Detailed information for compound 91517

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 586.657 | Formula: C28H34N4O8S
  • H donors: 1 H acceptors: 7 LogP: 5.67 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCOC(=O)NS(=O)(=O)c1ccccc1c1ccc(c(c1)[N+](=O)[O-])Cn1c(CCC)nc(c1C(=O)OC)CC
  • InChi: 1S/C28H34N4O8S/c1-5-8-16-40-28(34)30-41(37,38)24-13-10-9-12-21(24)19-14-15-20(23(17-19)32(35)36)18-31-25(11-6-2)29-22(7-3)26(31)27(33)39-4/h9-10,12-15,17H,5-8,11,16,18H2,1-4H3,(H,30,34)
  • InChiKey: BYGLUGHFELDJQW-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL No references
Rattus norvegicus Angiotensin II receptor (AT-1) type-1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 24.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II receptor (AT-1) type-1   359 aa 343 aa 23.0 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II receptor (AT-1) type-1   359 aa 325 aa 20.9 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 25.2 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 309 aa 18.8 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 329 aa 24.0 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II receptor (AT-1) type-1   359 aa 350 aa 23.1 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Schistosoma mansoni opsin-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 299 aa 25.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II receptor (AT-1) type-1   359 aa 346 aa 18.2 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II receptor (AT-1) type-1   359 aa 295 aa 27.1 %
Loa Loa (eye worm) hypothetical protein Angiotensin II receptor (AT-1) type-1   359 aa 308 aa 27.6 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 386 aa 24.4 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Brugia malayi GnHR receptor homolog Angiotensin II receptor (AT-1) type-1   359 aa 357 aa 20.4 %
Onchocerca volvulus Angiotensin II receptor (AT-1) type-1   359 aa 355 aa 23.9 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II receptor (AT-1) type-1   359 aa 354 aa 20.6 %
Brugia malayi ORL1-like opioid receptor Angiotensin II receptor (AT-1) type-1   359 aa 314 aa 20.4 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II receptor (AT-1) type-1   359 aa 300 aa 21.0 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II receptor (AT-1) type-1   359 aa 307 aa 22.1 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0001 0.0002
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0127 0.2031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0045 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Trichomonas vaginalis glutathione reductase, putative 0.0012 0.0052 0.2024
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0045 0.0134
Schistosoma mansoni smad1 5 8 and 0.0006 0.0006 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0045 0.0134
Onchocerca volvulus 0.0015 0.0082 0.4093
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0195 1
Brugia malayi neuropeptide F receptor 0.0009 0.0029 0.0458
Mycobacterium tuberculosis Probable dehydrogenase 0.0076 0.056 0.0714
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Entamoeba histolytica deoxycytidyl transferase, putative 0.0027 0.0175 0.8728
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0029 0.0458
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0045 0.0727
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0029 0.0084
Brugia malayi conserved hypotetical protein 0.0005 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus sex peptide receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0031 0.0201 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0012 0.0052 0.1248
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0029 0.0084
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0045 0.0134
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0029 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0045 0.0727
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0001 0.0002
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0009 0.0029 0.0458
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Trypanosoma brucei unspecified product 0.0027 0.0175 0.511
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0195 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0913 0.717 1
Schistosoma mansoni smad 0.0006 0.0006 0.0017
Schistosoma mansoni hypothetical protein 0.0009 0.0029 0.0084
Schistosoma mansoni DNA polymerase eta 0.0045 0.0317 0.0935
Schistosoma mansoni biogenic amine receptor 0.0009 0.0029 0.0084
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0029 0.1421
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni cpg binding protein 0.0032 0.0215 0.0635
Onchocerca volvulus Peroxidase homolog 0.0015 0.0082 0.4093
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0001 0.001
Schistosoma mansoni cpg binding protein 0.0031 0.0201 0.0594
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0109 0.281
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0045 0.0134
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0029 0.0084
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0127 0.0374
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0029 0.0084
Giardia lamblia DINP protein human, muc B family 0.0027 0.0175 0.8954
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0045 0.0727
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0001 0.001
Echinococcus granulosus geminin 0.0119 0.0903 0.2662
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0001 0.0031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0029 0.0458
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0029 0.0084
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1272 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0029 0.0084
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) MH2 domain-containing protein 0.0006 0.0006 0.0094
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0029 0.0084
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0029 0.0458
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus Smad4 0.0006 0.0006 0.0017
