TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 586.657 | Formula: C28H34N4O8S
H donors: 1 H acceptors: 7 LogP: 5.67 Rotable bonds: 16
Rule of 5 violations (Lipinski): 2
SMILES: CCCCOC(=O)NS(=O)(=O)c1ccccc1c1ccc(c(c1)[N+](=O)[O-])Cn1c(CCC)nc(c1C(=O)OC)CC
InChi: 1S/C28H34N4O8S/c1-5-8-16-40-28(34)30-41(37,38)24-13-10-9-12-21(24)19-14-15-20(23(17-19)32(35)36)18-31-25(11-6-2)29-22(7-3)26(31)27(33)39-4/h9-10,12-15,17H,5-8,11,16,18H2,1-4H3,(H,30,34)
InChiKey: BYGLUGHFELDJQW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Angiotensin II type 2 (AT-2) receptor	Starlite/ChEMBL	No references
Rattus norvegicus	Angiotensin II receptor (AT-1) type-1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	340 aa	24.1 %
Onchocerca volvulus		Angiotensin II receptor (AT-1) type-1	359 aa	309 aa	18.8 %
Onchocerca volvulus		Angiotensin II receptor (AT-1) type-1	359 aa	386 aa	24.4 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II receptor (AT-1) type-1	359 aa	300 aa	21.0 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	356 aa	23.3 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II receptor (AT-1) type-1	359 aa	354 aa	20.6 %
Onchocerca volvulus		Angiotensin II receptor (AT-1) type-1	359 aa	350 aa	24.0 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II receptor (AT-1) type-1	359 aa	343 aa	23.0 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II receptor (AT-1) type-1	359 aa	295 aa	27.1 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.8 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	305 aa	21.6 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 2 (AT-2) receptor	363 aa	328 aa	22.0 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.1 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor (AT-1) type-1	359 aa	308 aa	27.6 %
Onchocerca volvulus		Angiotensin II receptor (AT-1) type-1	359 aa	355 aa	23.9 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	21.4 %
Onchocerca volvulus		Angiotensin II receptor (AT-1) type-1	359 aa	314 aa	25.2 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II receptor (AT-1) type-1	359 aa	350 aa	23.1 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II receptor (AT-1) type-1	359 aa	346 aa	18.2 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	364 aa	20.9 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	342 aa	24.6 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	308 aa	22.1 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	311 aa	23.8 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.2 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II receptor (AT-1) type-1	359 aa	314 aa	20.4 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	310 aa	23.5 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II receptor (AT-1) type-1	359 aa	325 aa	20.9 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II receptor (AT-1) type-1	359 aa	307 aa	22.1 %
Brugia malayi	GnHR receptor homolog	Angiotensin II receptor (AT-1) type-1	359 aa	357 aa	20.4 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II receptor (AT-1) type-1	359 aa	300 aa	21.0 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 2 (AT-2) receptor	363 aa	398 aa	18.3 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II receptor (AT-1) type-1	359 aa	299 aa	25.8 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor (AT-1) type-1	359 aa	329 aa	24.0 %
Onchocerca volvulus		Angiotensin II type 2 (AT-2) receptor	363 aa	306 aa	22.5 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 2 (AT-2) receptor	363 aa	341 aa	22.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0005	0.0001	0.0031
Schistosoma mansoni	hypothetical protein	0.0119	0.0903	0.2662
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0009	0.0029	0.0084
Entamoeba histolytica	recQ family helicase, putative	0.0021	0.0127	0.5555
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	blooms syndrome DNA helicase	0.0011	0.0045	0.0134
Brugia malayi	MH2 domain containing protein	0.0006	0.0006	0.0094
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0009	0.0029	0.0458
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.002	0.006
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0045	0.0134
Brugia malayi	nuclear receptor NHR-88	0.0005	0.0001	0.001
Onchocerca volvulus		0.0009	0.0029	0.1421
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0084
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0005	0.0001	0.0002
Leishmania major	DNA polymerase eta, putative	0.0045	0.0317	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0076	0.056	0.0714
Brugia malayi	G-protein coupled receptor	0.0009	0.0029	0.0458
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0045	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0029	0.0084
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0012	0.0052	0.2644
Onchocerca volvulus		0.0011	0.0045	0.2253
Trypanosoma brucei	unspecified product	0.0019	0.0109	0.281
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0045	0.0727
Onchocerca volvulus		0.0009	0.0029	0.1421
Echinococcus granulosus	dro:myosuppressin receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0001	0.0002
Brugia malayi	Animal haem peroxidase family protein	0.0015	0.0082	0.1321
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0021	0.0127	0.0374
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0034	0.0548
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0012	0.0052	0.1248
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0009	0.0029	0.1421
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0045	0.0727
