Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | nucleoside phosphatase, putative | Curated by TDR Targets | No references |
Trypanosoma cruzi | nucleoside phosphatase, putative | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | nucleoside phosphatase, putative | nucleoside phosphatase, putative | 246 aa | 241 aa | 56.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.019 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.019 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.019 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.019 | 1 | 1 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.006 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.019 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.019 | 1 | 1 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.006 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.019 | 1 | 1 |
Trypanosoma brucei | nucleoside diphosphatase, putative | 0.0092 | 0.2422 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0 | 0.5 |
Plasmodium falciparum | nucleoside-diphosphatase, putative | 0.006 | 0 | 0.5 |
Leishmania major | ATP diphosphohydrolase | 0.0092 | 0.2422 | 0.5 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.006 | 0 | 0.5 |
Trichomonas vaginalis | adenosine/guanosine diphosphatase, putative | 0.006 | 0 | 0.5 |
Trypanosoma brucei | nucleoside phosphatase, putative | 0.0092 | 0.2422 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.019 | 1 | 1 |
Plasmodium vivax | nucleoside-diphosphatase mig-23, putative | 0.006 | 0 | 0.5 |
Leishmania major | nucleoside phosphatase, putative,guanosine diphosphatase, putative | 0.0092 | 0.2422 | 0.5 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.006 | 0 | 0.5 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.006 | 0 | 0.5 |
Trypanosoma cruzi | nucleoside phosphatase, putative | 0.0092 | 0.2422 | 1 |
Toxoplasma gondii | GDA1/CD39 (nucleoside phosphatase) family protein | 0.0092 | 0.2422 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0 | 0.5 |
Trichomonas vaginalis | guanosine-diphosphatase, putative | 0.006 | 0 | 0.5 |
Trichomonas vaginalis | adenosine diphosphatase, putative | 0.006 | 0 | 0.5 |
Plasmodium falciparum | apyrase, putative | 0.006 | 0 | 0.5 |
Schistosoma mansoni | adenosine diphosphatase | 0.0092 | 0.2422 | 0.2422 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | trypomastigote (BTO:0001398) | inferred from animal model system (ECO:0000179) | Trypanosoma cruzi | 34434 | |
Annotator: | millerja@u.washington.edu | Comment: | Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. | References: | 19255624 | |
catalytic activity (GO:0003824) | decreased (PATO:0000468) | trypomastigote (BTO:0001398) | inferred from animal model system (ECO:0000179) | Trypanosoma cruzi | 46102 | |
Annotator: | millerja@u.washington.edu | Comment: | Note: GeneBank ID is AY540630.1; included 3 hits (98% or better homology in BLAST search) to Tc genes in column A. Note: drugs also appear to reduce infectivity. Note: unable to find ARL 67156 in TDR Targets. | References: | 19255624 |