Detailed information for compound 912602

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 329.46 | Formula: C18H23N3OS
  • H donors: 1 H acceptors: 2 LogP: 3.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1nc2n(c1CNC(=O)C(C)(C)C)CCS2
  • InChi: 1S/C18H23N3OS/c1-12-5-7-13(8-6-12)15-14(11-19-16(22)18(2,3)4)21-9-10-23-17(21)20-15/h5-8H,9-11H2,1-4H3,(H,19,22)
  • InChiKey: BOLMUGKXNGDQJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.019 0.0192
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Echinococcus multilocularis epidermal growth factor receptor 0.0875 0.6275 0.6258
Echinococcus granulosus tyrosine protein kinase ABL1 0.0363 0.2296 0.226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0124 0.0439 0.0445
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0124 0.0439 0.0396
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Echinococcus granulosus tyrosine protein kinase Src42A 0.01 0.0254 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.0439 0.0396
Echinococcus granulosus tyrosine protein kinase Btk29A 0.1273 0.9362 0.936
Loa Loa (eye worm) hypothetical protein 0.0494 0.3316 0.3365
Echinococcus granulosus contactin 0.0092 0.019 0.0145
Entamoeba histolytica protein kinase, putative 0.0089 0.0168 0.4019
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0092 0.019 0.0145
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Schistosoma mansoni septate junction protein 0.0073 0.0046 0.0007
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0077 0.0077 0.0078
Schistosoma mansoni cell adhesion molecule 0.0092 0.019 0.0154
Echinococcus granulosus tyrosine protein kinase Lyn 0.0205 0.1068 0.1027
Loa Loa (eye worm) hypothetical protein 0.0597 0.4113 0.4173
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0875 0.6275 0.6258
Echinococcus granulosus tyrosine protein kinase Blk 0.0155 0.0678 0.0635
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0198 0.1016 0.0975
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0198 0.1016 0.0975
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.008 0.0102 0.0056
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Onchocerca volvulus 0.012 0.0411 0.0644
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Echinococcus granulosus epidermal growth factor receptor 0.1164 0.8515 0.8508
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.0439 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.019 0.0192
Brugia malayi Protein kinase domain containing protein 0.012 0.0411 0.0417
Echinococcus granulosus roundabout 2 0.014 0.0568 0.0524
Schistosoma mansoni thyroid hormone receptor 0.1024 0.7432 0.7531
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0124 0.0439 0.0445
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Loa Loa (eye worm) hypothetical protein 0.0074 0.0049 0.005
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0092 0.019 0.0193
Echinococcus multilocularis 0.0336 0.2087 0.2051
Onchocerca volvulus 0.012 0.0411 0.0644
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0073 0.0046 0.0007
Schistosoma mansoni hypothetical protein 0.0901 0.6471 0.6552
Brugia malayi Protein kinase domain containing protein 0.012 0.0411 0.0417
Schistosoma mansoni coup transcription factor 0.0124 0.0439 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0124 0.0439 0.0445
Onchocerca volvulus 0.0721 0.5079 0.8712
Echinococcus multilocularis tyrosine kinase 0.012 0.0411 0.0368
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0467 0.3102 0.307
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0124 0.0439 0.0396
Schistosoma mansoni growth factor receptor-bound protein 0.0109 0.0326 0.0293
Loa Loa (eye worm) TK/ROR protein kinase 0.0096 0.0223 0.0226
Loa Loa (eye worm) TK/EGFR protein kinase 0.1164 0.8515 0.864
Loa Loa (eye worm) hypothetical protein 0.0092 0.019 0.0193
Schistosoma mansoni roundabout 0.0073 0.0046 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0124 0.0439 0.0445
Echinococcus granulosus tyrosine protein kinase Fps85D 0.012 0.0411 0.0368
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0124 0.0439 0.0396
Brugia malayi SH2 domain containing protein 0.012 0.0411 0.0417
Schistosoma mansoni steroid hormone receptor ad4bp 0.0124 0.0439 0.0408
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0198 0.1016 0.0975
Onchocerca volvulus 0.012 0.0411 0.0644
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0098 0.0242 0.0246
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Schistosoma mansoni titin 0.0073 0.0046 0.0007
Schistosoma mansoni tyrosine kinase 0.0821 0.5851 0.5921
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0467 0.3102 0.307
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0124 0.0439 0.0445
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0073 0.0046 0.0046
