Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thioredoxin reductase | 0.0126 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0506 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0151 | 0.0814 | 0.0814 |
Loa Loa (eye worm) | glutathione reductase | 0.0126 | 0.0341 | 0.0341 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0126 | 0.0341 | 0.0341 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0126 | 0.0341 | 0.0341 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0637 | 1 | 1 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.043 | 0.6089 | 0.6089 |
Trypanosoma brucei | trypanothione reductase | 0.0126 | 0.0341 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0637 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0126 | 0.0341 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0126 | 0.0341 | 0.5 |
Brugia malayi | glutathione reductase | 0.0126 | 0.0341 | 0.0341 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0126 | 0.0341 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0637 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0814 | 0.0814 |
Leishmania major | trypanothione reductase | 0.0126 | 0.0341 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0126 | 0.0341 | 0.0341 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0126 | 0.0341 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0637 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0637 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0637 | 1 | 1 |
Onchocerca volvulus | 0.0134 | 0.0506 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0637 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0126 | 0.0341 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0126 | 0.0341 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0637 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0108 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0151 | 0.0814 | 0.0814 |
Plasmodium vivax | glutathione reductase, putative | 0.0126 | 0.0341 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0637 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0108 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0108 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0134 | 0.0506 | 0.0506 |
Echinococcus granulosus | geminin | 0.0151 | 0.0814 | 0.0814 |
Echinococcus multilocularis | acetylcholinesterase | 0.0637 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.