TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 278.327 | Formula: C13H14N2O3S
H donors: 1 H acceptors: 3 LogP: 3.89 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CCCC/N=c\1/c([N+](=O)[O-])c(O)sc2c1cccc2
InChi: 1S/C13H14N2O3S/c1-2-3-8-14-11-9-6-4-5-7-10(9)19-13(16)12(11)15(17)18/h4-7,16H,2-3,8H2,1H3
InChiKey: OIFQJNBWJOLRJF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor-like 1	0.0161	0.1707	0.3
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0058	0.0058
Onchocerca volvulus		0.0143	0.1505	0.4095
Brugia malayi	nuclear receptor RXR	0.0161	0.1707	0.3
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.1139	0.3528
Onchocerca volvulus		0.0281	0.3122	0.9142
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0304	0.3397	0.8448
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0416	0.3307
Brugia malayi	Nuclear hormone receptor E75	0.0143	0.1505	0.2644
Echinococcus multilocularis	tar DNA binding protein	0.0129	0.1332	0.1332
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1139	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1139	1
Onchocerca volvulus		0.0301	0.336	0.9885
Schistosoma mansoni	nuclear hormone receptor	0.0143	0.1505	0.3742
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0304	0.3397	0.8448
Schistosoma mansoni	thyroid hormone receptor	0.0304	0.3397	0.8448
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0304	0.3397	0.5969
Onchocerca volvulus		0.0304	0.3397	1
Brugia malayi	conserved hypotetical protein	0.0143	0.1505	0.2644
Loa Loa (eye worm)	acetyltransferase	0.0147	0.155	0.2724
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0416	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0304	0.3397	0.5969
Toxoplasma gondii	LsmAD domain-containing protein	0.0051	0.0416	0.3307
Brugia malayi	nuclear receptor NHR-88	0.0304	0.3397	0.5969
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0304	0.3397	0.5969
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.2035	0.2035
Onchocerca volvulus		0.0047	0.0372	0.0562
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0143	0.1505	0.2644
Brugia malayi	ecdysone receptor	0.0143	0.1505	0.2644
Brugia malayi	Nuclear hormone receptor-like 1	0.0161	0.1707	0.3
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1332	0.3313
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0304	0.3397	0.5969
Brugia malayi	Importin beta-1 subunit	0.0028	0.0146	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Brugia malayi	Muscleblind-like protein	0.0326	0.3653	0.6418
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0129	0.1332	0.234
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0304	0.3397	0.8448
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0143	0.1505	0.1505
Brugia malayi	Nuclear hormone receptor E75	0.0143	0.1505	0.2644
Echinococcus multilocularis	ecdysone induced protein 78C	0.0304	0.3397	0.3397
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.0283	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0112	0.1139	0.2002
Schistosoma mansoni	RAR-like nuclear receptor	0.0304	0.3397	0.8448
Loa Loa (eye worm)	RNA binding protein	0.0129	0.1332	0.234
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Brugia malayi	beta-lactamase family protein	0.0112	0.1139	0.2002
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1332	0.3313
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0143	0.1505	0.3742
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0304	0.3397	0.5969
Schistosoma mansoni	hypothetical protein	0.0357	0.4021	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0143	0.1505	0.4095
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0232	0.0576
Schistosoma mansoni	thyroid hormone receptor	0.0304	0.3397	0.8448
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0146	0.0362
Mycobacterium ulcerans	beta-lactamase	0.0112	0.1139	0.5
Loa Loa (eye worm)	nuclear hormone receptor	0.0143	0.1505	0.2644
Brugia malayi	hypothetical protein	0.0037	0.0246	0.0432
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0232	0.1605
Brugia malayi	chromobox protein homolog 3	0.0041	0.0296	0.052
Trypanosoma brucei	PAB1-binding protein , putative	0.0051	0.0416	0.3307
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0333	0.0895
Loa Loa (eye worm)	DR-78	0.0143	0.1505	0.2644
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0188	0.2035	0.3575
Entamoeba histolytica	hypothetical protein	0.0023	0.0083	0.1102
Onchocerca volvulus	Protein ultraspiracle homolog	0.0304	0.3397	1
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0304	0.3397	0.8448
Brugia malayi	acetyltransferase, GNAT family protein	0.0147	0.155	0.2724
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0083	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Schistosoma mansoni	nuclear hormone receptor	0.0304	0.3397	0.8448
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0143	0.1505	0.2644
Echinococcus multilocularis	FTZ F1 alpha	0.0304	0.3397	0.3397
Echinococcus multilocularis	snurportin 1	0.0299	0.3344	0.3344
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0043	0.0325	0.2471
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0304	0.3397	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0326	0.3653	0.6418
