Detailed information for compound 912153

Basic information

Technical information
  • TDR Targets ID: 912153
  • Name: 1-[2-(4-methoxyphenyl)ethenyl]-4-nitrobenzene
  • MW: 255.269 | Formula: C15H13NO3
  • H donors: 0 H acceptors: 2 LogP: 3.99 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=Cc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C15H13NO3/c1-19-15-10-6-13(7-11-15)3-2-12-4-8-14(9-5-12)16(17)18/h2-11H,1H3/b3-2+
  • InChiKey: PDFBJCRLHMEJQP-NSCUHMNNSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(E)-2-(4-methoxyphenyl)ethenyl]-4-nitrobenzene
  • 1-[2-(4-methoxyphenyl)vinyl]-4-nitro-benzene
  • 1-[(E)-2-(4-methoxyphenyl)vinyl]-4-nitro-benzene
  • 1-[(E)-2-(4-methoxyphenyl)vinyl]-4-nitrobenzene
  • 1-[2-(4-methoxyphenyl)vinyl]-4-nitrobenzene
  • 1-[2-(4-methoxyphenyl)ethenyl]-4-nitro-benzene
  • 1-[(E)-2-(4-methoxyphenyl)ethenyl]-4-nitro-benzene
  • 1472-68-0
  • 4648-33-3
  • Benzene, 1-methoxy-4-(2-(4-nitrophenyl)ethenyl)-
  • (E)-1-Methoxy-4-(2-(4-nitrophenyl)ethenyl)benzene
  • (E)-1-Methoxy-4-[2-(4-nitrophenyl)ethenyl]benzene
  • C14622
  • EU-0000494
  • Benzene, 1-methoxy-4-(2-(4-nitrophenyl)ethenyl)-, (E)-
  • (E)-Methoxy-4'-nitrostilbene
  • ZINC00186928
  • Oprea1_736244
  • Anisole, p-(p-nitrostyryl)-, (E)-
  • NSC149646
  • CBDivE_010727
  • Benzene, 1-methoxy-4-[2-(4-nitrophenyl)ethenyl]-, (E)-
  • NSC66820
  • 1-Methoxy-4-(2-(4-nitrophenyl)ethenyl)benzene

