TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 570.57 | Formula: C35H47BN2O4
H donors: 2 H acceptors: 2 LogP: 7.37 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCCC[C@@H](B1O[C@H]2[C@](O1)(C)[C@H]1C[C@@H](C2)C1(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCCc2c1cccc2
InChi: 1S/C35H47BN2O4/c1-5-6-19-31(36-41-30-22-25-21-29(34(25,2)3)35(30,4)42-36)38-33(40)28(20-23-13-8-7-9-14-23)37-32(39)27-18-12-16-24-15-10-11-17-26(24)27/h7-11,13-15,17,25,27-31H,5-6,12,16,18-22H2,1-4H3,(H,37,39)(H,38,40)/t25-,27-,28-,29-,30+,31-,35-/m0/s1
InChiKey: OLLXHMPFWVGDOS-KGUYINGYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0059	0.1792	0.1792
Mycobacterium tuberculosis	Probable dehydrogenase	0.0082	0.2685	0.2966
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.1843	0.3161
Onchocerca volvulus		0.0059	0.1792	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.1011	0.1011
Loa Loa (eye worm)	beta-lactamase	0.0039	0.1011	0.0857
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0281	0.0281
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.1585	0.1585
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0059	0.1792	0.634
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1011	0.1117
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1011	0.1011
Echinococcus granulosus	aldo keto reductase	0.0059	0.1792	0.3074
Toxoplasma gondii	aldo-keto reductase	0.0059	0.1792	0.634
Loa Loa (eye worm)	glutaminase 2	0.0273	1	1
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0059	0.1792	0.634
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1843	0.1843
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0925	0.1587
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0389	0.0224
Schistosoma mansoni	glutaminase	0.0273	1	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0	0.5
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0059	0.1792	0.1792
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0389	0.0389
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0082	0.2685	0.8667
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0389	0.0389
Brugia malayi	RNA binding protein	0.0061	0.1843	0.1843
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0389	0.0389
Loa Loa (eye worm)	oxidoreductase	0.0059	0.1792	0.1651
Leishmania major	aldo-keto reductase-like protein	0.0059	0.1792	0.634
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.1585	0.144
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0281	0.0281
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.1011	0.0857
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1415	0.1415
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1011	0.1011
Loa Loa (eye worm)	transcription factor SMAD2	0.0114	0.3899	0.3794
Echinococcus granulosus	dna polymerase kappa	0.002	0.0281	0.0483
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0281	0.0281
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.1011	0.1117
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0059	0.1792	0.1792
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0059	0.1792	0.1792
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0281	0.0995
Trypanosoma cruzi	aldo-keto reductase	0.0059	0.1792	0.634
Trichomonas vaginalis	aldo/keto reductase, putative	0.0059	0.1792	0.1792
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0281	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0389	0.0224
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.1011	0.2349
Schistosoma mansoni	potassium channel beta	0.0059	0.1792	0.1792
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0281	0.0483
Plasmodium falciparum	thioredoxin reductase	0.0036	0.0907	0.3208
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0389	0.0389
Leishmania major	proteasome beta 5 subunit, putative	0.0086	0.2827	1
Giardia lamblia	DINP protein human, muc B family	0.002	0.0281	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0281	0.0281
Echinococcus granulosus	voltage gated potassium channel subunit	0.0059	0.1792	0.3074
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0281	0.0281
Trichomonas vaginalis	glutaminase, putative	0.0273	1	1
Onchocerca volvulus		0.0059	0.1792	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0036	0.0907	0.3208
Trypanosoma brucei	aldo-keto reductase, putative	0.0059	0.1792	0.634
Loa Loa (eye worm)	oxidoreductase	0.0059	0.1792	0.1651
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0173	0.0296
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0281	0.0995
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.1843	0.1843
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1011	0.1011
Onchocerca volvulus		0.0059	0.1792	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0389	0.043
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0281	0.0114
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0389	0.1376
Brugia malayi	NADH-dependent xylose reductase	0.0059	0.1792	0.1792
Toxoplasma gondii	ABC1 family protein	0.0039	0.1011	0.3577
Entamoeba histolytica	aldose reductase, putative	0.0059	0.1792	0.5935
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Echinococcus granulosus	aldo keto reductase	0.0059	0.1792	0.3074
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.1011	0.1117
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0086	0.2827	0.4849
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.1792	0.1792
Giardia lamblia	Aldose reductase	0.0059	0.1792	0.634
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Echinococcus granulosus	dna polymerase eta	0.002	0.0281	0.0483
Echinococcus granulosus	proteasome prosome macropain	0.0086	0.2827	0.4849
Loa Loa (eye worm)	hypothetical protein	0.002	0.0281	0.0114
Treponema pallidum	NADH oxidase	0.0013	0	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Schistosoma mansoni	hypothetical protein	0.0017	0.0173	0.0173
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Loa Loa (eye worm)	RNA binding protein	0.0061	0.1843	0.1703
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0059	0.1792	0.5297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1415	0.1415
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1011	0.3577
Schistosoma mansoni	aldo-keto reductase	0.0059	0.1792	0.1792
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0082	0.2685	0.2966
Toxoplasma gondii	thioredoxin reductase	0.0036	0.0907	0.3208
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0389	0.0224
Trichomonas vaginalis	esterase, putative	0.0039	0.1011	0.1011
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0281	0.0311
Schistosoma mansoni	pol-related	0.0059	0.1792	0.1792
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1415	0.2426
Toxoplasma gondii	aldose reductase, putative	0.0059	0.1792	0.634