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0161	0.1707	0.4246
Brugia malayi	nuclear hormone receptor	0.0304	0.3397	0.5969
Brugia malayi	hypothetical protein	0.0033	0.0203	0.0356
Schistosoma mansoni	nuclear receptor nhr-48	0.0143	0.1505	0.3742
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.2035	0.506
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0161	0.1707	0.4246
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0498	0.5691	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Brugia malayi	Pre-SET motif family protein	0.0246	0.2721	0.478
Echinococcus granulosus	nuclear receptor nhr 48	0.0143	0.1505	0.3742
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0143	0.1505	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0296	0.0324
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0161	0.1707	0.1707
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0299	0.3344	0.5875
Brugia malayi	follicle stimulating hormone receptor	0.0498	0.5691	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.2035	0.506
Echinococcus multilocularis	nuclear receptor nhr 48	0.0143	0.1505	0.1505
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.1139	0.2833
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0143	0.1505	0.1505
Mycobacterium ulcerans	lipase LipD	0.0112	0.1139	0.5
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0112	0.1139	0.2833
Toxoplasma gondii	ABC1 family protein	0.0112	0.1139	1
Trypanosoma brucei	hypothetical protein, conserved	0.0112	0.1139	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Brugia malayi	steroid hormone receptor	0.0304	0.3397	0.5969
Echinococcus granulosus	muscleblind protein	0.0326	0.3653	0.9084
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0112	0.1139	0.2002
Brugia malayi	orphan nuclear receptor NR2E1	0.0143	0.1505	0.2644
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1332	0.3313
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0143	0.1505	0.4095
Brugia malayi	hypothetical protein	0.0161	0.1707	0.3
Loa Loa (eye worm)	steroid hormone receptor	0.0304	0.3397	0.5969
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0304	0.3397	0.5969
Brugia malayi	TAR-binding protein	0.0129	0.1332	0.234
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0112	0.1139	0.5
Onchocerca volvulus		0.0112	0.1139	0.2955
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1139	0.3528
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.04	0.0702
Echinococcus multilocularis	muscleblind protein 1	0.0326	0.3653	0.3653
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0084	0.0084
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0673	0.1183
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0058	0.0102
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0146	0.0146
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0143	0.1505	0.3742
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0304	0.3397	0.3397
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0161	0.1707	0.4246
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1707	0.3
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0673	0.0673
Brugia malayi	RNA binding protein	0.0129	0.1332	0.234
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0043	0.0325	0.0872
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0146	0.0807
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0143	0.1505	0.3742
Plasmodium vivax	ataxin-2 like protein, putative	0.0051	0.0416	0.3307
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0232	0.0576
Mycobacterium leprae	conserved hypothetical protein	0.0112	0.1139	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.2035	0.506
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0143	0.1505	0.1505
Brugia malayi	Steroid receptor seven-up type 2	0.0304	0.3397	0.5969
Mycobacterium ulcerans	esterase/lipase LipP	0.0112	0.1139	0.5
Schistosoma mansoni	zinc finger protein	0.0143	0.1505	0.3742
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1707	0.3
Brugia malayi	nuclear receptor RXR	0.0143	0.1505	0.2644
Schistosoma mansoni	hypothetical protein	0.0357	0.4021	1
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0296	0.0776
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0304	0.3397	0.8448
Brugia malayi	beta-lactamase	0.0112	0.1139	0.2002
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0304	0.3397	0.3397
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0146	0.0256
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0058	0.0102
Schistosoma mansoni	ran	0.0021	0.0058	0.0145
Trichomonas vaginalis	penicillin-binding protein, putative	0.0112	0.1139	0.3528
Echinococcus granulosus	FTZ F1 alpha	0.0304	0.3397	0.8448
Plasmodium vivax	SET domain protein, putative	0.0035	0.0232	0.1605
Onchocerca volvulus		0.0143	0.1505	0.4095
Trichomonas vaginalis	set domain proteins, putative	0.0281	0.3122	1
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Schistosoma mansoni	coup transcription factor	0.0304	0.3397	0.8448
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0146	0.0807
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0147	0.155	0.155
