Detailed information for compound 915363

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1308.51 | Formula: C69H93N7O18
  • H donors: 7 H acceptors: 12 LogP: 4.43 Rotable bonds: 36
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N(CCN(C(=O)O[C@H](C(c1ccccc1)NC(=O)c1ccccc1)C(=O)OC1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@@H]([C@]3(C(=O)[C@@H](C(=C1C)C2(C)C)OC(=O)C)C)O)OC(=O)C)C)C)NC(=O)[C@@H](NC(=O)[C@@H](C(C)C)N)CC(C)C
  • InChi: 1S/C69H93N7O18/c1-38(2)34-47(73-61(83)52(71)39(3)4)60(82)72-46(30-22-23-31-70)62(84)75(11)32-33-76(12)65(87)92-55(53(43-24-16-13-17-25-43)74-59(81)44-26-18-14-19-27-44)64(86)91-48-36-69(88)58(93-63(85)45-28-20-15-21-29-45)56-67(10,49(79)35-50-68(56,37-89-50)94-42(7)78)57(80)54(90-41(6)77)51(40(48)5)66(69,8)9/h13-21,24-29,38-39,46-50,52-56,58,79,88H,22-23,30-37,70-71H2,1-12H3,(H,72,82)(H,73,83)(H,74,81)/t46-,47-,48?,49-,50+,52+,53?,54+,55+,56-,58-,67+,68-,69+/m0/s1
  • InChiKey: RMFCVPMHNPCWIF-SOVIITAVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0359 0.1993 0.1975
Schistosoma mansoni hypothetical protein 0.0179 0.0914 0.109
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0029 0.001 0.0012
Echinococcus multilocularis hepatoma derived growth factor protein 0.0116 0.0536 0.0639
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0063 0.0215 0.0314
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Loa Loa (eye worm) hypothetical protein 0.0063 0.0215 0.0236
Leishmania major modification methylase-like protein 0.0581 0.3331 0.5335
Toxoplasma gondii hypothetical protein 0.0116 0.0536 0.0946
Brugia malayi uridine phosphorylase family protein 0.0104 0.0463 0.0498
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0581 0.3331 0.5333
Echinococcus multilocularis histone lysine n methyltransferase setb1 0.0036 0.0052 0.0062
Loa Loa (eye worm) hypothetical protein 0.0229 0.1211 0.1332
Onchocerca volvulus 0.0055 0.0165 0.0143
Leishmania major hypothetical protein, conserved 0.0115 0.0528 0.082
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0049 0.0133 0.0158
Loa Loa (eye worm) hypothetical protein 0.0114 0.0522 0.0574
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0433 0.2439 0.3897
Brugia malayi Bromodomain containing protein 0.0031 0.0022 0.0012
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0104 0.0463 1
Onchocerca volvulus 0.0402 0.2255 0.2238
Schistosoma mansoni phd finger protein 0.0116 0.0536 0.0639
Loa Loa (eye worm) hypothetical protein 0.0055 0.0165 0.0181
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0837 0.4873 1
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0131 0.0627 0.0747
Echinococcus granulosus protein arginine N methyltransferase 7 0.003 0.002 0.0023
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.0563 0.322 0.5155
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0022 0.0026
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0049 0.0133 0.0158
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0032 0.0031 0.0022
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0317 0.174 0.2074
Brugia malayi jmjC domain containing protein 0.0101 0.0444 0.0477
Echinococcus granulosus microtubule associated protein 2 0.1422 0.8388 1
Toxoplasma gondii phosphorylase family protein 0.0104 0.0463 0.0812
Loa Loa (eye worm) hypothetical protein 0.0359 0.1993 0.2191
Loa Loa (eye worm) hypothetical protein 0.0053 0.0154 0.017
Loa Loa (eye worm) hypothetical protein 0.0427 0.2405 0.2645
Brugia malayi MTAP 0.0563 0.322 0.3533
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0049 0.0133 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0229 0.1211 0.1444
Schistosoma mansoni methylthioadenosine phosphorylase 0.0104 0.0463 0.0552
Leishmania major S-adenosylmethionine decarboxylase 0.0433 0.2439 0.3897
Trypanosoma cruzi spermidine synthase, putative 0.1063 0.6227 1
Schistosoma mansoni cpg binding protein 0.0402 0.2255 0.2688
Giardia lamblia UPL-1 0.0104 0.0463 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0219 0.0241
Brugia malayi hypothetical protein 0.0359 0.1993 0.2182
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0536 0.0832
Leishmania major nucleoside phosphorylase-like protein 0.0104 0.0463 0.0714
Echinococcus granulosus methylthioadenosine phosphorylase 0.0563 0.322 0.3838
Schistosoma mansoni purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus multilocularis peregrin 0.0147 0.0721 0.086
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0563 0.322 0.354
Loa Loa (eye worm) hypothetical protein 0.0051 0.0143 0.0157
