Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha tubulin | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | alpha tubulin 2 | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible nitrate/nitrite response transcriptional regulatory protein NarL | 0.086 | 1 | 0.5 |
Echinococcus multilocularis | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Brugia malayi | tubulin alpha-2 chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit gamma | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0045 | 0 | 0.5 |
Brugia malayi | Tubulin beta-1 chain | 0.0045 | 0 | 0.5 |
Giardia lamblia | Gamma tubulin | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | tubulin gamma chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0045 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | alpha tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein | 0.086 | 1 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | alpha tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.086 | 1 | 0.5 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit alpha | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | alpha-tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Leishmania major | gamma-tubulin | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible two component transcriptional regulatory protein (probably LuxR-family) | 0.086 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Brugia malayi | tubulin alpha chain - mouse | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | BEN-1 protein | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulatory protein DevR | 0.086 | 1 | 0.5 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | nitrate/nitrite response regulator protein NarL | 0.086 | 1 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Brugia malayi | Tubulin gamma chain | 0.0045 | 0 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0045 | 0 | 0.5 |
Brugia malayi | Tubulin alpha-2 chain | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit alpha | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0045 | 0 | 0.5 |
Brugia malayi | Tubulin alpha-2 chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin subunit TubB | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | two component transcriptional regulator | 0.086 | 1 | 0.5 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit alpha | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin epsilon chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium ulcerans | putative regulatory protein | 0.086 | 1 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | alpha-tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0045 | 0 | 0.5 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0045 | 0 | 0.5 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible transcriptional regulatory protein | 0.086 | 1 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (LuxR-family) | 0.086 | 1 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0045 | 0 | 0.5 |
Brugia malayi | Tubulin alpha chain | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | tubulin gamma chain | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0045 | 0 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable transcriptional regulatory protein (probably LuxR/UhpA-family) | 0.086 | 1 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0045 | 0 | 0.5 |
Brugia malayi | beta-tubulin, identical | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | tubulin subunit beta | 0.0045 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | tubulin gamma chain | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | beta tubulin | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0045 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | alpha tubulin 1 | 0.0045 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0045 | 0 | 0.5 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0045 | 0 | 0.5 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0045 | 0 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0045 | 0 | 0.5 |
Brugia malayi | alpha-tubulin | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0045 | 0 | 0.5 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0045 | 0 | 0.5 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0045 | 0 | 0.5 |
Schistosoma mansoni | alpha tubulin | 0.0045 | 0 | 0.5 |
Echinococcus granulosus | tubulin alpha | 0.0045 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0045 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Displacement (binding) | = 0 % | Percent displacement from adenosine A2 receptor at 10e-7 M in rat striatal membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 5 % | Percent displacement from adenosine A1 receptor at 10e-5 M in rat brain membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 5 % | Percent displacement from adenosine A1 receptor at 10e-7 M in rat brain membrane in vitro. | ChEMBL. | 7996542 |
Displacement (binding) | = 19 % | Percent displacement from adenosine A2 receptor at 10e-5 M in rat striatal membrane in vitro. | ChEMBL. | 7996542 |
ED50 (functional) | > 60 mg kg-1 | Effective dose for phenylbenzoquinone-induced writhing in mice after peroral administration expressed as analgesic activity. | ChEMBL. | 7996542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.