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0045	0.0727
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0084
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0084
Echinococcus granulosus	7tm_1 domain containing protein	0.0009	0.0029	0.0084
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0012	0.0052	0.1248
Schistosoma mansoni	cpg binding protein	0.0032	0.0215	0.0635
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0005	0.0001	0.0002
Echinococcus multilocularis	neuropeptide receptor A26	0.0009	0.0029	0.0084
Echinococcus granulosus	cpg binding protein	0.0032	0.0215	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Echinococcus multilocularis	smad	0.0006	0.0006	0.0017
Giardia lamblia	Sgs1 DNA helicase, putative	0.0021	0.0127	0.6481
Echinococcus granulosus	neuropeptide s receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0035	0.0104
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Echinococcus multilocularis	orexin receptor type 2	0.0009	0.0029	0.0084
Brugia malayi	nuclear hormone receptor	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Plasmodium vivax	ATP-dependent DNA helicase Q1, putative	0.001	0.0042	0.0758
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0109	0.281
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0109	0.281
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	dna polymerase kappa	0.0027	0.0175	0.0517
Echinococcus granulosus	nuclear receptor nhr 48	0.0005	0.0001	0.0002
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Schistosoma mansoni	hypothetical protein	0.0434	0.339	1
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0021	0.0127	0.5074
Onchocerca volvulus		0.0015	0.0082	0.4093
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0045	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Schistosoma mansoni	coup transcription factor	0.0011	0.0045	0.0134
Plasmodium falciparum	thioredoxin reductase	0.0033	0.0224	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0012	0.0052	0.0185
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0029	0.0084
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0027	0.0175	0.8728
Trichomonas vaginalis	MYB3r3, putative	0.003	0.0195	0.9938
Schistosoma mansoni	zinc finger protein	0.0005	0.0001	0.0002
Trypanosoma brucei	trypanothione reductase	0.0033	0.0224	0.6778
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0726
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0045	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0045	0.0134
Echinococcus granulosus	neuropeptide receptor A26	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0005	0.0001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0045	0.0727
Echinococcus multilocularis	cpg binding protein	0.0032	0.0215	0.0635
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0029	0.0458
Schistosoma mansoni	nuclear receptor	0.0005	0.0001	0.0002
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0029	0.0084
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0045	0.2253
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0029	0.0084
Brugia malayi	Serotonin receptor	0.0009	0.0029	0.0458
Mycobacterium leprae	PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA	0.0913	0.717	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0033	0.0224	0.6778
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Echinococcus granulosus	mothers against decapentaplegic 5	0.0006	0.0006	0.0017
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0127	0.3439
Schistosoma mansoni	DNA polymerase IV / kappa	0.0008	0.0027	0.008
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0045	0.0134
Onchocerca volvulus		0.0031	0.0201	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0045	0.0727
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	animal heme peroxidase	0.0015	0.0082	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma brucei	DNA polymerase eta, putative	0.0045	0.0317	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0006	0.0006	0.0094
Echinococcus multilocularis	peroxidasin	0.0015	0.0082	0.0243
Echinococcus granulosus	Smad4	0.0006	0.0006	0.0017
Brugia malayi	Blistered cuticle protein 3	0.0015	0.0082	0.1321
Echinococcus multilocularis	allatostatin A receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0029	0.0084
Trypanosoma brucei	DNA polymerase IV, putative	0.0027	0.0175	0.511
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0076	0.056	0.0714
Loa Loa (eye worm)	TYRA-2 protein	0.0009	0.0029	0.0458
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	orexin receptor type 2	0.0009	0.0029	0.0084
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0012	0.0052	0.0846
Loa Loa (eye worm)	thioredoxin reductase	0.0033	0.0224	0.358
Brugia malayi	hypothetical protein	0.0005	0.0001	0.001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0005	0.0001	0.0031
Trypanosoma brucei	unspecified product	0.0019	0.0109	0.281
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Onchocerca volvulus		0.0009	0.0029	0.1421
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0015	0.0000000037959
Brugia malayi	Thioredoxin reductase	0.0033	0.0224	0.358
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0012	0.0052	0.0846
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0012	0.0052	0.0846
Leishmania major	DNA polymerase eta, putative	0.0026	0.0169	0.489
Brugia malayi	polk-prov protein	0.0008	0.0027	0.0436
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.002	0.006
Schistosoma mansoni	smad	0.0006	0.0006	0.0017