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0389	0.0422
Schistosoma mansoni	hypothetical protein	0.0017	0.0173	0.0173
Trichomonas vaginalis	aldo/keto reductase, putative	0.0059	0.1792	0.1792
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.1011	0.1117
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.1011	0.1117
Mycobacterium ulcerans	hypothetical protein	0.0039	0.1011	0.1011
Leishmania major	prostaglandin f synthase, putative	0.0059	0.1792	0.634
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0059	0.1792	0.634
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Brugia malayi	glutathione reductase	0.0036	0.0907	0.0907
Plasmodium falciparum	glutathione reductase	0.0036	0.0907	0.3208
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0389	0.0389
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0281	0.0483
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.1011	0.1011
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0059	0.1792	0.1651
Onchocerca volvulus		0.0039	0.1011	0.4434
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0059	0.1792	0.634
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1843	0.1843
Brugia malayi	Thioredoxin reductase	0.0036	0.0907	0.0907
Echinococcus granulosus	aldo keto reductase	0.0059	0.1792	0.3074
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0086	0.2827	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0173	0.0173
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0059	0.1792	0.1792
Echinococcus granulosus	GPCR family 2	0.0017	0.0173	0.0296
Trypanosoma brucei	unspecified product	0.002	0.0281	0.0995
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1843	0.1843
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.1843	0.1703
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Trichomonas vaginalis	aldo/keto reductase, putative	0.0059	0.1792	0.1792
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0389	0.0422
Mycobacterium tuberculosis	Probable oxidoreductase	0.0092	0.3038	0.3356
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0169	0.0187
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0389	0.0389
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0086	0.2827	1
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0173	0.0004
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.1011	0.1011
Loa Loa (eye worm)	thioredoxin reductase	0.0036	0.0907	0.0751
Onchocerca volvulus		0.0059	0.1792	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0082	0.2685	0.2966
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1415	0.2426
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.1011	0.3577
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Onchocerca volvulus		0.0059	0.1792	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0169	0.0169
Echinococcus multilocularis	aldo keto reductase	0.0059	0.1792	0.3074
Trypanosoma brucei	prostaglandin f synthase	0.0059	0.1792	0.634
Loa Loa (eye worm)	oxidoreductase	0.0059	0.1792	0.1651
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0059	0.1792	0.1792
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0059	0.1792	0.634
Mycobacterium ulcerans	glutaminase	0.0273	1	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Mycobacterium ulcerans	oxidoreductase	0.0059	0.1792	0.1792
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0281	0.0995
Plasmodium falciparum	aldo-keto reductase, putative	0.0059	0.1792	0.634
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.1585	0.1585
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0169	0.0598
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0389	0.1376
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Trypanosoma cruzi	aldo/keto reductase, putative	0.0059	0.1792	0.634
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0389	0.0389
Loa Loa (eye worm)	oxidoreductase	0.0059	0.1792	0.1651
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0173	0.0296
Onchocerca volvulus		0.0039	0.1011	0.4434
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0092	0.3038	1
Mycobacterium leprae	Possible oxidoreductase	0.0059	0.1792	0.5297
Schistosoma mansoni	hypothetical protein	0.0017	0.0173	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0389	0.0389
Echinococcus granulosus	geminin	0.0164	0.5831	1
Giardia lamblia	Aldose reductase	0.0059	0.1792	0.634
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0173	0.0296
Plasmodium vivax	thioredoxin reductase, putative	0.0036	0.0907	0.3208
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0281	0.0995
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0082	0.2685	0.2966
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.0147
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0281	0.0281
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.0147
Loa Loa (eye worm)	glutaminase	0.0273	1	1
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0086	0.2827	0.3123
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0	0.5
Plasmodium falciparum	aldehyde reductase, putative	0.0059	0.1792	0.634
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.1011	0.1117
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0389	0.0389
Leishmania major	hypothetical protein, conserved	0.0039	0.1011	0.3577
Brugia malayi	Proteasome A-type and B-type family protein	0.0086	0.2827	0.2827
Onchocerca volvulus		0.0059	0.1792	1
Schistosoma mansoni	hypothetical protein	0.0017	0.0173	0.0173
Loa Loa (eye worm)	MH2 domain-containing protein	0.0114	0.3899	0.3794
Mycobacterium tuberculosis	Probable oxidoreductase	0.0059	0.1792	0.198
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0086	0.2827	1
Trypanosoma brucei	trypanothione reductase	0.0036	0.0907	0.3208
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0059	0.1792	0.1792
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0158
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0059	0.1792	0.5935
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1843	0.1843
Loa Loa (eye worm)	oxidoreductase	0.0059	0.1792	0.1651
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0086	0.2827	1
Schistosoma mansoni	DNA polymerase eta	0.002	0.0281	0.0281
Trypanosoma cruzi	aldo/keto reductase, putative	0.0059	0.1792	0.634
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1011	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0281	0.0483
Loa Loa (eye worm)	glutathione reductase	0.0036	0.0907	0.0751
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0086	0.2827	0.2827
Schistosoma mansoni	hypothetical protein	0.0164	0.5831	0.5831
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0059	0.1792	0.3074
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1415	0.1415
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0086	0.2827	0.2704
