TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 387.479 | Formula: C17H17N5O2S2
H donors: 0 H acceptors: 5 LogP: 1.23 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(c1cccnc1)N1CCN(CC1)c1ccc(nn1)c1cccs1
InChi: 1S/C17H17N5O2S2/c23-26(24,14-3-1-7-18-13-14)22-10-8-21(9-11-22)17-6-5-15(19-20-17)16-4-2-12-25-16/h1-7,12-13H,8-11H2
InChiKey: NWTBHHFKSIOSET-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2605
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0044	0.0982	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0157	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0043	0.0124
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0115	0.0328
Mycobacterium ulcerans	methyltransferase	0.0134	0.3769	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Schistosoma mansoni	intermediate filament proteins	0.0027	0.047	0.1002
Schistosoma mansoni	lamin	0.0027	0.047	0.1002
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0044	0.0982	0.2803
Mycobacterium tuberculosis	Possible methyltransferase (methylase)	0.0134	0.3769	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0157	0.0392
Leishmania major	cathepsin L-like protease	0.0017	0.0157	0.0449
Onchocerca volvulus		0.0027	0.047	1
Toxoplasma gondii	cathepsin CPL	0.0017	0.0157	0.0449
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0157	0.0335
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0044	0.0982	0.2443
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Leishmania major	cathepsin L-like protease	0.0017	0.0157	0.0449
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0044	0.0982	0.2605
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0031	0.0599	0.1711
Echinococcus granulosus	cathepsin l1	0.0017	0.0157	0.0335
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0717	0.1528
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0044	0.0982	0.2443
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0028	0.0081
Trichomonas vaginalis	glutathione reductase, putative	0.0044	0.0982	1
Brugia malayi	Protein kinase domain containing protein	0.0033	0.0662	0.189
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1532	0.4374
Echinococcus multilocularis	Glutaredoxin protein 5	0.002	0.0272	0.058
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1532	0.3265
Leishmania major	cathepsin L-like protease	0.0017	0.0157	0.0449
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1532	0.3265
Echinococcus granulosus	geminin	0.0164	0.4692	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0044	0.0982	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0157	0.3348
Echinococcus multilocularis	cysteine protease	0.0017	0.0157	0.0335
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.047	0.1342
Onchocerca volvulus		0.0017	0.0157	0.3348
Brugia malayi	TAR-binding protein	0.0061	0.1532	0.4374
Toxoplasma gondii	NADPH-glutathione reductase	0.0044	0.0982	0.2803
Echinococcus granulosus	thioredoxin glutathione reductase	0.0126	0.3503	0.7464
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0044	0.0982	0.2803
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0126	0.3503	0.9292
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus granulosus	lamin dm0	0.0027	0.047	0.1002
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0087	0.0249
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0157	0.1603
Onchocerca volvulus		0.0017	0.0157	0.3348
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0044	0.0982	0.2803
Trypanosoma brucei	trypanothione reductase	0.0126	0.3503	1
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Leishmania major	trypanothione reductase	0.0126	0.3503	1
Echinococcus multilocularis	cysteine protease	0.0017	0.0157	0.0335
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0032	0.0627	0.179
Plasmodium falciparum	glutathione reductase	0.0044	0.0982	0.2443
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0044	0.0982	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0044	0.0982	0.2803
Mycobacterium tuberculosis	Probable oxidoreductase	0.0044	0.0982	0.2605
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Entamoeba histolytica	hypothetical protein	0.0035	0.0717	0.0717
Echinococcus granulosus	intermediate filament protein	0.0027	0.047	0.1002
Plasmodium vivax	vivapain-2	0.0017	0.0157	0.0392
Entamoeba histolytica	protein kinase, putative	0.0031	0.0599	0.0599
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.1179	0.3366
Onchocerca volvulus		0.0017	0.0157	0.3348
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0023	0.0342	0.0977
Echinococcus granulosus	nervana 2	0.002	0.0272	0.058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.0245
Brugia malayi	hypothetical protein	0.0035	0.0717	0.2046
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1532	0.3265
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0157	0.0157
Entamoeba histolytica	hypothetical protein	0.0035	0.0717	0.0717
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.066	0.1885
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0126	0.3503	0.7464
Plasmodium vivax	vivapain-2	0.0017	0.0157	0.0392
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0044	0.0982	0.2605
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.047	0.1342
Leishmania major	cathepsin L-like protease	0.0017	0.0157	0.0449
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1532	0.4374
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0157	0.0449
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0157	0.0335
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0245
Echinococcus granulosus	GPCR family 2	0.0015	0.0115	0.0245
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0021	0.0279	0.0797
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0157	0.0335
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0157	0.0335
Leishmania major	cathepsin L-like protease	0.0064	0.1597	0.4559
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0157	0.0392
Schistosoma mansoni	hypothetical protein	0.0164	0.4692	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0126	0.3503	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0157	0.0449
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0342	0.0729
Brugia malayi	Thioredoxin reductase	0.0126	0.3503	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0157	0.0335
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.0245
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1532	0.4374
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.047	0.1342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Plasmodium vivax	thioredoxin reductase, putative	0.0126	0.3503	0.8715
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0021	0.0279	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0028	0.0081
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0044	0.0982	0.2443
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1532	0.3265
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2093
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0455	0.1299
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0115	0.0328
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Loa Loa (eye worm)	hypothetical protein	0.0048	0.113	0.3226
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0115	0.0328
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0044	0.0982	0.2803
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Echinococcus multilocularis	geminin	0.0164	0.4692	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0662	0.0662
Leishmania major	cathepsin L-like protease	0.0064	0.1597	0.4559
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1532	0.4374
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0115	0.0245
Echinococcus multilocularis	nervana 2	0.002	0.0272	0.058
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0044	0.0982	1
