Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0338 | 0.0025 | 0.0025 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.166417 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0569 | 0.0576 | 0.0552 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.451 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.166417 | 0.5 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0569 | 0.0576 | 0.0552 |
Leishmania major | 0.166417 | 0.5 | 0.5 | |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.166417 | 0.5 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.166417 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0563 | 0.0562 | 0.0538 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.451 | 1 | 1 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.451 | 1 | 1 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.451 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.451 | 1 | 1 |
Leishmania major | 0.451 | 1 | 0.5 | |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.451 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1058 | 0.1747 | 0.1726 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.451 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1058 | 0.1747 | 0.1726 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.166417 | 0.5 | 0.5 |
Echinococcus multilocularis | insulin receptor | 0.0338 | 0.0025 | 0.0025 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1058 | 0.1747 | 0.1726 |
Schistosoma mansoni | tyrosine kinase | 0.0563 | 0.0562 | 0.0538 |
Schistosoma mansoni | tyrosine kinase | 0.0563 | 0.0562 | 0.0538 |
Schistosoma mansoni | tyrosine kinase | 0.0569 | 0.0576 | 0.0552 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1058 | 0.1747 | 0.1747 |
Toxoplasma gondii | fructose-bisphospatase II | 0.451 | 1 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.166417 | 0.5 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0569 | 0.0576 | 0.0552 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.166417 | 0.5 | 0.5 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.166417 | 0.5 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.166417 | 0.5 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1058 | 0.1747 | 0.1726 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0569 | 0.0576 | 0.0576 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 2.39 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 2.3903 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 15 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | > 15 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Percent growth inhibition (functional) | = 86.7 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 102.6 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.