Loa Loa (eye worm)	animal heme peroxidase	0.0015	0.0082	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	serotonin receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0045	0.0134
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0001	0.001
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0045	0.0134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.002	0.006
Loa Loa (eye worm)	Smad1	0.0006	0.0006	0.0094
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0127	0.2031
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	DNA helicase recq5	0.0021	0.0127	0.0374
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0045	0.0134
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0006	0.0006	0.0017
Giardia lamblia	DINP protein human, muc B family	0.0027	0.0175	0.8954
Entamoeba histolytica	recQ family DNA helicase	0.0011	0.0045	0.0211
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	larval opioid receptor	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Mycobacterium leprae	probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS	0.0359	0.2791	0.3375
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0001	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0029	0.0458
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0201	0.3227
Loa Loa (eye worm)	nuclear hormone receptor	0.0005	0.0001	0.001
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0011	0.0045	0.0923
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0009	0.0029	0.0084
Brugia malayi	GnHR receptor homolog	0.0009	0.0029	0.0458
Brugia malayi	sulfakinin receptor protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	animal heme peroxidase	0.0015	0.0082	0.1321
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0009	0.0029	0.0458
Echinococcus granulosus	sex peptide receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0027	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	thioredoxin glutathione reductase	0.0033	0.0224	0.0659
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Brugia malayi	nuclear receptor RXR	0.0006	0.0005	0.0087
Brugia malayi	Animal haem peroxidase family protein	0.0015	0.0082	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0087
Echinococcus multilocularis	neuropeptide s receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0045	0.0134
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0127	0.6183
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	opsin-like receptor	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0009	0.0029	0.1421
Echinococcus granulosus	peroxidasin	0.0015	0.0082	0.0243
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0029	0.0084
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0084	0.0627	0.0808
Echinococcus granulosus	g-protein coupled receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	cpg binding protein	0.0032	0.0215	0.0635
Brugia malayi	G protein-coupled receptor F59B2.13	0.0009	0.0029	0.0458
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0084
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	dna polymerase eta	0.0045	0.0317	0.0935
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0033	0.0224	0.0659
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0045	0.0625
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0127	0.6183
Brugia malayi	follicle stimulating hormone receptor	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	tailless protein	0.0005	0.0001	0.001
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Trichomonas vaginalis	DNA polymerase eta, putative	0.0027	0.0175	0.8864
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	nuclear receptor NHR-67	0.0005	0.0001	0.001
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0009	0.0029	0.0458
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0127	0.3439
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0084
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Echinococcus multilocularis	serotonin receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0009	0.0029	0.0084
Toxoplasma gondii	thioredoxin reductase	0.0033	0.0224	0.0801
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.0471	0.1391
Brugia malayi	Dopamine receptor protein 1	0.0009	0.0029	0.0458
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0005	0.0016
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0001	0.0031
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0009	0.0029	0.0084
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA	0.0913	0.717	1
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Onchocerca volvulus	Peroxidasin homolog	0.0015	0.0082	0.4093
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0127	0.2031
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.003	0.0195	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0009	0.0029	0.0084
Brugia malayi	Nuclear hormone receptor E75	0.0005	0.0001	0.001
Schistosoma mansoni	myosin xvIII	0.0009	0.0029	0.0084
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0045	0.0134
Echinococcus multilocularis	sex peptide receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trichomonas vaginalis	MYB, putative	0.003	0.0196	1
Trypanosoma brucei	unspecified product	0.0027	0.0175	0.511
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0726
Trypanosoma cruzi	DNA polymerase eta, putative	0.0045	0.0317	1
Schistosoma mansoni	DNA helicase recq1	0.0021	0.0127	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0317	0.5075
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0127	0.2031
Trypanosoma cruzi	DNA polymerase eta, putative	0.0026	0.0169	0.489