Schistosoma mansoni biogenic amine receptor 0.0009 0.0029 0.0084
Schistosoma mansoni neuropeptide receptor 0.0009 0.0029 0.0084
Echinococcus granulosus orexin receptor type 2 0.0009 0.0029 0.0084
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0045 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0015 0.0000000037959
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0045 0.0134
Giardia lamblia Myb 1-like protein 0.003 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0726
Plasmodium falciparum glutathione reductase 0.0033 0.0224 1
Brugia malayi Animal haem peroxidase family protein 0.0015 0.0082 0.1321
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0045 0.0134
Echinococcus granulosus dna polymerase kappa 0.0027 0.0175 0.0517
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0175 0.0148
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0084 0.0627 0.0808
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0045 0.0134
Brugia malayi neuropeptide F receptor 0.0009 0.0029 0.0458
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0008 0.0027 0.0098
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0001 0.0002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0001 0.0002
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0029 0.0458
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0127 0.6183
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0029 0.1421
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0001 0.001
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0127 0.6183
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0012 0.0052 0.0846
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0045 0.0134
Echinococcus granulosus peroxidasin 0.0015 0.0082 0.0243
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0045 0.0134
Brugia malayi hypothetical protein 0.0005 0.0001 0.001
Echinococcus granulosus somatostatin receptor 0.0009 0.0029 0.0084
Giardia lamblia NADH oxidase lateral transfer candidate 0.0012 0.0052 0.2644
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0317 1
Echinococcus granulosus neuropeptide receptor 0.0009 0.0029 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Echinococcus multilocularis dna polymerase kappa 0.0027 0.0175 0.0517
Schistosoma mansoni amine GPCR 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Brugia malayi nuclear receptor RXR 0.0005 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Loa Loa (eye worm) DR-78 0.0005 0.0001 0.001
Onchocerca volvulus Chorion peroxidase homolog 0.0015 0.0082 0.4093
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0045 0.2253
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0001 0.001
Onchocerca volvulus 0.0009 0.0029 0.1421
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0029 0.0458
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.002 0.006
Onchocerca volvulus Peroxidase homolog 0.0015 0.0082 0.4093
Onchocerca volvulus 0.0009 0.0029 0.1421
Brugia malayi nuclear receptor NHR-88 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0001 0.0002
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0359 0.2791 0.2771
Mycobacterium tuberculosis Probable oxidoreductase 0.0084 0.0627 0.0808
Onchocerca volvulus 0.0009 0.0029 0.1421
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0008 0.0027 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0175 0.511
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0045 0.0134
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0045 0.0727
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0029 0.0084
Brugia malayi glutathione reductase 0.0033 0.0224 0.358
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0045 0.0134
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0035 0.0563
Schistosoma mansoni nuclear receptor 0.0005 0.0001 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0029 0.0084
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0195 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Onchocerca volvulus 0.0005 0.0001 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0029 0.0084
Echinococcus granulosus g protein coupled receptor 0.0009 0.0029 0.0084
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0127 0.6481
Echinococcus granulosus cpg binding protein 0.0032 0.0215 0.0635
Echinococcus multilocularis somatostatin receptor 0.0009 0.0029 0.0084
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0012 0.0052 0.0846
Echinococcus granulosus hypothetical protein 0.0009 0.0029 0.0084
Brugia malayi follicle stimulating hormone receptor 0.0009 0.0029 0.0458
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0417 0.1494
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0029 0.0458
Schistosoma mansoni zinc finger protein 0.0005 0.0001 0.0002
Brugia malayi hypothetical protein 0.0006 0.0005 0.0087
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0175 0.511
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0195 1
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0045 0.0211
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus bloom syndrome protein 0.0021 0.0127 0.0374
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0224 0.6778
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi Animal haem peroxidase family protein 0.0015 0.0082 0.1321
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0076 0.056 0.0714
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0029 0.0084
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0006 0.0005 0.0016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0027 0.0175 0.8864
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0029 0.0084
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0029 0.0458
Brugia malayi ecdysteroid receptor 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0045 0.0727
Loa Loa (eye worm) MH1 domain-containing protein 0.0006 0.0006 0.0094
Schistosoma mansoni hypothetical protein 0.0434 0.339 1
Brugia malayi nuclear hormone receptor 0.0005 0.0001 0.001
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0027 0.0175 0.0517
Brugia malayi MH1 domain containing protein 0.0006 0.0006 0.0094