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1794 0.2875
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5762 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1209 0.1939
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1454 0.2523
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0625 0.284
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0452 0.0452
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0161 0.014
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5762 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0322 0.0517
Loa Loa (eye worm) hypothetical protein 0.0051 0.1117 0.1791
Brugia malayi beta-lactamase family protein 0.0036 0.0625 0.1002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0161 0.0309
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.1153 0.9734
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0161 0.014
Loa Loa (eye worm) hypothetical protein 0.003 0.0452 0.0724
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.1794 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0452 0.0784
Echinococcus multilocularis dna polymerase eta 0.002 0.0109 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1454 0.7982
Mycobacterium ulcerans hypothetical protein 0.0036 0.0625 0.3061
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0161 0.014
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0161 0.014
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1454 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.06 0.0962
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.1153 0.6199
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0161 0.0486
Echinococcus granulosus lamin dm0 0.0026 0.0322 0.0322
Loa Loa (eye worm) hypothetical protein 0.0053 0.1182 0.1895
Brugia malayi TAR-binding protein 0.0196 0.5762 0.9237
Loa Loa (eye worm) hypothetical protein 0.0054 0.1209 0.1939
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0161 0.014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.1115 0.1562
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.1794 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1182 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0109 0.0109
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.1153 0.9734
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0161 0.014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.6779 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.1153 0.1153
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1454 0.2523
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0625 0.0625
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.1794 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0109 0.0175
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0625 0.1002
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.1153 0.1849
Brugia malayi intermediate filament protein 0.0026 0.0322 0.0517
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.1209 0.1702
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0416 0.0416
Plasmodium vivax SET domain protein, putative 0.003 0.0452 0.2771
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0109 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.1153 0.2002
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1794 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Loa Loa (eye worm) hypothetical protein 0.002 0.0109 0.0175
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0625 0.0831
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1794 1
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0161 0.0309
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0109 0.0109
Mycobacterium tuberculosis Conserved protein 0.0036 0.0625 0.0831
Brugia malayi MAP kinase sur-1 0.0052 0.1153 0.1849
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1117 0.1791
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0452 0.2247
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0161 0.0486
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.1153 0.7677
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1794 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.5762 0.9237
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1794 1
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0161 0.0309
Brugia malayi hypothetical protein 0.0034 0.058 0.0929
Brugia malayi hypothetical protein 0.0053 0.1182 0.1895
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0161 0.0309
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.6238 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0245 0.0245
Leishmania major hypothetical protein, conserved 0.0036 0.0625 0.3061
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1454 0.7982
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Loa Loa (eye worm) TAR-binding protein 0.0196 0.5762 0.9237
Schistosoma mansoni lamin 0.0026 0.0322 0.0559
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.1115 0.1562
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.1153 0.1153
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0625 0.0831
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0452 0.0452
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0625 0.4807
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0109 0.0063
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.1153 0.9734
Onchocerca volvulus 0.0072 0.1794 0.2329
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0625 0.0831
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.1794 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0625 0.073
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Mycobacterium ulcerans hypothetical protein 0.0072 0.1794 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0625 0.073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.1153 0.1153
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.1209 0.6532
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.1153 0.1153
Brugia malayi Pre-SET motif family protein 0.003 0.0452 0.0724
Echinococcus multilocularis lamin 0.0026 0.0322 0.0322
Echinococcus multilocularis musashi 0.0026 0.0322 0.0322
Schistosoma mansoni lamin 0.0026 0.0322 0.0559
Echinococcus multilocularis lamin dm0 0.0026 0.0322 0.0322
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1182 0.9737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0452 0.0784
Onchocerca volvulus 0.0026 0.0322 0.023
Trichomonas vaginalis set domain proteins, putative 0.024 0.7171 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1153 0.9734
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0322 0.0517
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1794 0.2875
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0322 0.0517
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0109 0.0175
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0161 0.0309
Loa Loa (eye worm) hypothetical protein 0.0072 0.1794 0.2875
Loa Loa (eye worm) hypothetical protein 0.0026 0.0322 0.0517
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0625 0.3061
Onchocerca volvulus 0.003 0.0452 0.0414
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0625 0.073
Echinococcus multilocularis dna polymerase kappa 0.002 0.0109 0.0109
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.1209 1
Leishmania major hypothetical protein, conserved 0.0053 0.1182 0.6368
Mycobacterium tuberculosis Conserved protein 0.0036 0.0625 0.0831
Loa Loa (eye worm) hypothetical protein 0.0072 0.1794 0.2875
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0161 0.0486
Mycobacterium ulcerans lipase LipD 0.0036 0.0625 0.3061
Mycobacterium ulcerans beta-lactamase 0.0036 0.0625 0.3061
Loa Loa (eye worm) hypothetical protein 0.0072 0.1794 0.2875
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0161 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0625 0.1085
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0625 0.073
Echinococcus granulosus intermediate filament protein 0.0026 0.0322 0.0322
Onchocerca volvulus 0.0036 0.0625 0.0661
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.5762 0.9237
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0109 0.0063
Onchocerca volvulus 0.0036 0.0625 0.0661
Loa Loa (eye worm) oxidoreductase 0.0021 0.0161 0.0259
Echinococcus multilocularis tumor protein p63 0.0329 1 1
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0161 0.014
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1153 0.1479
Onchocerca volvulus 0.024 0.7171 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1209 0.1939
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1454 0.7982
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.1182 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0307 0.0492
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0161 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0625 0.4807
Trypanosoma brucei protein kinase, putative 0.0052 0.1153 0.9734
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0161 0.0309
Echinococcus granulosus tar DNA binding protein 0.0196 0.5762 0.5762
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0161 0.0259
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1794 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0161 0.014
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0109 0.019
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0625 0.0831
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0161 0.0309
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5762 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0161 0.0161
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0625 0.4807
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.1794 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0625 0.0831
Onchocerca volvulus 0.0048 0.1022 0.1228
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.1794 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.1182 0.9737
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0161 0.028
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0161 0.0309
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1117 0.1791
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.1153 0.6199
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.1182 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.1794 1
Echinococcus multilocularis tar DNA binding protein 0.0196 0.5762 0.5762
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1454 0.2066
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0161 0.0309
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1153 0.1479
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5762 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0625 0.284
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0625 0.1085
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0625 0.0625
Onchocerca volvulus 0.0025 0.0287 0.0179
Echinococcus granulosus lamin 0.0026 0.0322 0.0322
Brugia malayi beta-lactamase 0.0036 0.0625 0.1002
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0161 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1117 0.1791
Loa Loa (eye worm) beta-lactamase 0.0036 0.0625 0.1002
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0161 0.0309
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.1115 0.1562
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1153 0.1479
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0625 0.3061
Schistosoma mansoni DNA polymerase eta 0.002 0.0109 0.019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0625 0.1002
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.1153 0.9734
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1454 0.1454
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.1209 1
Onchocerca volvulus 0.0026 0.0322 0.023
Loa Loa (eye worm) hypothetical protein 0.0048 0.1022 0.1639
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0161 0.0309
Brugia malayi AMP-binding enzyme family protein 0.0072 0.1794 0.2875
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0259
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.1153 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0109 0.0175
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0161 0.014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1454 0.7982
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0625 0.0831
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0452 0.0784
Echinococcus granulosus dna polymerase kappa 0.002 0.0109 0.0109
Echinococcus granulosus dna polymerase eta 0.002 0.0109 0.0109
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.1794 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0024 0.0245 0.0425
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0161 0.0161
Brugia malayi Pre-SET motif family protein 0.0211 0.6238 1
Schistosoma mansoni tar DNA-binding protein 0.0196 0.5762 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0161 0.0309
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0452 0.0784
Loa Loa (eye worm) RNA binding protein 0.0196 0.5762 0.9237
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.1794 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0161 0.0074
Trichomonas vaginalis esterase, putative 0.0036 0.0625 0.073
Toxoplasma gondii ABC1 family protein 0.0036 0.0625 0.3587
Loa Loa (eye worm) hypothetical protein 0.0054 0.1209 0.1939
Brugia malayi RNA binding protein 0.0196 0.5762 0.9237
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0452 0.0452
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.1794 0.2572
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.06 0.0962
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0161 0.0486
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.1182 0.9737
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.1022 0.1774
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.1209 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.1115 0.1562
Loa Loa (eye worm) hypothetical protein 0.0021 0.0161 0.0259
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.1182 0.7897
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.1153 0.1479
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0161 0.0486
Onchocerca volvulus 0.0036 0.0625 0.0661
Brugia malayi beta-lactamase family protein 0.0036 0.0625 0.1002
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0161 0.014
Loa Loa (eye worm) hypothetical protein 0.0054 0.1209 0.1939
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0625 0.4423
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0625 0.0831
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0161 0.0309
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0161 0.0309
Schistosoma mansoni hypothetical protein 0.0035 0.06 0.1042
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.1794 1
Schistosoma mansoni intermediate filament proteins 0.0026 0.0322 0.0559
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0625 0.1002
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1454 0.1454
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0161 0.0259
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0625 0.073
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0161 0.0259
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.1794 0.2572
Mycobacterium tuberculosis Conserved protein 0.0036 0.0625 0.0831

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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