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0115 0.0528 0.082
Loa Loa (eye worm) hypothetical protein 0.0906 0.5287 0.5813
Echinococcus granulosus metastasis associated protein MTA1 0.0049 0.0133 0.0158
Schistosoma mansoni purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0115 0.0528 0.082
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0049 0.0133 0.0158
Onchocerca volvulus 0.028 0.1518 0.1499
Schistosoma mansoni jumonji domain containing protein 0.008 0.0319 0.038
Schistosoma mansoni hepatoma derived growth factor 0.0116 0.0536 0.0639
Leishmania major hypothetical protein, conserved 0.0116 0.0536 0.0832
Entamoeba histolytica hypothetical protein 0.0104 0.0463 0.1338
Trypanosoma cruzi spermidine synthase, putative 0.1063 0.6227 1
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0211 0.1104 0.1744
Schistosoma mansoni uridine phosphorylase 0.0104 0.0463 0.0552
Schistosoma mansoni bromo adjacent homology domain containing 0.0049 0.0133 0.0158
Toxoplasma gondii hypothetical protein 0.0115 0.0528 0.0932
Schistosoma mansoni hypothetical protein 0.0116 0.0536 0.0639
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.0563 0.322 0.6252
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0433 0.2439 0.2907
Schistosoma mansoni polybromo-1 0.0049 0.0133 0.0158
Trypanosoma cruzi spermidine synthase, putative 0.1063 0.6227 1
Brugia malayi NNMT/PNMT/TEMT family protein 0.0951 0.5554 0.6102
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Echinococcus granulosus peregrin 0.0147 0.0721 0.086
Trichomonas vaginalis set domain proteins, putative 0.169 1 1
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0063 0.0215 0.0314
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0079 0.0313 0.0373
Echinococcus multilocularis protein arginine N methyltransferase 7 0.003 0.002 0.0023
Brugia malayi PHD-finger family protein 0.0031 0.0022 0.0012
Loa Loa (eye worm) hypothetical protein 0.0073 0.0274 0.0301
Loa Loa (eye worm) hypothetical protein 0.0951 0.5554 0.6107
Brugia malayi jmjC domain containing protein 0.0039 0.0071 0.0067
Schistosoma mansoni hypothetical protein 0.0116 0.0536 0.0639
Loa Loa (eye worm) uridine phosphorylase 0.0104 0.0463 0.0509
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0032 0.0029 0.0035
Plasmodium vivax SET domain protein, putative 0.0166 0.0832 0.1306
Brugia malayi SET domain containing protein 0.0066 0.0234 0.0246
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0071 0.0085
Echinococcus granulosus hepatoma derived growth factor protein 0.0116 0.0536 0.0639
Toxoplasma gondii Purine nucleoside phosphorylase 0.0104 0.0463 0.0812
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.009 0.0376 0.0571
Trichomonas vaginalis CDC6, putative 0.0049 0.0133 0.0113
Brugia malayi MH2 domain containing protein 0.0119 0.0552 0.0596
Mycobacterium ulcerans spermidine synthase 0.0837 0.4873 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0166 0.0832 0.0992
Schistosoma mansoni suppressor of variegation 4-20-related 0.0145 0.0711 0.0847
Chlamydia trachomatis AMP nucleosidase 0.0104 0.0463 0.5
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0951 0.5554 0.6107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0052 0.0057
Loa Loa (eye worm) hypothetical protein 0.0116 0.0536 0.0589
Echinococcus multilocularis cpg binding protein 0.0404 0.2265 0.27
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0427 0.2405 0.2868
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0061 0.0072
Brugia malayi hypothetical protein 0.0063 0.0215 0.0225
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0154 0.0761 0.0908
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0031 0.0012
Trypanosoma brucei histone-lysine n-methyltransferase 0.0115 0.0528 0.082
Schistosoma mansoni protein arginine n-methyltransferase 0.0154 0.0761 0.0908
Treponema pallidum pfs protein (pfs) 0.0104 0.0463 0.5
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0581 0.3331 0.5333
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0049 0.0133 0.0158
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0463 0.0714
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0031 0.0038
Schistosoma mansoni hypothetical protein 0.0055 0.0167 0.0199
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Schistosoma mansoni histone J3 methyltransferase 0.0906 0.5287 0.6303
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0463 0.1338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0229 0.1211 0.1444
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0552 0.0607
