Detailed information for compound 915365

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 767.011 | Formula: C52H54N4O2++
  • H donors: 0 H acceptors: 0 LogP: 6.95 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: c1ccc(cc1)C[N@+]12CCC34C2CC2C(=CCOC5C2C3N(c2c4cccc2)C2OCC=C3C4C2C2N5c5ccccc5C52CC[N@+](C5C4)(C3)Cc2ccccc2)C1
  • InChi: 1S/C52H54N4O2/c1-3-11-33(12-4-1)29-55-23-21-51-39-15-7-9-17-41(39)53-47(51)45-37(27-43(51)55)35(31-55)19-25-57-49(45)54-42-18-10-8-16-40(42)52-22-24-56(30-34-13-5-2-6-14-34)32-36-20-26-58-50(53)46(48(52)54)38(36)28-44(52)56/h1-20,37-38,43-50H,21-32H2/q+2/t37?,38?,43?,44?,45?,46?,47?,48?,49?,50?,51?,52?,55-,56-/m1/s1
  • InChiKey: IXWVDIIFVCHSRO-IRISBOPRSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Mycobacterium leprae Probable oxidoreductase 0.007 0.2916 0.5
Echinococcus multilocularis steroid dehydrogenase 0.007 0.2916 0.2916
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Plasmodium falciparum steroid dehydrogenase, putative 0.007 0.2916 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 0.2916 1
Brugia malayi dehydrogenases, short chain protein 2 0.007 0.2916 0.4349
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.007 0.2916 0.2916
Onchocerca volvulus 0.007 0.2916 0.4349
Entamoeba histolytica hypothetical protein 0.007 0.2916 0.748
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.007 0.2916 0.748
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Leishmania major short chain dehydrogenase, putative 0.007 0.2916 1
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.007 0.2916 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.007 0.2916 0.748
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Entamoeba histolytica short chain dehydrogenase family protein 0.007 0.2916 0.748
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.007 0.2916 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Brugia malayi hypothetical protein 0.0079 0.346 0.5161
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.007 0.2916 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 0.2916 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 0.2916 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Entamoeba histolytica hypothetical protein 0.0079 0.346 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium ulcerans dehydrogenase 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Entamoeba histolytica hypothetical protein, conserved 0.007 0.2916 0.748
Echinococcus multilocularis carbonyl reductase 1 0.007 0.2916 0.2916
Giardia lamblia Hypothetical protein 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Toxoplasma gondii oxidoreductase, putative 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Schistosoma mansoni transcription factor LCR-F1 0.0079 0.346 0.346
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Onchocerca volvulus 0.007 0.2916 0.4349
Mycobacterium ulcerans short-chain dehydrogenase 0.007 0.2916 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Echinococcus multilocularis retinol dehydrogenase 13 0.007 0.2916 0.2916
Echinococcus granulosus oxidoreductase 0.007 0.2916 0.2916
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Leishmania major pteridine reductase 1 0.007 0.2916 1
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 0.2916 1
Leishmania major hypothetical protein, conserved 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Echinococcus multilocularis retinol dehydrogenase 11 0.007 0.2916 0.2916
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 0.2916 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.007 0.2916 1
Schistosoma mansoni retinal dehydrogenase 0.007 0.2916 0.2916
Loa Loa (eye worm) hypothetical protein 0.0033 0.0745 0.1111
Entamoeba histolytica short chain dehydrogenase family protein 0.007 0.2916 0.748
Toxoplasma gondii oxidoreductase, putative 0.007 0.2916 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.007 0.2916 1
Echinococcus multilocularis carbonyl reductase 1 0.007 0.2916 0.2916
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 1
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.007 0.2916 0.2916
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0042 0.1301 0.1941
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0042 0.1301 0.4221
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.6704 1
Onchocerca volvulus 0.007 0.2916 0.4349
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0122 0.0182
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Mycobacterium ulcerans oxidoreductase 0.007 0.2916 1
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.007 0.2916 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.2916 0.4349
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.007 0.2916 0.2916
Plasmodium vivax steroid dehydrogenase, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 0.2916 0.4349
Loa Loa (eye worm) hypothetical protein 0.0134 0.6704 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Brugia malayi Cytochrome P450 family protein 0.0023 0.0122 0.0182
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 0.2916 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.007 0.2916 0.4349
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0042 0.1301 0.1301
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.2916 0.2916
Echinococcus granulosus carbonyl reductase 1 0.007 0.2916 0.2916
