Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | No references |
Rattus norvegicus | Angiotensin II type 2 (AT-2) receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2854 | 0.2854 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.5915 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2854 | 0.2854 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.2854 | 0.2854 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.2854 | 0.2854 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.2854 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0543 | 0.1904 |
Echinococcus multilocularis | geminin | 0.0357 | 1 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0537 | 1 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.2854 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0024 | 0.0084 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2854 | 0.2854 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.2854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0024 | 0.0084 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0537 | 1 |
Brugia malayi | RNA binding protein | 0.0127 | 0.2854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2854 | 0.2854 |
Schistosoma mansoni | hypothetical protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.2854 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0537 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0543 | 0.1904 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0537 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0543 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0537 | 0.1883 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0537 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0537 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.2854 | 0.2854 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0543 | 0.1904 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 0.0035 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0053 | 0.0537 | 0.1883 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0024 | 0.0024 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.2854 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0537 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0537 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED30 (functional) | 0 mg kg-1 | Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by intravenous administration; Not tested | ChEMBL. | No reference |
ED30 (functional) | 0 mg kg-1 | Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by peroral administration; Not tested | ChEMBL. | No reference |
IC50 (binding) | = 2 nM | Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes | ChEMBL. | No reference |
IC50 (binding) | = 2 nM | Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes | ChEMBL. | No reference |
IC50 (binding) | = 40 nM | Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes | ChEMBL. | No reference |
IC50 (binding) | = 40 nM | Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.