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0001	0.0002
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0076	0.056	0.0714
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0045	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0011	0.0045	0.0625
Schistosoma mansoni	neuropeptide f receptor 76f	0.0009	0.0029	0.0084
Brugia malayi	MH2 domain containing protein	0.0006	0.0006	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0027	0.0175	0.2806
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0027	0.0175	0.0173
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0127	0.0374
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0045	0.0134
Mycobacterium tuberculosis	Probable reductase	0.0076	0.056	0.0714
Brugia malayi	hypothetical protein	0.0006	0.0005	0.0087
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0008	0.0028	0.0441
Onchocerca volvulus	Peroxidase homolog	0.0015	0.0082	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0153
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0012	0.0052	0.0846
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0021	0.0127	0.2031
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0042	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Onchocerca volvulus		0.0009	0.0029	0.1421
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0008	0.0028	0.0441
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0084
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0009	0.0029	0.0458
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0021	0.0127	0.0374
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0009	0.0029	0.0084
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0087
Loa Loa (eye worm)	MH2 domain-containing protein	0.0084	0.0624	1
Brugia malayi	nuclear hormone receptor	0.0005	0.0001	0.001
Echinococcus multilocularis	G protein coupled receptor 139	0.0009	0.0029	0.0084
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0009	0.0029	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0045	0.0727
Brugia malayi	MH1 domain containing protein	0.0006	0.0006	0.0094
Brugia malayi	hypothetical protein	0.0005	0.0001	0.001
Brugia malayi	Animal haem peroxidase family protein	0.0015	0.0082	0.1321
Brugia malayi	MH2 domain containing protein	0.0084	0.0624	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Onchocerca volvulus		0.0009	0.0029	0.1421
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0084
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0015	0.0000000037959
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0009	0.0029	0.0084
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0127	0.0454
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0084
Brugia malayi	RE15519p	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0846
Brugia malayi	putative neuropeptide receptor NPR1	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Brugia malayi	steroid hormone receptor	0.0011	0.0045	0.0727
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0045	0.0727
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0005	0.0001	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0045	0.0727
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0196	1
Brugia malayi	Dopamine receptor protein 2	0.0009	0.0029	0.0458
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0009	0.0029	0.0084
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0005	0.0001	0.0002
Onchocerca volvulus	Chorion peroxidase homolog	0.0015	0.0082	0.4093
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0009	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0045	0.0727
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Brugia malayi	G protein-coupled receptor	0.0009	0.0029	0.0458
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0084	0.0627	0.0101
Echinococcus multilocularis	nuclear receptor nhr 48	0.0005	0.0001	0.0002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Loa Loa (eye worm)	DR-78	0.0005	0.0001	0.001
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0045	0.0727
Onchocerca volvulus		0.0009	0.0029	0.1421
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.003	0.0195	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Onchocerca volvulus		0.0009	0.0029	0.1421
Brugia malayi	Dopamine receptor	0.0009	0.0029	0.0458
Echinococcus multilocularis	g-protein coupled receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0045	0.0727
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0008	0.0027	0.0098
Brugia malayi	Melatonin receptor type 1A	0.0009	0.0029	0.0458
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0035	0.0563
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Echinococcus granulosus	hypothetical protein	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0033	0.0224	0.0241
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0084
Trichomonas vaginalis	pc-MYB2, putative	0.003	0.0195	0.9938
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Trichomonas vaginalis	MYB72, putative	0.003	0.0195	0.9938
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0084
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0084	0.0627	0.0808
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0029	0.0458
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0009	0.0029	0.0084
Brugia malayi	AKH receptor	0.0009	0.0029	0.0458
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0012	0.0052	0.1248
Brugia malayi	ImpB/MucB/SamB family protein	0.0027	0.0175	0.2806
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0009	0.0029	0.0084
