Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0134 | 0.6438 | 0.6438 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4718 | 0.4718 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0101 | 0.4718 | 0.4718 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0101 | 0.4718 | 0.4718 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0101 | 0.4718 | 0.4718 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1139 | 0.372 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.125 | 0.4083 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.3061 | 0.3061 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0076 | 0.3424 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.4202 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0032 | 0.1139 | 0.1139 |
Brugia malayi | Isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.1141 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.2715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0032 | 0.1139 | 0.4194 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0034 | 0.125 | 0.4603 |
Schistosoma mansoni | hypothetical protein | 0.0069 | 0.3061 | 1 |
Brugia malayi | hypothetical protein | 0.0049 | 0.2027 | 0.2027 |
Brugia malayi | isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.1141 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.3424 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0069 | 0.3061 | 0.3061 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1139 | 0.4194 |
Brugia malayi | hypothetical protein | 0.0076 | 0.3424 | 0.3424 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.2715 | 0.2715 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.2715 | 0.2715 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0034 | 0.125 | 0.4603 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1139 | 0.372 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0203 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.3727 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.4202 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1139 | 0.372 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0134 | 0.6438 | 0.6438 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.3333 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.3333 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0032 | 0.1141 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3424 | 0.3424 |
Brugia malayi | MH2 domain containing protein | 0.0134 | 0.6438 | 0.6438 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2715 | 0.887 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0032 | 0.1139 | 0.4194 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.2715 | 0.2715 |
Echinococcus granulosus | GPCR family 2 | 0.0032 | 0.1139 | 0.4194 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.4202 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.3424 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0076 | 0.3424 | 1 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.2715 | 0.2715 |
Leishmania major | hypothetical protein, conserved | 0.0076 | 0.3424 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0032 | 0.1139 | 0.1139 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0076 | 0.3424 | 1 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.1141 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.2715 | 0.2715 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.4202 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2715 | 0.887 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1139 | 0.4194 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.2715 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.1139 | 0.372 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0032 | 0.1139 | 0.1139 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0076 | 0.3424 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0032 | 0.1141 | 0.4202 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2715 | 0.887 |
Brugia malayi | RNA binding protein | 0.0062 | 0.2715 | 0.2715 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0032 | 0.1141 | 0.4202 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1139 | 0.1139 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0032 | 0.1139 | 0.4194 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2715 | 0.887 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.2715 | 0.887 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0076 | 0.3424 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.