
Echinococcus granulosus | geminin | 0.0368 | 0.4404 | 1 |
Onchocerca volvulus | 0.0054 | 0.0464 | 0.1138 | |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0032 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0471 | 0.1788 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0228 | 0.5527 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0228 | 0.0831 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0274 | 0.1041 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0228 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0048 | 0.0387 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0048 | 0.0387 | 0.0879 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0054 | 0.0456 | 0.1036 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0253 | 0.0921 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0228 | 0.0831 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0041 | 0.0302 | 0.0686 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0312 | 0.1021 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0159 | 0.0577 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0274 | 0.0884 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0062 | 0.0558 | 0.0558 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.0464 | 0.1689 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0162 | 0.0614 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0071 | 0.0673 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0558 | 0.2121 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0228 | 0.0518 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0274 | 0.0884 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0387 | 0.0879 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.4404 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0145 | 0.0329 |
Brugia malayi | hypothetical protein | 0.003 | 0.0162 | 0.0589 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0162 | 0.3656 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.0162 | 0.6615 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0188 | 0.2142 | 0.2142 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.0464 | 0.1689 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0054 | 0.0456 | 0.1036 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0159 | 0.0159 |
Onchocerca volvulus | 0.0041 | 0.0302 | 0.0517 | |
Brugia malayi | PHD-finger family protein | 0.0078 | 0.0767 | 0.2792 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0084 | 0.0833 | 0.1891 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0042 | 0.0312 | 0.0552 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0188 | 0.2142 | 0.4865 |
Leishmania major | hypothetical protein, conserved | 0.0048 | 0.0387 | 1 |
Brugia malayi | CHD4 protein | 0.0017 | 0.0001 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.1299 | 0.4932 |
Echinococcus granulosus | chromobox protein 1 | 0.007 | 0.066 | 0.1499 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0598 | 0.1357 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0065 | 0.0598 | 0.227 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0228 | 0.0716 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0228 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0228 | 0.0716 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0032 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0228 | 0.5527 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0054 | 0.0464 | 0.1054 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0032 | 0.0117 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0227 | 0.2634 | 0.598 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0032 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1393 | 0.5288 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0228 | 0.0228 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0143 | 0.1581 | 0.6002 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0228 | 0.0754 |
Schistosoma mansoni | chromobox protein | 0.007 | 0.066 | 0.1499 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0223 | 0.0812 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.2407 | 0.9141 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0036 | 0.0228 | 0.0754 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0223 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0228 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0032 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0159 | 0.036 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0228 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0228 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0253 | 0.096 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0218 | 0.252 | 0.5722 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0253 | 0.0574 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.0471 | 0.1714 |
Trypanosoma cruzi | ISWI complex protein | 0.0048 | 0.0387 | 1 |
Loa Loa (eye worm) | CHromoDomain protein family member | 0.0017 | 0.0001 | 0.0005 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0032 | 0.0122 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0227 | 0.2634 | 0.598 |
Echinococcus multilocularis | geminin | 0.0368 | 0.4404 | 0.4404 |
Onchocerca volvulus | 0.0238 | 0.277 | 1 | |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.277 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0228 | 0.0754 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0054 | 0.0464 | 0.0464 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.003 | 0.0162 | 0.6615 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.0464 | 0.1054 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0062 | 0.0558 | 0.2033 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0162 | 0.3656 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0228 | 0.0866 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0227 | 0.2634 | 0.9587 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.0471 | 0.1714 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0054 | 0.0464 | 0.1138 |
Trichomonas vaginalis | chromobox protein, putative | 0.0042 | 0.0312 | 0.1021 |
Loa Loa (eye worm) | MBCTL1 | 0.0062 | 0.0558 | 0.2121 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0228 | 0.0518 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0228 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0228 | 0.0866 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.2407 | 0.8763 |
Echinococcus multilocularis | chromodomain helicase DNA binding protein 4 | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0228 | 0.0866 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0228 | 0.5527 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0218 | 0.252 | 0.252 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0833 | 0.3162 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0223 | 0.0507 |
Schistosoma mansoni | bromodomain containing protein | 0.0199 | 0.2284 | 0.5186 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0228 | 0.0518 |
Brugia malayi | MH2 domain containing protein | 0.0143 | 0.1581 | 0.5754 |
Schistosoma mansoni | zinc finger protein | 0.0062 | 0.0556 | 0.1263 |
Echinococcus granulosus | chromodomain helicase DNA binding protein 4 | 0.0017 | 0.0001 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0223 | 0.0507 |
Onchocerca volvulus | 0.0036 | 0.0228 | 0.0232 | |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0274 | 0.0998 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0054 | 0.0464 | 0.1762 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.013 | 0.0359 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0084 | 0.0833 | 0.1891 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0036 | 0.0228 | 0.0754 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.007 | 0.066 | 0.2506 |
Schistosoma mansoni | hypothetical protein | 0.0334 | 0.3978 | 0.9034 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0223 | 0.0223 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.066 | 0.2293 |
Trichomonas vaginalis | chromobox protein, putative | 0.007 | 0.066 | 0.2293 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0113 | 0.1203 | 0.2731 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0227 | 0.2634 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0228 | 0.5527 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0228 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0227 | 0.2634 | 0.2634 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0227 | 0.2634 | 0.598 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0228 | 0.0716 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0228 | 1 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0062 | 0.0558 | 0.1268 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.1468 | 0.5575 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0062 | 0.0558 | 0.1268 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0054 | 0.0464 | 0.0464 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0228 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.4404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0464 | 0.1762 |
Brugia malayi | hypothetical protein | 0.0156 | 0.1743 | 0.6345 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0227 | 0.2634 | 0.598 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0162 | 0.3656 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0054 | 0.0464 | 0.1054 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0062 | 0.0558 | 0.1268 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0056 | 0.048 | 0.1824 |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.066 | 0.066 |
Brugia malayi | Heterochromatin protein 1 | 0.007 | 0.066 | 0.2402 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0162 | 0.3656 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0036 | 0.0228 | 0.0754 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.0464 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.2578 | 0.9789 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.1743 | 0.6618 |
Onchocerca volvulus | 0.0156 | 0.1743 | 0.6053 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0084 | 0.0833 | 0.1891 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0159 | 0.6454 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0062 | 0.0558 | 0.0558 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0032 | 0.0073 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0036 | 0.0228 | 0.0754 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.2632 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0228 | 0.0716 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0228 | 0.0831 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0084 | 0.0833 | 0.0833 |
Mycobacterium tuberculosis | Conserved protein | 0.0036 | 0.0228 | 0.0754 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0223 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0054 | 0.0456 | 0.1036 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.0471 | 0.1788 |
Onchocerca volvulus | 0.0036 | 0.0228 | 0.0232 | |
Echinococcus multilocularis | chromobox protein 1 | 0.007 | 0.066 | 0.066 |
Brugia malayi | hypothetical protein | 0.002 | 0.0027 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0223 | 0.0507 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.