Detailed information for compound 912691

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 474.982 | Formula: C27H27ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 4.89 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCOc1ccc(cc1)c1ccc(cc1)C(=O)NC(c1ccc(cn1)Cl)Cn1cncc1
  • InChi: 1S/C27H27ClN4O2/c1-2-3-16-34-24-11-8-21(9-12-24)20-4-6-22(7-5-20)27(33)31-26(18-32-15-14-29-19-32)25-13-10-23(28)17-30-25/h4-15,17,19,26H,2-3,16,18H2,1H3,(H,31,33)
  • InChiKey: LVAOSTBFDVCIOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi Lanosterol 14-alpha demethylase Curated by TDR Targets No references
Trypanosoma cruzi Lanosterol 14-alpha demethylase Curated by TDR Targets No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) Get druggable targets OG5_129288 All targets in OG5_129288
Trypanosoma congolense Lanosterol 14-alpha demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Leishmania infantum lanosterol 14-alpha-demethylase, putative Get druggable targets OG5_129288 All targets in OG5_129288
Trypanosoma brucei gambiense lanosterol 14-alpha-demethylase,cytochrome P450 51A1, putative Get druggable targets OG5_129288 All targets in OG5_129288
Leishmania mexicana lanosterol 14-alpha-demethylase, putative Get druggable targets OG5_129288 All targets in OG5_129288
Trypanosoma cruzi Lanosterol 14-alpha demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Candida albicans cytochrome P450 lanosterol 14-alpha -demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Candida albicans cytochrome P450 lanosterol 14-alpha -demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Trypanosoma cruzi Lanosterol 14-alpha demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 Get druggable targets OG5_129288 All targets in OG5_129288
Leishmania braziliensis lanosterol 14-alpha-demethylase, putative Get druggable targets OG5_129288 All targets in OG5_129288
Leishmania donovani Lanosterol 14-alpha demethylase Get druggable targets OG5_129288 All targets in OG5_129288
Leishmania major lanosterol 14-alpha-demethylase, putative Get druggable targets OG5_129288 All targets in OG5_129288
Trypanosoma brucei Lanosterol 14-alpha demethylase Get druggable targets OG5_129288 All targets in OG5_129288
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 Lanosterol 14-alpha demethylase 481 aa 443 aa 24.6 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 Lanosterol 14-alpha demethylase 481 aa 443 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0033 0.0054
Leishmania major cathepsin L-like protease 0.0018 0.0092 0.0303
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0366 0.2407 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0287
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.002 0.0032
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0098 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0136
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0041 0.0021
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0149 0.0962 0.313
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0141 0.043
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0064 0.0396 0.161
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.043
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0041 0.0127
Loa Loa (eye worm) oxidoreductase 0.0008 0.002 0.0032
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.002 0.0029
Leishmania major cathepsin L-like protease 0.0018 0.0092 0.0303
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.002 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Schistosoma mansoni neuroligin 3 (S09 family) 0.0078 0.0491 0.0491
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0027 0.0069
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0209 0.0189
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0366 0.2407 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0022 0.0022
Toxoplasma gondii cytochrome p450 superfamily protein 0.0009 0.0027 0.0193
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0027 0.0054
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.002 0.0041
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0041 0.0021
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.029 0.0921
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.1541 0.1524
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0033 0.0237
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0054 0.0327 0.1041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0009 0.0027 0.0069
Leishmania major cathepsin L-like protease 0.0018 0.0092 0.0303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Echinococcus multilocularis nibrin 0.0011 0.0041 0.0021
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.002 0.0041
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.3479
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0041 0.0127
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0032
Onchocerca volvulus 0.0048 0.029 0.5744
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0437 0.1779
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0041 0.0496
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0324
Schistosoma mansoni DNA ligase IV 0.0011 0.0041 0.0041
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0449 0.2963 0.2963
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0009 0.0027 0.0028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0033 0.0033
Plasmodium vivax vivapain-2 0.0018 0.0092 0.9388
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0035 0.0015
Echinococcus multilocularis microtubule associated protein 2 0.1505 1 1
Onchocerca volvulus 0.0018 0.0092 0.1536
Trypanosoma cruzi major cysteine proteinase, putative 0.0055 0.0337 0.1362
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.1541 0.1524
Loa Loa (eye worm) hypothetical protein 0.0462 0.3051 1
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0141 0.0534
