Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0106 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0106 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.5 | 0.5 | |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0106 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0106 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0106 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0106 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0106 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0106 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0106 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0106 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0106 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0106 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0106 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 10.211 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms | WHO/TDR. | No reference |
% motility reduction (functional) | = 33.33 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Onchocerca ochengi microfilariae | WHO/TDR. | No reference |
IC50 (functional) | = 3.723 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | = 3.723 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 (functional) | > 10.211 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | > 10.211 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | > 10.211 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 | > 10.211 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 10.211 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 (functional) | > 10.211 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
IC50 (functional) | > 10.211 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Inhibition (functional) | = 33.33 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | |||
Trypanosoma cruzi | ChEMBL23 | ||
Trypanosoma brucei gambiense | |||
Leishmania infantum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.