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0047	0.0372	0.0926
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Loa Loa (eye worm)	hypothetical protein	0.005	0.04	0.0702
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Echinococcus granulosus	geminin	0.0357	0.4021	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Plasmodium falciparum	ataxin-2 like protein, putative	0.0051	0.0416	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0043	0.0325	0.0872
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0232	0.0232
Trypanosoma cruzi	PAB1-binding protein , putative	0.0051	0.0416	0.3307
Schistosoma mansoni	chromobox protein	0.0073	0.0673	0.1674
Schistosoma mansoni	hypothetical protein	0.0299	0.3344	0.8315
Echinococcus multilocularis	geminin	0.0357	0.4021	0.4021
Mycobacterium leprae	Probable lipase LipE	0.0112	0.1139	0.5
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0083	0.0229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0304	0.3397	0.5969
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1707	0.3
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0304	0.3397	0.5969
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0192	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0416	0.0731
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0304	0.3397	0.5969
Brugia malayi	tailless protein	0.0143	0.1505	0.2644
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.0283	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0058	0.0145
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0304	0.3397	0.5969
Brugia malayi	nuclear receptor NHR-67	0.0143	0.1505	0.2644
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0246	0.0611
Echinococcus granulosus	chromobox protein 1	0.0073	0.0673	0.1674
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0304	0.3397	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Onchocerca volvulus		0.0112	0.1139	0.2955
Echinococcus granulosus	ecdysone induced protein 78C	0.0304	0.3397	0.8448
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.835
Brugia malayi	nuclear hormone receptor family member odr-7	0.0143	0.1505	0.2644
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0188	0.2035	0.506
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0673	0.0673
Schistosoma mansoni	hypothetical protein	0.0037	0.0246	0.0611
Schistosoma mansoni	retinoic acid receptor RXR	0.0304	0.3397	0.8448
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0156	0.0318
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0143	0.1505	0.3742
Loa Loa (eye worm)	hypothetical protein	0.0326	0.3653	0.6418
Schistosoma mansoni	ran	0.0021	0.0058	0.0145
Echinococcus granulosus	tar DNA binding protein	0.0129	0.1332	0.3313
Onchocerca volvulus	Bile acid receptor homolog	0.0304	0.3397	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0304	0.3397	0.5969
Brugia malayi	nuclear receptor NHR-88	0.0143	0.1505	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1332	0.3313
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0304	0.3397	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0083	0.0081
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0043	0.0325	0.0809
Leishmania major	hypothetical protein, conserved	0.0112	0.1139	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0146	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0304	0.3397	0.8448
Brugia malayi	hypothetical protein	0.0161	0.1707	0.3
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0333	0.0895
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0304	0.3397	0.5969
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0304	0.3397	0.3397
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0043	0.0325	0.2471
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0304	0.3397	0.5969
Echinococcus granulosus	thyroid hormone receptor alpha	0.0143	0.1505	0.3742
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0304	0.3397	0.5969
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.835
Echinococcus granulosus	snurportin 1	0.0299	0.3344	0.8315
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0143	0.1502	0.3735
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1139	0.3528
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0304	0.3397	0.3397
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0188	0.2035	0.506
Brugia malayi	hypothetical protein	0.0143	0.1505	0.2644
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.835
Schistosoma mansoni	tar DNA-binding protein	0.0129	0.1332	0.3313
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0188	0.2035	0.2035
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0333	0.0438
Trichomonas vaginalis	esterase, putative	0.0112	0.1139	0.3528
Brugia malayi	RNA recognition motif domain containing protein	0.0129	0.1332	0.234
Brugia malayi	hypothetical protein	0.0301	0.336	0.5904
Schistosoma mansoni	nuclear receptor	0.0143	0.1505	0.3742
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0304	0.3397	0.8448
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0246	0.0611
Entamoeba histolytica	hypothetical protein	0.0037	0.0246	0.835
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0304	0.3397	0.5969