Brugia malayi Carboxylesterase family protein 0.0078 0.0491 0.1579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Echinococcus granulosus cathepsin L 0.0009 0.0033 0.0013
Loa Loa (eye worm) hypothetical protein 0.0018 0.0092 0.027
Mycobacterium ulcerans hypothetical protein 0.0026 0.0141 0.0506
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0366 0.2407 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0027 0.0054
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0089 0.0563 0.1817
Onchocerca volvulus 0.0018 0.0092 0.1536
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Echinococcus granulosus acetylcholinesterase 0.0462 0.3051 0.3037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0209 0.0189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0496
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0033 0.0033
Onchocerca volvulus 0.0011 0.0041 0.0442
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0462 0.3051 0.3051
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0041 0.0087
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0033 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0032
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0041 0.0496
Leishmania major cathepsin L-like protease 0.007 0.0437 0.1745
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Echinococcus multilocularis neuroligin 0.0078 0.0491 0.0471
Onchocerca volvulus 0.0032 0.018 0.3399
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0141 0.0506
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Brugia malayi Cathepsin L-like precursor 0.0012 0.0052 0.0136
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0009 0.0027 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0009 0.0027 0.0057
Mycobacterium tuberculosis Carboxylesterase LipT 0.0078 0.0491 0.1994
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0092 0.1583
Loa Loa (eye worm) ctsf protein 0.0018 0.0092 0.027
Brugia malayi cytochrome P450 0.0009 0.0027 0.0054
Echinococcus multilocularis muscleblind protein 0.0149 0.0962 0.0944
Brugia malayi Muscleblind-like protein 0.0149 0.0962 0.313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0305 0.0305
Schistosoma mansoni survival motor neuron protein 0.0048 0.029 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0305 0.0285
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0009 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0236 0.1541 0.5033
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0496
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0136
Echinococcus granulosus BC026374 protein S09 family 0.0078 0.0491 0.0471
Schistosoma mansoni gliotactin 0.0078 0.0491 0.0491
Loa Loa (eye worm) carboxylesterase 0.0078 0.0491 0.1579
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0305 0.0305
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0052 0.0585
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0287
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0041 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0141 0.2227
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0098 0.0353
Onchocerca volvulus 0.0018 0.0092 0.1536
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0034 0.0078
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.5358 0.5348
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.043
Schistosoma mansoni hypothetical protein 0.0048 0.029 0.029
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0078 0.0491 0.0471
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0098 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0141 1
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0009 0.0027 0.0028
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0029
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0078 0.0491 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.002 0.0032
Echinococcus granulosus cysteine protease 0.0009 0.0033 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0009 0.0027 0.0057
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.0563 0.0563
Schistosoma mansoni acetylcholinesterase 0.0078 0.0491 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Plasmodium vivax vivapain-2 0.0018 0.0092 0.9388
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0092 0.1332
Echinococcus multilocularis BC026374 protein (S09 family) 0.0078 0.0491 0.0471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0009 0.0027 0.0028
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0041 0.0041
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0491 0.0491
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Loa Loa (eye worm) acetylcholinesterase 1 0.0462 0.3051 1
Brugia malayi Cytochrome P450 family protein 0.0009 0.0027 0.0054
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0009 0.0027 0.0028
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.002 0.0029
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0041 0.0496
Echinococcus granulosus dual specificity 0.0089 0.0563 0.0544
Brugia malayi hypothetical protein 0.0011 0.0041 0.01
Echinococcus granulosus cytochrome P450 2K1 0.0009 0.0027 0.0007
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0033 0.0237
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0305 0.0305
Brugia malayi hypothetical protein 0.0236 0.1541 0.5033
Loa Loa (eye worm) histone methyltransferase 0.001 0.0035 0.0081
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0033 0.0094
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0022 0.0002
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0092 0.027
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0078 0.0491 0.1994
Echinococcus multilocularis cpg binding protein 0.0033 0.0192 0.0172
Brugia malayi Cytochrome P450 family protein 0.0009 0.0027 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0287