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0104 0.0463 1
Brugia malayi Pre-SET motif family protein 0.1539 0.9095 1
Loa Loa (eye worm) protein arginine N-methyltransferase 0.003 0.002 0.0021
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0115 0.0528 0.082
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0463 0.1338
Brugia malayi Disco-interacting protein 2 homolog 0.0427 0.2405 0.2636
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0463 0.1338
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0104 0.0463 0.1338
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0094 0.0113
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0115 0.0528 0.082
Brugia malayi hypothetical protein 0.0359 0.1993 0.2182
Loa Loa (eye worm) hypothetical protein 0.0359 0.1993 0.2191
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0433 0.2439 0.3897
Echinococcus multilocularis polybromo 1 0.0049 0.0133 0.0158
Echinococcus granulosus metastasis associated protein 1 mta1 0.0049 0.0133 0.0158
Onchocerca volvulus 0.0123 0.0578 0.0558
Loa Loa (eye worm) SET domain-containing protein 0.0145 0.0711 0.0781
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0552 0.0607
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0031 0.0012
Echinococcus multilocularis histone h3 methyltransferase 0.0906 0.5287 0.6303
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.0444 0.0529
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0166 0.0832 0.1488
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0463 0.0714
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0131 0.0627 0.0747
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0581 0.3331 1
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0581 0.3331 0.6066
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0049 0.0133 0.0158
Loa Loa (eye worm) hypothetical protein 0.0359 0.1993 0.2191
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0049 0.0133 0.0158
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0116 0.0536 0.0832
Leishmania major histone-lysine N-methyltransferase, putative 0.0115 0.0528 0.082
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0022 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.028 0.1518 0.1809
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0154 0.0761 0.1359
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0229 0.1211 0.1444
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0146
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0032 0.0031 0.0038
Echinococcus multilocularis uridine phosphorylase 1 0.0104 0.0463 0.0552
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0022 0.0004
Trypanosoma brucei spermidine synthase 0.1063 0.6227 1
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0463 0.0444
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0563 0.322 0.5155
Trypanosoma brucei transcription elongation factor s-II, putative 0.0116 0.0536 0.0832
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus multilocularis microtubule associated protein 2 0.1422 0.8388 1
Schistosoma mansoni cpg binding protein 0.0404 0.2265 0.27
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0104 0.0463 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0938 0.548 0.8795
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0104 0.0463 0.5
Brugia malayi PWWP domain containing protein 0.0116 0.0536 0.0578
Echinococcus multilocularis spermidine synthase 0.1063 0.6227 0.7424
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0906 0.5287 0.5808
Brugia malayi CXXC zinc finger family protein 0.0402 0.2255 0.247
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0104 0.0463 0.0444
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0115 0.0528 0.082
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0104 0.0463 1
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0433 0.2439 0.3897
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0458 0.2593 0.4831
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0094 0.0113
Echinococcus multilocularis tumor protein p63 0.0373 0.208 0.248
Brugia malayi SET domain containing protein 0.0129 0.0612 0.0663
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0063 0.0215 0.0314
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0154 0.0761 0.0908
Brugia malayi SET domain containing protein 0.0317 0.174 0.1904
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0146
Schistosoma mansoni hypothetical protein 0.0179 0.0914 0.109
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0145 0.0711 0.0847
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0186 0.0957 0.1141