Plasmodium vivax	hypothetical protein, conserved	0.0112	0.1139	1
Loa Loa (eye worm)	beta-lactamase	0.0112	0.1139	0.2002
Schistosoma mansoni	importin beta-1	0.0028	0.0146	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0232	0.0232
Schistosoma mansoni	chromobox protein	0.0073	0.0673	0.1674
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0718	0.8275	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0296	0.052
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.04	0.0702
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0156	0.0318
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0673	0.2007
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0161	0.1707	0.3
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0304	0.3397	0.8448
Plasmodium falciparum	importin beta, putative	0.0028	0.0146	0.2441
Onchocerca volvulus		0.0112	0.1139	0.2955
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0216	0.0538
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0143	0.1505	0.3742
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.0283	0.628
Loa Loa (eye worm)	hypothetical protein	0.0301	0.336	0.5904
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Mycobacterium ulcerans	hypothetical protein	0.0112	0.1139	0.5
Brugia malayi	ecdysteroid receptor	0.0304	0.3397	0.5969
Brugia malayi	hypothetical protein	0.0051	0.0416	0.0731
Schistosoma mansoni	nuclear receptor	0.0143	0.1505	0.3742
Brugia malayi	Heterochromatin protein 1	0.0073	0.0673	0.1183
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0143	0.1505	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0188	0.2035	0.3575
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0083	0.0229
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0083	0.0081
Trichomonas vaginalis	D-aminoacylase, putative	0.0112	0.1139	0.3528
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0304	0.3397	0.8448
Echinococcus granulosus	beta LACTamase domain containing family member	0.0112	0.1139	0.2833
Brugia malayi	nuclear hormone receptor	0.0143	0.1505	0.2644
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0304	0.3397	0.5969
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0232	0.0576
Loa Loa (eye worm)	TAR-binding protein	0.0129	0.1332	0.234
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0304	0.3397	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1505	0.2644
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0146	0.0807
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1707	0.3
Loa Loa (eye worm)	hypothetical protein	0.0112	0.1139	0.2002
Loa Loa (eye worm)	hypothetical protein	0.0304	0.3397	0.5969
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0304	0.3397	0.5969
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0304	0.3397	0.3397
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0246	0.2721	0.478
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0304	0.3397	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0215	0.0377
Leishmania major	hypothetical protein, conserved	0.0051	0.0416	0.3307
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0296	0.0776
Schistosoma mansoni	hypothetical protein	0.0023	0.0084	0.021
Brugia malayi	beta-lactamase family protein	0.0112	0.1139	0.2002
Brugia malayi	Pre-SET motif family protein	0.0035	0.0232	0.0407
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0143	0.1505	0.3742
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0304	0.3397	0.5969
Schistosoma mansoni	nuclear hormone receptor	0.0143	0.1505	0.3742
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0304	0.3397	0.3397
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0304	0.3397	0.5969
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0304	0.3397	0.5969
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0043	0.0325	0.2471
Brugia malayi	photoreceptor-specific nuclear receptor	0.0304	0.3397	0.5969
Brugia malayi	hypothetical protein	0.0143	0.1505	0.2644
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0143	0.1505	0.1505
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0304	0.3397	0.3397
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0304	0.3397	0.8448
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0232	0.0407
Schistosoma mansoni	hypothetical protein	0.0034	0.0215	0.0534
Brugia malayi	RNA, U transporter 1	0.008	0.0755	0.1327
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0084	0.021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0232	0.0576
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0143	0.1505	0.1505
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.04	0.0702
Echinococcus granulosus	chromobox protein 1	0.0073	0.0673	0.1674
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0215	0.0377
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0673	0.2007
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1707	0.3
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0112	0.1139	0.1139
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0147	0.155	0.3856
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0304	0.3397	0.5969
Echinococcus multilocularis	muscleblind protein	0.0326	0.3653	0.3653

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 912305