Echinococcus granulosus neuropeptide receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0008 0.0027 0.0436
Brugia malayi Dopamine receptor 0.0009 0.0029 0.0458
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0045 0.0727
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0001 0.0002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Brugia malayi steroid hormone receptor 0.0011 0.0045 0.0727
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0045 0.0134
Brugia malayi putative neuropeptide receptor 0.0009 0.0029 0.0458
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0029 0.0084
Brugia malayi Melatonin receptor type 1A 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Brugia malayi tailless protein 0.0005 0.0001 0.001
Echinococcus multilocularis thioredoxin glutathione reductase 0.0033 0.0224 0.0659
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0045 0.0134
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0127 0.2031
Loa Loa (eye worm) RecQ helicase 0.0021 0.0127 0.2031
Brugia malayi Blistered cuticle protein 3 0.0015 0.0082 0.1321
Echinococcus multilocularis smad 0.0006 0.0006 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0045 0.0134
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0029 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0029 0.0084
Schistosoma mansoni smad1 5 8 and 0.0006 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0029 0.0084
Echinococcus granulosus TGF beta signal transducer SmadC 0.0006 0.0006 0.0017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0029 0.0084
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0127 0.3439
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0029 0.0084
Echinococcus granulosus allatostatin A receptor 0.0009 0.0029 0.0084
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0001 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi hypothetical protein 0.0005 0.0001 0.001
Plasmodium falciparum glutathione reductase 0.0012 0.0052 0.1248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Plasmodium vivax thioredoxin reductase, putative 0.0033 0.0224 1
Loa Loa (eye worm) Smad1 0.0006 0.0006 0.0094
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0029 0.0084
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0012 0.0052 0.0025
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0029 0.0084
Echinococcus multilocularis serotonin receptor 0.0009 0.0029 0.0084
Mycobacterium tuberculosis Probable reductase 0.0076 0.056 0.0714
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0029 0.0084
Schistosoma mansoni smad1 5 8 and 0.0006 0.0006 0.0017
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0359 0.2791 0.2753
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0175 0.511
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0001 0.001
Onchocerca volvulus 0.0015 0.0082 0.4093
Brugia malayi hypothetical protein 0.0015 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Schistosoma mansoni hypothetical protein 0.0009 0.0029 0.0084
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0027 0.0175 0.2806
Brugia malayi G-protein coupled receptor 0.0009 0.0029 0.0458
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0045 0.2253
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0008 0.0028 0.0441
Echinococcus granulosus dnaJ subfamily B 0.0434 0.339 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0011 0.0045 0.2253
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Schistosoma mansoni biogenic amine receptor 0.0009 0.0029 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0001 0.0031
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0029 0.0458
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0045 0.0162
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Trichomonas vaginalis MYB, putative 0.003 0.0196 1
Onchocerca volvulus 0.0009 0.0029 0.1421
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0001 0.0002
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0127 0.0374
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Echinococcus multilocularis cpg binding protein 0.0032 0.0215 0.0635
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0012 0.0052 0.0829
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Onchocerca volvulus Peroxidasin homolog 0.0015 0.0082 0.4093
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0127 0.0374
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0027 0.0175 0.0517
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0042 0.0151
Schistosoma mansoni Smad4 0.0006 0.0006 0.0017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0045 0.0727
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0127 0.2031
Onchocerca volvulus 0.0009 0.0029 0.1421
Leishmania major trypanothione reductase 0.0033 0.0224 0.6778
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0045 0.0727
Schistosoma mansoni DNA polymerase IV / kappa 0.0008 0.0027 0.008
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0012 0.0052 0.0025
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0029 0.0084
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0175 0.0173
Loa Loa (eye worm) animal heme peroxidase 0.0015 0.0082 0.1321
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0076 0.056 0.0714
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0029 0.0084
Toxoplasma gondii NADPH-glutathione reductase 0.0012 0.0052 0.0185
Brugia malayi MH2 domain containing protein 0.0006 0.0006 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0009 0.0029 0.1421
Trichomonas vaginalis mercuric reductase, putative 0.0012 0.0052 0.2024
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Brugia malayi MH2 domain containing protein 0.0006 0.0006 0.0094
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) glutathione reductase 0.0033 0.0224 0.358
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0006 0.0006 0.0017
Giardia lamblia DNA damage repair protein 0.0008 0.0027 0.1392
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Trichomonas vaginalis C-MYB, putative 0.003 0.0195 0.9938
Onchocerca volvulus Peroxidasin homolog 0.0015 0.0082 0.4093
