Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.8374 | 0.9042 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.1293 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8374 | 1 |
Onchocerca volvulus | 0.0024 | 0.1293 | 0.5 | |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.024 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1293 | 0.1396 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.024 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0222 | 0.139 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0435 | 0.052 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1293 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8374 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.156 | 0.0307 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3679 | 0.3972 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.1293 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.4087 | 0.4413 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1293 | 0.1396 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0618 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.9262 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.1293 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.1293 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.1293 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8374 | 1 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1356 | 0.0073 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0947 | 0.1131 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.1293 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0618 | 0.0738 |
Brugia malayi | RNA binding protein | 0.0063 | 0.8374 | 0.8133 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.8374 | 0.9042 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.8374 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3667 | 0.2726 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.8374 | 0.8133 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.156 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.389 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0947 | 0.1131 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.156 | 0.1685 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.156 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.736 | 0.8788 |
Schistosoma mansoni | bromodomain containing protein | 0.0061 | 0.7978 | 0.9526 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0222 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.1293 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.156 | 0.5 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.1293 | 0.5 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0435 | 0.052 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.1293 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.024 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.156 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.156 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1293 | 0.1396 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.8374 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.156 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4417 | 0.4769 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8374 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.1293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.024 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8374 | 1 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.8374 | 0.8133 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0106 | 0.0114 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0435 | 0.052 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1293 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0947 | 0.1131 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.8374 | 0.9042 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.736 | 0.8788 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3258 | 0.389 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.1293 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 7.75 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Schistosoma mansoni Puerto Rican adult worms | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Onchocerca lienalis microfilariae | WHO/TDR. | No reference |
% motility reduction (functional) | = 25 % | Motility Reduction against Brugia malayi adult worms at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
IC50 (functional) | > 7.75 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | > 7.75 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | > 7.75 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | > 7.75 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 | > 7.75 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 7.75 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 (functional) | > 7.75 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 (functional) | > 7.75 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
IC50 (functional) | > 7.75 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
IC50 (functional) | = 5.185 uM | Anti Brugia malayi microfilariae activity in vitro | WHO/TDR. | No reference |
IC50 (functional) | = 5.185 uM | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Inhibition (functional) | = 25 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Inhibition (functional) | = 100 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania infantum | ChEMBL23 | ||
Trypanosoma cruzi | ChEMBL23 | ||
Plasmodium falciparum | |||
Trypanosoma brucei gambiense | |||
Homo sapiens | ChEMBL23 | ||
Brugia malayi | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.