Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.029 | 0.2905 | 0.4325 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0918 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0411 | 0.4264 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0213 | 0.0213 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0003 | 0.0003 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.029 | 0.2905 | 0.6812 |
Brugia malayi | isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0213 |
Schistosoma mansoni | tar DNA-binding protein | 0.0411 | 0.4264 | 0.6349 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0213 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0498 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.2905 | 0.4325 |
Loa Loa (eye worm) | RNA binding protein | 0.0411 | 0.4264 | 0.4264 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.029 | 0.2905 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0411 | 0.4264 | 0.6349 |
Loa Loa (eye worm) | TAR-binding protein | 0.0411 | 0.4264 | 0.4264 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0213 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0492 | 0.5188 | 0.5188 |
Brugia malayi | MH2 domain containing protein | 0.0492 | 0.5188 | 0.5188 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.6716 | 0.6716 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0492 | 0.5188 | 0.5188 |
Schistosoma mansoni | hypothetical protein | 0.0627 | 0.6716 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0636 | 0.0636 |
Brugia malayi | hypothetical protein | 0.0052 | 0.0213 | 0.0213 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0052 | 0.0213 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0498 |
Brugia malayi | Isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0918 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0627 | 0.6716 | 0.6716 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0498 |
Brugia malayi | TAR-binding protein | 0.0411 | 0.4264 | 0.4264 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0213 | 1 |
Brugia malayi | hypothetical protein | 0.009 | 0.0636 | 0.0636 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.0213 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.2905 | 0.2905 |
Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0213 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0052 | 0.0213 | 0.0498 |
Schistosoma mansoni | tar DNA-binding protein | 0.0411 | 0.4264 | 0.6349 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.029 | 0.2905 | 0.6812 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.029 | 0.2905 | 0.2905 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.2905 | 0.4325 |
Echinococcus multilocularis | GPCR, family 2 | 0.029 | 0.2905 | 0.6812 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0918 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0411 | 0.4264 | 0.6349 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0316 |
Brugia malayi | Latrophilin receptor protein 2 | 0.029 | 0.2905 | 0.2905 |
Loa Loa (eye worm) | hypothetical protein | 0.009 | 0.0636 | 0.0636 |
Echinococcus granulosus | GPCR family 2 | 0.029 | 0.2905 | 0.6812 |
Echinococcus multilocularis | tar DNA binding protein | 0.0411 | 0.4264 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0052 | 0.0213 | 0.0498 |
Schistosoma mansoni | eyes absent homolog | 0.009 | 0.0636 | 0.0947 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0213 | 1 |
Schistosoma mansoni | hypothetical protein | 0.029 | 0.2905 | 0.4325 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0213 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0411 | 0.4264 | 0.4264 |
Schistosoma mansoni | tar DNA-binding protein | 0.0411 | 0.4264 | 0.6349 |
Brugia malayi | RNA binding protein | 0.0411 | 0.4264 | 0.4264 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0213 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.029 | 0.2905 | 0.2905 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0411 | 0.4264 | 0.4264 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.029 | 0.2905 | 0.6812 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0213 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
(functional) | > 12.071 ug/ml | In vitro cytotoxicity evaluation on human fibroblasts measured by fluorescence after 72h | WHO/TDR. | No reference |
% motility reduction (functional) | = 0 % | Motility reduction assay in vitro against Brugia malayi microfilariae at 10 uM | WHO/TDR. | No reference |
% motility reduction (functional) | = 100 % | Motility reduction assay in Onchocerca ochengi microfilariae | WHO/TDR. | No reference |
IC50 (functional) | = 9.791 ug/ml | In vitro activity against Plasmodium falciparum measured by colorimetry after 72h | WHO/TDR. | No reference |
IC50 (functional) | = 9.791 ug/ml | WHO-TDR: Malaria | ChEMBL. | No reference |
IC50 (functional) | > 12.071 ug/ml | In vitro activity against Trypanosoma cruzi in human lung fibroblast measured by colorimetry after 7 days | WHO/TDR. | No reference |
IC50 (functional) | > 12.071 ug/ml | In vitro activity against Trypanosoma brucei measured by florescence after 24h | WHO/TDR. | No reference |
IC50 (functional) | > 12.071 ug/ml | In vitro activity against Leishmania infantum in mouse macrophages measured by cell viability after 5 days | WHO/TDR. | No reference |
IC50 (functional) | > 12.071 ug/ml | WHO-TDR: Leishmaniasis | ChEMBL. | No reference |
IC50 | > 12.071 ug/ml | WHO-TDR: Cytotoxicity | ChEMBL. | No reference |
IC50 (functional) | > 12.071 ug/ml | WHO-TDR: Chagas disease | ChEMBL. | No reference |
IC50 (functional) | > 12.071 ug/ml | WHO-TDR: Human African Trypanosomiasis (HAT) | ChEMBL. | No reference |
Inhibition (functional) | = 0 % | WHO-TDR: Lymphatic Filariasis | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | ||
Trypanosoma brucei gambiense | |||
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | |||
Leishmania infantum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.