Brugia malayi ORL1-like opioid receptor 0.0009 0.0029 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0127 0.3439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0045 0.0727
Echinococcus granulosus g protein coupled receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0015 0.0082 0.4093
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0127 0.3439
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0029 0.0084
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1272 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi hypothetical protein 0.0006 0.0005 0.0087
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0127 0.0454
Loa Loa (eye worm) thioredoxin reductase 0.0033 0.0224 0.358
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0012 0.0052 0.1248
Plasmodium vivax glutathione reductase, putative 0.0033 0.0224 1
Brugia malayi larval opioid receptor 0.0009 0.0029 0.0458
Echinococcus multilocularis mothers against decapentaplegic 5 0.0006 0.0006 0.0017
Brugia malayi nuclear hormone receptor 0.0011 0.0045 0.0727
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0029 0.0458
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0001 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0045 0.0134
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0045 0.0727
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0045 0.0727
Brugia malayi Serotonin receptor 0.0009 0.0029 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0109 0.281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Schistosoma mansoni neuropeptide receptor 0.0009 0.0029 0.0084
Schistosoma mansoni hypothetical protein 0.0009 0.0029 0.0084
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0001 0.001
Loa Loa (eye worm) blistered cuticle protein 3 0.0015 0.0082 0.1321
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0029 0.0458
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0029 0.0458
Echinococcus granulosus fmrfamide receptor 0.0009 0.0029 0.0084
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0029 0.0084
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) animal heme peroxidase 0.0015 0.0082 0.1321
Leishmania major DNA polymerase eta, putative 0.0026 0.0169 0.489
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.339 1
Echinococcus granulosus serotonin receptor 0.0009 0.0029 0.0084
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0045 0.2253
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Schistosoma mansoni opsin-like receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.002 0.006
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0084 0.0627 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0.0005 0.0087
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0027 0.0175 0.0517
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0084 0.0627 0.0808
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0029 0.0458
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0006 0.0006 0.0017
Schistosoma mansoni peroxidasin 0.0015 0.0082 0.0243
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0175 0.511
Brugia malayi ImpB/MucB/SamB family protein 0.0027 0.0175 0.2806
Schistosoma mansoni terminal deoxycytidyl transferase 0.0027 0.0175 0.0517
Brugia malayi polk-prov protein 0.0008 0.0027 0.0436
Schistosoma mansoni cpg binding protein 0.0032 0.0215 0.0635
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0033 0.0224 0.0241
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0006 0.0005 0.0016
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0008 0.0028 0.0441
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0026 0.0169 0.0605
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0045 0.0317 0.5075
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0027 0.0175 0.0173
Brugia malayi Animal haem peroxidase family protein 0.0015 0.0082 0.1321
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0029 0.0084
Brugia malayi Smad1 0.0006 0.0006 0.0094
Onchocerca volvulus 0.0009 0.0029 0.1421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0029 0.0084
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0175 0.511
Brugia malayi Dopamine receptor protein 2 0.0009 0.0029 0.0458
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0029 0.0458
Schistosoma mansoni myosin xvIII 0.0009 0.0029 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0045 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0045 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0045 0.0727
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0317 0.5075
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0029 0.0084
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1272 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0001 0.001
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0012 0.0052 0.1248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0045 0.0134
Schistosoma mansoni neuropeptide receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0009 0.0029 0.0084
Brugia malayi nuclear receptor RXR 0.0006 0.0005 0.0087
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0726
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0029 0.0084
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0045 0.0727
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0006 0.0005 0.0016
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0001 0.0002
Schistosoma mansoni nuclear receptor 0.0005 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Echinococcus multilocularis dna polymerase eta 0.0045 0.0317 0.0935
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0029 0.0458
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0127 0.5074
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0045 0.0727
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0153
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0034 0.0548
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0029 0.0084
Brugia malayi nuclear receptor NHR-67 0.0005 0.0001 0.001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0029 0.0084
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0029 0.0084
Echinococcus granulosus smad 0.0006 0.0006 0.0017