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0059	0.1792	0.5935
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.1843	0.1703
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1011	0.1117
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.0147
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0059	0.1792	0.1792
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.1843	0.1843
Mycobacterium ulcerans	lipase LipD	0.0039	0.1011	0.1011
Echinococcus granulosus	hypothetical protein	0.0059	0.1792	0.3074
Schistosoma mansoni	hypothetical protein	0.0037	0.0931	0.0931
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0389	0.043
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.1011	0.1734
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0059	0.1792	0.634
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.1011	0.1011
Echinococcus multilocularis	geminin	0.0164	0.5831	1
Onchocerca volvulus		0.0059	0.1792	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0389	0.1376
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0086	0.2827	0.9203
Echinococcus granulosus	tar DNA binding protein	0.0061	0.1843	0.3161
Mycobacterium ulcerans	beta-lactamase	0.0039	0.1011	0.1011
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0281	0.0311
Trypanosoma brucei	unspecified product	0.0014	0.0045	0.0158
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0158
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0389	0.0389
Toxoplasma gondii	proteasome subunit beta type, putative	0.0086	0.2827	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1585	0.144
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0931	0.0775
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0169	1
Brugia malayi	beta-lactamase family protein	0.0039	0.1011	0.1011
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1415	0.1415
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0082	0.2685	0.2966
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.0147
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0925	0.1587
Schistosoma mansoni	aldo-keto reductase	0.0059	0.1792	0.1792
Entamoeba histolytica	aldose reductase, putative	0.0059	0.1792	0.5935
Onchocerca volvulus		0.0039	0.1011	0.4434
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1415	0.2426
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0173	0.0296
Plasmodium vivax	glutathione reductase, putative	0.0036	0.0907	0.3208
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0931	0.0931
Brugia malayi	beta-lactamase family protein	0.0039	0.1011	0.1011
Plasmodium falciparum	proteasome subunit beta type-5	0.0086	0.2827	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Mycobacterium tuberculosis	Probable reductase	0.0082	0.2685	0.2966
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1415	0.1267
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Echinococcus multilocularis	dna polymerase eta	0.002	0.0281	0.0483
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0086	0.2827	0.2827
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0158
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0059	0.1792	0.1792
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0092	0.3038	0.3356
Brugia malayi	TAR-binding protein	0.0061	0.1843	0.1843
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.1011	0.1011
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0248	0.9052	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Leishmania major	trypanothione reductase	0.0036	0.0907	0.3208
Schistosoma mansoni	hypothetical protein	0.0164	0.5831	0.5831
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0281	0.0995
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Mycobacterium tuberculosis	Conserved protein	0.0059	0.1792	0.198
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.1011	0.3577
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1415	0.2426
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.1011	0.3577
Mycobacterium tuberculosis	Conserved protein	0.0039	0.1011	0.1117
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Brugia malayi	MH2 domain containing protein	0.0114	0.3899	0.3899
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Mycobacterium ulcerans	hypothetical protein	0.0059	0.1792	0.1792
Trypanosoma brucei	aldo/keto reductase, putative	0.0059	0.1792	0.634
Echinococcus multilocularis	aldo keto reductase	0.0059	0.1792	0.3074
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0281	0.0281
Brugia malayi	beta-lactamase	0.0039	0.1011	0.1011
Echinococcus multilocularis	aldo keto reductase	0.0059	0.1792	0.3074
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.1011	0.1011
Leishmania major	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.1011	0.1117
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0059	0.1792	0.3074
Leishmania major	DNA polymerase eta, putative	0.002	0.0281	0.0995
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0173	0.0004
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0173	0.0173
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0086	0.2827	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0389	0.0422
Trichomonas vaginalis	aldo-keto reductase, putative	0.0059	0.1792	0.1792
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0036	0.0907	0.1002
Plasmodium vivax	aldehyde reductase, putative	0.0059	0.1792	0.634
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0173	0.0296
Mycobacterium leprae	Probable lipase LipE	0.0039	0.1011	0.2349
Entamoeba histolytica	aldose reductase, putative	0.0059	0.1792	0.5935
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.1011	0.1734
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0045	0.0158
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0281	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1011	0.0857
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.1011	0.1117
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0092	0.3038	0.3356
Echinococcus multilocularis	aldo keto reductase	0.0059	0.1792	0.3074
Mycobacterium ulcerans	proteasome PrcB	0.0086	0.2827	0.2827
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1792	0.1651
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0059	0.1792	0.3074
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0169	0.0598
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0281	0.0995
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0086	0.2827	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0281	0.0995

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL499581

Bibliographic References

No literature references available for this target.

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Detailed information for compound 914121