TDR Targets

Basic information

Technical information

TDR Targets ID: 913165
Name: 1-(2-fluorophenyl)pyrrole-2,5-dione
MW: 191.159 | Formula: C10H6FNO2
H donors: 0 H acceptors: 2 LogP: 1.14 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C=CC(=O)N1c1ccccc1F
InChi: 1S/C10H6FNO2/c11-7-3-1-2-4-8(7)12-9(13)5-6-10(12)14/h1-6H
InChiKey: XKQAFSGPGGEGPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2-fluorophenyl)-3-pyrroline-2,5-quinone
63566-53-0
BAS 06262860
ZINC03885905
1-(2-Fluoro-phenyl)-pyrrole-2,5-dione
ST5279581

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	monoglyceride lipase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	valacyclovir hydrolase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania infantum	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	esterase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma cruzi	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania donovani	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania braziliensis	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei gambiense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Candida albicans	similar to YJU3	Get druggable targets OG5_127037	All targets in OG5_127037
Mycobacterium tuberculosis	Possible lysophospholipase	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium vivax	PST-A protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania mexicana	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma brucei	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Plasmodium falciparum	lysophospholipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Leishmania major	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trypanosoma congolense	monoglyceride lipase, putative	Get druggable targets OG5_127037	All targets in OG5_127037
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	Get druggable targets OG5_127037	All targets in OG5_127037
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	Get druggable targets OG5_127037	All targets in OG5_127037

