Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0085 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0085 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0085 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0085 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0085 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0085 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0085 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0085 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0085 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0085 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0085 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0085 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0085 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 12.025 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in Schistosoma mansoni Egyptian sambon adult worms | WHO/TDR. | No reference |
% motility reduction (functional) | = 25 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Onchocerca ochengi microfilariae | WHO/TDR. | No reference |
IC50 (functional) | = 4.093 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | = 4.093 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
IC50 (functional) | = 5.902 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | = 5.902 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
IC50 (functional) | > 12.025 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | > 12.025 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 (functional) | > 12.025 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 | > 12.025 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 12.025 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Schistosomiasis | ChEMBL. | No reference |
Inhibition (functional) | = 25 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | |||
Trypanosoma brucei gambiense | |||
Trypanosoma cruzi | ChEMBL23 | ||
Homo sapiens | ChEMBL23 | ||
Leishmania infantum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.