Echinococcus granulosus twitchin 0.0097 0.0229 0.0184
Loa Loa (eye worm) hypothetical protein 0.0077 0.0077 0.0078
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.1355 1 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Schistosoma mansoni cell adhesion molecule 0.0092 0.019 0.0154
Brugia malayi Plexin repeat family protein 0.0072 0.0039 0.0039
Echinococcus multilocularis tyrosine protein kinase HCK 0.0089 0.0168 0.0123
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.1273 0.9362 0.936
Loa Loa (eye worm) hypothetical protein 0.008 0.0102 0.0103
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0109 0.0326 0.0293
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0124 0.0439 0.0396
Echinococcus multilocularis plexin a4 0.0085 0.0141 0.0096
Loa Loa (eye worm) TK protein kinase 0.0508 0.3423 0.3474
Schistosoma mansoni retinoic acid receptor RXR 0.0124 0.0439 0.0408
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0155 0.0678 0.0635
Brugia malayi ephrin receptor 1 precursor 0.0287 0.171 0.1732
Loa Loa (eye worm) plexin A 0.0085 0.0141 0.0143
Brugia malayi Tyrosine-protein kinase abl-1 0.015 0.0642 0.065
Brugia malayi SH2 domain containing protein 0.012 0.0411 0.0417
Schistosoma mansoni ephrin receptor 0.0073 0.0046 0.0007
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0164 0.075 0.0724
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0901 0.6471 0.6455
Plasmodium falciparum protein kinase, putative 0.0082 0.0116 0.5
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0124 0.0439 0.0408
Loa Loa (eye worm) hypothetical protein 0.0252 0.1431 0.1452
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0198 0.1016 0.0975
Echinococcus multilocularis tyrosine protein kinase Src42A 0.01 0.0254 0.021
Echinococcus multilocularis ecdysone induced protein 78C 0.0124 0.0439 0.0396
Entamoeba histolytica protein kinase, putative 0.0072 0.004 0.0879
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Echinococcus multilocularis ephrin type A receptor 4 A 0.0603 0.4162 0.4135
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0092 0.019 0.0145
Schistosoma mansoni tyrosine kinase 0.0467 0.3102 0.312
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.024 0.0205
Echinococcus granulosus tyrosine kinase 0.0155 0.0678 0.0635
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0124 0.0439 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Schistosoma mansoni tyrosine kinase 0.0198 0.1016 0.0996
Brugia malayi Steroid receptor seven-up type 2 0.0124 0.0439 0.0445
Schistosoma mansoni tyrosine kinase 0.0875 0.6275 0.6352
Schistosoma mansoni thyroid hormone receptor 0.1024 0.7432 0.7531
Schistosoma mansoni tyrosine kinase 0.0198 0.1016 0.0996
Brugia malayi Protein kinase domain containing protein 0.012 0.0411 0.0417
Onchocerca volvulus 0.012 0.0411 0.0644
Loa Loa (eye worm) TK/INSR protein kinase 0.1336 0.9856 1
Brugia malayi steroid hormone receptor 0.0124 0.0439 0.0445
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Echinococcus multilocularis tyrosine protein kinase Abl 0.0257 0.147 0.1431
Schistosoma mansoni tyrosine kinase 0.0128 0.0469 0.0438
Echinococcus granulosus c src tyrosine kinase 0.0164 0.075 0.0707
Echinococcus granulosus insulin receptor 0.1336 0.9856 0.9855
Echinococcus multilocularis roundabout 2 0.0092 0.019 0.0145
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0901 0.6471 0.6455
Echinococcus multilocularis NCK adaptor protein 0.0109 0.0326 0.0282
Echinococcus multilocularis epidermal growth factor receptor 0.1164 0.8515 0.8508
Echinococcus granulosus epidermal growth factor receptor 0.0875 0.6275 0.6258
Brugia malayi Immunoglobulin I-set domain containing protein 0.0073 0.0046 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0124 0.0439 0.0396
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0198 0.1016 0.0975
Brugia malayi Peroxidasin 0.0074 0.0049 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Echinococcus granulosus fibroblast growth factor receptor 4 0.0467 0.3102 0.307
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0072 0.004 0.0879
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0092 0.019 0.0154
Echinococcus multilocularis neuroglian 0.0092 0.019 0.0145
Brugia malayi Variant SH3 domain containing protein 0.0109 0.0326 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0124 0.0439 0.0446
Schistosoma mansoni tyrosine kinase 0.0821 0.5851 0.5921
Schistosoma mansoni tyrosine kinase 0.0164 0.075 0.0724
Schistosoma mansoni RAR-like nuclear receptor 0.0124 0.0439 0.0408
Schistosoma mansoni cell adhesion molecule 0.0073 0.0046 0.0007
Loa Loa (eye worm) TK/EPH protein kinase 0.0684 0.4792 0.4863
Schistosoma mansoni nuclear hormone receptor 0.0124 0.0439 0.0408
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0092 0.019 0.0145
