Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.4372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0135 | 0.0221 | 0.0221 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | gamma aminobutyric acid receptor subunit | 0.0135 | 0.0221 | 0.0221 |
Entamoeba histolytica | hypothetical protein | 0.0158 | 0.0274 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | gamma aminobutyric acid receptor subunit | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0158 | 0.0274 | 0.0274 |
Toxoplasma gondii | fructose-bisphospatase II | 0.4372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0352 | 0.0722 | 0.0722 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0158 | 0.0274 | 0.0274 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | nAChR subunit | 0.0158 | 0.0274 | 0.0274 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Cation transporter family protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nAChR subunit | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.0671 | 0.0671 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.4372 | 1 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Onchocerca volvulus | Putative nachr subunit | 0.0293 | 0.0586 | 1 |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0135 | 0.0221 | 0.0221 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0465 | 0.0983 | 0.0983 |
Onchocerca volvulus | 0.0158 | 0.0274 | 0.1438 | |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.4372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Cation transporter family protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Acetylcholine receptor protein, alpha-like chain 1 precursor | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Schistosoma mansoni | acetylcholine receptor subunit beta | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0158 | 0.0274 | 0.0274 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0158 | 0.0274 | 0.0274 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | LGC-31 protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | ACC-1 protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | Neuronal acetylcholine receptor protein, alpha-2 chain precursor | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0158 | 0.0274 | 0.0274 |
Onchocerca volvulus | 0.0158 | 0.0274 | 0.1438 | |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0293 | 0.0586 | 0.0586 |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Leishmania major | 0.4372 | 1 | 0.5 | |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0352 | 0.0722 | 0.0722 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit type | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0135 | 0.0221 | 0.0221 |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Echinococcus multilocularis | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | neuronal acetylcholine receptor protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | ACC-1 protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.4372 | 1 | 1 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.4372 | 1 | 1 |
Schistosoma mansoni | acetylcholine receptor-related | 0.0135 | 0.0221 | 0.0221 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0293 | 0.0586 | 0.0586 |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0158 | 0.0274 | 0.0274 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | acetylcholine receptor protein | 0.0135 | 0.0221 | 0.0221 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.4372 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0274 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0221 | 0.0221 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0135 | 0.0221 | 0.0221 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0293 | 0.0586 | 0.0586 |
Onchocerca volvulus | 0.0293 | 0.0586 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0465 | 0.0983 | 0.0983 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.4372 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Schistosoma mansoni | nAChR subunit | 0.0293 | 0.0586 | 0.0586 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0293 | 0.0586 | 0.0586 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0293 | 0.0586 | 0.0586 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0293 | 0.0586 | 0.0586 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.0586 | 0.0586 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.