Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Adenosine deaminase homolog | 0.0366 | 1 | 0.5 |
Leishmania major | adenine aminohydrolase | 0.0366 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.0366 | 1 | 0.5 |
Plasmodium falciparum | adenosine deaminase | 0.0366 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0366 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0366 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0366 | 1 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0366 | 1 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.0366 | 1 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.0366 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.0366 | 1 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.0366 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0366 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.0366 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.0366 | 1 | 0.5 |
Echinococcus multilocularis | adenosine deaminase | 0.0366 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.0366 | 1 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.0366 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 91.14 uM | Inhibition of biotin-dUTP labeled HIV-1 reverse transcriptase after 30 mins colorimetric streptavidin alkaline phosphatase reporter system | ChEMBL. | 20347295 |
IC50 (binding) | = 91.14 uM | Inhibition of HIV1 reverse transcriptase by ELISA | ChEMBL. | 20371182 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.