Mycobacterium ulcerans	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1272	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0045	0.0727
Trichomonas vaginalis	C-MYB, putative	0.003	0.0195	0.9938
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0084
Schistosoma mansoni	hypothetical protein	0.0009	0.0029	0.0084
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0127	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Brugia malayi	ecdysone receptor	0.0005	0.0001	0.001
Leishmania major	trypanothione reductase	0.0033	0.0224	0.6778
Plasmodium falciparum	thioredoxin reductase	0.0012	0.0052	0.1248
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.002	0.006
Trichomonas vaginalis	glutathione reductase, putative	0.0012	0.0052	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0026	0.0169	0.0605
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0005	0.0087
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0027	0.0175	0.0517
Echinococcus granulosus	thyroid hormone receptor alpha	0.0005	0.0001	0.0002
Brugia malayi	ecdysteroid receptor	0.0011	0.0045	0.0727
Onchocerca volvulus		0.0009	0.0029	0.1421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0005	0.0001	0.001
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0009	0.0029	0.0084
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0012	0.0052	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0045	0.0727
Brugia malayi	hypothetical protein	0.0015	0.0082	0.1321
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0045	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0029	0.0084
Toxoplasma gondii	Myb family DNA-binding domain-containing protein	0.003	0.0196	0.0701
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Mycobacterium ulcerans	3-phosphoshikimate 1-carboxyvinyltransferase	0.0359	0.2791	0.2771
Echinococcus granulosus	allatostatin A receptor	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0009	0.0029	0.1421
Schistosoma mansoni	hypothetical protein	0.0119	0.0903	0.2662
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Echinococcus granulosus	smad	0.0006	0.0006	0.0017
Brugia malayi	glutathione reductase	0.0033	0.0224	0.358
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0029	0.0458
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0084
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.003	0.0195	1
Loa Loa (eye worm)	animal heme peroxidase	0.0015	0.0082	0.1321
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0045	0.0727
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0006	0.0006	0.0017
Trypanosoma brucei	DNA polymerase IV, putative	0.0027	0.0175	0.511
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Brugia malayi	neuropeptide F receptor	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	serotonin receptor	0.0009	0.0029	0.0084
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0012	0.0052	0.0025
Mycobacterium tuberculosis	Probable oxidoreductase	0.0084	0.0627	0.0808
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0009	0.0029	0.0084
Toxoplasma gondii	shikimate dehydrogenase substrate binding domain-containing protein	0.0359	0.2791	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0005	0.0087
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0127	0.6183
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0045	0.0134
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Schistosoma mansoni	nuclear receptor	0.0005	0.0001	0.0002
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0045	0.0134
Onchocerca volvulus		0.0009	0.0029	0.1421
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0027	0.0175	0.0517
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0045	0.0727
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0005	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0005	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0084
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0009	0.0029	0.1421
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Brugia malayi	ImpB/MucB/SamB family protein	0.0045	0.0317	0.5075
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Brugia malayi	ORL1-like opioid receptor	0.0009	0.0029	0.0458
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0045	0.0134
Schistosoma mansoni	DNA polymerase eta	0.0045	0.0317	0.0935
Brugia malayi	Peroxidasin	0.0015	0.0082	0.1321
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0012	0.0052	0.0846
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0008	0.0027	0.0098
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0009	0.0029	0.0458
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	MH2 domain-containing protein	0.0006	0.0006	0.0094
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0009	0.0029	0.0458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0021	0.0127	0.0454
Trypanosoma cruzi	trypanothione reductase, putative	0.0012	0.0052	0.0846
Schistosoma mansoni	neuropeptide F-like receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	G protein coupled receptor 139	0.0009	0.0029	0.0084
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0201	0.3227
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0153
Echinococcus granulosus	7TM GPCR rhodopsin	0.0009	0.0029	0.0084
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0001	0.0002
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0009	0.0029	0.0084
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0045	0.0727
Brugia malayi	Serotonin receptor	0.0009	0.0029	0.0458
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0009	0.0029	0.0458
Giardia lamblia	Myb 1-like protein	0.003	0.0196	1