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.002 0.002
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.002 0.0032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0141 1
Schistosoma mansoni topbp1 0.0011 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0092 0.9311
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0141 0.0506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0033 0.0328
Loa Loa (eye worm) hypothetical protein 0.0149 0.0962 0.313
Onchocerca volvulus 0.0018 0.0092 0.1536
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0033 0.0237
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0437 0.1779
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0041 0.1722
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0009 0.0027 0.0028
Echinococcus granulosus cathepsin l1 0.0018 0.0092 0.0072
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0563 0.2305
Brugia malayi hypothetical protein 0.0036 0.0209 0.0653
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0092 0.027
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0092 0.0303
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0009 0.0027 0.0057
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0491 0.0491
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0141 0.0506
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0009 0.0027 0.0028
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0033 0.0237
Echinococcus multilocularis tumor protein p63 0.0366 0.2409 0.2393
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Echinococcus multilocularis acetylcholinesterase 0.0462 0.3051 0.3037
Schistosoma mansoni BC026374 protein (S09 family) 0.0078 0.0491 0.0491
Schistosoma mansoni cathepsin s 0.0006 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0052 0.0727
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0141 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0496
Entamoeba histolytica protein kinase, putative 0.0089 0.0563 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.018 0.0558
Loa Loa (eye worm) cysteine protease 0.0018 0.0092 0.027
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0009 0.0027 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.3479
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0287
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0029
Echinococcus granulosus carboxylesterase 5A 0.0462 0.3051 0.3037
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0009 0.0027 0.0028
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0092 0.0092
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0009 0.0027 0.0028
Schistosoma mansoni cpg binding protein 0.0032 0.018 0.018
Loa Loa (eye worm) cytochrome P450 0.0009 0.0027 0.0054
Brugia malayi Carboxylesterase family protein 0.0078 0.0491 0.1579
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0029
Brugia malayi cathepsin L-like precursor 0.0012 0.0052 0.0136
Plasmodium vivax vivapain-1 0.0009 0.0033 0.2588
Echinococcus multilocularis cysteine protease 0.0018 0.0092 0.0072
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0141 0.0506
Loa Loa (eye worm) hypothetical protein 0.0012 0.0052 0.0136
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0366 0.2407 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0009 0.0027 0.0057
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0141 0.0506
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0009 0.0027 0.0028
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0092 0.027
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.002 0.0056
Leishmania major cathepsin L-like protease 0.0018 0.0092 0.0303
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0009 0.0027 0.0028
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0327 0.0327
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0089 0.0563 0.2274
Leishmania major cytochrome p450-like protein 0.0009 0.0027 0.0028
Loa Loa (eye worm) hypothetical protein 0.0089 0.056 0.1807
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0141 0.0506
Schistosoma mansoni cytochrome P450 0.0009 0.0027 0.0027
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0009 0.0027 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0092 0.0342
Echinococcus granulosus para nitrobenzyl esterase 0.0078 0.0491 0.0471
Onchocerca volvulus 0.0078 0.0491 1
Brugia malayi Carboxylesterase family protein 0.0462 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0098 0.0287
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0009 0.0027 0.0028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0092 0.0072
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0033 0.0237
Trichomonas vaginalis spcc417.12 protein, putative 0.0078 0.0491 1
Brugia malayi DKFZp564C0469 protein 0.0011 0.0041 0.01
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Echinococcus granulosus nibrin 0.0011 0.0041 0.0021
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0009 0.0027 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0009 0.0027 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0009 0.0027 0.0057
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.002 0.0029
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0011 0.0041 0.0598
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0368 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.018 0.0558
Entamoeba histolytica cysteine protease, putative 0.0018 0.0092 0.1332
Trypanosoma brucei cytochrome P450, putative 0.0009 0.0027 0.0028
Leishmania major cytochrome p450-like protein 0.0009 0.0027 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Schistosoma mansoni topbp1 0.0011 0.0041 0.0041
Brugia malayi Carboxylesterase family protein 0.0078 0.0491 0.1579
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.002 0.1115
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.3479
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.002 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0009 0.0027 0.0057