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0029 0.0084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0015 0.0000000037959
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0045 0.0134
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0029 0.0084
Plasmodium falciparum thioredoxin reductase 0.0033 0.0224 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0153
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0029 0.0084
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0001 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni DNA helicase recq1 0.0021 0.0127 0.0374
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0045 0.0134
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0076 0.056 0.0714
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0076 0.056 0.0714
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Schistosoma mansoni coup transcription factor 0.0011 0.0045 0.0134
Brugia malayi Peroxidasin 0.0015 0.0082 0.1321
Mycobacterium ulcerans DNA polymerase IV 0.0027 0.0175 0.0148
Schistosoma mansoni amine GPCR 0.0009 0.0029 0.0084
Echinococcus multilocularis Smad4 0.0006 0.0006 0.0017
Brugia malayi Animal haem peroxidase family protein 0.0015 0.0082 0.1321
Brugia malayi AKH receptor 0.0009 0.0029 0.0458
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0029 0.0084
Schistosoma mansoni adenoreceptor 0.0009 0.0029 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0029 0.0084
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0127 0.5555
Schistosoma mansoni opsin-like receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0005 0.0001 0.0031
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0042 0.0758
Brugia malayi Dopamine receptor protein 1 0.0009 0.0029 0.0458
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0025
Toxoplasma gondii thioredoxin reductase 0.0033 0.0224 0.0801
Brugia malayi G protein-coupled receptor 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0001 0.0002
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0029 0.0084
Schistosoma mansoni histamine h1 receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.003 0.0196 0.0701
Plasmodium falciparum thioredoxin reductase 0.0012 0.0052 0.1248
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0029 0.0084
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0029 0.0084
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0029 0.0084
Treponema pallidum NADH oxidase 0.0012 0.0052 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0045 0.0134
Trichomonas vaginalis DNA polymerase eta, putative 0.0027 0.0175 0.8864
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0127 0.0374
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0045 0.0625
Brugia malayi Serotonin receptor 0.0009 0.0029 0.0458
Trichomonas vaginalis MYB72, putative 0.003 0.0195 0.9938
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0045 0.0134
Brugia malayi Animal haem peroxidase family protein 0.0015 0.0082 0.1321
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0195 0.9938
Schistosoma mansoni peroxidasin 0.0015 0.0082 0.0243
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0035 0.0104
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0027 0.0175 0.511
Echinococcus multilocularis sex peptide receptor 0.0009 0.0029 0.0084
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0045 0.0923
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0012 0.0052 0.1248
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0012 0.0052 0.0846
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0913 0.717 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Onchocerca volvulus Dual oxidase homolog 0.0015 0.0082 0.4093
Loa Loa (eye worm) animal heme peroxidase 0.0015 0.0082 0.1321
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0029 0.0084
Brugia malayi Thioredoxin reductase 0.0033 0.0224 0.358
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus multilocularis serotonin receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni hypothetical protein 0.0119 0.0903 0.2662
Trichomonas vaginalis pc-MYB2, putative 0.003 0.0195 0.9938
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0029 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0109 0.281
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0471 0.1391
Schistosoma mansoni hypothetical protein 0.0009 0.0029 0.0084
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0201 0.3227
Trichomonas vaginalis MYB3r3, putative 0.003 0.0195 0.9938
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Onchocerca volvulus 0.0009 0.0029 0.1421
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0029 0.0084
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0029 0.0458
Loa Loa (eye worm) animal heme peroxidase 0.0015 0.0082 0.1321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0029 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0045 0.0134
Schistosoma mansoni amine GPCR 0.0009 0.0029 0.0084
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0001 0.0002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0127 0.2031
Onchocerca volvulus 0.0009 0.0029 0.1421
Onchocerca volvulus 0.0009 0.0029 0.1421
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0196 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0045 0.0134
Schistosoma mansoni DNA helicase recq5 0.0021 0.0127 0.0374
Onchocerca volvulus 0.0009 0.0029 0.1421
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0029 0.0084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0029 0.0084
Leishmania major DNA polymerase kappa, putative 0.0027 0.0175 0.511
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Echinococcus granulosus dna polymerase eta 0.0045 0.0317 0.0935
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0045 0.0727
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0012 0.0052 0.0846
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0042 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Loa Loa (eye worm) hypothetical protein 0.0011 0.0045 0.0727
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.003 0.0195 1