Echinococcus multilocularis	dna polymerase kappa	0.0027	0.0175	0.0517
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0005	0.0001	0.0002
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	histamine h1 receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0009	0.0029	0.1421
Schistosoma mansoni	smad1 5 8 and	0.0006	0.0006	0.0017
Trichomonas vaginalis	C-MYB, putative	0.003	0.0195	0.9938
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0196	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0029	0.0084
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0015	0.0082	0.4093
Trichomonas vaginalis	mercuric reductase, putative	0.0012	0.0052	0.2024
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0009	0.0029	0.0084
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0005	0.0001	0.0002
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0005	0.0001	0.001
Mycobacterium tuberculosis	Probable dehydrogenase	0.0076	0.056	0.0714
Brugia malayi	nuclear receptor RXR	0.0005	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0045	0.0134
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0027	0.0175	0.0173
Plasmodium vivax	glutathione reductase, putative	0.0033	0.0224	1
Echinococcus granulosus	fmrfamide receptor	0.0009	0.0029	0.0084
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0012	0.0052	0.0185
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0006	0.0006	0.0017
Schistosoma mansoni	Smad4	0.0006	0.0006	0.0017
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0021	0.0127	0.3439
Schistosoma mansoni	adenoreceptor	0.0009	0.0029	0.0084
Leishmania major	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Echinococcus granulosus	geminin	0.0119	0.0903	0.2662
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0009	0.0029	0.0458
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0027	0.0175	0.0517
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0045	0.0134
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0009	0.0029	0.0084
Treponema pallidum	NADH oxidase	0.0012	0.0052	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	dnaJ subfamily B	0.0434	0.339	1
Schistosoma mansoni	smad1 5 8 and	0.0006	0.0006	0.0017
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0005	0.0016
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0045	0.0727
Loa Loa (eye worm)	blistered cuticle protein 3	0.0015	0.0082	0.1321
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0011	0.0045	0.0162
Plasmodium vivax	thioredoxin reductase, putative	0.0033	0.0224	1
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0127	0.5074
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0012	0.0052	0.0846
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0005	0.0001	0.0031
Brugia malayi	neuropeptide F receptor	0.0009	0.0029	0.0458
Plasmodium falciparum	glutathione reductase	0.0012	0.0052	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0045	0.0134
Brugia malayi	G-protein coupled receptor	0.0009	0.0029	0.0458
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0005	0.0087
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0012	0.0052	0.0846
Mycobacterium ulcerans	DNA polymerase IV	0.0027	0.0175	0.0148
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0109	0.281
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0035	0.0104
Echinococcus multilocularis	somatostatin receptor	0.0009	0.0029	0.0084
Brugia malayi	orphan nuclear receptor NR2E1	0.0005	0.0001	0.001
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0045	0.0134
Onchocerca volvulus		0.0009	0.0029	0.1421
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Brugia malayi	MH1 domain containing protein	0.0006	0.0006	0.0094
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0127	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0087
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0009	0.0029	0.0084
Onchocerca volvulus		0.0009	0.0029	0.1421
Schistosoma mansoni	biogenic amine receptor	0.0009	0.0029	0.0084
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0045	0.0727
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.002	0.006
Schistosoma mansoni	growth hormone secretagogue receptor	0.0009	0.0029	0.0084
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0009	0.0029	0.0084
Loa Loa (eye worm)	glutathione reductase	0.0033	0.0224	0.358
Trichomonas vaginalis	pc-MYB2, putative	0.003	0.0195	0.9938
Trypanosoma brucei	DNA polymerase IV, putative	0.0027	0.0175	0.511
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0045	0.0727
Brugia malayi	conserved hypotetical protein	0.0005	0.0001	0.001
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0045	0.0134
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0045	0.0727
Brugia malayi	Smad1	0.0006	0.0006	0.0094
Mycobacterium ulcerans	DNA polymerase IV	0.0027	0.0175	0.0148
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0045	0.0134
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0846
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0009	0.0029	0.0458
Onchocerca volvulus		0.0009	0.0029	0.1421
Brugia malayi	Animal haem peroxidase family protein	0.0015	0.0082	0.1321
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0045	0.0134
Echinococcus granulosus	somatostatin receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	melatonin receptor type 1A	0.0009	0.0029	0.0458
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Schistosoma mansoni	peroxidasin	0.0015	0.0082	0.0243
Treponema pallidum	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1272	1	1
