Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | No references |
Trypanosoma cruzi | trypanothione reductase, putative | Curated by TDR Targets | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 189 aa | 197 aa | 20.8 % |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | trypanothione reductase, putative | 492 aa | 548 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0116 | 1 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0116 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0116 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0066 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0116 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0116 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0116 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0066 | 0 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0116 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0116 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0066 | 0 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0066 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0066 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0066 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0066 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0066 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0116 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0116 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0116 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0066 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0066 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0116 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0116 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0066 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0116 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased (PATO:0000468) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 35349 | ||
Annotator: | millerja@u.washington.edu | Comment: | Compound structures in Figure 1 of referenced publication | References: | 3135548 | |
growth (GO:0040007) | decreased (PATO:0000468) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 50541 | ||
Annotator: | millerja@u.washington.edu | Comment: | Compound structures in Figure 1 of referenced publication | References: | 3135548 |