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0104 0.0463 0.0714
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0022 0.0024
Schistosoma mansoni hepatoma derived growth factor 0.0116 0.0536 0.0639
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0071 0.0085
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0463 0.1338
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0031 0.0038
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Loa Loa (eye worm) hypothetical protein 0.0049 0.0133 0.0146
Brugia malayi hypothetical protein 0.0116 0.0536 0.0578
Schistosoma mansoni hypothetical protein 0.003 0.002 0.0023
Brugia malayi hypothetical protein 0.0116 0.0536 0.0578
Loa Loa (eye worm) PWWP domain-containing protein 0.0116 0.0536 0.0589
Plasmodium vivax spermidine synthase, putative 0.1063 0.6227 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0229 0.1211 0.1444
Loa Loa (eye worm) hypothetical protein 0.0031 0.0022 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0463 0.0444
Schistosoma mansoni hypothetical protein 0.0049 0.0133 0.0158
Brugia malayi GATA zinc finger family protein 0.0049 0.0133 0.0135
Schistosoma mansoni methylthioadenosine phosphorylase 0.0563 0.322 0.3838
Leishmania major spermidine synthase 0.1063 0.6227 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0563 0.322 0.3838
Echinococcus granulosus disco interacting protein 2 0.0427 0.2405 0.2868
Loa Loa (eye worm) CXXC zinc finger family protein 0.0402 0.2255 0.2479
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0211 0.1104 0.1744
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Toxoplasma gondii histone lysine methyltransferase SET1 0.0072 0.0271 0.0461
Echinococcus granulosus methyltransferase protein 5 0.003 0.002 0.0023
Echinococcus granulosus cpg binding protein 0.0404 0.2265 0.27
Toxoplasma gondii DNA methyltransferase 2, putative 0.0581 0.3331 0.6066
Echinococcus granulosus protein arginine N methyltransferase 8 0.0032 0.0031 0.0038
Brugia malayi F/Y-rich N-terminus family protein 0.0034 0.004 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0166 0.0832 0.0992
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0071 0.0085
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0145 0.0711 0.0847
Loa Loa (eye worm) hypothetical protein 0.0951 0.5554 0.6107
Entamoeba histolytica hypothetical protein 0.0116 0.0536 0.1559
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Echinococcus granulosus spermidine synthase 0.1063 0.6227 0.7424
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0029 0.001 0.0012
Echinococcus granulosus uridine phosphorylase 1 0.0104 0.0463 0.0552
Echinococcus multilocularis PWWP domain containing protein 2A 0.0116 0.0536 0.0639
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0165 0.0196
Brugia malayi ELM2 domain containing protein 0.0049 0.0133 0.0135
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0032 0.0031 0.0012
Schistosoma mansoni uridine phosphorylase 0.0104 0.0463 0.0552
Toxoplasma gondii hypothetical protein 0.0938 0.548 1
Treponema pallidum uridine phosphorylase (udp) 0.0104 0.0463 0.5
Trypanosoma cruzi spermidine synthase, putative 0.1063 0.6227 1
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.009 0.0376 0.0571
Echinococcus granulosus tumor protein p63 0.0373 0.208 0.248
Leishmania major arginine N-methyltransferase-like protein 0.0032 0.0031 0.0019
Onchocerca volvulus 0.0116 0.0536 0.0515
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0104 0.0463 0.0442
Echinococcus multilocularis disco interacting protein 2 0.0427 0.2405 0.2868
Schistosoma mansoni methylthioadenosine phosphorylase 0.0563 0.322 0.3838
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1539 0.9095 1
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0104 0.0463 0.0498
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0433 0.2439 0.3897
Loa Loa (eye worm) SET domain-containing protein 0.0317 0.174 0.1913
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0711
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0032 0.0031 0.0038
Schistosoma mansoni SET domain protein 0.0133 0.0637 0.0759
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0581 0.3331 0.3972
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Brugia malayi SET domain containing protein 0.0145 0.0711 0.0771
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Leishmania major methylthioadenosine phosphorylase, putative 0.0563 0.322 0.5155
Brugia malayi Carm1-pending protein 0.0154 0.0761 0.0827
