Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0018 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0018 | 0.023 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0164 | 0.0188 |
Echinococcus multilocularis | tar DNA binding protein | 0.0251 | 0.519 | 0.7243 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0164 | 0.0229 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0392 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0283 | 0.0394 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0251 | 0.519 | 0.5952 |
Brugia malayi | GH02984p | 0.0337 | 0.7166 | 0.8217 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0337 | 0.7166 | 1 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0337 | 0.7166 | 1 |
Echinococcus granulosus | solute carrier family 5 | 0.0037 | 0.0312 | 0.0435 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0283 | 0.0324 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0056 | 0.0741 | 0.1034 |
Brugia malayi | TAR-binding protein | 0.0251 | 0.519 | 0.5952 |
Toxoplasma gondii | transporter, solute:sodium symporter (SSS) family protein | 0.0037 | 0.0312 | 0.3946 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0392 | 0.0546 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0164 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0624 | 0.0716 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.014 | 0.1771 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0231 | 0.4742 | 0.5437 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.014 | 0.016 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.1682 | 0.1929 |
Echinococcus granulosus | tar DNA binding protein | 0.0251 | 0.519 | 0.7243 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.014 | 0.0195 |
Brugia malayi | MH2 domain containing protein | 0.0231 | 0.4742 | 0.5437 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2626 | 0.3665 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0392 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0164 | 0.0229 |
Echinococcus multilocularis | solute carrier family 5 | 0.0037 | 0.0312 | 0.0435 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0097 | 0.168 | 0.1926 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.014 | 0.0195 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.079 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.7166 | 0.8217 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0058 | 0.079 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.079 | 0.0906 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.1682 | 0.2347 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.519 | 0.7243 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.014 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.014 | 0.016 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.519 | 0.7243 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.519 | 0.7243 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.014 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.0392 | 0.0546 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.2626 | 0.3665 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0058 | 0.079 | 0.1103 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0037 | 0.0312 | 0.0435 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0405 | 0.8721 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.3247 | 0.4531 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0037 | 0.0312 | 0.0435 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.519 | 0.7243 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0037 | 0.0312 | 0.0435 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0392 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0405 | 0.0566 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.0978 | 0.1365 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.014 | 0.1771 |
Plasmodium vivax | SET domain protein, putative | 0.0058 | 0.079 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0251 | 0.519 | 0.5952 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0312 | 0.0358 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0139 | 0.2626 | 0.3012 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.1682 | 0.2347 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.3247 | 0.4531 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.0392 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0251 | 0.519 | 0.7243 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.168 | 0.1926 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0283 | 0.0394 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0037 | 0.0312 | 0.0435 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0018 | 0.1297 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.0862 | 0.0988 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.2626 | 0.3665 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0058 | 0.079 | 0.1103 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0018 | 1 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.014 | 1 |
Schistosoma mansoni | high-affinity choline transporter | 0.0337 | 0.7166 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2626 | 0.3665 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0037 | 0.0312 | 0.0435 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.014 | 0.0195 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0164 | 0.0229 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0058 | 0.079 | 0.1103 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0066 | 0.0978 | 0.1122 |
Onchocerca volvulus | 0.0037 | 0.0312 | 0.0174 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0164 | 0.0229 |
Loa Loa (eye worm) | TAR-binding protein | 0.0251 | 0.519 | 0.5952 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.0392 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0251 | 0.519 | 0.5952 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0405 | 0.0566 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0139 | 0.2626 | 0.3665 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0018 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0978 | 0.1122 |
Trichomonas vaginalis | set domain proteins, putative | 0.0461 | 1 | 1 |
Schistosoma mansoni | sodium/solute symporter | 0.0037 | 0.0312 | 0.0435 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.0392 | 0.0546 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0018 | 0.0021 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0164 | 0.0188 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0283 | 0.0394 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.014 | 0.016 |
Brugia malayi | Sodium:solute symporter family protein | 0.0037 | 0.0312 | 0.0358 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0283 | 0.0324 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.014 | 0.1771 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0164 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0164 | 0.0188 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0164 | 0.0229 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0392 | 0.0449 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0037 | 0.0312 | 0.0435 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.1226 | 0.1711 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.079 | 0.1103 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0018 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0164 | 0.0188 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0164 | 0.0229 |
Brugia malayi | Pre-SET motif family protein | 0.0405 | 0.8721 | 1 |
Echinococcus granulosus | geminin | 0.0166 | 0.3247 | 0.4531 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0037 | 0.0312 | 0.0435 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0018 | 0.023 |
Schistosoma mansoni | inositol transporter | 0.0037 | 0.0312 | 0.0435 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0164 | 0.0229 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0097 | 0.168 | 0.1926 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0097 | 0.168 | 0.1926 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0164 | 0.0229 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0283 | 0.0394 |
Echinococcus multilocularis | geminin | 0.0166 | 0.3247 | 0.4531 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.014 | 0.0195 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0139 | 0.2626 | 0.3012 |
Brugia malayi | Pre-SET motif family protein | 0.0058 | 0.079 | 0.0906 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0058 | 0.079 | 0.1103 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0058 | 0.079 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0018 | 1 |
Echinococcus granulosus | peregrin | 0.003 | 0.014 | 0.0195 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0018 | 0.1297 |
Schistosoma mansoni | inositol transporter | 0.0037 | 0.0312 | 0.0435 |
Brugia malayi | RNA binding protein | 0.0251 | 0.519 | 0.5952 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0139 | 0.2626 | 0.3665 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0139 | 0.2626 | 0.3665 |
Onchocerca volvulus | 0.0058 | 0.079 | 0.0659 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0231 | 0.4742 | 0.5437 |
Echinococcus multilocularis | peregrin | 0.003 | 0.014 | 0.0195 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.