Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.0545 | 0.5 | 0.5 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.0545 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.0545 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Brugia malayi | GNS1/SUR4 family protein | 0.0545 | 0.5 | 0.5 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.0545 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.0545 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.0545 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Trypanosoma brucei | Fatty acid elongase | 0.0545 | 0.5 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0545 | 0.5 | 0.5 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0545 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 14.369 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Onchocerca lienalis microfilariae | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms | WHO/TDR. | No reference |
IC50 (functional) | = 3.642872282 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
IC50 (functional) | = 3.6428722823 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | = 4.658235659 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
IC50 (functional) | = 4.6582356592 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | > 14.369 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | > 14.369 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 | > 14.369 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 14.369 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 (functional) | > 14.369 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
Inhibition (functional) | = 100 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Leishmania infantum | ChEMBL23 | ||
Trypanosoma cruzi | ChEMBL23 | ||
Trypanosoma brucei gambiense | |||
Plasmodium falciparum | |||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.