Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0037 | 0.0281 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0037 | 0.0276 | 0.0341 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0489 | 0.0606 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0037 | 0.0281 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0037 | 0.0276 | 0.8261 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0037 | 0.0281 | 0.0466 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.356 | 0.441 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | TAR-binding protein | 0.0123 | 0.2841 | 0.3519 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0364 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0489 | 0.0606 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.022 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.0556 | 0.0689 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0284 | 0.7626 | 0.9447 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0556 | 0.0689 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0262 | 0.698 | 0.8646 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0927 | 0.1149 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.2611 | 0.4323 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.2841 | 0.3519 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0489 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | thyroid hormone receptor | 0.0161 | 0.3965 | 0.4911 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0037 | 0.0276 | 0.0457 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0037 | 0.0276 | 0.0341 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.025 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0112 | 0.2515 | 0.3116 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.025 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0037 | 0.0276 | 0.0457 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0364 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0276 | 0.0341 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.025 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | hypothetical protein | 0.0035 | 0.022 | 0.0364 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.025 | 0.0414 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.022 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2855 | 0.3536 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.022 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0193 | 0.4923 | 0.6098 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | coup transcription factor | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.022 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.356 | 0.441 |
Schistosoma mansoni | nuclear hormone receptor | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | thyroid hormone receptor | 0.0161 | 0.3965 | 0.4911 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0123 | 0.2841 | 0.4705 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.025 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.217 | 0.3593 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0276 | 0.0457 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0489 | 0.0606 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.022 | 0.0272 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.022 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0284 | 0.7626 | 0.9447 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0193 | 0.4923 | 0.6098 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.356 | 0.5896 |
Echinococcus multilocularis | tar DNA binding protein | 0.0123 | 0.2841 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.217 | 0.2688 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.2841 | 0.3519 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.2841 | 0.3519 |
Onchocerca volvulus | 0.0037 | 0.0276 | 0.8261 | |
Echinococcus granulosus | geminin | 0.0164 | 0.4041 | 0.5006 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0556 | 0.0689 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0276 | 0.0457 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.0556 | 0.0689 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Loa Loa (eye worm) | glutamate receptor | 0.0091 | 0.1869 | 0.2315 |
Loa Loa (eye worm) | RNA binding protein | 0.0123 | 0.2841 | 0.3519 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0364 | 1 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.025 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.025 | 0.025 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.025 | 0.031 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0489 | 0.0606 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0059 | 0.0927 | 0.1536 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.025 | 0.025 |
Brugia malayi | ecdysteroid receptor | 0.0037 | 0.0276 | 0.0457 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0489 | 0.0606 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0193 | 0.4923 | 0.6098 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0037 | 0.0276 | 0.0457 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0161 | 0.3965 | 0.4911 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0556 | 0.0689 |
Brugia malayi | beta-lactamase | 0.0036 | 0.025 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2855 | 0.3536 |
Brugia malayi | steroid hormone receptor | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | glutamate receptor | 0.0231 | 0.6038 | 0.7479 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0059 | 0.0927 | 0.1149 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0209 | 0.5392 | 0.893 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1538 | 0.2548 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.025 | 0.0414 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.8073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0556 | 0.0689 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0556 | 0.0689 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0556 | 0.0689 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.025 | 0.031 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0037 | 0.0276 | 0.8261 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.022 | 0.0272 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0316 | 0.8572 | 0.8535 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0364 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0364 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0364 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.025 | 0.031 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0281 | 0.0348 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0231 | 0.6038 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0276 | 0.0341 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0556 | 0.0689 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0037 | 0.0281 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0123 | 0.2841 | 0.3519 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.022 | 0.0272 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.025 | 0.031 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.8073 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.2841 | 0.3519 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0037 | 0.0276 | 0.0457 |
Echinococcus granulosus | FTZ F1 alpha | 0.0037 | 0.0276 | 0.0341 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0037 | 0.0276 | 0.8261 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0037 | 0.0276 | 0.0341 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.0556 | 0.0689 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0037 | 0.0276 | 0.0457 |
Schistosoma mansoni | tar DNA-binding protein | 0.0123 | 0.2841 | 0.3519 |
Echinococcus multilocularis | geminin | 0.0164 | 0.4041 | 0.5006 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.025 | 0.031 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0059 | 0.0927 | 0.1149 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0037 | 0.0281 | 0.0348 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0489 | 0.0606 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.025 | 0.0414 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.0556 | 0.0921 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.0556 | 0.0689 |
Brugia malayi | TAR-binding protein | 0.0123 | 0.2841 | 0.4705 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.025 | 0.031 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0112 | 0.2515 | 0.4166 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.0556 | 0.0921 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0233 | 0.6094 | 0.5994 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0276 | 0.0341 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4041 | 0.5006 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.356 | 0.5896 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.217 | 0.2688 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0489 | 0.081 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0037 | 0.0276 | 0.0341 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0364 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.4041 | 0.5006 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0489 | 0.0606 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0316 | 0.8572 | 0.8535 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.8073 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0037 | 0.0276 | 0.0457 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0281 | 0.0348 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.8073 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0037 | 0.0276 | 0.0341 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0284 | 0.7626 | 0.9447 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.0556 | 0.0689 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.2611 | 0.3234 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0037 | 0.0276 | 0.0341 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.2611 | 0.3234 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2855 | 0.3536 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0123 | 0.2841 | 0.3519 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0037 | 0.0276 | 0.0341 |
Brugia malayi | RNA binding protein | 0.0123 | 0.2841 | 0.4705 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0364 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.