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0022 0.0026
Echinococcus multilocularis metastasis associated protein MTA1 0.0049 0.0133 0.0158
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0581 0.3331 0.5335
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0104 0.0463 0.1338
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0536 0.0832
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0022 0.0004
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus granulosus SET and MYND domain containing protein 3 0.0075 0.0286 0.0341
Echinococcus granulosus PWWP domain containing protein 2A 0.0116 0.0536 0.0639
Echinococcus granulosus PWWP domain containing protein 2A 0.0116 0.0536 0.0639
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0433 0.2439 0.2681
Toxoplasma gondii phosphorylase family protein 0.0104 0.0463 0.0812
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Schistosoma mansoni hypothetical protein 0.0031 0.0022 0.0026
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0116 0.0536 0.0832
Loa Loa (eye worm) Carm1-pending protein 0.0154 0.0761 0.0837
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Echinococcus multilocularis protein arginine methyltransferase 0.0032 0.0031 0.0038
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0317 0.174 0.2074
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0032 0.0031 0.0016
Schistosoma mansoni cpg binding protein 0.0404 0.2265 0.27
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0071 0.0078
Echinococcus granulosus purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Brugia malayi Pre-SET motif family protein 0.0201 0.1048 0.1142
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0433 0.2439 0.3897
Echinococcus granulosus geminin 0.0179 0.0914 0.109
Onchocerca volvulus 0.0427 0.2405 0.2389
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0075 0.0286 0.0341
Echinococcus granulosus histone lysine n methyltransferase setb1 0.0036 0.0052 0.0062
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0116 0.0536 0.0832
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0581 0.3331 0.3972
Trichomonas vaginalis origin recognition complex subunit, putative 0.0049 0.0133 0.0113
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0115 0.0528 0.082
Loa Loa (eye worm) spermidine synthase 0.1063 0.6227 0.6847
Echinococcus granulosus polybromo 1 0.0049 0.0133 0.0158
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0433 0.2439 0.2907
Echinococcus granulosus bromo adjacent y domain containing 1 0.0049 0.0133 0.0158
Schistosoma mansoni hypothetical protein 0.0116 0.0536 0.0639
Loa Loa (eye worm) hypothetical protein 0.012 0.0558 0.0613
Plasmodium falciparum purine nucleoside phosphorylase 0.0104 0.0463 0.0711
Brugia malayi Spermidine synthase 0.1063 0.6227 0.6844
Onchocerca volvulus 0.0116 0.0536 0.0515
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.0563 0.322 0.5155
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Schistosoma mansoni microtubule-associated protein tau 0.1422 0.8388 1
Plasmodium falciparum spermidine synthase 0.1063 0.6227 1
Trypanosoma brucei uridine phosphorylase 0.0104 0.0463 0.0714
Echinococcus granulosus protein arginine methyltransferase 0.0032 0.0031 0.0038
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus multilocularis purine nucleoside phosphorylase 0.0104 0.0463 0.0552
Echinococcus granulosus DNA methyltransferase 2, putative 0.0581 0.3331 0.3972
Entamoeba histolytica hypothetical protein 0.0063 0.0215 0.0589
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0049 0.0133 0.0158
Brugia malayi polybromodomain protein 0.0049 0.0133 0.0135
Leishmania major hypothetical protein, conserved 0.0115 0.0528 0.082
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0032 0.0031 0.0016
Echinococcus multilocularis PWWP domain containing protein 2A 0.0116 0.0536 0.0639
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0433 0.2439 0.2673
Mycobacterium leprae probable uridine phosphorylase 0.0104 0.0463 0.5
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0063 0.0215 0.0589
Schistosoma mansoni enhancer of zeste ezh 0.0317 0.174 0.2074
Echinococcus granulosus histone h3 methyltransferase 0.0906 0.5287 0.6303
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0104 0.0463 0.0444
Brugia malayi Protein arginine N-methyltransferase 0.003 0.002 0.001
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.0444 0.0529
Echinococcus multilocularis geminin 0.0179 0.0914 0.109

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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