Schistosoma mansoni opsin-like receptor 0.0009 0.0029 0.0084
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0127 0.5074
Trypanosoma brucei unspecified product 0.0019 0.0109 0.281
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0045 0.0134
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.002 0.006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Trypanosoma cruzi trypanothione reductase, putative 0.0012 0.0052 0.0846
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0175 0.511
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0359 0.2791 0.3375
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0029 0.0084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0127 0.0454
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0045 0.0134
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0045 0.0134
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0029 0.0084
Brugia malayi sulfakinin receptor protein 0.0009 0.0029 0.0458
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0127 0.6183
Echinococcus granulosus g protein coupled receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0196 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0012 0.0052 0.0153
Brugia malayi nuclear receptor NHR-88 0.0005 0.0001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0084 0.0624 1
Schistosoma mansoni neuropeptide receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0045 0.0727
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.002 0.006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Brugia malayi hypothetical protein 0.0009 0.0029 0.0458
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0001 0.0002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0045 0.0134
Trypanosoma brucei unspecified product 0.0019 0.0109 0.281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0015 0.0000000037959
Loa Loa (eye worm) hypothetical protein 0.0009 0.0029 0.0458
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0012 0.0052 0.0846
Onchocerca volvulus 0.0009 0.0029 0.1421
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.0045 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0045 0.0727
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Brugia malayi CXXC zinc finger family protein 0.0031 0.0201 0.3227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0045 0.0727
Schistosoma mansoni hypothetical protein 0.0119 0.0903 0.2662
Trypanosoma brucei DNA polymerase IV, putative 0.0027 0.0175 0.511
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.002 0.006
Brugia malayi GnHR receptor homolog 0.0009 0.0029 0.0458
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.003 0.0195 0.9938
Schistosoma mansoni amine GPCR 0.0009 0.0029 0.0084
Brugia malayi RE15519p 0.0009 0.0029 0.0458
Brugia malayi MH2 domain containing protein 0.0084 0.0624 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0082 0.1321
Echinococcus multilocularis geminin 0.0119 0.0903 0.2662
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0045 0.0134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0012 0.0052 0.0846
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0045 0.0134
Loa Loa (eye worm) hypothetical protein 0.0006 0.0005 0.0087
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0029 0.0084
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0317 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0127 0.2031
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0029 0.0084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Trypanosoma cruzi DNA polymerase eta, putative 0.0026 0.0169 0.489
Echinococcus multilocularis peroxidasin 0.0015 0.0082 0.0243
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0029 0.0458
Echinococcus granulosus thioredoxin glutathione reductase 0.0033 0.0224 0.0659
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0029 0.0084
Leishmania major DNA polymerase eta, putative 0.0045 0.0317 1
Trichomonas vaginalis C-MYB, putative 0.003 0.0195 0.9938
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0029 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0027 0.0175 0.511
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0012 0.0052 0.0185
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0127 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0045 0.0727
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0359 0.2791 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0029 0.0084
Brugia malayi ecdysone receptor 0.0005 0.0001 0.001
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0029 0.0084
Brugia malayi MH1 domain containing protein 0.0006 0.0006 0.0094
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0029 0.0084
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0029 0.0084
Echinococcus granulosus mothers against decapentaplegic 5 0.0006 0.0006 0.0017
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0029 0.0084
Loa Loa (eye worm) transcription factor SMAD2 0.0084 0.0624 1
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0029 0.0084
Trypanosoma brucei trypanothione reductase 0.0033 0.0224 0.6778
Brugia malayi G-protein coupled receptor 0.0009 0.0029 0.0458

Activities

Activity type Activity value Assay description Source Reference
ED30 (functional) 0 mg kg-1 Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by intravenous administration; Not tested ChEMBL. No reference
ED30 (functional) 0 mg kg-1 Effective dose of the compound to lower blood pressure by 30 mmHg in renal hypertensive rats by peroral administration; Not tested ChEMBL. No reference
IC50 (binding) = 7 nM Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes ChEMBL. No reference
IC50 (binding) = 7 nM Displacement of [125I]- Ang II from angiotensin II AT1 receptor in rat adrenal cortical microsomes ChEMBL. No reference
IC50 (binding) = 20 nM Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes ChEMBL. No reference
IC50 (binding) = 20 nM Displacement of [125I]- Ang II from angiotensin II AT2 receptor in rat adrenal cortical microsomes ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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