Schistosoma mansoni hypothetical protein 0.0036 0.0209 0.0209
Leishmania major cathepsin L-like protease 0.0018 0.0092 0.0303
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0141 0.0506
Loa Loa (eye worm) STAT protein 0.0131 0.0844 0.274
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0098 0.0325
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Treponema pallidum DNA ligase (lig) 0.0011 0.0041 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0052 0.0727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0033 0.0328
Leishmania major cathepsin L-like protease 0.007 0.0437 0.1745
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0009 0.0027 0.0028
Loa Loa (eye worm) CYP4Cod1 0.0009 0.0027 0.0054
Onchocerca volvulus 0.0054 0.0327 0.652
Entamoeba histolytica protein kinase, putative 0.0089 0.0563 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Echinococcus granulosus muscleblind protein 0.0149 0.0962 0.0944
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Leishmania major cytochrome p450-like protein 0.0009 0.0027 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0009 0.0027 0.0057
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0041 0.0496
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0305 0.0967
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0009 0.0027 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Trypanosoma cruzi cruzipain precursor, putative 0.007 0.0437 0.1779
Plasmodium falciparum replication factor C subunit 1, putative 0.0011 0.0041 0.2682
Echinococcus granulosus tumor protein p63 0.0366 0.2409 0.2393
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0092 0.1536
Loa Loa (eye worm) cytochrome P450 family protein 0.0009 0.0027 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0089 0.0563 0.2305
Schistosoma mansoni hypothetical protein 0.0009 0.0027 0.0027
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0078 0.0491 0.0471
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0009 0.0027 0.0057
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0041 0.0127
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0009 0.0027 0.0057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0141 0.0506
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Brugia malayi Cathepsin L-like precursor 0.0012 0.0052 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0141 0.0534
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.002 0.0029
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0009 0.0027 0.0057
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0092 0.0072
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0962 0.0944
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0324
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Echinococcus multilocularis 0.0009 0.0027 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0009 0.0033 0.0054
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0009 0.0027 0.0028
Onchocerca volvulus 0.0018 0.0092 0.1536
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.2963 0.2949
Echinococcus granulosus acetylcholinesterase 0.0462 0.3051 0.3037
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0141 0.043
Brugia malayi Protein kinase domain containing protein 0.0089 0.0563 0.1817
Onchocerca volvulus 0.0018 0.0092 0.1536
Echinococcus multilocularis acetylcholinesterase 0.0462 0.3051 0.3037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0305 0.0967
Echinococcus granulosus cpg binding protein 0.0033 0.0192 0.0172
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0022 0.0002
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0092 0.9311
Mycobacterium ulcerans carboxylesterase, LipT 0.0078 0.0491 0.1971
Echinococcus multilocularis carboxylesterase 5A 0.0462 0.3051 0.3037
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0052 0.0136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Entamoeba histolytica protein kinase domain containing protein 0.0089 0.0563 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0033 0.0033
Onchocerca volvulus 0.0078 0.0491 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0141 0.0506
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0092 0.0072
Loa Loa (eye worm) hypothetical protein 0.0011 0.0041 0.01
Trypanosoma cruzi cysteine peptidase, putative 0.007 0.0437 0.1779
Loa Loa (eye worm) carboxylesterase 0.0078 0.0491 0.1579
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0033 0.0094
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0033 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Plasmodium vivax vivapain-3 0.0009 0.0033 0.2588
Toxoplasma gondii cathepsin CPL 0.0018 0.0092 0.2078
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0092 0.0072
Echinococcus multilocularis dual specificity 0.0089 0.0563 0.0544
Echinococcus multilocularis para nitrobenzyl esterase 0.0078 0.0491 0.0471
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0033 0.0094
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0033 0.0094
Leishmania major cathepsin L-like protease 0.007 0.0437 0.1745
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Brugia malayi Carboxylesterase family protein 0.0462 0.3051 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.056 0.1807
Echinococcus granulosus cathepsin l1 0.0012 0.0052 0.0032
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0052 0.0052
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0041 0.0384
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0032
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0008 0.002 0.0041
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0092 0.1536
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0141 0.2227
Onchocerca volvulus 0.0026 0.0141 0.2569
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0035 0.0015
Onchocerca volvulus 0.0078 0.0491 1