Plasmodium vivax tyrosine kinase-like protein, putative 0.0082 0.0116 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0073 0.0046 0.0046
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0092 0.019 0.0145
Echinococcus multilocularis neuroglian 0.009 0.0177 0.0132
Brugia malayi Sex muscle abnormal protein 5 0.0109 0.0326 0.033
Brugia malayi photoreceptor-specific nuclear receptor 0.0124 0.0439 0.0445
Echinococcus granulosus tyrosine protein kinase HCK 0.0089 0.0168 0.0123
Schistosoma mansoni tyrosine kinase 0.1336 0.9856 1
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Echinococcus granulosus neuroglian 0.0092 0.019 0.0145
Schistosoma mansoni tyrosine kinase 0.0875 0.6275 0.6352
Echinococcus multilocularis tyrosine protein kinase Srms 0.0155 0.0678 0.0635
Brugia malayi nuclear receptor NHR-88 0.0124 0.0439 0.0445
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0092 0.019 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0124 0.0439 0.0445
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Plasmodium falciparum tyrosine kinase-like protein 0.0082 0.0116 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0603 0.4162 0.4135
Brugia malayi Variant SH3 domain containing protein 0.0077 0.0077 0.0078
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0096 0.0223 0.0178
Loa Loa (eye worm) SRC-1 0.0198 0.1016 0.1031
Echinococcus multilocularis roundabout 2 0.0092 0.019 0.0145
Echinococcus multilocularis FTZ F1 alpha 0.0124 0.0439 0.0396
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0124 0.0439 0.0408
Onchocerca volvulus 0.012 0.0411 0.0644
Schistosoma mansoni tyrosine kinase 0.1336 0.9856 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0411 0.0417
Schistosoma mansoni nephrin 0.0109 0.0321 0.0288
Echinococcus granulosus tyrosine protein kinase Fyn 0.0198 0.1016 0.0975
Echinococcus granulosus tyrosine kinase 0.012 0.0411 0.0368
Brugia malayi Furin-like cysteine rich region family protein 0.1164 0.8515 0.8622
Brugia malayi Nuclear hormone receptor-like 1 0.1281 0.9423 0.9541
Echinococcus granulosus neuroglian 0.009 0.0177 0.0132
Schistosoma mansoni nck2/grb4 0.0109 0.0326 0.0293
Schistosoma mansoni growth factor receptor-bound protein 0.0109 0.0326 0.0293
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Echinococcus granulosus tyrosine protein kinase Srms 0.012 0.0411 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0124 0.0439 0.0445
Onchocerca volvulus 0.0124 0.0439 0.0692
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0124 0.0439 0.0396
Onchocerca volvulus Protein ultraspiracle homolog 0.0124 0.0439 0.0692
Echinococcus granulosus roundabout 2 0.0092 0.019 0.0145
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0363 0.2296 0.226
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0124 0.0439 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0124 0.0439 0.0445
Loa Loa (eye worm) hypothetical protein 0.0073 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0155 0.0678 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0124 0.0439 0.0445
Schistosoma mansoni cell adhesion molecule 0.0099 0.0246 0.0211
Brugia malayi Variant SH3 domain containing protein 0.0109 0.0326 0.033
Loa Loa (eye worm) hypothetical protein 0.0109 0.0326 0.0331
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Echinococcus multilocularis thyroid hormone receptor alpha 0.1024 0.7432 0.7421
Schistosoma mansoni vav2 0.0077 0.0077 0.0039
Loa Loa (eye worm) hypothetical protein 0.0122 0.0423 0.0429
Brugia malayi Nuclear hormone receptor-like 1 0.1339 0.9876 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0164 0.075 0.0724
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0124 0.0439 0.0446
Echinococcus granulosus tyrosine protein kinase shark 0.1008 0.7305 0.7292
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Loa Loa (eye worm) hypothetical protein 0.1274 0.9368 0.9506
Echinococcus multilocularis growth factor receptor bound protein 2 0.0109 0.0326 0.0282
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0109 0.0326 0.0331
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0124 0.0439 0.0446
Onchocerca volvulus Bile acid receptor homolog 0.0124 0.0439 0.0692
Loa Loa (eye worm) TK/ABL protein kinase 0.0363 0.2296 0.2329
Loa Loa (eye worm) hypothetical protein 0.0072 0.0039 0.0039
Schistosoma mansoni tyrosine kinase 0.0297 0.1786 0.178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.0439 0.0396
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1281 0.9423 0.9561
Schistosoma mansoni tyrosine kinase 0.1229 0.9024 0.9153
Echinococcus granulosus plexin a4 0.0085 0.0141 0.0096
Echinococcus multilocularis c src tyrosine kinase 0.0164 0.075 0.0707
Brugia malayi protein-tyrosine kinase 0.0155 0.0678 0.0686
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.012 0.0411 0.0368