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0831 0.124
Echinococcus granulosus steroid dehydrogenase 0.007 0.2916 0.2916
Brugia malayi Cytochrome P450 family protein 0.0023 0.0122 0.0182
Schistosoma mansoni hypothetical protein 0.019 1 1
Mycobacterium ulcerans carveol-like dehydrogenase 0.007 0.2916 1
Echinococcus granulosus carbonyl reductase 1 0.007 0.2916 0.2916
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.007 0.2916 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0079 0.346 0.346
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Plasmodium vivax hypothetical protein, conserved 0.007 0.2916 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.007 0.2916 1
Schistosoma mansoni short-chain dehydrogenase/reductase 0.007 0.2916 0.2916
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.007 0.2916 0.2916
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.007 0.2916 1
Schistosoma mansoni carbonyl reductase 0.007 0.2916 0.2916
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Echinococcus granulosus hypothetical protein 0.007 0.2916 0.2916
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Toxoplasma gondii carbonyl reductase 1, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0079 0.346 0.346
Onchocerca volvulus 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.007 0.2916 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 0.2916 1
Mycobacterium ulcerans oxidoreductase 0.007 0.2916 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0042 0.1301 0.4221
Trichomonas vaginalis steroid dehydrogenase, putative 0.007 0.2916 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0745 0.1111
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.007 0.2916 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.165 0.246
Leishmania major short chain dehydrogenase/reductase, putative 0.007 0.2916 1
Echinococcus granulosus carbonyl reductase 1 0.007 0.2916 0.2916
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Brugia malayi exodeoxyribonuclease III family protein 0.0042 0.1301 0.1941
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.007 0.2916 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Echinococcus multilocularis retinol dehydrogenase 11 0.007 0.2916 0.2916
Treponema pallidum exodeoxyribonuclease (exoA) 0.0042 0.1301 0.5
Onchocerca volvulus 0.007 0.2916 0.4349
Brugia malayi hypothetical protein 0.007 0.2916 0.4349
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.007 0.2916 0.4349
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium ulcerans dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.007 0.2916 1
Loa Loa (eye worm) dehydrogenase 0.007 0.2916 0.4349
Onchocerca volvulus Huntingtin homolog 0.0134 0.6704 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Onchocerca volvulus Sepiapterin reductase homolog 0.007 0.2916 0.4349
Onchocerca volvulus 0.007 0.2916 0.4349
Onchocerca volvulus Huntingtin homolog 0.0134 0.6704 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.007 0.2916 1
Trypanosoma brucei oxidoreductase-like protein 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.007 0.2916 0.2916
Echinococcus multilocularis geminin 0.019 1 1
Brugia malayi oxidoreductase 0.007 0.2916 0.4349
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Brugia malayi dehydrogenases, short chain protein 9 0.007 0.2916 0.4349
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Giardia lamblia Reductase, putative 0.007 0.2916 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.007 0.2916 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.007 0.2916 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Entamoeba histolytica hypothetical protein 0.0079 0.346 1
Leishmania major short chain dehydrogenase, putative 0.007 0.2916 1
Schistosoma mansoni carbonyl reductase 0.007 0.2916 0.2916
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 0.2916 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.007 0.2916 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.007 0.2916 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.007 0.2916 0.2916
Mycobacterium ulcerans short-chain dehydrogenase 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.007 0.2916 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Echinococcus multilocularis steroid dehydrogenase 0.007 0.2916 0.2916
Schistosoma mansoni ap endonuclease 0.0042 0.1301 0.1301
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.007 0.2916 1
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.007 0.2916 0.4349
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.007 0.2916 0.2916
Mycobacterium ulcerans ketoacyl reductase 0.007 0.2916 1
Schistosoma mansoni hypothetical protein 0.019 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0042 0.1301 0.4221
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Trypanosoma cruzi oxidoreductase-like protein, putative 0.007 0.2916 1
Mycobacterium tuberculosis Possible ketoacyl reductase 0.007 0.2916 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0831 0.124
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 0.2916 1
Leishmania major oxidoreductase-like protein 0.007 0.2916 1
Leishmania major hypothetical protein, conserved 0.007 0.2916 1
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.007 0.2916 0.2916
Leishmania major short chain dehydrogenase-like protein 0.007 0.2916 1