Echinococcus multilocularis	lamin dm0	0.0027	0.047	0.1002
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0157	0.0335
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0342	0.0342
Giardia lamblia	Kinase, AGC PKA	0.0021	0.0279	0.0279
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.113	0.3226
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0027	0.047	0.1342
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Onchocerca volvulus		0.0017	0.0157	0.3348
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0044	0.0982	0.2803
Echinococcus granulosus	lamin	0.0027	0.047	0.1002
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1532	0.3265
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.0245
Plasmodium falciparum	thioredoxin reductase	0.0126	0.3503	0.8715
Plasmodium vivax	phosphoethanolamine N-methyltransferase	0.0142	0.4019	1
Onchocerca volvulus		0.0017	0.0157	0.3348
Echinococcus granulosus	serine/threonine protein kinase	0.0023	0.0342	0.0729
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1532	0.3265
Brugia malayi	intermediate filament protein	0.0027	0.047	0.1342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus multilocularis	lamin	0.0027	0.047	0.1002
Toxoplasma gondii	AGC kinase	0.0031	0.0599	0.1711
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0157	0.0449
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0044	0.0982	0.2803
Loa Loa (eye worm)	glutathione reductase	0.0126	0.3503	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0157	0.3348
Echinococcus granulosus	serine threonine protein kinase nrc	0.0021	0.0279	0.0595
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0043	0.0092
Entamoeba histolytica	protein kinase 2, putative	0.0021	0.0279	0.0279
Plasmodium falciparum	glutathione reductase	0.0126	0.3503	0.8715
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0087	0.0249
Leishmania major	cathepsin L-like protease	0.0017	0.0157	0.0449
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1532	0.3265
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0157	0.3348
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0245
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0717	0.1528
Leishmania major	cathepsin L-like protease	0.0064	0.1597	0.4559
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0982	0.2803
Echinococcus multilocularis	musashi	0.0027	0.047	0.1002
Onchocerca volvulus		0.0017	0.0157	0.3348
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.1427	0.4075
Trichomonas vaginalis	mercuric reductase, putative	0.0044	0.0982	1
Mycobacterium ulcerans	mycolic acid synthase UmaA	0.0134	0.3769	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0157	0.0335
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0115	0.0328
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0245
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0157	0.0449
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0096	0.2591	0.2591
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.002	0.0272	0.058
Entamoeba histolytica	hypothetical protein	0.0035	0.0717	0.0717
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1597	0.4559
Echinococcus multilocularis	nervana 2	0.002	0.0272	0.058
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0157	0.0449
Schistosoma mansoni	hypothetical protein	0.0035	0.0717	0.1528
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0021	0.0279	0.0695
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0032	0.0627	0.179
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2093
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.113	0.3226
Schistosoma mansoni	hypothetical protein	0.0033	0.066	0.1407
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.1597	0.4559
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2803
Plasmodium vivax	glutathione reductase, putative	0.0126	0.3503	0.8715
Loa Loa (eye worm)	fibroinase	0.0017	0.0157	0.0449
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Loa Loa (eye worm)	hypothetical protein	0.0033	0.066	0.1885
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0044	0.0982	0.2605
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0157	0.0335
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Brugia malayi	p70 ribosomal S6 kinase beta	0.0031	0.0599	0.1711
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Loa Loa (eye worm)	cysteine protease	0.0017	0.0157	0.0449
Onchocerca volvulus		0.0017	0.0157	0.3348
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0717	0.1528
Giardia lamblia	DNA repair protein RAD52	0.0337	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Toxoplasma gondii	thioredoxin reductase	0.0126	0.3503	1
Brugia malayi	glutathione reductase	0.0126	0.3503	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0157	0.1603
Echinococcus multilocularis	rac serine:threonine kinase	0.0023	0.0342	0.0729
Entamoeba histolytica	hypothetical protein	0.0096	0.2591	0.2591
Mycobacterium tuberculosis	Possible mycolic acid synthase UmaA	0.0134	0.3769	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0023	0.0342	0.0729
Loa Loa (eye worm)	ctsf protein	0.0017	0.0157	0.0449
Treponema pallidum	NADH oxidase	0.0044	0.0982	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Loa Loa (eye worm)	thioredoxin reductase	0.0126	0.3503	1
Brugia malayi	RNA binding protein	0.0061	0.1532	0.4374
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Plasmodium falciparum	phosphoethanolamine N-methyltransferase	0.0142	0.4019	1
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0157	0.0157
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0044	0.0982	0.0982
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0157	0.0392
Onchocerca volvulus		0.0027	0.047	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0044	0.0982	0.2803
Entamoeba histolytica	hypothetical protein	0.0035	0.0717	0.0717
Trypanosoma cruzi	Protein kinase B	0.0023	0.0342	0.0977
Schistosoma mansoni	lamin	0.0027	0.047	0.1002
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.0245
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0044	0.0982	0.2803
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0157	0.0449
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0157	0.1603
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1597	0.4559
Entamoeba histolytica	protein kinase, putative	0.0033	0.0662	0.0662
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.1597	0.4559
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0043	0.0092
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0044	0.0982	0.2443
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0245
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0044	0.0982	0.2605
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.113	0.3226
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0044	0.0982	0.2605
Trichomonas vaginalis	AGC family protein kinase	0.0013	0.0035	0.0355
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0033	0.0662	0.189
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0033	0.0662	0.189
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.1597	0.4559
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0157	0.0449
Echinococcus granulosus	Glutaredoxin protein 5	0.002	0.0272	0.058
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.002	0.0272	0.058
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0023	0.0342	0.0342
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0044	0.0982	0.2803
Schistosoma mansoni	hypothetical protein	0.0164	0.4692	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0021	0.0279	0.0595
Trichomonas vaginalis	AGC family protein kinase	0.0033	0.0662	0.6741
Echinococcus granulosus	nervana 2	0.002	0.0272	0.058
Plasmodium falciparum	thioredoxin reductase	0.0044	0.0982	0.2443
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0021	0.0279	0.0695