Loa Loa (eye worm) hypothetical protein 0.0462 0.3051 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0033 0.1658
Schistosoma mansoni cpg binding protein 0.0033 0.0192 0.0192
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0091 0.0324
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0041 0.01
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0041 0.01
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0011 0.0041 0.0087
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0098 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0029
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0009 0.0027 0.0028
Giardia lamblia Replication factor C, subunit 1 0.0011 0.0041 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0209 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0092 0.1583
Trypanosoma cruzi cytochrome P450, putative 0.0009 0.0027 0.0069
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0305 0.0285
Onchocerca volvulus 0.0078 0.0491 1
Echinococcus multilocularis cathepsin L 0.0009 0.0033 0.0013
Trypanosoma cruzi FHA domain containing protein, putative 0.0011 0.0041 0.0127
Brugia malayi Cytochrome P450 family protein 0.0009 0.0027 0.0054
Brugia malayi Cathepsin L-like precursor 0.0018 0.0092 0.027
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0416 0.0416
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0041 0.0496
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0078 0.0491 0.1994
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0008 0.002 0.0041
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0305 0.0285
Onchocerca volvulus 0.0078 0.0491 1
Mycobacterium leprae putative cytochrome p450 0.0009 0.0027 0.0556
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0141 0.043
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0089 0.0563 0.2274
Brugia malayi Cytochrome P450 family protein 0.0009 0.0027 0.0054
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0009 0.0027 0.0057
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0033 0.0013
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0009 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0032
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.002 0.0029
Brugia malayi Carboxylesterase family protein 0.0078 0.0491 0.1579
Onchocerca volvulus 0.0018 0.0092 0.1536
Schistosoma mansoni microtubule-associated protein tau 0.1505 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0092 0.1583
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0078 0.0491 0.0491
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0092 0.1583
Schistosoma mansoni cpg binding protein 0.0033 0.0192 0.0192
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0092 0.1332
Entamoeba histolytica hypothetical protein 0.0089 0.0563 1
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Loa Loa (eye worm) hypothetical protein 0.0078 0.0491 0.1579
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0009 0.0027 0.0028
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0009 0.0027 0.0057
Echinococcus granulosus neuroligin 0.0078 0.0491 0.0471
Brugia malayi hypothetical protein 0.0011 0.0041 0.01
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0033 0.0094
Echinococcus granulosus dnaJ subfamily B 0.0449 0.2963 0.2949
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0092 0.0072
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0366 0.2407 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0009 0.0027 0.0028
Echinococcus multilocularis cysteine protease 0.0018 0.0092 0.0072
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0009 0.0027 0.0057
Plasmodium vivax unspecified product 0.0009 0.0033 0.2588
Entamoeba histolytica hypothetical protein 0.0011 0.0041 0.0384
Loa Loa (eye worm) fibroinase 0.0018 0.0092 0.027
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0033 0.0237
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0141 0.2227
Entamoeba histolytica cysteine protease, putative 0.0009 0.0033 0.0237
Onchocerca volvulus 0.0012 0.0052 0.0675
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0092 0.9311
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0092 0.0072
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0009 0.0027 0.0028
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0092 0.1536
Loa Loa (eye worm) carboxylesterase 0.0462 0.3051 1
Entamoeba histolytica hypothetical protein 0.0036 0.0209 0.3479
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0009 0.0027 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.007 0.0437 0.1745
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0032
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0366 0.2407 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0305 0.0285
Plasmodium vivax replication factor C subunit 1, putative 0.0011 0.0041 0.3498
Brugia malayi topoisomerase 0.0011 0.0041 0.01
Mycobacterium leprae Conserved hypothetical protein 0.0009 0.0027 0.0556
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0041 0.0598
Brugia malayi hypothetical protein 0.0078 0.0491 0.1579
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0041 0.0496
Brugia malayi STAT protein, DNA binding domain containing protein 0.0131 0.0844 0.274
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0022 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Targets
growth (GO:0040007) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 46252  
Annotator: millerja@u.washington.edu Comment: Compounds 2, 4, 17, 19 in referenced publication References: 18022567
growth (GO:0040007) decreased (PATO:0000468) inferred from enzyme inhibition (ECO:0000184) Trypanosoma cruzi 31242  
Annotator: millerja@u.washington.edu Comment: Compounds 2, 4, 17, 19 in referenced publication References: 18022567

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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