Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | intermediate filament protein | 0.0114 | 0.0853 | 0.2365 |
Brugia malayi | hypothetical protein | 0.008 | 0.0516 | 0.1431 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0225 | 0.0136 |
Loa Loa (eye worm) | TAR-binding protein | 0.0398 | 0.3608 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0516 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.008 | 0.0516 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0114 | 0.0853 | 0.0771 |
Echinococcus granulosus | GPCR family 2 | 0.005 | 0.0225 | 0.0136 |
Brugia malayi | Latrophilin receptor protein 2 | 0.005 | 0.0225 | 0.0623 |
Brugia malayi | TAR-binding protein | 0.0398 | 0.3608 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0398 | 0.3608 | 0.355 |
Brugia malayi | MH2 domain containing protein | 0.0262 | 0.2289 | 0.6344 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0225 | 0.0623 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0444 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0475 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0114 | 0.0853 | 0.2365 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0444 | 0.1051 |
Echinococcus granulosus | intermediate filament protein | 0.0114 | 0.0853 | 0.0771 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0444 | 0.1051 |
Echinococcus multilocularis | tar DNA binding protein | 0.0398 | 0.3608 | 0.355 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0398 | 0.3608 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0444 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0444 | 0.1051 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.008 | 0.0516 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0444 | 0.1232 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0475 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0157 | 0.1267 | 0.3511 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0242 | 0.0671 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0444 | 0.1051 |
Echinococcus granulosus | lamin | 0.0114 | 0.0853 | 0.0771 |
Schistosoma mansoni | intermediate filament proteins | 0.0114 | 0.0853 | 0.2171 |
Loa Loa (eye worm) | intermediate filament protein | 0.0114 | 0.0853 | 0.2365 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0475 | 0.1095 |
Schistosoma mansoni | tar DNA-binding protein | 0.0398 | 0.3608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0833 | 0.2309 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0444 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.008 | 0.0516 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0061 | 0.0338 | 0.0936 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0157 | 0.1267 | 0.3511 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0225 | 0.0384 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0444 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0279 | 0.0772 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0444 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0398 | 0.3608 | 1 |
Brugia malayi | RNA binding protein | 0.0398 | 0.3608 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0398 | 0.3608 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0398 | 0.3608 | 1 |
Onchocerca volvulus | 0.0072 | 0.0444 | 0.3573 | |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0475 | 0.1317 |
Schistosoma mansoni | tar DNA-binding protein | 0.0398 | 0.3608 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0444 | 0.8607 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0444 | 0.1232 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0444 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0055 | 0.0279 | 0.0191 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.0475 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.1267 | 0.3511 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0225 | 0.0384 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0157 | 0.1267 | 0.3511 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0853 | 0.2365 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.005 | 0.0225 | 0.0623 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0155 | 0.1244 | 0.3281 |
Schistosoma mansoni | lamin | 0.0114 | 0.0853 | 0.2171 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0444 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0061 | 0.0338 | 0.0936 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0444 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Onchocerca volvulus | 0.0072 | 0.0444 | 0.3573 | |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0444 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0225 | 0.0136 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.0475 | 0.1095 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0107 | 0.0784 | 0.2174 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0462 | 0.4227 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0444 | 0.1009 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0444 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0114 | 0.0853 | 0.0771 |
Onchocerca volvulus | 0.0072 | 0.0444 | 0.3573 | |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0784 | 0.2174 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0444 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0107 | 0.0784 | 0.1975 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0444 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0225 | 0.0384 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.1244 | 0.3448 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0444 | 0.1232 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0516 | 1 |
Onchocerca volvulus | 0.0114 | 0.0853 | 0.686 | |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0475 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0075 | 0.0475 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0444 | 0.0358 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.005 | 0.0225 | 0.0623 |
Loa Loa (eye worm) | RNA binding protein | 0.0398 | 0.3608 | 1 |
Onchocerca volvulus | 0.0114 | 0.0853 | 0.686 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0114 | 0.0853 | 0.2365 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.008 | 0.0516 | 0.5 |
Onchocerca volvulus | 0.0155 | 0.1244 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0225 | 0.0384 |
Echinococcus multilocularis | lamin | 0.0114 | 0.0853 | 0.0771 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.0475 | 0.0389 |
Schistosoma mansoni | tar DNA-binding protein | 0.0398 | 0.3608 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.005 | 0.0225 | 0.0136 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.005 | 0.0225 | 0.0136 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0258 | 0.0716 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0444 | 0.1051 |
Schistosoma mansoni | lamin | 0.0114 | 0.0853 | 0.2171 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0444 | 0.1009 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0516 | 0.1431 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.008 | 0.0516 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0444 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0444 | 0.1051 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0262 | 0.2289 | 0.6344 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0444 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0262 | 0.2289 | 0.6344 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0444 | 0.1232 |
Echinococcus multilocularis | musashi | 0.0114 | 0.0853 | 0.0771 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.008 | 0.0516 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.1057 | 1 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.005 | 0.0225 | 0.0136 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0444 | 0.1232 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0444 | 0.1051 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0444 | 0.0358 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0055 | 0.0279 | 0.0191 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0444 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0444 | 0.1232 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0258 | 0.0716 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0444 | 0.1051 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0444 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Antiemetic activity (functional) | = 77 % | Antiemetic activity of the compound was evaluated in vivo by the suppression of apomorphine-induced emesis in dogs at oral dose of 1.0 mg/kg | ChEMBL. | 9873469 |
Gastric emptying (functional) | = 49 % | Compound was tested for its effect on the gastric emptying rate of phenol red semisolid meal through the stomach at oral dose of 3.0 mg/kg in rats. | ChEMBL. | 9873469 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.