Activities

Activity type	Activity value	Assay description	Source	Reference
(functional)	> 11.624 ug/ml	In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h	WHO/TDR.	No reference
% motility reduction (functional)	= 0 %	Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms	WHO/TDR.	No reference
% motility reduction (functional)	= 0 %	Motility reduction assay in Onchocerca ochengi microfilariae	WHO/TDR.	No reference
% motility reduction (functional)	= 50 %	Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM	WHO/TDR.	No reference
IC50 (functional)	= 0.376 ug/ml	In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days	WHO/TDR.	No reference
IC50 (functional)	= 0.376 ug/ml	WHO-TDR: Leishmaniasis	ChEMBL.	No reference
IC50 (functional)	> 11.624 ug/ml	In vitro activity against Plasmodium falciparum measured by colorimetry after 72h	WHO/TDR.	No reference
IC50 (functional)	> 11.624 ug/ml	In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days	WHO/TDR.	No reference
IC50 (functional)	> 11.624 ug/ml	In vitro activity against Trypanosoma brucei measured by florescence after 24h	WHO/TDR.	No reference
IC50	> 11.624 ug/ml	WHO-TDR: Cytotoxicity	ChEMBL.	No reference
IC50 (functional)	> 11.624 ug/ml	WHO-TDR: Chagas disease	ChEMBL.	No reference
IC50 (functional)	> 11.624 ug/ml	WHO-TDR: Human African Trypanosomiasis (HAT)	ChEMBL.	No reference
IC50 (functional)	> 11.624 ug/ml	WHO-TDR: Malaria	ChEMBL.	No reference
Inhibition (functional)	= 0 %	WHO-TDR: Schistosomiasis	ChEMBL.	No reference
Inhibition (functional)	= 50 %	WHO-TDR: Lymphatic Filariasis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma brucei gambiense
Plasmodium falciparum
Trypanosoma cruzi	ChEMBL23
Homo sapiens	ChEMBL23
Leishmania infantum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2093537
Search by WHO/TDR

Bibliographic References

No literature references available for this target.

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Detailed information for compound 913247