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	esterase, putative	monoglyceride lipase	303 aa	254 aa	19.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Brugia malayi	AKH receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Brugia malayi	Dopamine receptor protein 2	0.0007	0	0.5
Schistosoma mansoni	amine GPCR	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Mycobacterium ulcerans	lysophospholipase	0.0084	1	0.5
Brugia malayi	sulfakinin receptor protein	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Brugia malayi	GnHR receptor homolog	0.0007	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0007	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	amine GPCR	0.0007	0	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.0007	0	0.5
Echinococcus multilocularis	somatostatin receptor	0.0007	0	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Brugia malayi	putative neuropeptide receptor	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0	0.5
Brugia malayi	Serotonin receptor	0.0007	0	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.0084	1	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0	0.5
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0007	0	0.5
Trypanosoma cruzi	monoglyceride lipase, putative	0.0084	1	0.5
Schistosoma mansoni	biogenic amine receptor	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0007	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0	0.5
Brugia malayi	larval opioid receptor	0.0007	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	amine GPCR	0.0007	0	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	1	0.5
Echinococcus granulosus	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0007	0	0.5
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.0084	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0007	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0007	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0007	0	0.5
Plasmodium falciparum	lysophospholipase, putative	0.0084	1	0.5
Brugia malayi	ORL1-like opioid receptor	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0007	0	0.5
Schistosoma mansoni	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0007	0	0.5
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Plasmodium vivax	PST-A protein	0.0084	1	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0007	0	0.5
Echinococcus granulosus	G protein coupled receptor 139	0.0007	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Leishmania major	monoglyceride lipase, putative	0.0084	1	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	1	0.5
Brugia malayi	neuropeptide F receptor	0.0007	0	0.5
Echinococcus granulosus	sex peptide receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0084	1	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0007	0	0.5
Brugia malayi	Dopamine receptor	0.0007	0	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0007	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Schistosoma mansoni	biogenic amine receptor	0.0007	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0007	0	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0	0.5
Echinococcus multilocularis	g-protein coupled receptor	0.0007	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Plasmodium falciparum	lysophospholipase, putative	0.0084	1	0.5
Schistosoma mansoni	histamine h1 receptor	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0	0.5
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0007	0	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0007	0	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Plasmodium falciparum	lysophospholipase, putative	0.0084	1	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.0084	1	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0007	0	0.5
Schistosoma mansoni	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0007	0	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0007	0	0.5
Brugia malayi	Melatonin receptor type 1A	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0007	0	0.5
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0007	0	0.5
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	fmrfamide receptor	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus granulosus	g protein coupled receptor	0.0007	0	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Plasmodium falciparum	esterase, putative	0.0084	1	0.5
Onchocerca volvulus		0.0007	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0	0.5
Brugia malayi	RE15519p	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0007	0	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0007	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0007	0	0.5
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0007	0	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0007	0	0.5
Schistosoma mansoni	amine GPCR	0.0007	0	0.5
Mycobacterium ulcerans	hypothetical protein	0.0084	1	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0007	0	0.5
Brugia malayi	Serotonin receptor	0.0007	0	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0007	0	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0007	0	0.5
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0007	0	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	adenoreceptor	0.0007	0	0.5
Echinococcus granulosus	neuropeptide receptor	0.0007	0	0.5
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0007	0	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0007	0	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0007	0	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0007	0	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0007	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0007	0	0.5
Brugia malayi	G protein-coupled receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0007	0	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Brugia malayi	G-protein coupled receptor	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Brugia malayi	follicle stimulating hormone receptor	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0007	0	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	1	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	allatostatin A receptor	0.0007	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0007	0	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0084	1	0.5
Echinococcus granulosus	neuropeptide s receptor	0.0007	0	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus granulosus	serotonin receptor	0.0007	0	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Loa Loa (eye worm)	TYRA-2 protein	0.0007	0	0.5
Mycobacterium tuberculosis	Possible lysophospholipase	0.0084	1	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0007	0	0.5
Brugia malayi	Dopamine receptor protein 1	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	sex peptide receptor	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0007	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Echinococcus granulosus	somatostatin receptor	0.0007	0	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0007	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0007	0	0.5
Echinococcus multilocularis	G protein coupled receptor 139	0.0007	0	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0007	0	0.5
Schistosoma mansoni	amine GPCR	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Brugia malayi	G-protein coupled receptor	0.0007	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0007	0	0.5
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0007	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0007	0	0.5
Echinococcus granulosus	7TM GPCR rhodopsin	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0007	0	0.5
Schistosoma mansoni	opsin-like receptor	0.0007	0	0.5
Schistosoma mansoni	hypothetical protein	0.0007	0	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0007	0	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0007	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0007	0	0.5
Brugia malayi	neuropeptide F receptor	0.0007	0	0.5
Echinococcus granulosus	orexin receptor type 2	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5
Onchocerca volvulus		0.0007	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0007	0	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0007	0	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0007	0	0.5
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0007	0	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0007	0	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Trypanosoma brucei	monoglyceride lipase, putative	0.0084	1	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0007	0	0.5
Echinococcus multilocularis	serotonin receptor	0.0007	0	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0007	0	0.5
Schistosoma mansoni	myosin xvIII	0.0007	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0007	0	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.0007	0	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0007	0	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0007	0	0.5
Brugia malayi	hypothetical protein	0.0007	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
% motility reduction (functional)	= 0 %	Motility reduction assay in Schistosoma mansoni Puerto Rican adult worms	WHO/TDR.	No reference
% motility reduction (functional)	= 20 %	Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM	WHO/TDR.	No reference
% motility reduction (functional)	= 100 %	Motility reduction assay in Onchocerca ochengi microfilariae	WHO/TDR.	No reference
IC50	1.813 ug/ml	WHO-TDR: Cytotoxicity	ChEMBL.	No reference
IC50 (functional)	= 3.282 ug/ml	In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days	WHO/TDR.	No reference
IC50 (functional)	3.282 ug/ml	WHO-TDR: Chagas disease	ChEMBL.	No reference
IC50 (functional)	> 5.735 ug/ml	In vitro activity against Plasmodium falciparum measured by colorimetry after 72h	WHO/TDR.	No reference
IC50 (functional)	> 5.735 ug/ml	In vitro activity against Trypanosoma brucei measured by florescence after 24h	WHO/TDR.	No reference
IC50 (functional)	> 5.735 ug/ml	In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days	WHO/TDR.	No reference
IC50 (functional)	> 5.735 ug/ml	WHO-TDR: Leishmaniasis	ChEMBL.	No reference
IC50 (functional)	> 5.735 ug/ml	WHO-TDR: Malaria	ChEMBL.	No reference
IC50 (functional)	> 5.735 ug/ml	WHO-TDR: Human African Trypanosomiasis (HAT)	ChEMBL.	No reference
IC50 (binding)	= 4.47 uM	Displacement of [3H]2-OG from human MGL by liquid scintillation counting	ChEMBL.	19583260
IC50 (binding)	= 295 uM	Displacement of [3H]ethanolamine from human recombinant FAAH by liquid scintillation counting	ChEMBL.	19583260
Inhibition (functional)	= 0 %	WHO-TDR: Schistosomiasis	ChEMBL.	No reference
Inhibition (functional)	= 20 %	WHO-TDR: Lymphatic Filariasis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Leishmania infantum	ChEMBL23
Trypanosoma brucei gambiense
Homo sapiens	ChEMBL23
Plasmodium falciparum
Trypanosoma cruzi	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL579012
Search by WHO/TDR

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 913165