Echinococcus multilocularis insulin receptor 0.1336 0.9856 0.9855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0124 0.0439 0.0446
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Loa Loa (eye worm) hypothetical protein 0.0122 0.0423 0.0429
Loa Loa (eye worm) TK protein kinase 0.0155 0.0678 0.0688
Echinococcus granulosus peroxidasin 0.0074 0.0049 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.019 0.0192
Brugia malayi plexin A 0.0085 0.0141 0.0143
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0073 0.0046 0.0012
Brugia malayi hypothetical protein 0.012 0.0411 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0124 0.0439 0.0445
Brugia malayi Prion-like- 0.0073 0.0046 0.0046
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0467 0.3102 0.307
Schistosoma mansoni tyrosine kinase 0.1008 0.7305 0.7402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0124 0.0439 0.0446
Echinococcus multilocularis roundabout 2 0.014 0.0568 0.0524
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0198 0.1016 0.0975
Onchocerca volvulus Tyrosine kinase homolog 0.0817 0.5824 1
Schistosoma mansoni ephrin receptor 0.0549 0.374 0.377
Entamoeba histolytica SH2-protein kinase domain containing protein 0.012 0.0411 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0198 0.1016 0.0975
Echinococcus granulosus ecdysone induced protein 78C 0.0124 0.0439 0.0396
Echinococcus multilocularis peroxidasin 0.0074 0.0049 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0508 0.3423 0.3466
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0124 0.0439 0.0408
Brugia malayi Tyrosine-protein kinase abl-1 0.0257 0.147 0.1489
Loa Loa (eye worm) hypothetical protein 0.0124 0.0439 0.0446
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0856 0.6126 0.6216
Brugia malayi Nuclear hormone receptor-like 1 0.1281 0.9423 0.9541
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0124 0.0439 0.0445
Onchocerca volvulus 0.012 0.0411 0.0644
Schistosoma mansoni septate junction protein 0.0073 0.0046 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0124 0.0439 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0856 0.6126 0.6203
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Brugia malayi Protein kinase domain containing protein 0.012 0.0411 0.0417
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0096 0.0223 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0124 0.0439 0.0445
Brugia malayi Protein kinase domain containing protein 0.1336 0.9856 0.9979
Echinococcus granulosus tyrosine protein kinase Src64B 0.0198 0.1016 0.0975
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0124 0.0439 0.0408
Echinococcus granulosus roundabout 2 0.0092 0.019 0.0145
Schistosoma mansoni neuroglian 0.0092 0.019 0.0154
Echinococcus multilocularis tyrosine protein kinase shark 0.1008 0.7305 0.7292
Onchocerca volvulus 0.0494 0.3316 0.5666
Schistosoma mansoni tyrosine kinase 0.0821 0.5851 0.5921
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0124 0.0439 0.0446
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0124 0.0439 0.0446
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0198 0.1016 0.0975
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0124 0.0439 0.0408
Schistosoma mansoni tyrosine kinase 0.0942 0.6795 0.6882
Loa Loa (eye worm) steroid hormone receptor 0.0124 0.0439 0.0446
Brugia malayi ecdysteroid receptor 0.0124 0.0439 0.0445
Loa Loa (eye worm) TK protein kinase 0.0089 0.0168 0.017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0124 0.0439 0.0445
Brugia malayi Protein kinase domain containing protein 0.012 0.0411 0.0417
Brugia malayi nuclear hormone receptor 0.0124 0.0439 0.0445
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0198 0.1016 0.0975
Loa Loa (eye worm) hypothetical protein 0.0147 0.0622 0.0631
Schistosoma mansoni tyrosine kinase 0.1164 0.8515 0.8634
Echinococcus multilocularis tyrosine protein kinase Blk 0.0155 0.0678 0.0635
Echinococcus granulosus growth factor receptor bound protein 2 0.0109 0.0326 0.0282
Echinococcus granulosus NCK adaptor protein 0.0109 0.0326 0.0282
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0411 0.0417
Echinococcus granulosus FTZ F1 alpha 0.0124 0.0439 0.0396
Schistosoma mansoni nephrin 0.0092 0.019 0.0154
Brugia malayi Protein kinase domain containing protein 0.0651 0.4537 0.4593
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.0439 0.0396
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0124 0.0439 0.0692
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0124 0.0439 0.0396
Brugia malayi SRC-1 0.0198 0.1016 0.1029
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0109 0.0326 0.0331
Schistosoma mansoni adapter molecule crk 0.0109 0.0326 0.0293

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.