Brugia malayi	hypothetical protein	0.0009	0.0029	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0009	0.0029	0.0458
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0027	0.0175	0.0517
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0006	0.0006	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0015	0.0000000037959
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0012	0.0052	0.0153
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus granulosus	neuropeptide FF receptor 2	0.0009	0.0029	0.0084
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0045	0.0727
Schistosoma mansoni	cpg binding protein	0.0031	0.0201	0.0594
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0021	0.0127	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	Smad4	0.0006	0.0006	0.0017
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0027	0.0175	0.8864
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0005	0.0001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0009	0.0029	0.0084
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0001	0.0002
Chlamydia trachomatis	phosphoshikimate 1-carboxyl vinyltransferase	0.0359	0.2791	0.2753
Schistosoma mansoni	peroxidasin	0.0015	0.0082	0.0243
Trichomonas vaginalis	r2r3-MYB transcription factor, putative	0.003	0.0195	0.9938
Schistosoma mansoni	amine GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	transcription factor SMAD2	0.0084	0.0624	1
Brugia malayi	putative neuropeptide receptor	0.0009	0.0029	0.0458
Onchocerca volvulus	Dual oxidase homolog	0.0015	0.0082	0.4093
Plasmodium falciparum	glutathione reductase	0.0033	0.0224	1
Echinococcus granulosus	dnaJ subfamily B	0.0434	0.339	1
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.003	0.0195	1
Onchocerca volvulus		0.0015	0.0082	0.4093
Onchocerca volvulus	Peroxidasin homolog	0.0015	0.0082	0.4093
Echinococcus multilocularis	geminin	0.0119	0.0903	0.2662
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0045	0.0134
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0045	0.0134
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0021	0.0127	0.0374
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0045	0.0134
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0042	0.0151
Onchocerca volvulus	Peroxidase homolog	0.0015	0.0082	0.4093
Onchocerca volvulus		0.0009	0.0029	0.1421
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0045	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0009	0.0029	0.0084
Echinococcus multilocularis	dro:myosuppressin receptor	0.0009	0.0029	0.0084
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0045	0.0134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Wolbachia endosymbiont of Brugia malayi	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.1272	1	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0012	0.0052	0.0829
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0005	0.0087
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0045	0.0134
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0417	0.1494
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0005	0.0016
Onchocerca volvulus		0.0009	0.0029	0.1421
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0045	0.2253
Schistosoma mansoni	smad1 5 8 and	0.0006	0.0006	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0084
Giardia lamblia	DNA damage repair protein	0.0008	0.0027	0.1392
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0027	0.0175	0.511
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0029	0.0458
Entamoeba histolytica	myb-like DNA-binding domain containing protein	0.003	0.0195	1
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0127	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0001	0.001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0084
Schistosoma mansoni	neuropeptide receptor	0.0009	0.0029	0.0084
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0076	0.056	0.0714
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0045	0.0727
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0029	0.0084
Brugia malayi	Animal haem peroxidase family protein	0.0015	0.0082	0.1321
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0012	0.0052	0.1248
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0045	0.0134
Echinococcus multilocularis	dna polymerase eta	0.0045	0.0317	0.0935
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0009	0.0029	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0082	0.1321
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0175	0.511
Brugia malayi	nuclear hormone receptor family member odr-7	0.0005	0.0001	0.001
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0009	0.0029	0.0084

Activities

Activity type	Activity value	Assay description	Source	Reference
ED30 (functional)	0 mg kg-1	Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by intravenous administration; Not tested	ChEMBL.	No reference
ED30 (functional)	0 mg kg-1	Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by peroral administration; Not tested	ChEMBL.	No reference
IC50 (binding)	= 7 nM	Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes	ChEMBL.	No reference
IC50 (binding)	= 7 nM	Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes	ChEMBL.	No reference
IC50 (binding)	= 20 nM	Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes	ChEMBL.	No reference
IC50 (binding)	= 20 nM	Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL59728

Bibliographic References

No literature references available for this target.

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Detailed information for compound 91517