Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | heterochromatin protein 1, putative | 0.0013 | 0.0008 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0013 | 0.0008 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0013 | 0.0008 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.273 | 0.4944 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.0565 | 0.0862 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.307 | 0.4746 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 0.0565 | 0.1024 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.008 | 0.6461 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1024 |
Brugia malayi | hypothetical protein | 0.0041 | 0.273 | 0.2724 |
Trichomonas vaginalis | chromobox protein, putative | 0.008 | 0.6461 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.273 | 0.4217 |
Brugia malayi | chromobox protein homolog 3 | 0.0045 | 0.307 | 0.3065 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Echinococcus granulosus | chromobox protein 1 | 0.008 | 0.6461 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.273 | 0.4217 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1808 | 0.2789 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.5512 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0565 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0019 | 0.0565 | 0.1024 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.0565 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.5512 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 0.0565 | 0.0557 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.273 | 0.4944 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0013 | 0.0008 | 0.5 |
Trichomonas vaginalis | chromobox protein, putative | 0.008 | 0.6461 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.307 | 0.4746 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 0.0565 | 0.0862 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Onchocerca volvulus | 0.0035 | 0.2136 | 0.6276 | |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0045 | 0.307 | 0.9031 |
Echinococcus granulosus | chromobox protein 1 | 0.008 | 0.6461 | 1 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.007 | 0.5512 | 0.5508 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.0565 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.008 | 0.6461 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.2662 | 0.4113 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0013 | 0.0008 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 0.0565 | 0.0862 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.0565 | 0.1011 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.1808 | 0.2789 |
Trichomonas vaginalis | chromobox protein, putative | 0.0048 | 0.3399 | 0.5254 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0048 | 0.3399 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.008 | 0.6461 | 1 |
Schistosoma mansoni | chromobox protein | 0.008 | 0.6461 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.007 | 0.5512 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 0.0565 | 0.0862 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.0565 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.2662 | 0.4113 |
Brugia malayi | Heterochromatin protein 1 | 0.008 | 0.6461 | 0.6458 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.007 | 0.5512 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0565 | 0.0557 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 0.0565 | 0.0862 |
Trichomonas vaginalis | chromobox protein, putative | 0.0048 | 0.3399 | 0.5254 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.5512 | 0.853 |
Toxoplasma gondii | chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 | 0.0013 | 0.0008 | 0.5 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.007 | 0.5512 | 0.853 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0565 | 0.0862 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.273 | 0.4944 |
Toxoplasma gondii | 'chromo' (CHRromatin Organization MOdifier) domain-containing protein | 0.0013 | 0.0008 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 0.0565 | 0.0862 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 0.0565 | 0.0862 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.007 | 0.5512 | 0.5508 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1024 |
Plasmodium falciparum | heterochromatin protein 1 | 0.0013 | 0.0008 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 0.0565 | 0.0862 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 0.0565 | 0.1024 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.0565 | 0.0862 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.008 | 0.6461 | 0.6458 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0565 | 0.0557 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.273 | 0.4217 |
Plasmodium falciparum | chromodomain-helicase-DNA-binding protein 1 homolog, putative | 0.0013 | 0.0008 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 0.0565 | 0.0862 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.007 | 0.5512 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.0565 | 0.0557 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.0565 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.273 | 0.4944 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.273 | 0.4217 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.007 | 0.5512 | 0.853 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.307 | 0.3065 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 0.0565 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.2136 | 0.213 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.