Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 12.277 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Onchocerca ochengi microfilariae | WHO/TDR. | No reference |
IC50 (functional) | = 4.438 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | = 4.438 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
IC50 (functional) | = 5.345 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | = 5.345 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 (functional) | > 12.277 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | > 12.277 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 (functional) | > 12.277 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 | > 12.277 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 12.277 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Leishmania infantum | ChEMBL23 | ||
Trypanosoma brucei gambiense | |||
Plasmodium falciparum |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.