Echinococcus granulosus hypothetical protein 0.007 0.2916 0.2916
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0042 0.1301 0.4221
Leishmania major hypothetical protein, conserved 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Brugia malayi Dehydrogenases, short chain protein 2 0.007 0.2916 0.4349
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Brugia malayi Retinol dehydrogenase 12 0.007 0.2916 0.4349
Leishmania major hypothetical protein, conserved 0.007 0.2916 1
Mycobacterium ulcerans ketoacyl reductase 0.007 0.2916 1
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 0.2916 0.748
Echinococcus multilocularis transient receptor potential cation channel 0.007 0.2916 0.2916
Leishmania major dehydrogenase-like protein 0.007 0.2916 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Loa Loa (eye worm) hypothetical protein 0.0048 0.165 0.246
Entamoeba histolytica hypothetical protein 0.0079 0.346 1
Mycobacterium ulcerans ketoacyl reductase 0.007 0.2916 1
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Onchocerca volvulus 0.007 0.2916 0.4349
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.2916 0.2916
Schistosoma mansoni short chain dehydrogenase 0.007 0.2916 0.2916
Echinococcus multilocularis conserved hypothetical protein 0.007 0.2916 0.2916
Trypanosoma cruzi short chain dehydrogenase, putative 0.007 0.2916 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Brugia malayi hypothetical protein 0.0134 0.6704 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Schistosoma mansoni carbonyl reductase 0.007 0.2916 0.2916
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium ulcerans short-chain dehydrogenase 0.007 0.2916 1
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.2916 1
Schistosoma mansoni hypothetical protein 0.0033 0.0745 0.0745
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.165 0.246
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.007 0.2916 0.2916
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0042 0.1301 0.4221
Schistosoma mansoni hypothetical protein 0.0079 0.346 0.346
Echinococcus multilocularis carbonyl reductase 1 0.007 0.2916 0.2916
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.007 0.2916 1
Leishmania major short chain dehydrogenase/reductase, putative 0.007 0.2916 1
Echinococcus multilocularis oxidoreductase 0.007 0.2916 0.2916
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium tuberculosis Possible oxidoreductase 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.007 0.2916 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.007 0.2916 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.007 0.2916 0.4349
Entamoeba histolytica hypothetical protein, conserved 0.007 0.2916 0.748
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.2916 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Echinococcus granulosus retinol dehydrogenase 11 0.007 0.2916 0.2916
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 0.2916 0.748
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0122 0.0182
Onchocerca volvulus 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable dehydrogenase 0.007 0.2916 1
Leishmania major quinonoid dihydropteridine reductase 0.007 0.2916 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.2916 0.2916
Echinococcus granulosus retinol dehydrogenase 11 0.007 0.2916 0.2916
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Echinococcus granulosus WW domain containing oxidoreductase 0.007 0.2916 0.2916
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Loa Loa (eye worm) oxidoreductase 0.007 0.2916 0.4349
Leishmania major hypothetical protein, conserved 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.2916 1
Loa Loa (eye worm) hypothetical protein 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable oxidoreductase 0.007 0.2916 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.007 0.2916 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.007 0.2916 0.4349
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.007 0.2916 1
Entamoeba histolytica hypothetical protein 0.0079 0.346 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0122 0.0182
Echinococcus granulosus carbonyl reductase 1 0.007 0.2916 0.2916
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0042 0.1301 0.1301
Giardia lamblia Short-chain dehydrogenase, putative 0.007 0.2916 1
Loa Loa (eye worm) dehydrogenase 0.007 0.2916 0.4349
Brugia malayi hypothetical protein 0.007 0.2916 0.4349
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.007 0.2916 0.748
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Brugia malayi Dehydrogenases, short chain protein 30 0.007 0.2916 0.4349
Echinococcus multilocularis carbonyl reductase 1 0.007 0.2916 0.2916
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.165 0.246
Mycobacterium ulcerans short chain dehydrogenase 0.007 0.2916 1
Mycobacterium ulcerans short-chain dehydrogenase 0.007 0.2916 1
Schistosoma mansoni ap endonuclease 0.0042 0.1301 0.1301
Trichomonas vaginalis short-chain dehydrogenase, putative 0.007 0.2916 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.007 0.2916 1
Schistosoma mansoni steroid dehydrogenase 0.007 0.2916 0.2916
Leishmania major 3-keto-dihydrosphingosine reductase 0.007 0.2916 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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